Hassan Imran Afridi

Hassan Imran Afridi
University of Sindh · National Centre of Excellence in Analytical Chemistry

Professor

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402
Publications
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Publications

Publications (402)
Article
Background Coronavirus disease 2019 (COVID-19) is a systemic disease affecting multiple organs. Furthermore, viral infection depletes several trace elements and promotes complex biochemical reactions in the body. Smoking has been linked to the incidence of COVID-19 and associated mortality, and it may impact clinical effects, viral and bacterial co...
Article
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A new electrochemical method for the detection of cefixime (CFX) was developed by fabricating a silver nanoparticle amalgam paste microelectrode (AgNP-APME) equipped with square wave cathodic stripping voltammetric (SW-CSV). The proposed sensor was fabricated using the micro pipette tip and tied with the AgNP amalgam paste and pure copper wire used...
Article
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The infection caused by Helicobacter pylori (H. pylori) disrupts the metabolism and absorption of essential trace elements. Stomach disorders are related to changes in essential trace element metabolism caused by increased toxic metal exposure and H. pylori infection. The aim of the work is to link the development of stomach-related illnesses to an...
Article
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The current study has aims to investigate the soil quality and phytoextraction of cadmium (Cd), chromium (Cr), and lead (Pb) from saline soils using Alhagi maurorum (camelthorn), Tamarix aphylla (saltcedar), Salvadora persica (mustard bush), and Suaeda nigra (bush seep weed). The saline bulk soil, rhizospheric soil, and different parts of selected...
Article
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Breast cancer is the most familiar solid tumor analyzed in women. Trace elements have critical roles in cancer biology. In this research, the relationship between carcinogenic element, cadmium (Cd), and anti-carcinogenic elements, zinc (Zn), in the scalp hair and blood samples of four stages of female breast cancer patients was studied. We have det...
Article
Background Metal ion aberrant metabolism is essential for health and disease, and its research has sparked a lot of interest. This study aims to compare the critical mineral resources—magnesium (Mg), sodium (Na), calcium (Ca) and potassium (K)—in biological materials (scalp hair, blood, and serum) of 87 Ewing Sarcoma (ES) hypertensive men and women...
Article
Background The influence of essential nutrients such as calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), selenium (Se), and zinc (Zn) on male fertility has been extensively studied. For reproductive health, adequate spermatogenesis, sperm maturation and motility, as well as optimal sperm function, these essential elements are required. Several...
Article
Coenzyme Q10 (CoQ10) is a nutrient-like fat substance usually found in the heart, liver, kidney, and pancreas. Breast cancer is the most well-known tumor that has been analyzed and its incidence has been found to increase with age. To determine the levels of CoQ10 in female patients with breast cancer, 40 blood samples from female patients with dif...
Article
Facial cosmetics are the most commonly consumed product, mainly by the women from all over the world irrespective of their age. The facial cosmetics may be contaminated with several toxic elements, which can get absorb on to the facial skin and migrate to the blood vessels. Hence the absorbed toxic elements can cause further adverse effects on the...
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The relationship between occupational exposure and different skin diseases including scalp psoriasis and Pityriasis amiantacea has been studied. The information about imbalance of essential trace elements in psoriatic patients is still scarce. In the present follow-up study, the scalp hair and blood samples of patients (labors of cement factory) ha...
Article
A novel fluoride selective voltammetric method has been developed by using the 3-amino phenylboronic acid (APBA)-zirconium oxide (ZrO2) nanoparticles modified gold (APBA-ZrO2-NPs/Au) electrode for sensitive detection of F⁻ at trace levels in water and toothpaste. A co-precipitation approach was applied to synthesize ZrO2 nanoparticles (ZrO2-NPs) us...
Article
In present study, the comparisons of electrolytes, calcium (Ca), potassium (K), magnesium (Mg), sodium (Na) phosphorus (P), and essential trace elements, iron (Fe), zinc (Zn), copper (Cu) and selenium (Se) were carried out in milk samples of different cattle (cow, buffalo, goat, sheep, and camel) and human as total and soluble form (whey of milk)....
Article
Background: Breast cancer is an uncommon (rare) disease in men, approximately 1% of the total breast cancer cases in the world. By reason of the rare occurrence, there is no clinical or hospital study giving the information about the essential trace and toxic elements in the biological samples of male breast cancer patients. Methods: The aim of...
Article
Background Ewing’s sarcoma is a very rare type of cancerous tumor that grows in bones or the soft tissue around the bones, such as cartilage or the nerves. It frequently affects the people at the age of 10 to 20 years and has elevated rate of being cured. Methods Assessment of essential trace [zinc (Zn)] and toxic [cadmium (Cd)] elements in biolog...
Article
A simple and novel ultrasonically modified dual-cloud point extraction (Um-DCPE) method has been developed to preconcentrate a toxic heavy metal, lead (Pb²⁺), in aquifer water of different depths in the region of Thar coalfield, Pakistan, prior to analysed by flame atomic absorption spectrometry (FAAS). The Pb²⁺ in water samples have been complex w...
Article
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Neurodegeneration disorders are complex and multifaceted, leading to many chronic diseases, like Parkinson's disease (PD). Electrolytes imbalance has a significant role in the pathophysiology of neurological disorders, which might serve as a bio-indicator of these problems. In the present study, the disturbances of the electrolytes, calcium (Ca), m...
Article
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Abstract Workers of the Lakhra coal mining Sindh Pakistan were affected by a multifactorial exposure of heavy metals. The prevalence of lead (Pb) exposures in work-related symptoms among workers of indoor and outdoor mining of Lakhra coal mining was evaluated in detail. The biological samples (scalp hair and blood) of 270 workers of Lakhra coal min...
Article
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Type 1 Diabetes mellitus (T1DM) is one of the familiar childhood immune-mediated onsets and can lead to early mortalities and morbidities. It can arise at any stage, but the peak of occurrence is reported less than 18 years of age. T1DM cases in Pakistan were less than 2% of the total diabetic population. The current work designed to assess the con...
Article
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Background: Recently, Coronavirus Disease 2019 (COVID-19) has been affected by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed important global health anxiety. At this time, the treatment options for this disease are only moderately successful. Smoking has been related to COVID-19 and its mortality, and it has th...
Article
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The present research assesses the chemical fractionation of cadmium (Cd), chromium (Cr), and lead (Pb) detected in saline soil samples of Hyderabad Pakistan. Based on the reagents used in the BCR three-step conventional sequential extraction (CSE) for partitioning Cd, Cr, and Pb in saline soil samples, a Microwave induced single-step extraction (MS...
Article
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This study reveals the phytoextraction of trace metals (cobalt ‘Co’, copper ‘Cu’ and zinc ‘Zn’) by selected plants Alhagi maurorum, Tamarix aphylla, Salvadora persica and Suaeda nigra in saline soil. The two parts (roots and shoots) of selected plants were collected from different sites and desalinated rhizospheric soil samples (adhering to the roo...
Article
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Immense epidemiological studies have been indicated about adverse effects of the welding fumes on the health of the welders, especially respiratory problems and other physiological disorders. The different types of welding mechanisms produce aerosols/fumes that contain different metals including chromium (Cr) and manganese (Mn). In the present stud...
Article
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The present study is based on developing a dual-step ultrasonically modified cloud point extraction (DsUm-CPE) method for enrichment of mercury (Hg) in artificial saliva extract (ASE) of the numerous snuff products (dry and moist snuff, having green, brown and black in colors). This method relies on the complexation of Hg with ammonium O, O-diethyl...
Article
Full-text available
The present research assessed the chemical fractionation of Cobalt (Co), Copper (Cu), and Zinc (Zn), detected in saline soil samples of Hyderabad Pakistan. The partitioning of Co, Cu, and Zn in soil samples was carried by single‐step extraction using microwave irradiation energy. The validity of the methods was confirmed using the same operating co...
Article
T1DM is the most acquainted childhood immune-caused onset and may lead to early mortalities and morbidities. It can emanate in any age group but is highest reported in lesser than 18 years of age. In Pakistan only, T1DM institutes ~ 2% of the all diabetic population. This work was formulated to assess the concentration of manganese (Mn), zinc (Zn)...
Article
T1DM is the most acquainted childhood immune-caused onset and may lead to early mortalities and morbidities. It can emanate in any age group but is highest reported in lesser than 18 years of age. In Pakistan only, T1DM institutes ~ 2% of the all diabetic population. This work was formulated to assess the concentration of manganese (Mn), zinc (Zn)...
Article
Rapid and environmentally friendly ultrasound-assisted dispersive liquid–liquid microextraction (US-DLLμE) and vortex assisted-emulsification liquid–liquid microextraction (VA-ELLμE) methods are proposed for the speciation of selenium in domestic and mineral water samples. A deep eutectic solvent (DES) prepared with different ratios of choline chlo...
Article
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In the present study an innovative tandem ionic liquid‐based dispersive microextraction method using an in‐syringe air‐assisted vesicle system was developed to determine the ultra‐trace levels of lead (PbII) and cadmium (CdII) ions in synthetic sweat extract of branded and nonbranded facial cosmetic products. This method is based on injecting 2‐ami...
Article
Full-text available
The current study aims to examine the concentration of some toxic elements such as, cadmium (Cd), chromium (Cr), lead (Pb) and nickel (Ni) and physicochemical parameters such as electric conductivity (EC), pH, total dissolved solids (TDS), and biological oxygen demand (BOD) in the wastewater of dye manufacturing, textile dyeing, and small dyeing in...
Article
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Presently, the exposure of heavy metals (cadmium and lead) was determined in biological sample (serum) of women (pregnant and nonpregnant) who belong to low socioeconomic group (malnutrition). The cadmium (Cd) and lead (Pb) were determined in drinking water and locally produced cigarette (bidi), smoking by women of childbearing age. The preconcentr...
Article
ABSTRCT It was investigated that toxic metals (cadmium and lead) enhanced in coal gangue soil used for the reclamation of soil, creates adverse impacts on atmosphere. Presently the chemical fractionation of toxic metals in coal, inner and outer coal gangue soil samples of Lakhra coalfield were studied along with the impact on the orchard grass grow...
Article
The toxic metals in coal have different modes of occurrence required their frequent assessment by accurate and time‐saving chemical fractionation schemes. In the current study, the conventional sequential extraction BCR (SE‐BCR) method applied to recognize the chemical fraction of lead (Pb) in coal samples of recently developed Thar coalfield. The...
Article
An innovative and simple single drop ionic liquid based non-dispersive microextraction (SDILNDµE) method has been proposed for enrichment of arsenic (As), cadmium (Cd), nickel (Ni) and lead (Pb) in eye makeup products prior to analysis with electrothermal atomic absorption spectrometry (ETAAS). A narrow glass column was used to provide more contact...
Preprint
Full-text available
Background: Neurodegeneration is complex and multifaceted leading to many chronic diseases like Parkinson’s disorder. Electrolytes imbalance have significant role in the pathophysiology of neurological disorders, which might be serve as a bio-indicator of the neurological problems. In present study, the disturbances of electrolytes (calcium, magnes...
Article
Full-text available
For physiological and biochemical studies, it is considered essential to have knowledge about the accumulation of mineral elements in plants and their distribution in different parts of the fruit and these data being essential for geographical origins of different food commodities. In the age of food industry globalization, the origin of food is es...
Article
Full-text available
The present study was undertaken to generate a database for selenium (Se) content present in minced and processed meat products abundantly available in the market and to estimate the dietary Se intake in different types of minced/raw and processed meat in Pakistan. The concentration of Se was determined in meat samples of different brands of beef,...
Article
The occupational exposure of toxic metals is an important concern, because of its potential accumulation in living organisms, leading to long term toxic effects. The occupational and environmental contacts of toxic metals, cadmium (Cd) and lead (Pb) have been evaluated by determination of them in biological samples (blood and scalp hair) of adolesc...
Article
Full-text available
In the present study the cadmium (Cd) was determined in serum samples of psoriatic patients. The severity of psoriasis was evaluated according to criteria based on standard clinical diagnosis using Psoriasis Area Severity Index (PASI) score. In present study, an innovative tunable green solvent system based microextraction (TSS‐ME) was applied for...
Article
Full-text available
The purpose of the current study was to determine the contents of macro and micro minerals (Na, K, Ca, Mg, Cu, Cr, Fe, Mn, Zn) in the twenty-six common spices and estimate of their daily intake by the consumption of common spices. The mineral dissolution from common spices has been done by using acid digestion method and quantified by flame and gra...
Article
The current study represented a novel nano-silver amalgam pastes microelectrode (nano-Ag-APME) as a suitable alternative for the assay of cefadroxil contents in pharmaceutical formulations and biological specimen. The proposed electrode prepared in a plastic tip of micropipette tied with the nano-silver amalgam pastes mainly comprise of silver nano...
Article
A novel, speedy and modified ultrasonic-assisted dual dispersive liquid–liquid microextraction (UDDLLμE) method using a green deep eutectic solvent (DES) for the enrichment and preconcentration of cadmium (Cd²⁺) in water samples of ground water/aquifers of Thar coalfield, Pakistan was developed. The ammonium pyrrolidine dithiocarbamate (APDC) compl...
Article
Full-text available
Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system and environmental factors. In the present study, cadmium (Cd) and zinc (Zn) were analyzed in biological samples (blood and scalp hair) of smoker and nonsmoker males who have mild and severe psoriasis. The patients were evaluated according to crite...
Article
Full-text available
Tuberculosis is one of the major causes of illnesses and deaths throughout world particularly in Asia. Smoking is linked with tuberculosis recurrence and its mortality and may influence bacteriological conversion, clinical symptoms and treatment outcome. The aim of current study was to estimate association among essential trace elements {zinc (Zn),...
Article
Full-text available
The current study aims to assess the concentration of cadmium (Cd) and lead (Pb) in five tissues of Cirrhinus mrigala, Labeo rohita, and Catla catla collected from fishponds of Jamshoro and Larkana, Sindh, Pakistan. Meanwhile, the levels of Cd and Pb in feeding materials, water, and sediments of fishponds of both areas were also studied. The daily...
Article
In early nineteen century, a gas field was operational in southern part of Sindh, Pakistan for power production. The plant was completely un-operational for last three decades, whereas all wastage and raw materials are still dumped there, which might be the source to contaminate the ground water. The most of the workers population still living in d...
Article
An innovative deep eutectic solvent with ultrasound-assisted based dispersive liquid-liquid microextraction method was first time develop for separation and preconcentration of trivalent chromium in environmental water samples. The `deep eutectic solvent with ultrasound-assisted based dispersive liquid-liquid microextractionmethodwas prepared froma...
Article
A novel ionic liquid-based vortex assisted dispersive liquid-liquid micro extraction procedure(IL-VADLLμE) was proposed for the enrichment of toxic metals, cadmium (Cd) and lead (Pb) in different types of water samples, domestic treated and groundwater (tube well and hand pump). Whereas, the concentration of both toxic metals was also determined in...
Article
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The current study was conducted to evaluate the arsenic (As) and fluoride (F⁻) concentrations in growing media (stored rainwater and soil), of district Tharparkar, Pakistan. The bioaccumulation/transportation of As and F from growing media to different types of vegetables (wild cucumis, Indian squish and cluster bean) was evaluated. Total concentra...
Article
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The quantitative assessments and daily intake of arsenic (As), cadmium (Cd), nickel (Ni) and lead (Pb) were conducted in the 26 common spices collected from the market of Hyderabad, Pakistan. Conventional acid digestion procedure was applied for dissolution of common spices and the contents of toxic elemental were determined by graphite furnace ato...
Article
Full-text available
The present study evaluates the chemical fractionation of cadmium (Cd), a toxic heavy metal found in the coal samples of the Thar coalfield, Pakistan. An ultrasonic- assisted single-step extraction (USE) method was developed based on the reagents employed in the BCR three-step sequential extraction scheme (BCR-SES) for partitioning of Cd in coal sa...
Article
Full-text available
Acute leukemia (AL) is a common childhood malignancy. It is clinically and morphologically heterogeneous. The present work was intended to estimate the concentration of calcium (Ca) and magnesium (Mg) in serum and whole blood samples of children having AL; 1- to 5- and 6- to 10-year-old children age group was chosen of both genders. Healthy childre...
Article
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In many parts of the world, cadmium metal concentration in drinking water is higher than some international guideline values. To reduce its level below the safety limit, a sustainable and environmental friendly approach is crucial. Thereby, present article introduce an efficient, non-pathogenic and a novel fungal biosorbent Pleurotus eryngii for th...
Article
An innovative ultrasonic assisted microextraction method using a deep eutectic solvent for entrapping the organ metallic complexes was developed to pre-concentrate the trace quantities of cadmium (Cd) and lead (Pb) in lipsticks and eye shadows of different brands prior to flame atomic absorption spectrometry analysis. A deep eutectic solvent (DES)...
Article
In present study, the interaction of a toxic (cadmium) and essential element (zinc) was determined in scalp hair of pregnant and non-pregnant women resident in a rural area of Thraparkar, Pakistan, where malnutrition is prevalent. In the malnourished group (pregnant and nonpregnant women), deficiency of the essential element (zinc) due to malnutrit...
Article
Full-text available
Interaction between toxic and essential elements is of particular interest, because the deficiency of essential element can dramatically increase the absorption rate of toxic metals inside the body. This study was conducted to evaluate the possible correlation of lead (Pb) with calcium (Ca), iron (Fe), and zinc (Zn) in biological samples (whole blo...