Hassan Mozaffari-khosravi

Hassan Mozaffari-khosravi
Shahid Sadoughi University of Medical Sciences and Health Services | SSU · Nutrition

PhD

About

144
Publications
26,775
Reads
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2,175
Citations
Citations since 2016
104 Research Items
1819 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Additional affiliations
January 1995 - December 2015
Shahid Sadoughi University of Medical Sciences and Health Services
Position
  • Head of Department

Publications

Publications (144)
Article
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Objective This study aimed to investigate the relations of total meat intake and its subtypes, including red and processed meat, white meat, poultry, fish, and organ meat to the risk of general/central obesity. Methods This cross-sectional study included a total of 7312 Iranian adults with the age range of 35–70 years from the Shahedieh cohort stu...
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The increment of platelet aggregation factors has been considered a key phenomenon in atherosclerosis. Studies have shown that garlic (Allium sativum) is associated with a reduction in platelet aggregation and thrombosis. Hence, the present systematic review was conducted to evaluate the effect of garlic on platelet aggregation. All randomized cont...
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Background Osteoarthritis is associated with obesity, dyslipidemia and cardiovascular diseases. It has been hypothesized that L-carnitine can improve cardiovascular risk factors. We aimed to investigate the effect of L-carnitine supplementation on lipid accumulation product (LAP) and atherogenic indices in women with overweight/obesity who have kne...
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Worldwide type 2 diabetes (T2D) prevalence is increasing dramatically. The present study aimed to evaluate the association between dietary habits and T2D in an Iranian adult population using a cross-sectional analysis of the Shahedieh cohort study. Participants were adults aged 35–70 years ( n 9261) from Zarch and Shahedieh, Yazd, Iran, who attende...
Article
Background: The hepatoprotective effects of phytochemicals are controversial. A dietary phytochemical index (DPI) has been suggested as an alternative method for quantifying the phytochemical content of foods. Aim: To assess the DPI in relation to liver function tests among a representative sample of Iranian adults. Methods: A total of 5111 pa...
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Background Patients with type 2 diabetes mellitus (T2DM) are prone to develop non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD). We aimed to investigate whether the resveratrol supplementation improves novel hepatic and cardiovascular indices in these patients. Methods We conducted a double-blind, randomized controlled tr...
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Background: Increasing population aging is a global challenge and has occurred very rapidly in all parts of the world. The elderly population is more at risk of diseases, and their improper condition may impair their ability to live and cook at home. Food insecurity endangers public health as well as nutritional status, especially in the elderly. T...
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The cluster of differentiation 36 (CD36) is one of the main receptors implicated in the pathogenesis of the cardiovascular disease. This study aimed to assess the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors including body mass index (BMI), waist circumference (WC), total cholesterol (TC), triglyceride, HDL-C, LD...
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ARTICLE INFO ABSTRACT ORIGINAL ARTICLE Background: The importance of healthy nutrition in increasing immunity and reducing disease has been identified for many years. Nutrient deficiencies lead to decreased immune function and thus increase the incidence or exacerbation of infections. This study aimed to investigate the knowledge, attitude, and nut...
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Purpose Established data revealed a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. There are conflicting data regarding the association between adherence of dietary approach to stop hypertension (DASH) and obesity. Therefore, this study aims to investigate this relationship among a large sample...
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Background: Diabetes is one of the major public health concerns. Prediabetes can increase the risk of developing some non-communicable diseases such as type 2 diabetes. Given the increasing trend of prediabetes, it is critical to control it and prevent its complications. Curcumin is a major bioactive component of turmeric. Zinc is an antioxidant n...
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ARTICLE INFO ABSTRACT ORIGINAL ARTICLE Background: The importance of healthy nutrition in increasing immunity and reducing disease has been identified for many years. Nutrient deficiencies lead to decreased immune function and thus increase the incidence or exacerbation of infections. This study aimed to investigate the knowledge, attitude, and nut...
Preprint
Full-text available
Background: Obesity is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Patients with NAFLD are at increased risk for hypertension. Some investigations have hypothesized that Cornus mas L. fruit can improve blood pressure and obesity. We investigated the effect of Cornus mas L. fruit extract on blood pressure va...
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Background & Aims Non-alcoholic fatty liver disease (NAFLD) is associated with high risk of cardiovascular diseases. The experimental studies have suggested that Cornus mas L. (cornelian cherry) fruit can improve cardiovascular risk factors such as obesity, insulin resistance and dyslipidemia. We designed a study to investigate the effect of cornel...
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Background The growing number of adolescents who are overweight or obese (OW / OB) is a public concern. The present study was aimed to evaluate physical activity (PA) and sedentary behaviors (SB) (screen time (ST) and homework time (HT)) among Yazd OW/OB adolescents. Methods This cross-sectional study was performed among 510 students aged 12-16 in...
Article
The cover image is based on the Article Type The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A phase 2 randomized, placebo-controlled trial with a multi-arm, parallel-group design by Majid Karandish et al., https://doi.org/10.1002/ptr.7136.
Article
Background: Exceeded weight during the first 1000 days of life can lead to adulthood obesity and health-related problems. In the present study, we aimed to find the prevalence of overweight and obesity and their related demographic factors in the first year of life in Yazd. Methods: In a cross-sectional study, recorded data of 600 infants were coll...
Preprint
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Objectives: Data demonstrated a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. Inconsistent data regarding the association between adherence of Healthy Eating Index-2015 (HEI-2015) and obesity is identified. Thus, this study intends to address this relationship among a large sample of both urban...
Preprint
Full-text available
Objectives: Data demonstrated a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. Inconsistent data regarding the association between adherence of Healthy Eating Index-2015 (HEI-2015) and obesity is identified. Thus, this study intends to address this relationship among a large sample of both urban...
Preprint
Full-text available
Objective Data demonstrated a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. Inconsistent data regarding the association between adherence of Healthy Eating Index-2015 (HEI-2015) and obesity is identified. Thus, this study intends to address this relationship among a large sample of both urban a...
Article
Full-text available
The Mediterranean (MED) diet was associated with a reduced risk of chronic disease, but the epidemiological studies reported inconsistent findings related to the MED diet and non-alcoholic fatty liver disease (NAFLD) risk. This age and the gender-matched case-control study were conducted among 247 adult patients. The MED diet score was obtained bas...
Article
This double-blind randomized clinical trial aimed to investigate impact of Cornus mas L. fruit extract (CMFE) on liver function in nonalcoholic fatty liver disease (NAFLD). Fifty patients were randomly assigned into the CMFE and placebo groups to receive 20 ml of the extract or placebo for 12 weeks, respectively. Serum alanine aminotransferase, asp...
Article
Background and Aims Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease is closely linked to type 2 diabetes mellitus (T2DM). Omega-3 supplementation has been proposed as a strategy to manage T2DM and NAFLD. The present study aimed to investigate the effect of omega-3 supplementation on fatty liver index, lipid accumu...
Preprint
Full-text available
Background The growing number of adolescents who are overweight or obese (OW / OB) is a public concern. The present study was aimed to evaluate PA and sedentary behaviors (SB) (screen time (ST) and homework time (HT)) among Yazd OW/OB adolescents before the COVID-19 pandemic. Methods This cross-sectional study was performed among 510 students aged...
Article
Elevated levels of liver enzymes are the main markers of liver dysfunction. Liver enzymes are the important indicators of non-alcoholic fatty liver disease (NAFLD) in the general population. Previous randomized clinical trials (RCTs) investigated the effects of Mediterranean diet (MedDiet) as a plant-based diet on features of NAFLD like liver enzym...
Preprint
Full-text available
PurposeEstablished data revealed a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. There are conflicting data regarding the association between adherence of Dietary Approach to Stop Hypertension (DASH) and obesity. Therefore, this study intends to investigate this relationship among a large sampl...
Article
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The prevalence of type 2 diabetes mellitus (T2DM) is increasing dramatically worldwide. Dysregulation of microRNA (miRNA) as key regulators of gene expression, has been reported in numerous diseases including diabetes. The aim of this study was to investigate the expression levels of miRNA-122, miRNA-126-3p and miRNA-146a in diabetic and pre-diabet...
Preprint
Full-text available
Objectives: Established data revealed a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. There are conflicting data regarding the association between adherence of Dietary Approach to Stop Hypertension (DASH) and obesity. Therefore, this study intends to investigate this relationship among a large...
Article
Full-text available
This systematic review and meta‐analysis aimed to assess effect of consuming anthocyanins (ACNs; pure ACNs or products containing ACNs) on liver enzymes levels including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma‐glutamyl transferase (GGT). Although no significant impact was detected on the liver enzymes, a signific...
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Background: Hibiscus sabdariffa linnaeus (HSL) is a tropical plant with a high content of anthocyanin, traditionally found to have beneficial biological activities. This randomized, double-blind, placebo-controlled, and parallel trial was conducted to assess some renal and cardiovascular effects of supplementation with HSL in patients with diabetic...
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Management of prediabetes is a critical step to prevent type‐2 diabetes. Curcumin and zinc have been studied as an antioxidant, antiinflammatory, and antidiabetic agents. In this clinical trial, 84 subjects were randomized into curcumin (500 mg), zinc (30 mg), zinc and curcumin, and placebo groups for 90 days. At the baseline and the end of the stu...
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Background: Recent investigations have proposed that sesame and canola oils might affect body fat distribution. This study aimed to examine the effects of sesame, canola, and sesame-canola (a blend of sesame and canola oils) oils on body weight and composition in adults with type 2 diabetes mellitus (T2DM) in the context of a randomized, triple-bl...
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Backgrounds L-carnitine decreases oxidation and inflammation by reducing the fatty acid in plasma and using oxygen in ATP synthesis. As such, knee osteoarthritis (KOA) can be improved by reducing apoptotic chondrocytes. This study was designed to compare the effect of L-carnitine supplementation and low-calorie diet on improving KOA among obese wom...
Article
The present study sought to evaluate the effect of resveratrol supplementation on mRNA expression levels of peroxisome proliferator‐activated receptor alpha (PPARα), p53, p21, p16, and serum levels of cluster of differentiation 163 (CD163) to TNF‐like weak inducer of apoptosis (TWEAK) ratio in patients with type 2 diabetes. In this double‐blind ran...
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Background: Zinc as one of the important trace elements in human health has been suggested to be a supplement for modifying the level of adipokines, whereas findings from studies have been inconsistent. This study aimed to systematically review the evidence provided by randomized controlled trials (RCTs) regarding the effect of zinc supplementatio...
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Objective The aim of this study was to evaluate the effect of hypocaloric high-protein, low-carbohydrate weight loss diet supplemented with fennel on anthropometric and androgen indices in overweight and obese women with polycystic ovary syndrome (PCOS). Methods A randomized controlled trial with a factorial design was performed on sixty-four over...
Article
Introduction L-Carnitine is a substance produced from endogenous synthesis and dietary sources. This amino acid has antioxidant properties by reducing the effects of oxidative stress. The purpose of this study was to investigate the effects of L-carnitine supplementation on oxidative and metabolic status in patients with Type 2 diabetes mellitus (T...
Article
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Background: The prevalence of prediabetes is increasing worldwide. Unfortunately, prediabetes is related to non-communicable diseases. A high risk of developing type 2 diabetes mellitus (T2DM) is reported in people with prediabetes. Curcumin, a polyphenol, might lead to its therapeutic role in obesity and some obesity-related metabolic diseases. Zi...
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ARTICLE INFO ABSTRACT ORIGINAL ARTICLE Background: The important risk factors in obesity are related to unhealthy nutritional habits. The aim of this study was to estimate and compare the macro-and micro-nutrients" intake in breakfast and midmorning snacks. Methods: This cross-sectional study was conducted among 569 students (12-16 years) by the mu...
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The previous meta-analysis of clinical trials revealed a beneficial effect of vitamin E supplementation on serum C-reactive protein (CRP) concentrations; however, it is unknown whether this vitamin has the same influence on other inflammatory biomarkers. Also, several clinical trials have been published since the release of earlier meta-analysis. T...
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Healthy lifestyles are important during adolescence due to their impact on health-related problems and life expectancy during adulthood. Despite the emphasis on the importance of healthy habits, the high prevalence of breakfast skipping, physical inactivity, and insufficient sleep is reported among adolescents. This study was aimed to investigate t...
Article
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Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils...
Article
Background Patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) have disturbed glycemic control and elevated inflammatory markers. Omega-3 is known to ameliorate this disordered condition. We aimed to investigate the effect of omega-3 fatty acids on inflammatory markers and insulin resistance indices in T2DM an...
Article
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Background & Aims Vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular post-artum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods A total of 45 pregnant women with GDM...
Article
Objective To assess the association between patterns of nutrient intake and metabolic syndrome (MetS) in a large sample of Iranian adults. Design Baseline data from the Shahedieh cohort study were used in the current cross-sectional study. Dietary intakes were assessed through the use of a validated semi-quantitative FFQ. Nutrient patterns (NP) we...
Article
Background & aims The inter-individual variations of the metabolic markers in response to dietary interventions may be mediated by genetic factors. We examined whether the type of dietary oils can modulate the effects of −75G/A polymorphism in APOA-1 gene on cardiometabolic markers. Methods This study was a randomized, triple-blind, cross-over cli...
Article
Background and aims Previous studies have indicated that garlic consumption may be beneficial in improving inflammation. This systematic review and meta-analysis aimed to examine the effect of garlic supplementation on inflammatory biomarkers. Methods PubMed/Medline, Scopus and ISI web of science were searched up to February 2019. Random effects m...
Article
Background Limited data exists on the association between dietary patterns and enzymes mainly produced by the liver. Objective To examine the relationship between empirically derived dietary patterns and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma glutamyl transferase (GGT) levels a...
Article
Background Insulin resistance and hyperinsulinemia are involved in the etiology of metabolic syndrome (MetS) and its components. Objective The current study assessed the association of dietary insulin load (DIL) and dietary insulin index (DII) with the odds of having MetS among a large population of Iranian adults. Design This study was a cross-s...
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Background: The dramatic increase in the prevalence of type 2 diabetes mellitus (T2DM) is a global major challenge to health. Circulating microRNAs have been suggested as promising biomarkers for different disorders such as diabetes. Imbalances in the gut microbiome have been revealed to contribute to the progression of multiple diseases including...
Preprint
Full-text available
Backgrounds: L-carnitine decreases oxidation and inflammation by reducing the fatty acid in plasma and using oxygen in ATP synthesis. So, knee osteoarthritis (KOA) can be improved by reducing apoptotic chondrocytes. The aim of this study was to compare the effect of L-carnitine supplementation along with low calorie diet and low calorie diet alone...
Article
Full-text available
The aim of this study was investigated the effects of fennel supplementation with energy-restricted diets on body fat and muscle percentage and insulin resistance in women with PCOS. Sixty-four overweight/obese women with PCOS were randomly allocated to 4 groups for 12 weeks as follows: (1) standard diet + fennel (SDF), (2) high-protein, low-carboh...
Article
Objective(s) Diabetic patients with hypertension are at a high risk of cardiovascular complications. The present study made an attempt to determine the effect of oral L-carnitine supplementation on blood pressure in patients with type 2 diabetes mellitus (T2DM). Materials and methods In this randomized, double-blind, placebo-controlled trial, 70 p...
Article
Background and aim Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. This study therefore aimed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of randomized controlled trials (RCTs) and to con...
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The aim was to determine the relationship between dietary patterns derived by principal component analysis (PCA) in association with obesity from a large group of Iranian adults in the urban and suburb areas. A cross‐sectional study was conducted on 10,693 Iranian adults. The data were collected from two cohort studies: Shahedieh city annexed to Ya...
Article
The present study sought to investigate the effect of micronized resveratrol supplementation on serum levels of asymmetric de‐methyl‐arginine (ADMA) and paraoxonase‐1 (PON1) activity in patients with type 2 diabetes (T2D). In this double‐blinded randomized trial, 76 patients with T2D were recruited. Participants were randomly assigned to consume 1,...
Article
Aim Although antidepressants can relieve the symptoms of depression in patients with type-2 diabetes mellitus, the effect of vitamin D supplementation as an antidepressant remains unclear. The present study aimed to investigate the impact of intramuscular vitamin D supplement injections on depression and anthropometric indices in patients with type...
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Background and aims: Inflammatory processes has been shown to be associated with the development of type 2 diabetes mellitus (T2DM) in which vitamin D supplementation might exert beneficial outcomes. We examined the effects of vitamin D supplement on inflammatory and cell adhesion molecule in patients with T2DM. Methods: This study consisted of...
Preprint
Ninety individuals were included in this case-control study:30 type 2 diabetes mellitus, 30 pre-diabetes and 30 healthy individuals (males and females, age: 25-65, body mass index: 25-35). MicroRNAs expression was determined by real-time polymerase chain reaction. Furthermore, plasma concentrations of tumor necrosis factor alpha (TNF-α) and interle...
Preprint
Full-text available
Background Lifestyle and its relationship to aspects of sleep quality have been reported in many studies. An unhealthy lifestyle is associated with less sleep duration and sleep patterns. Breakfast skipping is as an important part of unhealthy lifestyle. Poor sleep quality and skipping breakfast are common in adolescents. The aim of this study was...
Article
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Background and aims Many countries lack resources to identify patients at risk of developing Type 2 diabetes mellitus (diabetes). We aimed to develop and validate a diabetes risk score based on easily accessible clinical data. Methods Prospective study including 5277 participants (55.0% women, 51.8±10.5 years) free of diabetes at baseline. Compari...
Preprint
Background: vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular post‐artum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods: A total of 45 pregnant women with GDM parti...
Article
Background: Studies on the relationship of urinary sodium with overweight and obesity led to controversial results. Furthermore, no study has ever investigated the association between sodium status and obesity in Iranian adults. The present study examined the association of urinary sodium levels with overweight and obesity in adults living in Yazd,...