Haytham M. Daradka

Department of Medical Laboratory Sciences, Faculty of Pharmacy, Jadara University, P.O. Box 733, Irbid 21110, Jordan · Medical Laboratory Sciences

Background There is a growing interest in medicinal plants in recent years due to their many therapeutic benefits and low side effects. Among the medicinal plants is the African Adansonia digitata (baobab) that has edible fruit. In the current study, the effect of A. digitata juice consumption on the lipid profile was investigated. In addition, inh...

Background/ aim: The most common endocrine disorder in the world is type 2 DM, affecting 85-90% of all people with diabetes. Several studies have found an association between serum ferritin levels and HbA1c, so the current study was undertaken to examine the association between serum ferritin levels and HbA1c in Jordanian patient’s sample with type...

The antifungal activity of 10 plant extracts was tested against the phytopathogenic fungi, Alternaria alternata and Fusarium oxysporum, the pathogens of early blight and wilt diseases of tomato. Plants tested related to different families. Three doses (10, 50 and 100 mg/ml) of plant extracts were assayed on A. alternata and F. oxysporum by measurin...

ABSTRACT: Oxidative stress is a condition that might predispose individuals to diseases, including cancer. The 8- hydroxydeoxyguanosine (8-OHdG) is an index that reflects DNA damage caused by oxidative stress in the body. In this study, Commiphora molmol (Myrrh) (C. molmol) (Myrrh) that belongs to the family Burseraceae were investigated for its po...

Background: Many types of infection can cause diabetic foot ulcers Infections involving the bacteria; E. coli, Acinetobacter spp (MDR) and K. pneumoniae, pseudomonas aeruginosa, so the assessment of Bacterial profile and patterns is needed to understand the source and management of these injuries. Objective: To determine Bacterial infections profil...

Different phytochemicals from various plant species exhibit promising medicinal properties against cancer. Juniperus phoenicea is a plant species that has been found to present medicinal properties. Herein, crude extract and fractions of J. phoenicea were examined to determine its anticancer properties against several cancer cells. The active fract...

Background: Many types of infection can cause pus Infections involving the bacteria; E.coli, so the assessment of multidrug Bacterial profile and patterns is needed to understand the source and management of these injuries. Purpose: To determine infections and patterns toward antibiotics of pus isolates and recurrent wound infections in nongovernme...

Background: Pulcria crispa (P. crispa) is an herbal plant traditionally used to treat common ailments. Objective: In this study, we investigated P. crispa for its phytochemical constituents, antioxidant properties and effects on biochemical and hematological parameters as well as safety in albino rats. Methods: Phytochemical analysis of ethanolic e...

Pulicaria crispa is traditional medicinal plant belong to Asteraceae family which is commonly known as Githjath. This plant distributed in warm countries, it has used in folk medicine for the treatment of various ailments, the plant has been used for many years in conventional medicine for the cure of heart diseases and as gastroprotective, due to...

Abstract Pulicaria crispa is traditional medicinal plant belong to Asteraceae family which is commonly known as Githjath. This plant distributed in warm countries, it has used in folk medicine for the treatment of various ailments, the plant has been used for many years in conventional medicine for the cure of heart diseases and as gastroprotective...

Aim: The aim of this study is to evaluate the difference in pharmacokinetic parameters between the same brand drugs containing Cephalexin as the active ingredient distributed to both the private sector and the governmental sector in Jordan. Method: Plasma samples of two healthy volunteer groups have been examined at different time intervals after o...

Oxidative stress is a status that can prevent people from suffering from diseases including cancer. The 8-hydroxydeoxyguanosine (8-OHdG) is a marker that reflects oxidative DNA damage in the body. In this study, Traganum nudatum plants were investigated for their potential to protect cellular DNA from oxidative damage by evaluating 8-OHdG assays in...

Oxidative stress is a status that can prevent people from suffering from diseases including cancer. The 8-hydroxydeoxyguanosine (8-OHdG) is a marker that reflects oxidative DNA damage in the body. In this study, Traganum nudatum plants were investigated for their potential to protect cellular DNA from oxidative damage by evaluating 8-OHdG assays in...

Tobacco and waterpipe use among university students, Saudi Arabia: impact of tobacco sales ban Background: Waterpipe smoking is a method of tobacco consumption that continues to spread globally. In 2002, a ban of tobacco sales was adopted in the Saudi Arabian cites of Mecca and Medina. Aims: This study aimed to examine prevalence of waterpipe and...

Oxidative stress is a condition that might predispose the individuals to diseases including cancer. The 8-hydroxydeoxyguanosine (8-OHdG) is a marker that reflects oxidative DNA damage in the body. In this study, seven Saudi medicinal plants were investigated for their potential against oxidative DNA damage using the 8-OHdG assay in cultured human l...

ABSTRACT Objective: Aerial parts of Zygophyllum simplex are often used for the medical treatment of skin’s horny patches and as an analgesic, anti-inflammatory and anthelmintic due to its unique bioactivities. Method: The antihyperlipidemic and antioxidant effects of the ethanolic extract of Z. simplex leaves in high-fat diet (HFD) induced hyperlip...

Traganum nudatum (T. nudatum) is a medicinal plant widely used in folk medicine. In this study, we have undertaken the biological effects of T. nudatum ethanolic whole plant extracts in alloxan induced diabetic rats. Sixty albino rats (260 g) were used in this experiment and divided into six groups. Diabetes was induced in five rat groups by a sing...

Background and objective: Zygophyllum simplex is commonly used in Saudi Arabia for the treatment of horny patches of skin and as an anthelmintic, analgesic and anti-inflammatory. The experiment was to aimed at to evaluate the constituents of Zygophyllum simplex extract and their effect on blood biochemical parameters in Wistar male rats. Methodol...

The objective of this cross-sectional study was to determine the prevalence and patterns and determinants of consanguineous marriage among a representative population from Almadina Almunawwarah Province, in the Kingdom of Saudi Arabia. This area is known to attract Saudis from different parts of the country because it is in the heart of this religi...

Background: Cyperus esculentus tubers (tiger nut) are one of the ancient food sources known to humanity. It is traditionally used in the Middle East to stimulate sexual arousal in men. However, there has been no scientific evidence about its assumed aphrodisiac properties. This study aimed to investigate the influence of tiger nut on the copulator...

: The effects of : Both plants were administered orally to two separate mice groups at a dose of 800 mg/kg/day for 35 days and compared with control group. After treatment, 5 mice of each group were sacrificed and total mice weights, reproductive organs’ weights, spermatogenesis, and androgenic serum markers were investigated. The remaining mice fr...

The aim of our study was to evaluate the effect of Artemisia absinthium (A. absinthium) ethanol extract on alloxan-induced diabetic rats. Forty-eight albino rats (300 g) were used in this experiment and divided into six groups. Diabetes was induced in five rat groups by a single intraperito-neal injection of alloxan (150 mg/kg body weight). After h...

Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. The aim of the present study is to assess the effects of ethanol extract derived from seeds of Apium graveolens on fertility of diabetic male rats. Seventy adult male albino rats were divided into s...

Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. The aim of the present study is to assess the effects of ethanol extract derived from seeds of Apium graveolens on fertility of diabetic male rats. Seventy adult male albino rats were divided into s...

Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. The aim of the present study is to assess the effects of ethanol extract derived from seeds of Apium graveolens on fertility of diabetic male rats. Seventy adult male albino rats were divided into s...

The hypolipidemic effects of 70% ethanol extract of Artemisia absinthium in hypercholesterolemic -fed rabbits. Hypercholesterolemia was induced in male rabbits by high cholesterol diet (HCD) (350 mg/kg) for 8 weeks. Hypercholesterolemic rabbits were allocated into groups, treated with simvastatin (SIM 5 mg/kg), different extracts of Artemisia absin...

Onion (Allium cepa) is one of the most commonly cultivated species of the family Liliaceae, and has long been used in dietary and therapeutic applications. Treatment with fresh onion juice has been reported to promote testosterone production in male rats. Testosterone is the male sex hormone responsible for enhancing sexual libido and potency. This...

Treatment effects of dried Orchis anatolica root bulbs on male Sprague–Dawley rats' reproductive system, fertility, and biochemical markers were investigated. Two treatment groups of rats (ten each) were used in this experiment. One group received low daily doses of 500 mg and the other received high dose of 1,000 mg/kg of O. anatolica root bulbs p...

The aim of our study was to evaluate the effect of Orchis anatolica roots ethanol extraction on alloxan-induced diabetic rats. Thirty-six albino rats (200 g) were used in this experiment and divided into six groups. Diabetes was induced in five rat groups by a single intraperitoneal injection of alloxan (150 mg/kg body weight). After hyperglycemia...

The present study has investigated the effects of Orchis antolica (dose of 400 mg/kg/Body Wight) on female rats reproductive system for two time periods 4 and 12 weeks. Forty adult female Sprague-Dawley rats were divided into two treatment and two control groups of 10 rats each. The two treated groups received 400 mg/kg/body weight of Orchis antoli...

We explore through this study blood parameters changes after 7 days treatment with Orchis anatolica (O. anatolica) plant roots ethanol extract in Albino rats. An intra-peritoneal glucose tolerance test (IPGTT) was carried on to evaluate the hypoglycemic effect of the extract on blood glucose and insulin titer using Albino rats fasting for 18 hours....

Orchis anatolica Boiss. is a plant species that grows in the Mediterranean region and assumed to have an aphrodisiac property. This study investigates the effects of ingestion of dried O. anatolica root on the sexual behavior and weights of reproductive organs in adult male rats. Sexually active male rats were divided into two groups (control and e...

We report here the preliminary antimicrobial activity of substances produced by Bacillus subtilis NB-6 (air flora isolate), Bacillus megaterium NB-3 (air flora isolate), Burkholderia mallei NB-8 (water isolate) and Corynebacterium kutscheri NB-1 (soil isolate) against a number of methicillin-resistant Staphylococcus aureus (MRSA). The MRSA were iso...

Ingestion of Salvia fruticosa by adult Sprague-dawley rats at levels of 800 mg kg -1 body weight for 30 days was investigated for its effects on sexual behavior. Salvia fruticosa powder was orally administered to sexually active rats in a daily dose of 800 mg kg -1 body weight daily for 30 days. The sexual behavior was then monitored by trained obs...

Objective: To study the effect of Ballota undulata (70% ethanol) extract on blood biochemical parameters and Insulin in Sprague-Dawley strain (albino) rats. Materials and methods: The plant extract was orally administered to the albino rats (n=10) at a dose of 400 mg/kg body weight for 7 days. Its effects on glucose, total cholesterol, triglyceride...

Abstract: The seeds of Nigella sativa Linn. (Ranunculaceae herbaceous plant), commonly known as black seed or black cumin, are used as herbal medicine all over the world for the treatment and prevention of a number of diseases and conditions like asthma, diarrhoea and dyslipidaemia. The aim of this study is to see effects of Nigella sativa on the r...

The aim of this research was to study the effect of 70% ethanol extract of Euphorbia prostrata on lipid profile in rabbits. The plant extract was orally administered to the atherogenic rabbits (atherogenic diet + cholesterol powder supplement at 400 mg/kg/body weight/ day dissolved in 5 mL coconut oil) at dose of 0.0012 kg body weight/day. During t...

The objectives of this study is to investigate the toxic effects of Artemisia herba Alba (300 mg/kg/ body wight) on the reproductive system after administration to female Sprague-Dawley rats weighting 250-300 g for two time periods 4 and 12 weeks. Twenty adult female rats were divided into two groups and exposed to Topiramate diet at a concentratio...

Aim The objective of this study was to characterize the adverse effects of industrial metal salts during the early stages of pregnancy. Methods Successfully mated female rats were exposed to the following metal salts via intragastric intubation; manganese sulfate, lead acetate, aluminum chloride, ferrous chloride and ferric chloride in doses of 50...

Aim of this study is to investigate the toxic effects of Citrullus colocynthis L. (400 mg/kg/body wight) on the reproductive system after administration to female Sprague-Dawley rats weighting 250-300 g for two time periods 4 and 12 weeks. Twenty adult female rats were divided into two groups and Citrullus colocynthis L. were intraperitoneally inje...

Ingestion of propranolol at 10 and 15 mg kg(-1) body weight for 35 days by adult male mice was investigated for its effects on fertility. Body weight and absolute and relative testes weights were reduced and the average weights of epididymis, ventral prostate and seminal vesicle decreased significantly. A significant decline of spermatogenesis in t...

Aim of this research to study the effect of Citrullus colocynthis (70% EtOH) extract on lipid profile on Rabbits. The plant extract was orally administered to the atherogenic rabbits (atherogenic diet + cholesterol powder supplement 400 mg/kg/body weight/day dissolved in 5 mL coconut oil) at dose of 1.2 g kg(-1) body weight/day. During the hall per...

Ingestion of aqueous 70% ethanol extract of Ballota nigra (400 mg/kg body weight for 7 days) by albino rats (n=10) was investigated to study its effects on glucose, total cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), troponin I (TnI), serum creatine kinase (CK), total protein, total bilirubin and bloo...

The hypoglycemic effect of Ballota nigra extract on albino rats was investigated. Alloxan-induced diabetes mellitus was accompanied by several fold increases in plasma glucose. Administration of aqueous extract of B. nigra extract significantly reduced glucose in both healthy and diabetic rats. These results suggest that B. nigra possess hypoglycem...

Ingestion of Frankincense (Boswellia thurifera (B. thurifera)) resin at a dose of 250 and 500 mg/kg body weight fo r6 0d ays by adult male rats was investigated for effects on fertility. Average weights of epididymis, ventral prostate and seminal vesicles increased significantly. Sperm motility and density were also significantly increased in cauda...

The aqueous extracts of Artemisia herba alba. solution was fed orally to male albino rats at a dose of 100 mg/kg body weight for 60 d. A total of 20 rats were involved in this study and were divided into two groups. Group (A) a vehicle-treated control and group (B) a treated group with Artemisia herba-alba. The dose induces a significant decrease i...

Ingestion of rosemary (Rosmarinus officinalis L.) by two groups of adult Sprague-Dawley rats at levels of 250 and 500 mg/kg body wt for 63 days was investigated for its effects on fertility. Body weight and absolute and relative testes weights were not affected, but the average weights of epididymides, ventral prostates, seminal vesicles, and prepu...

Ingestion of rosemary (Rosmarinus officinalis L.) by two groups of adult Sprague-Dawley rats at levels of 250 and 500 mg/kg body wt for 63 days was investigated for its effects on fertility. Body weight and absolute and relative testes weights were not affected, but the average weights of epididymides, ventral prostates, seminal vesicles, and prepu...

The effect of Citrullus colocynthis L aqueous extract in 70% ethanol on blood biochemical parameters including: total cholesterol, triglycerides, total bilirubin, total protein, blood urea, serum creatine kinase (CK), serum lactate dehydrogenase (LDL), serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) were determined a...

The objective of this study is to investigate the toxic effects of Ruta graveolens (250 rag/kg body weight) on the reproductive system after administration to female Sprague-Dawley rats weighing 250-300 g for two time periods of 4 and 12 weeks. Twenty adult female rats were divided into two groups and exposed to Ruta graveolens diet at a concentrat...

Mild hyperlipidaemia induced by cholesterol feeding to male rats altered testicular histology. The sperm motility and density were significantly reduced in cauda epididymides and testes in mild hyperlipidaemic rats. The testicular cell population i.e. spermatocytes (primary and secondary) and spermatids were significantly reduced (P < or = 0.01 to...

After 3 and 6 hours of Piper longum fruit (50%-ETOH) extract oral administration (150 mg.), blood glucose levels of normal rats were decreased by 14.3% to 19.1%. While it was depleted by 11.1% to 50.4% in mild hyperglycemic rats after administration of P. longum fruit extract. Similarly in severe hyperglycemic rat it was reduced to 30.1% to 34.4%....