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Publications (32)
Objectives: Cardiovascular diseases and depression are frequently seen together. Despite the developments in the treatment efficacy of agomelatine, a widely used antidepressant, its safety profile on cardiac tissue has not been sufficiently investigated. The aim of this study was to evaluate effects of agomelatine on contraction in rat myocardial t...
Objectives: Individuals with myocardial infarction (MI) frequently exhibit a heightened prevalence of depression, which elevates the likelihood of negative cardiovascular outcomes. This study aimed to assess the potential synergistic effects of sertraline, an antidepressant utilised for the prevention and treatment of depression commonly associated...
Aim: Apelin-13 is known to be one of the predominant neuropeptides with a marked crucial role in circuits involved in mood disorders. Abnormalities of the hippocampus and amygdala play an important role in the development and/or maintenance of pathological anxiety. Here, we assessed the potential anxiolytic effect of Apelin-13 on anxiety-like behav...
Aim: Individuals with depression have cognitive deficits, including diminished thinking and concentration ability, as well as memory difficulties. Certain antidepressants used for depression are recognised to positively influence cognitive functions, including learning and memory. We aimed to examine the impact of sertraline, a selective serotonin...
Depression is responsible for neuropathies such as decreased neurogenesis and increased dendritic atrophy. There is information that antidepressant treatments have an effect by increasing hippocampal neurogenesis and neurotrophic factor expression. The neuropeptide Y1 (NPY1R) receptor agonist has been suggested to have anxiolytic effects. Based on...
Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterised by cognitive dysfunction, memory loss and mood changes. Hippocampal neurogenesis has been suggested to play a role in learning and memory. Neurokinin 3 receptor (NK3R) has been shown to be prevalent in the hippocampus region. The aim of the project was to investigat...
Değerli okuyucularımız; Sağlık bilimleri alanında özveri ile çalışan akademisyenlerimizin büyük emekleri ile hazırladığımız kitabımız, geniş kapsamlı bir yaklaşım ile bizlere güncel bilgiler sunmaktadır. Tıpta temel bilimler ile klinik bilimler birlikte çalışarak sürekli önemli gelişmeler kaydetmektedir. Konular üzerinde araştırma yaparken ona birç...
Değerli okuyucularımız; Sağlık bilimleri alanında özveri ile çalışan akademisyenlerimizin büyük emekleri ile hazırladığımız kitabımız, geniş kapsamlı bir yaklaşım ile bizlere güncel bilgiler sunmaktadır. Tıpta temel bilimler ile klinik bilimler birlikte çalışarak sürekli önemli gelişmeler kaydetmektedir. Konular üzerinde araştırma yaparken ona birç...
Değerli okuyucularımız; Sağlık bilimleri alanında özveri ile çalışan akademisyenlerimizin büyük emekleri ile hazırladığımız kitabımız, geniş kapsamlı bir yaklaşım ile bizlere güncel bilgiler sunmaktadır. Tıpta temel bilimler ile klinik bilimler birlikte çalışarak sürekli önemli gelişmeler kaydetmektedir. Konular üzerinde araştırma yaparken ona birç...
Sevgili okuyucularımız, Bu kitabı bilim gibi uzun bir yol kat etmekte olan ve temel tıp alanında çalışan değerli arkadaşlarımızın katkıları ile yayımladık. Bir işe başlamak onun başarılması için oldukça önemli bir aşamadır, bu nedenle hayatta hiçbir şeyi ertelememek gerektiğini unutmayalım. Sağlık bilimlerinde temel ve klinik bilimleri birbirinden...
Sevgili okuyucularımız, Bu kitabı bilim gibi uzun bir yol kat etmekte olan ve temel tıp alanında çalışan değerli arkadaşlarımızın katkıları ile yayımladık. Bir işe başlamak onun başarılması için oldukça önemli bir aşamadır, bu nedenle hayatta hiçbir şeyi ertelememek gerektiğini unutmayalım. Sağlık bilimlerinde temel ve klinik bilimleri birbirinden...
Alzheimer’s disease (AD) is accepted as a form of progressive dementia. Cholinergic systems are commonly affected in AD. Neurokinin 3 receptor (NK3R) is involved in learning memory-related processes. It is known that the activation of NK3R affects the release of many neurotransmitters. The aim of this project was to investigate the effects of NK3R...
Background:
Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice.
Methods:
Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kissp...
Amaç: Morfin, kronik ağrı tedavisinde tercih edilen opioidlerdendir. Tekrarlayan kullanımı bağımlılığa neden olabilir. Opioid bağımlılığının kalp kontraksiyonuna olan etkilerini araştırmak amacıyla deneysel morfin bağımlılığı/yoksunluğu oluşturulan sıçanlarda miyokardiyal kontraktilite/histolojik değişiklikler araştırıldı. Gereçler ve Yöntem: Resmi...
Purpose: While most studies of fluoxetine have focused on its effects on the cardio/cerebrovascular systems, what is known about its vasomotor effect is still limited. This study was planned to investigate the vasoactive effects of fluoxetine on smooth muscle in rat thoracic aortic rings in an experimental setup.
Materials and Methods: 24 adult Wi...
Depression is a chronic, recurrent and life-threatening disease affecting approximately 15% of the world population. Depression is responsible for neuropathologies like decreased neurogenesis and increased dendritic atrophy. Antidepressant treatments increase hippocampal neurogenesis and neurotrophic factor expression. Based on this information, it...
Amaç: Lateral hipotalamik alanda (LHA) intravenöz glukoz uygulanmasının noradrenalin, dopamin ve metabolitleri olan dihidroksi fenil glikol (DHPG)- dihidroksifenilasetik asit (DOPAC) düzeylerine etkilerinin beyin mikrodiyaliz yöntemi ile araştırılması amaçlandı. Gereçler ve Yöntem: Normal beslenen 2 grup ve 24 saat besin alımı kısıtlanan 2 grup (se...
Alzheimer's disease (AD) is accepted as a form of progressive and irreversible dementia. It is known that cholinergic systems are commonly affected in AD. Neurokinin 3 receptor (NK3R) is involved in learning and memory related processes. Activation of NK3R is known to facilitate the release of many neurotransmitters such as acetylcholine (Ach), dop...
We aimed to investigate the effects of two different chronic immobilization stress protocols on depression-related behaviors and brain mineral levels. Adult female Wistar albino rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 min daily for 7 days), and immobilization stress-2 (45 min twice a day for 7...
AIM: Quantitative real time polymerase chain reaction (qPCR) analysis are often used for molecular level understanding of pathophysiology of Alzheimer’s Disease (AD). Housekeeping genes (HKGs) are widely used as an internal control and for normalization of qPCR data. Previous literature reported that different experimental procedures can effect exp...
Alterations of essential elements in the brain are associated with the pathophysiology of many neuropsychiatric disorders. It is known that chronic/overwhelming stress may cause some anxiety and/or depression. We aimed to investigate the effects of two different chronic immobilization stress protocols on anxiety-related behaviors and brain minerals...
There are several reports on unfavourable effects of metabolic cage housing on animal welfare mainly due to the characteristic structures of these cages such as single housing and grid flooring. This study was aimed to compare the effects of long-term metabolic cage housing and conventional housing (normal grouped housing in standard cages) on the...
Statins have cholesterol-independent effects including an increased vascular nitric oxide activity and are commonly used by patients with cardiovascular disease. Such patients frequently have cardiovascular diseases, which may be treated with cilostazol, a platelet aggregation inhibitor. This study was designed to investigate whether combined use o...
The novel antidepressant agomelatine is an agonist of melatonin receptors (MT1 and MT2). This drug has also serotonin 2c receptor antagonist properties. There is no evidence with regards to agomelatine action on smooth muscle contractility. Aim of this study was to investigate effect of agomelatine on spontaneous and prostoglandin F2 alpha (PGF2 al...
