Hasan Al Faruque

Hasan Al Faruque
University of Utah | UOU · Department of Pharmaceutics and Pharmaceutical Chemistry

DVM, PhD

About

30
Publications
9,531
Reads
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127
Citations
Introduction
Hasan Al Faruque graduated from the School of Medicine, Kyungpook National University, and worked as a Postdoc at the DGIST, Division of Biotechnology. Currently, he is working as a Postdoctoral Fellow at the University of Utah. Hasan performs research in Molecular Biology, Exosomes, and Cell Biology. His most recent publication is Enhanced effect of autologous EVs delivering paclitaxel in pancreatic cancer. His current research focuses on drug delivery and immunotherapy in cancer.
Additional affiliations
January 2021 - May 2022
Daegu Gyeongbuk Institute of Science and Technology
Position
  • Researcher
September 2017 - December 2020
Daegu Gyeongbuk Institute of Science and Technology
Position
  • PostDoc Position
March 2011 - August 2017
Kyungpook National University
Position
  • Fellow
Education
March 2011 - August 2017
Kyungpook National University
Field of study
  • Biomedical Science
July 2003 - December 2004
Bangladesh Agricultural University
Field of study
  • Theriogenology
September 1998 - June 2003
Bangladesh Agricultural University
Field of study
  • Veterinary Science

Publications

Publications (30)
Article
We engineered human pancreatic cancer cell (PANC-1)-derived extracellular vesicles (EVs) by conjugating the functional ligand RGD and magnetic nanoparticles (MNPs) onto EV surfaces (rmExo), for pancreatic cancer therapy. Paclitaxel (PTX) loaded into rmExo (rmExo-PTX) was intravenously injected into xenograft mice prepared using PANC-1 cells, which...
Article
Full-text available
Cancer screening and diagnosis can be achieved by analyzing specific molecules within serum-derived extracellular vesicles (EVs). This study sought to profile EV-derived proteins to identify potential lung cancer biomarkers. EVs were isolated from 80 serum samples from healthy individuals and cancer patients via polyethylene glycol (PEG)-based prec...
Article
Full-text available
Until now, magnetic hyperthermia is applied to remove solid tumors by targeting magnetic nanoparticles (MNPs) to tumor sites. In this study, leukemia cells in the bloodstream were directly removed under whole-body hyperthermia, using leukemia cell-specific MNPs. Epithelial cellular adhesion molecule (EpCAM) antibody was immobilized on the surface o...
Article
Aim: To mitigate the side effects of medical treatment by Prussian blue (PB), a well-known adsorbent for radioactive cesium (Cs), PB-deposited magnetic nanoparticles (MNPs), were prepared and analyzed on the adsorbent capacity for Cs removal. Materials & methods: The PB-deposited MNPs were prepared by photo-deposition method and investigated for th...
Article
Full-text available
Identification of the structure-function relationship of heparin, particularly between 2-O-, 6-O-, and N-sulfation and its anticoagulant or anti-inflammatory activities, is critical in order to evaluate the biological effects of heparin, especially in conjunction with modifications for oral formulation. In this study, we demonstrated that removal o...
Chapter
Autoimmunity is a phenomenon in which the body’s immune system fights off its own tissues and causes harmful complications for the body. Abnormalities in T-cell activities and expression of autoantibodies are the main causes of this phenomenon. Besides, metabolic disorders are also a matter of concern. In particular, in this chapter, the relationsh...
Article
Full-text available
CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular comprising four distinct modules. CCN Proteins achieve their pri...
Article
Recently, natural exosomes have attracted attention as an ideal drug carrier to overcome the limitations of existing drug delivery systems which are toxicity induction and low cancer-targeting performance. In this study, we propose an exosome-based hybrid nanostructure (EHN) with improved targeting ability and therapeutic efficacy against colorecta...
Article
Full-text available
Apoptosis plays an essential role in the pathophysiologic processes of rheumatoid arthritis. A molecular probe that allows spatiotemporal observation of apoptosis in vitro, in vivo, and ex vivo concomitantly would be useful to monitoring or predicting pathophysiologic stages. In this study we investigated whether cyclic apoptosis-targeting peptide-...
Preprint
Full-text available
CCNs are specific type of matricellular proteins, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members in mammals. The architecture of CCN proteins is multimodular and comprises four distinct motifs. CCN proteins achieve their specific physiological fu...
Article
We developed a forward-looking (FL) multimodal endoscopic system that offers color, spectral classified, high-frequency ultrasound (HFUS) B-mode, and integrated backscattering coefficient (IBC) images for tumor detection in situ. Examination of tumor distributions from the surface of the skin to deeper inside is essential for determining a treatmen...
Article
Full-text available
Backgrounds: Shortening of primary cilia in kidney epithelial cells is associated with kidney injury and involved with the induced level of α-tubulin in urine. Therefore, rapid detection and quantification of α-tubulin in the urine samples could be used to the preliminary diagnosis of kidney injury. Methods: Cellulose-based nanobeads modified wi...
Article
Full-text available
We propose a multimodal endoscopic system based on white light (WL), multispectral (MS), and photometric stereo (PS) imaging for the examination of colorectal cancer (CRC). Recently, the enhancement of the diagnostic accuracy of CRC colonoscopy has been reported; however, tumor diagnosis for a variety of lesion types remains challenging using curre...
Research
Full-text available
CRS 2018 in New York
Article
Methotrexate (MTX), an anchor drug for rheumatoid arthritis (RA), has been suffered from refractoriness and high toxicity limiting effective dosage. To mitigate these challenges, the ability to selectively deliver MTX to arthritis tissue is a much sought-after modality for the treatment of RA. In this study, we prepared mineralized nanoparticles (M...
Presentation
Full-text available
Oral presentation about pH responsive charge convertible and redox responsive crosslinked nanoparticles for targeted delivery of MTX in chronic inflammatory arthritis.
Article
Purpose: Proper diagnosis and treatment of rheumatoid arthritis are extremely important to optimize treatment outcomes. Dynamic contrast-enhanced MRI (DCE-MRI) may be used as a biomarker to detect inflammatory changes in synovial joints and to discriminate active and inactive stages of the disease. The aim of this study was to investigate vascular...
Poster
Full-text available
MMP-2 cleavable peptide complex consisted of fas-1 domain and RGD peptide blocks the interaction between βig-h3 and resident cells and leads to the amelioration of inflammatory arthritis.
Article
Background Transforming growth factor-β-inducible gene-h3 (βig-h3) is an ECM protein, which consists of integrin-interacting structures including four homologous fas-1 domains and an Arg-Gly-Asp (RGD) motif, is abundantly found within synovial tissues and fluid of rheumatoid arthritis (RA). In the pathogenesis of RA, βig-h3 intensifies inflammatory...
Article
Full-text available
Contagious ecthyma (CE) is one of the most widespread viral diseases; primarily affect goat and sheep but also reported from human, reindeer, musk ox, dog, cat, red squirrel etc. The disease is caused by contagious ecthyma virus (CEV) and he virus is circulating in Bangladesh. Present study was aimed at isolation, identification and molecular chara...
Article
Background Apoptosis is a well-organized process that is an important and active regulatory pathway of cell infiltration within inflammatory tissues. Decision on response after treatment with disease modifying anti-rheumatic drugs in rheumatoid arthritis has been performed by measuring acute phase reactants and clinical parameters such as disease a...
Article
Background Targeted delivery to inflamed joint and site specific drug release are the key factors for effective therapy against inflammatory arthritis. The critical dose-limiting factor for methotrexate, an anchor drug for inflammatory arthritis, is toxicity on the liver and bone marrow, which may overcome by targeted delivery based on the microenv...
Article
Postpartum negative energy balance (NEB) in the dairy cattle is associated with delayed return to ovarian cyclicity and reduced fertility. Lactation significantly delayed postpartum follicular growth and ovulation. Low energy intake also had a delaying effect, especially when only the lactating animals were considered. The aim of the present study...

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Projects

Project (1)
Project
Exosome mediated delivery to cancer