Hassan Sefrioui

Hassan Sefrioui
Moroccan Foundation for Advanced Research Science and Innovation | MAScIR · Biotechnology Medical

MS, PhD

About

43
Publications
8,047
Reads
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314
Citations
Introduction
Hassan Sefrioui is director at the medical Biotechnology center, Moroccan Foundation of Advanced Research Science and Innovation. Hassan does research in oncology and infectious Diseases. Their current project is 'development of a cost effective diagnotic kits for an early detection of cancer and infectious diseases.'
Additional affiliations
January 2010 - present
Moroccan Foundation for Advanced Research Science and Innovation
Position
  • Managing Director
Description
  • Prof. Hassan Sefrioui has over 20 years experience in both academia and industrial settings. He was heading drug discovery centre at Tigenix (Belgium). Hassan holds a Ph.D. in Medical Science from the University of Leuven (Belgium)

Publications

Publications (43)
Article
Full-text available
In this work, three isoxazoline-thiazolidine-2,4-dione derivatives were synthesized and characterized by FT-IR, ¹H-NMR, ¹³C-NMR and ESI-MS spectrometry. All compounds have been investigated for their α-amylase and α-glucosidase inhibitory activities. In vitro enzymatic evaluation revealed that all compounds were inhibitory potent against α-glucosid...
Article
Full-text available
JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS https://doi.org/10.1080/07391102.2021.1911854 Synthesis, a-glucosidase and a-amylase inhibitory activities, acute toxicity and molecular docking studies of thiazolidine-2,4-diones derivatives. Saad Fettacha, , Fatima Zahra Tharib, , Zakaria Hafidic , Hamza Tachallaitb, , Khalid Karrouchid, , Mohamme...
Article
Full-text available
Lateral flow assays (lateral flow immunoassays and nucleic acid lateral flow assays) have experienced a great boom in a wide variety of early diagnostic and screening applications. As opposed to conventional examinations (High Performance Liquid Chromatography, Polymerase Chain Reaction, Gas chromatography-Mass Spectrometry, etc.), they obtain the...
Article
The aim of this study was to assess the contamination of breast milk by aflatoxin M1 among nursing mothers from Rabat, Morocco, and to explore its association with several maternal parameters and dietary habits. In addition, the health risk assessment of the newborns by the estimation of the daily intake. A competitive Enzyme Linked Immunosorbent...
Article
The aim of the present study is to evaluate the level of contamination of breast milk (BM) by ochratoxin A, among Moroccan lactating mothers in the city of Rabat, and to identify the associated factors of exposure, also to estimate the degree of exposure of the breastfeed infant. The analysis of ochratoxin A (OTA) was accomplished by ELISA method o...
Article
Full-text available
Nanobodies (Nbs) are mini antibodies 10 times smaller than conventional antibodies. They constitute a new class of antibodies devoid of light chains. Their paratope consists of a single variable domain "VHH" (heavy chain variable domain) formed by a single peptide chain. Nevertheless, Nbs maintain the same repertoire of diversity and affinity chara...
Preprint
Although information exists regarding the rate of benzodiazepines (BZDs) use in different countries, little information is available concerning the BZDs consumption in Morocco. To describe prescription rate in Morocco, a retrospective descriptive analysis of BZDs and their agonists use with the institute IQIVIA database was performed during the per...
Article
Full-text available
The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. Unfortunately, these drugs are present in the illegal street market, lea...
Article
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Background Rapid diagnosis of drug resistance in tuberculosis (TB) is pivotal for the timely initiation of effective antibiotic treatment to prevent the spread of drug-resistant strains. The development of low-cost, rapid and robust methods for drug-resistant TB detection is highly desirable for resource-limited settings. Methods We report the use...
Article
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Accurate measurement of Human epidermal growth factor receptor (HER2) gene expression is central for breast or stomach cancer therapy orientation and prognosis. The current standards testing methods for HER2 expression are immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). In the current study, we explored the use of quantita...
Article
Full-text available
Prostate cancer (PCa) remains one of the most widespread and perplexing of all human malignancies. Assessment of gene expression is thought to have an important impact on cancer diagnosis, prognosis and therapeutic decisions. In this context, we explored combined expression of PCa related target genes AMACR and PCA3 in 126 formalin fixed paraffin e...
Article
Full-text available
Background: Tuberculosis (TB) is a major global health problem and remains the leading cause of morbidity and mortality in developing countries. Routinely used TB diagnostic methods, in most endemic areas, are time-consuming, often less-sensitive, expensive and inaccessible to most patients. Therefore, there is an urgent need for the development o...
Article
Full-text available
Although monitoring of BCR-ABL1 translocation has become an established practice in the management of chronic myeloid leukemia (CML), the detection limit of the BCR-ABL1 transcripts needs more standardization. The aim of the present study was to evaluate the clinical performances of a novel assay for the quantification of BCR-ABL1 fusion transcript...
Article
Full-text available
Chronic myeloid leukemia (CML) is characterized by BCR-ABL translocation and an increased number and migration of immature myeloid cells into the peripheral blood. The detection limit of the BCR-ABL transcript, particularly after treatment, is controversial. In the present study, we used quantitative real-time reverse transcription-polymerase chain...
Article
Full-text available
Germline mutations in the BRCA1 gene are known predictive markers for the development of hereditary breast cancer. Nevertheless, no comprehensive study has been performed targeting the presence and relevance of BRCA1 mutations in Moroccan breast cancer patients. We here present an analysis of BRCA1 gene regions (exon 2 and exon 11a/b) of 50 female...
Article
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Further development in organ transplantation requires the utilization of new immunosuppressive drugs that-in addition to being effective against rejection-do not block tolerance. We previously reported that FTY 720, a drug that alters lymphocyte trafficking, has marked anti-rejection properties. We now investigate how FTY 720 influences tolerance i...
Article
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Although in utero transplantation (IUT) has resulted in donor-specific tolerance to postnatal solid organ transplantation, the mechanisms of this tolerance remain poorly understood. Our recent findings demonstrate that under specific conditions prenatal injection of allogeneic cells may lead to allosensitization instead of tolerance. These laborato...
Article
Full-text available
Objective: We have previously reported immunity to donor antigens following in utero transplantation (IUT) of cytokine-stimulated allogeneic hematopoietic stem cells (sca(+)/lin(-)) (day 9 of gestation). Transplanted mice showed accelerated rejection of donor skin grafts and high anti-donor cytotoxic response, a finding not seen in the control mic...
Article
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We have previously shown that allogeneic bone marrow (BM) chimeras preconditioned with total lymphoid irradiation and low-dose total body irradiation (TLI/TBI) develop a stronger graft-versus-leukemia (GVL) effect than chimeras preconditioned with high-dose total body irradiation only (TBI). Here, we report on the possible role of cytokines in the...
Article
Full-text available
Background. We have previously shown that allogeneic bone marrow CBRl) chimeras preconditioned with total lymphoid irradiation and low-dose total body irradiation (TLI/TBI) develop a stronger graft-versus leukemia (GVL) effect than chimeras preconditioned with high-dose total body irradiation only (TBI). Here, we report on the possible role of cyto...
Article
Full-text available
Previous studies have demonstrated that delayed donor leukocyte infusion (DLI) can increase graft-versus-leukemia (GVL) without increasing graft-versus-host-disease (GVHD) in MHC mismatched bone marrow (BM) chimeras. In our report, the immune status of minor antigen mismatched BM chimeras given DLI was studied. Particularly the role of donor ASGM1...
Article
Delayed infusion of donor lymphocytes (DLI) after bone marrow transplantation (BMT) has been shown clinically and experimentally to result in a graft-versus-leukemia (GVL) effect with reduced incidence of severe graft-versus-host disease (GVHD). Recently we corroborated this and showed that C3H -AKR minor histocompatibility antigenmismatched BM chi...
Article
Prenatal transplantation of hematopoietic stem cell (HSC)is potential cure for congenital diseases. However, the degree of engraftment is low (<10%) and the tolerance is transient. We hypothesized that moderate immune responses in the fetal period may lead to donor cells rejection. We have developed a murine model of in utero transplantation to stu...
Article
It has previously been demonstrated that adding T cell-depleted (TCD) host bone marrow (BM) to an MHC-mismatched BM inoculum allows for induction of long-term stable chimeras without graft-versus-host disease (GVHD) even when non-TCD allogeneic BM was used. The present study was undertaken to investigate immune tolerance mechanisms in minor antigen...
Article
Full-text available
Possible mechanisms involved in the protective effect of staphylococcal enterotoxin B (SEB) injection on the subsequent development of experimental autoimmune encephalomyelitis (EAE) were investigated. Only partial clonal deletion and anergy of Vbeta8 + T-lymphocytes were documented after myelin basic protein immunization in SEB injected mice. Brai...
Article
Full-text available
We have previously demonstrated that in a concordant hamster-to-nude rat cardiac transplant model, T-independent specific B-lymphocyte and natural killer (NK)-cell tolerance could be induced, leading to long-term xenograft (Xg) survival. Here, we investigated whether the same could be achieved in a clinically more relevant semi-discordant model inv...
Article
Chloroquine is known to inhibit several functions of macrophages, but its effect on the nitric oxide (NO)-dependent parasite killing capacity of macrophages has not been documented. NO synthesis by interferon-γ-induced mouse and casein-elicited rat macrophages was significantly and irreversibly inhibited by chloroquine. The activity of the inducibl...
Article
ALLOGENEIC bone marrow (BM) transplantation is an effective procedure for the treatment of various malignant disorders of hematologic origin.1,2 Several reports indicate that the fatality rate in leukemic patients can be significantly decreased after allogeneic bone marrow transplantation.1,2Previously, we demonstrated that mice conditioned with TL...

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Projects (2)
Project
the goal is to develop a test strip kit for POC use for an early detection of Rheumatoid Arthritis.