Haufroid Marie

Haufroid Marie
University of Namur | FUNDP · Department of Chemistry

Scientific researcher

About

6
Publications
886
Reads
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29
Citations
Introduction
Motivated, multi-tasking individual looking for a position in the field of research and development or manufacturing processes requiring responsibility. Skills in chemistry and biology with pharmaceutical implications and drug design. Ability to popularise scientific terminology for a wider audience. Willingness to take on new challenges.
Additional affiliations
September 2016 - present
University of Namur
Position
  • Research Assistant
September 2016 - present
University of Namur
Position
  • PhD Student
Education
September 2016 - March 2022
University of Namur
Field of study
  • Chemistry
September 2014 - June 2016
University of Namur
Field of study
  • Chemistry

Publications

Publications (6)
Article
The equilibrium between phosphorylation and dephosphorylation is one of the most important processes that takes place in living cells. Human phosphoserine phosphatase (hPSP) is a key enzyme in the production of serine by the dephosphorylation of phospho-L-serine. It is directly involved in the biosynthesis of other important metabolites such as gly...
Article
The human phosphoserine phosphatase (hPSP) catalyses the last step in the biosynthesis of L-serine. It involves conformational changes of the enzyme lid once the substrate, phosphoserine (PSer), is bound in the active site. Here, Elastic Network Model (ENM) is applied to the crystal structure of hPSP to probe the transition between open and closed...
Article
Full-text available
Mycobacterium tuberculosis is still the deadliest bacterial pathogen worldwide and the increasing number of multidrug-resistant tuberculosis cases further complicates this global health issue. M. tuberculosis phosphoserine phosphatase SerB2 is a promising target for drug design. Besides being a key essential metabolic enzyme of the pathogen’s serin...
Article
Full-text available
Tuberculosis is still the leading cause of death by a single infectious agent. Effective chemotherapy has been used and improved since the 1950s, but strains resistant to this therapy and most antibacterial drugs on the market are emerging. Only 10 new drugs are in clinical trials, and two of them have already demonstrated resistance. This paper gi...
Article
Docking studies of 4-phenylthiazolinethione on human IDO1 suggest complexation of the heme iron by the exocyclic sulfur atom further reinforced by hydrophobic interactions of the phenyl ring within pocket A of the enzyme. On this basis, chemical modifications were proposed to increase inhibition activity. Synthetic routes had to be adapted and opti...

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