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Publications (92)
18F‐fluorodeoxyglucose positron emission tomography‐computed tomography (18F‐FDG PET/CT) parameters have shown a significant prognostic role in relapsed/refractory large B‐cell lymphoma (LBCL) patients undergoing CD19‐targeted chimeric antigen receptor (CAR) T‐cell therapy. While a substantial body of evidence exists on the prognostic value of PET/...
As indolent non‐Hodgkin's lymphomas (iNHLs) are very radiosensitive, radiation treatment (RT) has been established as an essential curative and palliative modality for early and advanced stages of the disease. Several studies have explored the role of very low‐dose RT for palliation in indolent non‐Hodgkin's lymphomas, demonstrating that this appro...
Background
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides a comprehensive assessment of health and risk factor trends at global, regional, national, and subnational levels. This study aims to examine the burden of diseases, injuries, and risk factors in the USA and highlight the disparities in health outcomes ac...
Background
The capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insights can facilitate effective planning, investment, and implementation strategies. Forecasting trends in disease and injury burden is not only crucial for policy makers but also garners substantial interest from...
This appendix provides supplementary tables and figures for the paper titled “The burden of diseases, injuries, and risk factors by state in the USA, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021.”
Introduction: While CD19-targeted chimeric antigen receptor (CAR) T-cell therapy can lead to durable remission in many patients with relapsed/refractory large-B cell lymphoma (LBCL), the majority will develop relapsed or refractory disease, necessitating effective salvage strategies. Therefore, we aim to evaluate the long-term outcomes of salvage r...
Background
There is currently no practice-based, multicenter database of poisoned patients admitted to intensive care units (ICUs). The INTOXICATE study, endorsed by the ESICM and EAPCCT, aimed to determine the rate of eventful admissions among acutely intoxicated adult ICU patients.
Methods
Ethical approval was obtained for this multicenter, pros...
CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has appreciably advanced treatment for relapsed or refractory large B-cell lymphoma (LBCL). During the critical interim of four to six weeks, until CAR T-cells are ready, radiation therapy (RT) can be used to control the disease. We present the case of a 64-year-old female with relapsed/r...
Radiation therapy (RT) is utilized as a bridging strategy for patients with aggressive B-cell lymphoma prior to CD19-targeted chimeric antigen receptor (CAR T)-cell therapy. RT has been shown to provide local control without exacerbating the toxicities associated with subsequent CAR T-cell infusion. However, a consensus on the optimal radiation dos...
Summary
Background Future trends in disease burden and drivers of health are of great interest to policy makers and the public
at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We
have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injur...
Summary
Background
Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injur...
This appendix provides further authorship detail for “Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021.”
This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors.
Supplement to: GBD 2021 Forecast...
Background
Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important follow...
EAGLE is an international study bringing together surgeons, anaesthetists and theatre teams around the world to share best practice. The common goal is to reduce the global anastomotic leak rate after right colectomy and ileocaecal resection.
Feel free to join ESCP Safe-anastomosis programme.
Background: Cancer patients are at higher risk of serious complications of COVID-19. Few studies evaluated the impact of COVID-19 on cancer patients in low- and middle-income countries. Our study aims to evaluate the outcomes of COVID-19 infection in cancer patients treated at our institution.
Methods: Medical records of patients with a positive C...
Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods: The internationally intended protocol, iteratively co-devel...
Background
In early stage diffuse large B-cell lymphoma (ESDLBL), tumor bulkiness is an important determinant of treatment and prognosis. Tumor bulk is usually measured on transverse computed tomography (CT) plane and variably defined from 5 to 10 cm.
Objectives
Our study aims to investigate the prognostic significance of bulky disease measured on...
PURPOSE
Axillary soft tissue (AXT) involvement with tumor cells extending beyond the positive lymph node (LN+) and extracapsular extension (ECE) has been overlooked in breast pathology specimen analysis.
MATERIALS AND METHODS
We analyzed 2,162 LN+ patients, dividing them into four groups on the basis of axillary pathology: (1) LN+ only, (2) LN+ an...
CD19‐targeted chimeric antigen receptor (CAR) T‐cell therapy has revolutionized treatment for patients with relapsed/refractory large B‐cell lymphoma (LBCL). However, data available concerning the impact of the prognostic value of quantitative 18F‐fluorodeoxyglucose positron emission tomography‐computed tomography (FDG PET/CT) parameters on the CAR...
BACKGROUND: The CovidSurg-Cancer Consortium aimed to explore the impact of COVID-19 in surgical patients and services for solid cancers at the start of the pandemic. The CovidSurg-Gynecologic Oncology Cancer subgroup was particularly concerned about the magnitude of adverse outcomes caused by the disrupted surgical gynecologic cancer care during th...
Importance Considering the lack of equipoise regarding the timing of cholecystectomy in patients with moderately severe and severe acute biliary pancreatitis (ABP), it is critical to assess this issue.
Objective To assess the outcomes of early cholecystectomy (EC) in patients with moderately severe and severe ABP.
Design, Settings, and Participan...
Importance:
Considering the lack of equipoise regarding the timing of cholecystectomy in patients with moderately severe and severe acute biliary pancreatitis (ABP), it is critical to assess this issue.
Objective:
To assess the outcomes of early cholecystectomy (EC) in patients with moderately severe and severe ABP.
Design, settings, and partic...
Importance:
Postoperative urinary retention (POUR) is a well-recognized complication of inguinal hernia repair (IHR). A variable incidence of POUR has previously been reported in this context, and contradictory evidence surrounds potential risk factors.
Objective:
To ascertain the incidence of, explore risk factors for, and determine the health...
Despite the success of CAR T-cell therapy in patients with relapsed/refractory large- B cell lymphoma (LBCL), there is a need for effective salvage strategies post-CD19-targeted chimeric antigen receptor (CAR T)-cell therapy failure. We conducted a multi-institutional retrospective study of patients who relapsed following CAR T-cell therapy [axicab...
Lymph node swelling is a side effect of the mRNA COVID-19 vaccines, a distressing side effect for women treated for breast cancer. The purpose of this study is to present side effects reported by a cohort of patients treated for breast cancer. A survey link was sent to 4945 women who received breast cancer treatment and were prospectively screened...
The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult pa...
Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Objective
Brain metastasis (BM) from bone and soft tissue sarcomas (STS) is very rare and mostly predicts dismal prognosis. Owing to its’ rarity, data on optimal therapy including surgical management, chemotherapy, and radiotherapy is scarce. We sought to assess the prevalence, disease characteristics, and outcomes of BM in bone and STS patients tr...
Objectives
To evaluate the outcomes of advanced‐stage laryngeal squamous cell carcinoma (SCC) patients treated with functional‐preservation strategy with a specific focus on laryngo‐esophageal dysfunction disease‐free survival (LEDDFS).
Methods and materials
A retrospective review was conducted of stage III‐IVB laryngeal SCC patients who were trea...
Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Background
The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Background
The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Purpose/Objective(s)
To evaluate the outcomes of advanced-stage laryngeal squamous cell carcinoma (SCC) patients (pts) treated with functional-preservation strategy at a tertiary cancer center with a specific focus on laryngo-esophageal dysfunction disease free survival (LDDFS).
Materials/Methods
Retrospective review was conducted of stage III-IVB...
Purpose/Objective(s)
To evaluate the safety and efficacy of bridging radiation therapy (RT) in patients with relapsed/refractory high-grade B cell lymphomas (HGBCL) undergoing CD19-targeted chimeric antigen receptor (CAR) T-cell therapy.
Materials/Methods
A multi-institutional retrospective study was performed for 352 patients with HGBCL treated w...
Purpose/Objective(s)
Presence of MYC, BCL2, and/or BCL6 translocations (i.e., double/triple-hit lymphoma [DHL/THL]) among patients with large cell lymphoma (LCL) is associated with reduced chemosensitivity, but less is known on its impact on radiotherapy (RT) efficacy.
Materials/Methods
This retrospective, multi-institutional, international cohort...
Purpose/Objective(s)
To define the prognostic value of quantitative positron emission tomography/computed tomography (PET/CT) parameters in diffuse large B-cell lymphoma (DLBCL) patients undergoing CAR T-cell therapy.
Materials/Methods
Sixty-three patients who had PET-CT scans done pre-CAR T infusion were retrospectively identified and analyzed in...
Purpose/Objective(s)
We sought to describe our early experience of using salvage RT (SRT) in patients with high-grade B-cell lymphoma (HGBCL) who relapsed after CD19 targeted chimeric antigen receptor (CAR) T cell therapy.
Materials/Methods
A multi-institutional retrospective study was conducted for consecutive HGBCL patients who received axi-cel...
Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...
Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality.
Methods Prospective cohort study in 10...
Context:
In early-stage diffuse large B-cell lymphoma (DLBCL), tumor bulkiness and stage-adjusted International Prognostic Index (sa-IPI) are the main determinants of treatment and prognosis. Bulky disease is variably defined from 5 to 10 cm.
Objectives:
The aim of our study is to investigate the prognostic significance of bulky disease measured...
Context:
We hypothesized that specific clinicopathologic characteristics are correlated with survival outcomes among high-grade B cell lymphomas (HGBCL) patients treated with CD19-targeted chimeric antigen receptor (CAR) T-cell therapy.
Objectives:
To identify the prognostic factors for survival outcomes among patients with relapsed/refractory H...
Context:
We hypothesized that CD19-targeted chimeric antigen receptor (CAR) T-cell therapy is safe and feasible among high-grade B cell lymphoma (HGBCL) patients with secondary central nervous system (CNS) lymphoma.
Objectives:
To evaluate the safety and efficacy of CD19-targeted CAR T-cell therapy in patients with relapsed/refractory HGBCL with...
Background/objectives: Reports about the implementation of recommendations from acute pancreatitis guidelines are scant. This study aimed to evaluate, on a patient-data basis, the contemporary practice patterns of management of biliary acute pancreatitis and to compare these practices with the recommendations by the most updated guidelines.
Method...
An estimated 30-40% of patients with diffuse large B cell lymphoma (DLBCL) will either relapse or have refractory disease with first-line chemoimmunotherapy. The standard approach for relapsed/refractory disease is salvage chemotherapy followed by autologous stem cell transplantation, but this approach cures fewer than 20% of patients in the modern...
the MANCTRA-1 Collaborative Group (see Appendix 1), coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit
Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerb...
e13601
Background: The COVID-19 pandemic has led to deteriorated outcomes among immunocompromised patients, significantly impacting cancer patients. However, little is known about the impact of the COVID-19 pandemic on cancer patients in low and middle-income countries. Therefore, we sought to investigate the characteristics and clinical outcomes o...