Hassan Ahmadvand

Hassan Ahmadvand
Lorestan University of Medical Sciences | LUMS · Department of Clinical Biochemistry and Genetics

PhD in Clinical Biochemistry, Professor (Full)

About

180
Publications
31,840
Reads
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1,983
Citations
Citations since 2017
64 Research Items
1408 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Additional affiliations
January 2007 - December 2013
Lorestan University of Medical Sciences
January 2007 - December 2010
Isfahan University of Medical Sciences
January 2006 - January 2016
Lorestan University of Medical Sciences
Position
  • Head of Department of Biochemistry and Genetics

Publications

Publications (180)
Article
Full-text available
This study aims to determine the effects of rosmarinic acid which involved the mechanisms to decrease the postoperative peritoneal adhesion formation in rats. Various incisions and removing a 1 × 1 cm piece of peritoneum was used to induce the peritoneal adhesions. Experimental groups were as follows: 1—Sham group. 2—Control group: Peritoneal adhes...
Article
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Background: According to the international diabetes federation, 629 million adults will suffer from diabetes by 2045. Wet cupping therapy is a combination of bleeding and dry cupping and has been used in traditional medicine as a complementary therapy for diabetes. Limonene was shown to have both antioxidant and antidiabetic activity but its potent...
Article
This study was designed, for the first time, to examine the possible nephroprotective effects of exogenous glutathione (EGSH) (100 mg/kg, intraperitoneally) on gentamicin-induced acute kidney injury (GM-induced AKI). EGSH reduced renal histopathological changes, inflammatory cell infiltration, and improved renal dysfunction in rats with AKI. EGSH a...
Article
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Objective: Hepatic encephalopathy (HE) is a serious neurological syndrome which is caused by acute and chronic liver diseases. In this study, the effect of gallic acid (GA) as an activator of AMP-activated protein kinase (AMPK) on memory and anxiety-like behaviors in rats with HE caused by bile duct ligation (BDL) was investigated. Materials and...
Article
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Background and Objective: Reactive oxygen species are the main factors involved in kidney damage during renal ischemia-reperfusion (RIR). Since D-limonene has antioxidant, anti-diabetic, anti-apoptotic, and lipid peroxidation effects, it prevents mitochondrial dysfunction and inhibits ROS, this study was conducted to evaluate the effects of pretrea...
Article
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BACKGROUND AND OBJECTIVE: Gentamicin is one of the aminoglycoside antibiotics that commonly causes nephrotoxicity. Antioxidants are effective in reducing gentamicin-induced nephrotoxicity. In this study, we investigated the possible effect of L-Glutamine on the reduction of renal tissue damages and renal function recovery in gentamicin-induced neph...
Article
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Background Testicular torsion/detorsion triggers tissue ischemia/reperfusion, leading to reactive oxygen species overgeneration and apoptosis. The saliva of leeches is full of anti-inflammatory, anticoagulants, antioxidants, and antimicrobial agents. Therefore, this study aimed to assess the protective mechanism of leech therapy on testicular ische...
Article
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This study was the first to evaluate the possible protective effects of cinnamic acid (CA) against Gentamicin (GM) induced liver and kidney dysfunctions in rats. Adult male Wistar rats were randomly assigned to 4 equal groups (n ¼ 8): Control group (saline, 0.5 ml/day), CA group (CA, 50 mg/kg/day), GM group (GM, 100 mg/kg/day), and GM þ CA group (1...
Article
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Introduction: Methotrexate (MTX), used in the treatment of cancerous patients, causes toxicity in the different organs of the body. This study of rosmarinic acid (RA) is as an antioxidant on nephrotoxicity and hepatotoxicity induced by MTX. Methods: Rats (n = 32) were divided into four groups: sham; MTX; 100 mg\kg RA + MTX; 200 mg/kg RA + MTX. T...
Article
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This study was conducted to evaluate the anti-diabetic and antioxidant effects of hydroalcoholic pomegranate peel extract (APE) in alloxan-induced diabetes rat models. We divided 60 rats into the following six equal groups (n = 10): Healthy control; diabetic control (100 mg/kg alloxan); sham + glibenclamide (10 mg/kg); diabetic + glibenclamide (10...
Article
Introduction: Diabetes mellitus (DM) is a multi-factorial condition associated with oxidative stress. Limonene, as a plant-derived antioxidant, can be used for treating DM. Objectives: An investigation on antioxidant effects in diabetic rats exposed to D-limonene. Materials and Methods: Sixty male Wistar rats were categorized into six groups as fol...
Article
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Clinical application of gentamicin (GM) is well known to be associated with the development of acute kidney injury (AKI). This study was the first to investigate the possible protective effects of D-limonene (D-lim) on AKI following GM administration in rats. 32 rats arranged in four groups (n=8): (1) the control group received saline intraperitone...
Article
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Introduction: Camphor is a natural antioxidant with anti-inflammatory and tissue repair properties. Nephrotoxicity is the most important side effect of gentamicin (GEM) administration. Therefore, investigating the effect of natural antioxidants can resolve this complication. Objectives: We aimed to assay the effect of camphor on biochemical factors...
Article
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OBJECTIVE: This study aimed to investigate the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) expression and its role in cytokine production from peripheral blood mononuclear cells (PBMCs) in patients with coronary artery disease (CAD) and non-CAD participants (NCAD). METHODS: Blood samples were taken fr...
Article
Background. The present research was an attempt to assess maternal serum values of 25-hydroxy vitamin D3 [25(OH)D3], adiponectin and the lipid ratios and comparison of their associations with insulin resistance and insulin sensitivity in gestational diabetes mellitus (GDM). Material and methods. It was conducted on 100 participants including 49 wom...
Article
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Gallic acid (GA), as a strong antioxidant, was selected in this study to investigate its possible nephroprotective effects against gentamicin (GM)-induced nephrotoxicity. Twenty-four rats were separated into three groups (n=8): group 1 (control group) received saline (0.5 mL/day), group 2 (GM group) received GM (100 mg/kg/day), and group 3 (treated...
Article
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This study aimed to evaluate the effects of glutamine (Gln) on diabetic nephropathy and other complications in a rat model of type 2 diabetes mellitus. Streptozotocin/nicotinamide induced diabetic rats were enrolled as an animal model of type 2 diabetes mellitus. Animals were divided into control, diabetic , and Gln (1000 mg/l in drinking water, ei...
Article
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Background: Troxerutin has antioxidant and anti-inflammatory properties and in this study, its antioxidant effect on the reduction of oxidative stress induced by ischemia-reperfusion sciatic nerve injury was investigated. In this study, 64 male rats were randomly divided into 8 groups as follows: 1- IR2: ischemia (3 hours) and reperfusion (2 day...
Article
In this study, bulk and thin films of the Pr and Ce co-doped yttrium iron garnet, Pr0.5CexY2.5-xFe5O12, with various contents of Ce, x=0.25, 0.5 and 0.75, were synthesized and investigated. The solid-state method was used to synthesize the bulk samples and the films were deposited by the Pulsed Laser Deposition (PLD) method. The phase and structure...
Article
Testicular dysfunction is a complication of diabetes mellitus (DM). Juglans regia L. (JRL) leaf extract is a source of phenolic compounds that exhibits hypoglycemic and antioxidative properties. We investigated whether JRL leaf extract could inhibit the adverse effects of DM on oxidative stress, testis histology and testosterone hormone production....
Article
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Background: Diabetes leads to both structural and functional dysfunction in the tissues and causes problems such as fibrosis. The purpose of this study was to investigate the effect of 6 weeks moderate intensity endurance training on skeletal muscle fibrosis in diabetic rats. Methods: Twenty eight adult male wistar rats in the weight range of 200-2...
Article
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Diabetic myopathy refers to the manifestations in the skeletal muscle as a result of altered glucose homeostasis which reflects as fibrosis. Since physical exercise has been indicated a protective strategy for improving glucose metabolism in skeletal muscle, we tested a hypothesis under which the endurance exercise training could reverse the produc...
Article
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Objectives: The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats. Materials and methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used as an an...
Article
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BACKGROUND: Oleuropein is a natural antioxidant and scavenging free radicals. In the present study, we examined effect of oleuropein on paraoxonase 1 (PON1) activity, lipid peroxidation, lipid profile, atherogenic indices, and relationship of PON1 activity by high-density lipoprotein cholesterol (HDL-C) and atherogenic indices in gentamicin (GM)-in...
Article
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Objectives: Cisplatin-induced peripheral neuropathy is a debilitating side effect in patients receiving this drug. Recent studies suggest hyperbaric oxygen (HBO) therapy as a new treatment approach for models of neural injury. The aim of the current study was to determine the protective effects of HBO preconditioning against peripheral neuropathy...
Article
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We investigated the effect of thioctic acid (TA) on kidney function, oxidative stress, and inflammatory status in serum and kidney homogenates of a rat subjected to ischemia–reperfusion injury (IRI). Materials and Methods: Thirty male Wistar rats were randomly divided into three equal groups: sham, IR, and IR + TA in 50 mg/kg once-daily intraperito...
Article
Abstract Aims One of the most common urologic emergencies is spermatic cord torsion, which can damage testicular tissue and reduce fertility. Salvia miltiorrhiza (SM) hydroalcoholic extract possess high antioxidant properties, and its efficacy in ischemia-reperfusion (I/R) injury prevention has been demonstrated in cardiac, renal, and liver tissue...
Article
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The aim of this study was to investigate the expression of long non-coding RNA urothelial carcinoma-associated 1 (UCA1) and its role in TNF-? production as one of the main inflammatory cytokines, in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy non-CAD (NCAD) individuals as the control group....
Article
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This study determined the chemical composition of volatile components and antioxidant properties of Allium jesdianum (AJ), Nasturtium officinalis (NO), Eremurus spectabilis (ES), Tragopogon graminifolium (TG) and Falcaria vulgaris (FV) which grow in the west of Iran. Total phenol content, total flavonoid, free radical scavenging ability (by IC50 va...
Article
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Introduction : Gentamicin sulphate (GS) induces nephrotoxicity by increasing of reactive oxygen species (ROS). Objectives : The aim of this research was to assess the renoprotective effect of dimethyl sulfoxide (DMSO) as an antioxidant agent against GS-induced nephrotoxicity. Materials and Methods: Forty male rats (Sprague-Dawley) were divided equa...
Article
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Introduction : Reactive oxygen species (ROS) are the main factors in pathogenesis of renal ischemia-reperfusion (I/R) injury. Objectives : The aim of this study was to evaluate the renoprotective effect of rosmarinic acid (ROA) as an antioxidant substance against renal I/R injury. Materials and Methods : Forty male rats were divided into five group...
Article
Background: Adipokines have endocrine roles in metabolism and immunity. Dysregulation of adipokine levels is associated with several diseases with chronic inflammation. We aimed to assess the serum concentrations of chemerin, apelin, and adiponectin in irritable bowel syndrome (IBS). Furthermore, we evaluated the possible association of these adip...
Article
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Context: The pathogenesis of renal damage as a risk factor of renal failure can be due to oxidative stress resulting from an imbalance between the production of free radicals and antioxidants. Therefore, antioxidant therapy can be a good strategy to decrease the effects of such diseases. Hence, the aim of this review was to evaluate the protective...
Article
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Diabetes is the most common metabolic disease of humans that its prevalence is increasing worldwide .The status of antioxidants in the serum is one of the most important indicators for controlling and treatment of diabetes, because it plays an important role in protection against oxygen species and oxidative stress .The purpose of this study is to...
Article
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Background: Myeloperoxidase (MPO) is involved in the initiation, progression, and complications of atherosclerosis in diabetic patients. Objectives: In the current study, the impact of alpha-lipoic acid (LA), a natural antioxidant and a cofactor in the enzyme complexes on MPO, catalase (CAT) and glutathione peroxidase (GPx) activity, glutathione (G...
Article
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Background: Oxidative stress plays an important role in the development of atherosclerosis. An association exists between the alterations of liver markers and the risk of coronary heart disease (CHD). This study was designed to investigate the status of oxidative stress and liver markers in patients with CHD. Methods: This study included 50 CHD...
Article
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Background: Renal ischemia-reperfusion injury (RIR) occurs when there is a temporary restriction of blood flow to the kidneys followed by an influx of blood, re-oxygenating the tissues. This occurs as a severe complication of major surgery. This process causes significant damage to the tissues and is responsible for the development of acute kidney...
Article
Background: Renal ischemia-reperfusion injury (RIR) occurs when there is a temporary restriction of blood flow to the kidneys followed by an influx of blood, re-oxygenating the tissues. This occurs as a severe complication of major surgery. This process causes significant damage to the tissues and is responsible for the development of acute kidney...
Article
Introduction: Diabetes mellitus (DM) affects many patients all over the world. It involves different parts of the body, such as brain, eyes, kidneys, vessels, and so on. The lack of balance between free radicals and antioxidants is a possible mechanism involved in the pathogenesis of diabetes. Antioxidant treatment, especially natural forms, can be...
Article
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Background There is increasing evidence indicating an aberrant expression of miRNAs in colorectal cancer (CRC) development. Growing evidence has suggested that polyunsaturated fatty acids (PUFAs) could modulate the remodeling of the epigenome. No study has yet been published to examine the direct effect of PUFA on the promoter methylation of miRNAs...
Article
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Introduction: Glutathione (GSH) protects the tissue and cell from oxidative injury. Objectives: In the current study, we investigated the possible effects of GSH on liver markers, oxidative stress and inflammatory indices in rat with renal ischemia reperfusion (RIR) injury. Materials and Methods: Twenty-four adult male Wistar rats were divided i...
Article
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Citation: Ahmadvand H, Babaeenezhad E, Hadipour-Moradi F, Cheraghi-Venool A. Effect of gallic acid on liver oxidative stress markers in renal ischemia-reperfusion injury in rats. Ann Res Antioxid. 2017;2(1):e03. Introduction: Renal ischemia-reperfusion (RIR) is one of the reasons of acute renal failure (ARF). Furthermore, RIR induces oxidative stre...
Article
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Introduction: Selenium (Se) is an antioxidant and reactive oxygen species (ROS) scavenger. Objectives: This study was conducted to evaluate the effects of Se on renal functional parameters, oxidative stress biomarkers, myeloperoxidase (MPO) activity, and the nitric oxide (NO) level in renal ischemia-reperfusion (IR) injury in rats. Materials an...
Article
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Background: Paraoxonase 1 (PON1) is an enzyme attached to high density lipoprotein (HDL-C) which has antioxidant and anti-atherogenic activities. Objectives: In this study, we investigated the effects of alpha lipoic acid on PON1 activity, lipid profile and atherogenic index as well as correlation between PON1 activities and HDL-C in diabetic rats....
Article
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Background There is accumulating evidence that Juglans regia L. (GRL) leaf extract has hypoglycemic and antioxidative properties. The present study aimed to investigate the protective effects of GRL leaf extract against diabetic nephropathy (DN). Methods In total, 28 male adult Sprague-Dawley rats were used. The DN rat model was generated by intra...
Poster
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The effect of sodium selenite and vitamin E on renal antioxidant enzyme activities in renal ischemia-reperfusion injury in rats
Article
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Objectives: Recent studies revealed the neuroprotective effects of epigallocatechin-3-gallate (EGCG) on a variety of neural injury models. The purpose of this study was to determine the neuroprotective effects of EGCG following sciatic nerve transection (SNT). Methods: Rats were randomly divided into four groups each as follows: Sham-operated group...
Article
Full-text available
Background It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their rela...
Article
Full-text available
Background: Recent studies shows that hyperbaric oxygen (HBO) therapy exerts some protective effects against neural injuries. The purpose of this study was to determine the neuroprotective effects of HBO following sciatic nerve transection (SNT). Methods: Rats were randomly divided into five groups (n = 14 per group): Sham-operated (SH) group, S...
Article
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Background Deltamethrin (DM) is a synthetic pyrethroid insecticide which can lead to pathological effects in mammals through oxidative stress. On the other hand, virgin olive oil (VOO) is a rich source of phenolic compounds with antioxidants. The aim of the present study was to determine the protective effects of VOO against DM-induced hepatotoxici...
Article
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Background: Dyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people. Me...
Article
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Background: The major aim of this study was evaluating the effect of atorvastatin treatment on thiobarbituric acid reactive substances (TBARS), ferric reducing the ability of plasma (FRAP), small dense low-density lipoprotein cholesterol (sdLDL) and lipid profile in coronary artery disease (CAD) patients. Methods: This study was carried out on 8...
Article
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Background Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evidence that Juglans regia L. (GRL) leaf extract, a rich source of phenolic components, has hypoglycemic and antioxidative properties....
Article
Full-text available
Objective(s) Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy. Materials and Methods The DR rat model was generated by injection of strept...
Article
Full-text available
Background Oleuropein is a potent antioxidant and free-radical scavenger with antiinflammatory properties. Objectives In the present study, we evaluated the protective effects of oleuropein on myeloperoxidase (MPO) activity, nitrite, urea, creatinine and glomerulosclerosis in alloxan-induced type 1 diabetic rats. Materials and Methods Thirty Spra...
Article
Full-text available
The present study examined the effects of dietary Myrtle (Myrtus communis L.) on non-specific immune parameters and bactericidal activity of skin mucus in rainbow trout (Oncorhynchus mykiss) fingerlings. Three hundred and sixty fingerlings (6.50 ± 0.55 g (were distributed in twelve cages (65 × 65 × 65 cm) with a metal framework. The study included...
Article
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Numerous meta-analyses have been shown that the nephrotic syndrome is one of the most important reasons of renal failure in children that is monies-taking for health organizations around the world. Because of the global and strategic importance of this issue we intend to investigate the different aspects of nephrotic syndrome to propose our suggest...
Article
مقدمه: اطلاعات کم و ضد و نقیضی در رابطه با ارتباط سطوح سرمی هموسیستئین، نسبت آديپونکتین به هموسیستئین و اسید اوريک با شاخص های مقاومت به انسولین در ديابت بارداری گزارش شده است. لذا مطالعه حاضر با هدف بررسی سطوح سرمی هموسیستئین، آديپونکتین، نسبت آديپونکتین به هموسیستئین و اسید اوريک و ارتباط آنها با شاخص های مقاومت به انسولین در ديابت بارداری در مقا...
Article
Diabetes is the most common metabolic disease of humans that its prevalence is increasing worldwide. The status of antioxidants in the serum is one of the most important indicators for controlling and treatment of diabetes, because it plays an important role in protection against oxygen species and oxidative stress. The purpose of this study is to...
Article
Full-text available
Background and Aim: Diabetes is a major public health problem worldwide. Oxidative stress is a risk factor in diabetes. The aim of this study is to evaluate the possible beneficial effect of caffeic acid (CA) on serum lipid parameters and atherogenic index in alloxan-induced male diabetic rats. Materials and Methods: 40 male Wistar rats were random...
Article
Full-text available
This study investigated the effect of dietary Myrtle (Myrtus communis L.) powder on the growth performance, immune responses and haematological parameters of rainbow trout fingerlings. Twelve cages were assigned to four treatments in triplicate and thirty fish (6.50±0.55 g) were stocked. Treatments were different levels 0 (control), 0.5 (M0.5), 1 (...