hatem shehata

hatem shehata
Cairo University | CU · Department of Neurology

M.D

About

114
Publications
21,403
Reads
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546
Citations
Citations since 2016
65 Research Items
478 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Additional affiliations
October 2011 - present
Cairo University
Position
  • Professor (Full)

Publications

Publications (114)
Article
Full-text available
Botulinum toxin type A (BTX-A) has been reported to have analgesic effects independent of its action on muscle tone, mostly by acting on neurogenic inflammatory mediators and controlling the neurotransmitter release of sensory and autonomic nerve terminals that are involved in many chronic painful conditions as chronic intractable trigeminal neural...
Article
Full-text available
Corticobasal syndrome (CBS) is a sporadic tauopathy that manifests by a various combination of motor and cognitive deficits, which makes its diagnosis challenging. Treatment of CBS is symptomatic and based on evidence from other similar disorders due to the lack of studies on CBS. The aim of the study was to investigate low-frequency repetitive tra...
Article
Full-text available
Background: Chronic migraine is a prevalent disabling disease, with major health-related burden and poor quality of life. Long-term use of preventive medications carries risk of side effects. Objectives: The aim of this study was to compare repetitive transcranial magnetic stimulation (rTMS) to botulinum toxin-A (BTX-A) injection as preventive ther...
Article
Full-text available
Background: The reported prevalence of headache disorders in Arab regions varies consid- erably between countries. This may be due to a lack of standardized survey instruments that capture the prevalence. Purpose of the study: Our goal was to construct and validate a structured headache question- naire for Arabic-speaking headache patients to be us...
Conference Paper
Full-text available
Background: Multiple sclerosis (MS) affects more than 2 million people globally. Besides its significant impact on the quality of life, MS ranks second among chronic diseases in direct expenditures. Treatment interruption in active MS patients can result in relapse or recurrence of the disease activity. Till now, there are no consensus guidelines c...
Preprint
Full-text available
In epilepsy, early diagnosis, accurate determination of epilepsy type, proper selection of anti-seizure treatment, and monitoring; all are essential. However, despite recent therapeutic advances and conceptual reconsiderations in the classification and management of epilepsy, serious gaps are still encountered in day-to-day practice in Egypt as wel...
Article
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Background: The COVID-19 pandemic has reached over 276 million people globally with 5.3 million deaths as of 22nd December 2021. COVID-19-associated acute and long-term neurological manifestations are well recognized. The exact profile and the timing of neurological events in relation to the onset of infection are worth exploring. The aim of the c...
Conference Paper
Full-text available
Fingolimod is an anti-trafficking oral multiple sclerosis (MS) disease modifying drug (DMD) that prevents the egress of activated lymphocytes from lymph nodes to peripheral circulation and hence migration into the central nervous system (CNS). Many reports have described patients with increases in clinical and radiographic disease activity after ce...
Article
Full-text available
Background Multiple sclerosis (MS) is a major cause of neurological disability in adults. Depression is one of the most common psychiatric comorbidities in MS patients with negative impact on patients’ quality of life. The aim of the study is to evaluate the role of diffusion tensor imaging (DTI) in monitoring the therapeutic response after high-fr...
Article
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Abstract During the current COVID-19 pandemic, many queries are raised regarding its nature, outcome, and sequelae. This letter raises the concern of potential impact on increasing the incidence of multiple sclerosis whose pathology involves a possible viral etiology. Besides, the potential neurotropism of the acute respiratory distress syndrome co...
Article
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Background Given the diversity of multiple sclerosis (MS) symptoms including cognitive impairment in certain domains, the need to develop a rapid and at the same time thorough tool for cognitive assessment is mandatory and represents an unmet need in the clinical and research fields of MS. The Brief International Cognitive Assessment for MS (BICAMS...
Article
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Background The safety of Ramadan fasting for Muslim patients suffering from multiple sclerosis (MS) is still a matter of debate. This work aimed to study the clinical course of MS during Ramadan fasting and to clarify the predictors of relapses and symptoms exacerbation. Methods This retrospective study included 153 Muslim patients with MS. Data r...
Article
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Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate res...
Article
Objective: This study aimed to report the severity of COVID-19 in a cohort of Egyptian patients with multiple sclerosis (MS) with particular attention on the impact of disease modifying drugs (DMDs). Methods and study population: We included 119 MS patients recruited from two centers, Ain-Shams university and Cairo university with confirmed or susp...
Article
Full-text available
Background In Egypt, the characterization of Neuromyelitis Optica Spectrum Disorder (NMOSD) is lacking. Objectives To determine the demographics, clinical features, aquaporin4 antibodies (AQP4-IgG) status, and neuroimaging of Egyptian NMOSD patients. Methods Retrospective analysis of 70 NMOSD patients’ records from the MS clinic, Kasr Alainy hosp...
Article
Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). Aberrant expression of transcription factor forkhead box P3 (FoxP3) has been suggested to underlie different immunological disorders as FOXP3 expression is essential for T regulatory cells (Tregs) to maintain their suppressive and anti-inflamma...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
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Background Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of rec...
Article
Full-text available
Sherif M Hamdy, Maged Abdel-Naseer, Hatem S Shehata, Nevin M Shalaby, Amr Hassan, Alaa Elmazny, Ehab Shaker, Mona AF Nada, Sandra M Ahmed, Mohamed I Hegazy, Husam S Mourad, Ahmed Abdelalim, Rehab Magdy, Alshimaa S Othman, Doaa A Mekkawy, Nirmeen A Kishk Neurology Department, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Alaa El...
Article
Full-text available
Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended ho...
Article
Full-text available
The emergence of the novel coronavirus disease 2019 (COVID-19) pandemic has become a major public health challenge of global concern since December 2019, when the virus was recognized in Wuhan, the capital city of Hubei province in China and epicenter of the COVID-19 epidemic. Given the novelty of COVID-19 and the lack of specific anti-virus therap...
Article
Full-text available
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant...
Poster
Background: Stroke is a frequent cause of problems in body function resulting in limitations of functional activity. Stroke generally leads to greater postural instability, and muscle weakening compared with healthy individuals. Strength of non-paretic limbs can be less than predicted and it tends to be more impaired proximally than distally. The s...
Article
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Background: Studies have shown that interferon-beta (IFN-β) treatment is associated with headaches in patients with multiple sclerosis (MS). Headaches can affect quality of life and overall function of patients with MS. We examined the frequency, relationships, patterns, and characteristics of headaches in response to IFN-β in patients with relapsi...
Poster
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Sexuality and partnership are crucial to our wellbeing and they have a major influence on the quality of life. Among other clinical manifestations of Multiple Sclerosis (MS); sexual dysfunction (SD) is a highly prevalent symptom yet it is still under-reported and under-diagnosed. Our objective is to address the prevalence and pattern of sexual dysf...
Poster
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Introduction: Caregivers have been described as invisible patients, who may present with the so-called caregiver syndrome with adverse effects on their emotional, social, financial, physical, and spiritual functioning. Objectives: to determine the burden of caregivers of patients with multiple sclerosis (PwMS) in Egypt. Methods: This multi-center,...
Poster
Full-text available
Introduction: Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) are rare inflammatory central nervous system disorders sharing common pathophysiological features, data about their demographics and clinical characteristics is lacking in the Egyptian population. Objectives: To characterize Egyptian patients with NMO/NMOSD...
Article
Full-text available
Background and purpose: The development of new biomarkers for multiple sclerosis (MS) is of paramount importance to improve our ability to predict disease progression and disability. The aim of this study was to evaluate the potential role of the optic nerve diameter (OND) measured by ultrasonography as a biomarker of early disability in patients...
Research
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Background: Micro-RNAs (miRNAs) are evolving as biological markers for multiple sclerosis (MS) both in activity and remission. miR-96 is associated with remission, however, the exact mechanism through which it contributes to the anti-inflammatory pathway is not clear. Objective: To study the expression of miR-96 and IL-10 (anti-inflammatory mediato...
Article
Background: Micro-RNAs (miRNAs) are evolving as biological markers for multiple sclerosis (MS) both in activity and remission. miR-96 is associated with remission, however, the exact mechanism through which it contributes to the anti-inflammatory pathway is not clear. Objective: To study the expression of miR-96 and IL-10 (anti-inflammatory medi...
Article
Full-text available
Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes...
Poster
Full-text available
Background: Depression is common in MS and may impact information processing speed. Some patients fail to improve with standard antidepressants. Prefrontal repetitive transcranial magnetic stimulation (rTMS) is an alternative therapeutic tool. Diffusion tensor imaging (DTI) evaluates the integrity of white matter connectivity in vivo yielding an in...
Conference Paper
Background: High prevalence of migraine in patients with multiple sclerosis (pwMS) has been supported by abundant controlled and uncontrolled studies. Yet; the temporal association, headache semiology and MS characteristics of those patients remain to be determined. Objectives: To investigate the prevalence and characteristics of headaches in MS sa...
Article
Full-text available
Introduction Although the frequency of pediatric-onset multiple sclerosis (POMS) has increased in recent decades, it is still highly uncommon, which creates a need for the involvement of more registries from various clinical centers. Objective To characterize the demographic, clinical, and paraclinical features of Egyptian patients with POMS. Pat...
Poster
Full-text available
Background: Multiple sclerosis (MS) is a common neurological disease which causes physical, psychological and cognitive disabilities. Prevalence of MS in Egypt is about 60/100,000. Cognitive impairment in MS occurs irrelative to disease course or duration. Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS) is a validated test f...
Article
Introduction: Ataxia is a common yet difficult symptom to man- age in people with multiple sclerosis (MS) with a variety of treat- ments, ranging from pharmacotherapy and neurorehabilitation to stereotactic surgical interventions. However, little is known about the role of repetitive transcranial magnetic stimulation (rTMS) in management of ataxia...
Article
Background: There is increasing evidence that environmental factors play a role in the development and may be progression of multiple sclerosis (MS). Objectives: To assess MS severity and progression in MS Egyptian patients who have been residing in Gulf area in their early life. Patients and methods: The study design was retrospective case-control...
Article
Full-text available
Background: Multiple sclerosis (MS) is a common neurological disease which causes physical, psychological and cognitive disa- bilities. Prevalence of MS in Egypt is about 60/100,000. Cognitive impairment in MS occurs irrelative to disease course or duration. Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS) is a validated test...
Article
Full-text available
Background Multiple sclerosis (MS) is a complex autoimmune disease with a heterogeneous presentation and diverse disease course. Recent studies indicate a rising prevalence of MS in the Middle East. Objective To characterize the demographics and disease features of Egyptian patients attending four tertiary referral MS centers in Cairo. Materials...
Article
Full-text available
Introduction Refractory epilepsy is a common clinical manifestation in patients with tuberous sclerosis complex (TSC), which can be complicated by many life-threatening conditions, such as status epilepticus (SE). However, very few reports mention the patterns and semiology of SE in those patients. Objective To study the clinical characteristics a...
Article
Full-text available
Background The reported prevalence of headache disorders in Arab regions varies considerably between countries. This may be due to a lack of standardized survey instruments that capture the prevalence. Purpose of the study Our goal was to construct and validate a structured headache questionnaire for Arabic-speaking headache patients to be used as...
Article
Background: Cytokines are major contributors in the immune disruption in multiple sclerosis (MS). Objective: Evaluating the proinflammatory (IL-17A) and anti-inflammatory (IL-10) cytokines in relapsing-remitting (RR) MS patients at time of relapse and during remission. Subjects and method: A case-control study including 30 RRMS patients and 15...
Article
Full-text available
INTRODUCTION. Parkinson disease (PD) is a common neuro- degenerative disorder in Egypt [1], which is the most populous country in the Middle East; however, little has been recorded in describing the clinical characteristics and natural disease course of PD in Egypt. OBJECTIVES. Identify the demography and clinical profile among Egyptian patients wi...
Article
Background and aims: Symptomatic therapies in multiple sclerosis (MS) have shown a great efficacy in improving patients’ quality of life (QoL); yet, their importance is frequently overlooked. Objective. To assess the role of integrated approach comprising the use of onabotulinum toxin (BTX-A), repetitive transcranial magnetic stimulation (rTMS) in...
Conference Paper
Full-text available
Objective: Evaluating the long term efficacy and safety of rTMS sessions in management of 'on-freezing' and unpredicted offs in advanced Parkinson's disease (PD). Freezing of gait (FOG) is an independent feature of Parkinson's disease that is related to both motor and cognitive deficits. Treatment of off-FOG is relatively straightforward, but 'on-f...
Article
Background Stroke is a major cause of mortality and morbidity worldwide. Poor knowledge of stroke risk factors, symptoms and appropriate response to stroke are possible causes of poor outcome. Objective The aim of this study was to evaluate the knowledge and attitude towards different aspects of stroke in a sample of Cairo University Hospitals' wor...
Conference Paper
Full-text available
BACKGROUND/OBJECTIVE. Egypt is the most populous country in the Middle East; however, a little is known about the prevalence, natural history, clinical and paraclinical characterization of multiple sclerosis (MS) in Egypt. We reported a retrospective cohort of Egyptian MS patients attending a tertiary referral center in Cairo (1998-2014) with avera...
Article
Full-text available
BACKGROUND: There is abundance of epidemiological studies of headache in developed and western countries; however, data in developing countries and in Egypt are still lacking. This study aims to detect the prevalence of primary headache disorders in both urban and rural sectors in Fayoum governorate, Egypt. METHODS: A total of 2600 subjects were in...
Conference Paper
Full-text available
Background: Refractory epilepsy is a common clinical manifestation in patients with tuberous sclerosis complex (TSC), which could be complicated by many life-threatening conditions as status epilepticus (SE). Few reports mentioned the incidence, patterns and semiology of SE in those patients. Objectives: To study the aetiology, clinical profile, an...
Article
Full-text available
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which shows heterogeneity in its various clinical and pathological patterns. A number of inflammatory conditions may mimic MS which makes definite diagnosis of MS sometimes challenging. The Kasr Al-Ainy MS unit “KAMSU”, Cairo University, out of the believe that...