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Hassan Hussein Musa

Hassan Hussein Musa
University of Khartoum/ Darfur University College

(BSc, MSc, PhD, Professor of Molecular Genetics & Immunology)

About

233
Publications
89,158
Reads
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1,856
Citations
Citations since 2017
111 Research Items
1267 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Additional affiliations
February 2014 - April 2017
University of Khartoum
Position
  • Professor
February 2014 - April 2017
University of Khartoum
Position
  • Professor

Publications

Publications (233)
Preprint
Full-text available
Background: Folic acid metabolism has a major role in DNA methylation and synthesis. Genetic Polymorphisms in folate may disrupt enzyme activities and maybe affect the malignant risk. Methionine synthase reductase are very important enzyme for the folate cycle.
Article
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The success of mRNA vaccines against SARS-CoV-2 implies that this technology can be applied to target any pathogen. However, the scientific production and research trends using the bibliometric method are still unknown. The top 100 most cited articles on mRNA vaccine research were obtained from the Scopus database from 1995 to 2021. Bibliometrix, a...
Article
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Bibliometric analysis is an important tool used for unraveling and mapping the cumulative scientific knowledge and evolutionary nuances of established domains by logically interpreting vast amounts of unstructured data. A lot has been done in various fields, however, no bibliometric report is yet made on Moringa oleifera. M. oleifera Lam is a multi...
Article
Traditional herbal medicine has been playing an essential role in primary health care globally. The aim of this work is to present an overview of traditional herbal medicine research productivity over the past years. The data was accessed from the Scopus database (www.scopus.com), while VOSviewer.Var1.6.6, Bibliometrix, and R studio were used for f...
Article
Full-text available
Significant research progress has been made towards understanding the Chikungunya virus (CHIKV); however, the research productivity and milestones remain unclear. In this study, we investigated the global research outputs on CHIKV and assessed the landscape and future research directions. The Web of Science Core Collection (WoSCC) database was used...
Article
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Background: The Journal of African Health Sciences (AHS) is an internationally refereed journal in the field of health sciences with vast research contributions in the world and Africa region. Objective: The study aimed to document the scientific production and explore the AHS research bibliometric characteristics since its first issue. Methods...
Article
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African sheep manifest diverse but distinct physio-anatomical traits, which are the outcomes of natural- and human-driven selection. Here, we generated 34.8 million variants from 150 indigenous northeast African sheep genomes sequenced at an average depth of ∼54× for 130 samples (Ethiopia, Libya) and ∼20× for 20 samples (Sudan). These represented s...
Article
In impoverished nations, donkeys help people make a living. The welfare of donkeys in Sudan is neglected compared with developed countries. However, there is no information available about donkey welfare in Nyala. This study aimed to assess the welfare of donkeys in Nyala. Donkeys were divided into two groups (n=50), working and nonworking. The don...
Article
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Background: Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using...
Article
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Background: Vitamin D endocrine system was formally known as a key player in calcium and phosphatehomoeostasis and in regulation of bone remodelling. It is influences maternal and fetal cell differentiation and cell growth immune regulation, insulin secretion and anti-proliferative processes Methods: A case control study was conducted at the Nation...
Article
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Recurrent Spontaneous abortion (RSA) is defined as consecutive pregnancy loss before 20 weeks of gestation. This study aimed to detect p53 codon 72 polymorphisms among Sudanese women with recurrent spontaneous abortion. A case-control study was conducted at the national centre of neurological sciences, Khartoum, Sudan. All patients attending the ob...
Article
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Recurrent Pregnancy Loss (RPL) is recognized as the loss of a clinical pregnancy before 20 completed weeks of gestational age. This was a descriptive-analytical case-control study conducted at the research laboratory of the national centre of neurological sciences (NCNS), Khartoum, Sudan. The study aimed to detect factor XIII gene polymorphisms amo...
Article
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Obesity is a metabolic disease associated with high morbidity and mortality worldwide. Previously we showed that Gum Arabic (GA) inhibited obesity in fed with diet-induced obesity. However, the mechanism underlying the mode of action is not fully elucidated. Here we aimed to identify the effects of GA on CCAAT-enhancer-binding protein- α (C/EBP- α)...
Article
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Background and objective Adipose-derived mesenchymal stem cells (AdMSC) are multipotent adult mesenchymal cells isolated and cultured from the stromal vascular fraction derived from adipose tissue. The present study was conducted to analyze the global trends in AdMSC research using bibliometric and visual analysis tools. Methods The literature sea...
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Background: GSTs (glutathione S-transferases) are enzymes that are well known for their capacity to detoxify hazardous substances. Previous research has found a link between GST polymorphisms and acute lymphoblastic leukaemia (ALL). The outcomes differed depending on the study and population. Objectives: To analyze the relation between polymorphism...
Article
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Introduction Cancer is a major public health problem and a global leading cause of death where the screening, diagnosis, prediction, survival estimation, and treatment of cancer and control measures are still a major challenge. The rise of Artificial Intelligence (AI) and Machine Learning (ML) techniques and their applications in various fields hav...
Article
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Background: The global outbreak of the COVID-19 pandemic and its impact on the overall health and well-being of the people brought fear, anxiety, worry, and mental health issues. Thus, a bibliometric analysis of COVID-19 and anxiety-related publications was performed to understand better the current research status and prospects to support policyma...
Article
Full-text available
Background: Folic acid metabolism has a major role in DNA methylation and synthesis. Genetic Polymorphisms in folate may disrupt enzyme activities and maybe affect the malignant risk. Methionine synthase reductase are very important enzyme for the folate cycle. Objectives: To study the possible relation between polymorphisms of MTRRA66G genes and s...
Article
Full-text available
Azadirachta indica (Neem) A. Juss as an ethnobotanical has been used to treat various diseases due to its medicinal, insecticidal, and landscaping properties and has recently been used to synthesize other materials. The current study attempted to aggregate research innovations on Neem through a bibliometric analysis for articles published between 1...
Article
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Background: Recurrent spontaneous abortion (RSA) has traditionally been defined by two or more consecutive pregnancy losses before 20 weeks' gestation. RSA has been estimated to occur in approximately 1% of all couples. The World Health Organization (WHO) defines it as expulsion or extraction of an embryo or fetus weighting 500 g or less. Methods:...
Preprint
Full-text available
Sudan, the largest country in Africa, acts as a corridor between North and sub-Saharan Africa along the river Niles. It comprises warm arid and semi-arid grazing lands, and it is home to the second-largest African population of indigenous livestock. Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryla...
Preprint
Full-text available
Abstract African sheep manifest diverse but distinct physio-anatomical traits which are the outcomes of natural- and human-driven selection. Here, we generated 34.8 million variants from 150 indigenous African sheep genomes sequenced at an average depth of ∼54x for 130 samples (Ethiopia, Libya) and ∼10x for 20 samples (Sudan), representing sheep f...
Article
Full-text available
Introduction: COVID-19 pandemic public health emergency is one of the worse disease outbreaks in the history of infectious disease. The consequence has resulted in over 4 million deaths globally. Therefore, a more in-depth understanding of the dynamics of the disease, vaccine development, and safety has become crucial for the disease eradication. O...
Article
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Introduction: In Sudan, cancer a common health challenge, is the leading cause of death after malaria and viral pneumonia. The aim of the review is to determine the risk factors associated with esophageal cancer (EC) among Sudanese population. Methods: All published online data concerning EC epidemiology, diagnosis, and management in Sudan were...
Article
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Background: This study explored top 100 most-cited articles on global malnutrition. It presents advancement of malnutrition research effort globally. Methods: A comprehensive Web of Science database search was performed using Medical Subject Headings (MeSH) with search terms “title Malnutrition*” OR “undernutrition*” OR “Nutrition Deficiency*” OR...
Article
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Results: The top 100 most-cited malnutrition articles were published between 1940 and 2019. The number of citations ranges from 235 to 2,890, with a median of 342.5, and the interquartile range (IQR) was 195.5. The United States was the most contributing country, World Health Organization (WHO) has more publications on malnutrition than any other i...
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Introduction: The Ebola Virus outbreak in Africa is believed to be one of the deadliest viral infections that causes severe hemorrhagic fever in human and nonhuman primates, which has resulted in increased mortality rates in the affected African countries. Thus, the current study mapped and quantified global research output and trends in the EBOV v...
Article
The study provides a comprehensive analysis of trends of the global scientific research on the effects of the COVID-19 Pandemic on Mental health from the first published literature up to June 27, 2021. Relevant documents were searched using mesh terms based on the query of two searches, “COVID-19 & Mental Health” scenarios joined by the Boolean ope...
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The incidence of thyroid cancer (TC) has rapidly increased in the world. The study aims to provide a detailed evaluation of thyroid cancer research output. Data were retrieved from the Web of Science (WOS) Core Collection and Scopus databases for bibliometric analysis. A total of 10689 and 9063 documents of TC were retrieved from Scopus and WO...
Article
Thirty-nine years ago, scrub typhus (ST), a disease, was not among the Chinas notifiable diseases. However, ST has re-emerged to become a growing public health issue in the southwest part of China. The major factors contributing to an increased incidence and prevalence of this disease include rapid globalization, urbanization, expansion of humans i...
Article
Background Mycetoma is a neglected tropical disease that attracts little attention in regard to research and publications and hence this study was undertaken to determine the trends and global scientific research output in mycetoma-related fields. Methods Mycetoma data were retrieved from the Web of Science (WoS) and Scopus databases. The MeSH Bro...
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the top 50 most-cited articles and hosted keywords used in EC, in addition to the most productive authors, institution, and countries that provided a systematic overview of research and information that may offer deep insights into the study in the medical field and policymaker to prioritizing future research efforts in EC research.
Article
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Sickle cell disease (SCD) remains a global public health problem in sub‐Saharan Africa and other countries. Limited information is available on the scientific research productivity on SCD. The study aims to assess the growth of global scientific research output on SCD and provide historical insights for a scientific research community. A bibliometr...
Article
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Introduction: Malnutrition is a significant cause of child morbidity and mortality, and it remains a global health issue with high prevalence. Here, we carried out a bibliometric survey to provide global scientific research output on malnutrition and identify the research gaps and future research direction from published papers searched in Web of S...
Article
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The recent outbreak of the highly contagious coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2 has created a global health crisis with socioeconomic impacts. Although, recently, vaccines have been approved for the prevention of COVID-19, there is still an urgent need for the discovery of more efficacious and safer drugs...
Preprint
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Background: Sudan is a Sub-Saharan African country with a high prevalence rate of Tuberculosis. Natural Resistant Associated Macrophage Protein 1 (NRAMP1) plays a potential role in the development of immunity against TB, and it has a critical role in disease resistance. The aim of the study was to evaluate the association of NRAMP1 polymorphism at...
Article
Coronavirus disease-2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2, has spread to almost every region of the globe and has affected more than 24,299,923 people worldwide, resulting in 894,476 deaths as of September 7, 2020. The clinical manifestations of this disease include headache, fever, dry cough, and atypical pneumonia that lead...
Article
Full-text available
Esophageal cancer (EC) is 8th common cause of cancer death in the world. Moreover, it is considered a public health issues due to it is incredibly aggressive nature and poor survival rate. The study reviewed the epidemiology, diagnosis, treatment and provides an overview of the global scientific research on EC. Bibliometrics studies have played a f...
Article
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Objective: The rise of zoonotic diseases has become a global health issue around the world. The present study is aimed at assessing the global status and the trends in scrub typhus (ST) research. Methods: Publications related to ST studies from 1945 to 21st July 2020 were retrieved from the Scopus database. The search for the ST literature was c...
Article
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To date, SARS-CoV-2 (the virus that causes COVID-19) has spread to almost every region of the world, infecting millions and resulting in the deaths of hundreds of thousands of people. Although it was predicted that Africa would suffer a massive loss of life, the number of COVID-19 cases has been relatively low across the continent. Researchers have...
Article
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Background: Dengue fever (DF) is an arthropod-borne disease caused by dengue virus (DENV). DENV is a member of the genus Flavivirus in the family Flaviviridae. Recently, DENV has been reported as an important emerging infectious viral pathogen in Sudan. Multiple outbreaks and sporadic cases of DF have been frequently reported in the eastern region...
Article
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The purpose of the study is to assess the scientific research productions in Asian Pacific Journal of Tropical Medicine (APJTM) from its first issue up to Dec 2019. We used the Web of Science Core Collection (SCI-EXPANDED, SSCI) to extract the relevant documents. Additionally, the data analysis using ORIGIN PRO 2018, HistCite, bibliometrix R-packag...
Article
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The ongoing pandemic of novel coronavirus disease, COVID19, which first reported in Wuhan, China, inDecember 2019, [1] and caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV2) has resulted to more than 6,881,352 confirmed cases in the world, and 399,895 global deaths, as reported in 8:36am CEST, 8 June 2020. [2] It has been reported...
Article
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The inflammatory process in the atherosclerotic artery may lead to increased blood levels of inflammatory cytokines. The aim of this study is to understand the role of inflammatory markers in the development of coronary artery disease. Therefore, a case-control study was conducted amongst coronary artery disease patients who attended the Sudan Hear...
Article
Full-text available
Introduction: Mesenchymal stem cells (MSCs) were described as adherent cells with a fibroblast-like appearance, have a great capacity for self-renewal while maintaining their multipotency and differentiation into multiple tissues in vivo and in vitro. Methods: MSCs were isolated from cord blood of Sudanese donors using Ficoll-Hypaque gradient densi...
Article
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Background: Traumatic brain injuries (TBIs) is a leading cause of death, disability, and resources consumption. Cerebral hemorrhagic contusions are primary brain lesion and often one of the most visible lesions following TBIs. Interleukin-one beta (IL-1β) is pro-inflammatory cytokines it is circulatory level and gene have been implicated in second...
Article
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Background: Traumatic cerebral hemorrhage is a common type of traumatic brain injury. This medical condition exists in two phases: primary, which occurs at the time of trauma, and secondary, which occurs later as a result of multiple biochemical, metabolic, and inflammatory changes that develop over time. The secondary injury is mainly irreversible...
Article
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Background: Acute inflammation in the brain after trauma is mediated by acute inflammatory cells (neutrophils) that contributes to ischemic brain damage, neurological deterioration, and poor outcome. Migration of neutrophils to brain is mediated by intercellular adhesion molecule-1 (ICAM-1). The aim was to determine an association between neutroph...
Article
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Obesity is defined as a state of increased abdominal fat depo-sition consequential from chronic nutrient intake, where energy intake much exceeds energy expenditure [1]. Energy intake is balanced by food intake and energy expenditure was influenced by several factors including basal metabolism rate, physical activity [2], body size and lifespan [3]...
Article
Full-text available
Introduction: Mesenchymal stem cells (MSCs) were described as adherent cells with a fibroblast-like appearance, have a great capacity for self-renewal while maintaining their multipotency and differentiation into multiple tissues in vivo and in vitro. Methods: MSCs were isolated from cord blood of Sudanese donors using Ficoll-Hypaque gradient densi...
Article
Full-text available
Few epidemiological studies have been undertaken of measles disease among Sudanese, although measles is the third leading cause of death since 1995 among childhood diseases that can be prevented by immunization. The measles vaccine was introduced into the EPI program in 1985. In the run-up to the introduction of the vaccine, the country suffered fr...
Article
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Introduction: Sudan, the most diverse country in the African continent, is experiencing growing cancers problems. However, little is known about thyroid cancer epidemiology and patterns. the study aimed to analyse and describe the epidemiological characteristics and trends of thyroid cancer in, in the period1st January 2005 and 31st December 2015....
Article
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Dromedary camels (Camelus dromedarius) are single-humped animals found throughout the deserts of Africa, the Arabian Peninsula, and the southwest of Asia. This well-adapted species is mainly used for milk and meat production, although some specific types exhibit superior running performance and are used in racing competitions. However, neither perf...
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Aim: Obesity and Blood Pressure (BP) is a serious public health issue. The study aims to assess the prevalence of BP and the factors associated with High Blood Pressure (HBP) among student in Jiangsu Province, China. Methods: A cross-sectional epidemiological study. A total of 101886 students (62,065 boys and 39,821 girls) aged range from 7-22 yea...