Harry J Witchel

Harry J Witchel
University of Sussex · Brighton and Sussex Medical School

About

140
Publications
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Introduction
Harry J Witchel currently works at the Brighton and Sussex Medical School, University of Sussex. Dr Witchel does research in Physiology, Cell Biology and Neuroscience. His current projects currently include 'Measuring Engagement and Boredom Using Objecitve Movement Metrics', measuring disability in multiple sclerosis using movement metrics, and teaching physiology with digital assessment and learning objects.

Publications

Publications (140)
Article
Full-text available
Background Spelling errors in documents lead to reduced trustworthiness, but the mechanism for weighing the psychological assessment (i.e., integrative versus dichotomous) has not been elucidated. We instructed participants to rate content of texts, revealing that their implicit trustworthiness judgments show marginal differences specifically cause...
Article
We consider how educational technology might promote students' holistic development. Based on a new edited book in the Methods in Physiology series, we contextualize how far technology has taken bioscience education, and also speculate on where technology needs to go. Technology, in conjunction with innovations in pedagogy, has profoundly influence...
Article
This warning narrative explores the tension in student-centered learning between attempting to teach individual students the skills of scientific writing in good faith versus encouraging student responsibility. There are often protocols to facilitate student learning that systematically apportion tasks between different members of staff. These prot...
Article
The role of interdisciplinary research (IDR) to address research questions posed by global social, economic, ecological and political changes is widely recognised (e.g. addressing Covid-19). Physiology is by nature an interdisciplinary science - understanding how fundamental processes work and interact with other systems in the body in good health...
Article
Full-text available
Objective: Burgoon's theory of conversational involvement suggest that when people engage with a person, they will move slightly closer to them, often subtly and subconsciously. However, some studies have failed to extend this to human-computer interaction. Our hypothesis is that during online reading, engagement is associated with an expenditure o...
Conference Paper
INTRODUCTION: Mind wandering is often an interposing mental state in which a person has thoughts unrelated to the primary task they are performing. It leads to diminished performance and error risk on the primary task. Recently mind wandering being proposed as comprising two different states: deliberate/intentional and spontaneous/unintentional. OB...
Conference Paper
Full-text available
Postural movement of a seated person, as determined by lateral aspect video analysis, can be used to estimate learning-relevant emotions. In this article the motion of a person interacting with a computer is automatically extracted from a video by detecting the position of motion-tracking markers on the person’s body. The detection is done by detec...
Article
Full-text available
Mind wandering is a commonly intruding cognitive state that leads to diminished performance and increased error risk during a primary task. A controversy over whether easier or more difficult tasks increase mind wandering has led to mind wandering being proposed as two different states: deliberate and spontaneous. We hypothesise that forced engagem...
Article
Full-text available
Background The written format and literacy competence of screen-based texts can interfere with the perceived trustworthiness of health information in online forums, independent of the semantic content. Unlike in professional content, the format in unmoderated forums can regularly hint at incivility, perceived as deliberate rudeness or casual disreg...
Preprint
BACKGROUND The written format and literacy competence of screen-based texts can interfere with the perceived trustworthiness of health information in online forums, independent of the semantic content. Unlike in professional content, the format in unmoderated forums can regularly hint at incivility, perceived as deliberate rudeness or casual disreg...
Conference Paper
Full-text available
Fidgeting may be a way to monitor second-by-second student engagement, which would be especially useful for gauging and improving the effectiveness of online learning. This session is based on research that found less fidgeting during a formative online reading comprehension test indicated students were more engaged Online formative assessments ar...
Book
Full-text available
The book presents pedagogic research articles:- Research matters: framing and situating pedagogic research Dr Rachel Masika and Dr Adrian Chown From pedagogic innovation to publication: resituating your pedagogic research Dr Kathleen M. Quinlan Diagramming wrongly: bridging theory and practice with ‘indisciplined’ diagramming Paul Grivell and...
Article
Student self-assessment using computer-based quizzes has been shown to increase subject memory and engagement. Some types of self-assessment quizzes can be associated with a dilemma between 1) medical students who want the self-assessment quiz to be clearly related to upcoming summative assessments or curated by the exam-setters, and 2) university...
Article
Full-text available
Introduction: Inertial sensors generate objective and sensitive metrics of movement disability that may indicate fall risk in many clinical conditions including multiple sclerosis (MS). The Timed-Up-And-Go (TUG) task is used to assess patient mobility because it incorporates clinically-relevant submovements during standing. Most sensor-based TUG re...
Conference Paper
Full-text available
Introduction: Automated tutoring systems aim to respond to the learner's cognitive state in order to maintain engagement. The end-user's state might be inferred by interactive timings, bodily movements or facial expressions. Problematic computerized stimuli are known to cause smiling during periods of frustration. Methods: Forty-four seated, health...
Chapter
More accurate non-participatory parameters and psychoacoustics to assess human perceptual responses to the acoustic environment are critical to inform effective urban sound planning and applied soundscape practice. Non-participatory observation methods are widely used by experts to capture animal behavior. In 2012, Lavia and Witchel applied these p...
Conference Paper
Full-text available
The dual task paradigm (DTP), where performance of a walking task co-occurs with a cognitive task to assess performance decrement, has been controversially mooted as a more suitable task to test safety from falls in outdoor and urban environments than simple walking in a hospital corridor. There are a variety of different cognitive tasks that have...
Conference Paper
Measuring fidgeting is an important goal for the psychology of mind-wandering and for human computer interaction (HCI). Previous work measuring the movement of the head, torso and thigh during HCI has shown that engaging screen content leads to non-instrumental movement inhibition (NIMI). Camera-based methods for measuring wrist movements are limit...
Conference Paper
Full-text available
In human computer interactions --- especially gaming --- the role of empathy has been mooted as a necessary prerequisite for higher levels of engagement and immersion. More recently other forms of engagement, including intellectual/cognitive engagement, have been proposed. In this study we present a carefully controlled dataset of human-computer in...
Conference Paper
Full-text available
Counter to prior claims that empathy is required for higher levels of engagement in human-computer interaction, our team has previously found that, in an analysis of 844 stimulus presentations, empathy is sufficient for high engagement, but is not necessary. Here, we ran a carefully controlled study of human-computer interactions with musical stimu...
Data
Equivalent simulation system as Movie 1 but containing a molecule of amiodarone docked into the pore cavity in its low energy score configuration in the starting structure (see Figs. 6 and 7 of main text). During the simulation amiodarone retained a stable configuration within the pore cavity and blocked diffusion of K+ ions into the pore and the c...
Data
Starting structure and molecular dynamics simulation of the drug-free MthK-based hERG pore model. The first 3 s illustrates the simulation starting structure with the pore model embedded in a lipid bilayer and the location of K+ (pink) and Cl− ions (yellow) equivalent to a concentration of 140 mM KCl; waters have been removed for clarity. The rest...
Article
Full-text available
The antiarrhythmic drug amiodarone delays cardiac repolarisationthrough inhibition of hERG-encoded potassium channels responsible for the rapid delayed rectifier potassiumcurrent (IKr). This study aimed to elucidate molecular determinants of amiodarone binding to the hERG channel. Whole-cell patch-clamp recordings were made at 37 °C of ionic curren...
Chapter
Full-text available
Soundscape research represents a paradigm shift, as it involves human and social sciences and physical measurements to account for the diversity of soundscapes across countries and cultures. Moreover, it treats environmental sounds as a resource rather than a waste. "Soundscape and the Built Environment" is the first book to systematically discuss...
Conference Paper
Full-text available
In 2011, we conducted a sonic arts-based applied research night- noise intervention, designed in line with a sound-scape management approach, in a busy UK city centre clubbing and entertainment district. In 2014, our new series of experiments were undertaken in a pedestrian subway (i.e. an underground passageway for pedestrians). The goals of the p...
Article
Full-text available
Background: Estimating engagement levels from postural micromovements has been summarized by some researchers as: increased proximity to the screen is a marker for engagement, while increased postural movement is a signal for disengagement or negative affect. However, these findings are inconclusive: the movement hypothesis challenges other finding...
Presentation
Full-text available
Soundscape and science outreach to raise awareness of soundscape principles to general audiences. The day’s theme was Get Connected: ’what does it really mean to ‘get connected’? Are we all equally connected, and if not what can be done to address this? What should we really be seeking connections to? How are our world and our lives being shaped by...
Article
Designers increasingly have the opportunity to influence the development of materials as they emerge from the laboratory. In order for this to be successful, designers need to be able to communicate effectively with materials scientists so that materials can be developed with desired functionalities and properties. This paper reviews evidence in fa...
Conference Paper
Full-text available
In this paper, we investigate the influence of music on human walking behaviors in a public setting monitored by surveillance cameras. To this end, we propose a novel algorithm to characterize the frequency and phase of the walk. It relies on a human-by-detection tracking framework, along with a robust fitting of the human head bobbing motion. Prel...
Conference Paper
Full-text available
Brighton & Hove is a thriving UK seaside city facing new and on-going noise issues. It is a destination city with a wide range of restaurants, bars and clubs, which, along with an impressive arts and cultural offer adds to the excitement and interest both for residents and visitors. Brighton provides support to the creative arts, attracts business...
Article
Full-text available
This paper presents the results of a multimodal study of oral perception conducted with a set of material samples made from metals, polymers and woods, in which both the somatosensory and taste factors were examined. A multidimensional scaling analysis coupled with subjective attribute ratings was performed to assess these factors both qualitativel...
Article
Full-text available
Diverse non-cardiac drugs adversely influence cardiac electrophysiology by inhibiting repolarising K(+) currents mediated by channels encoded by the human ether-a-go-go-related gene (hERG). In this study, pharmacological blockade of hERG K(+) channel current (IhERG) by a novel investigative serotonin-selective reuptake inhibitor (SSRI), CONA-437, w...
Conference Paper
Full-text available
Discrete, three-minute, computer-presented stimuli (designed to range from engaging to incredibly boring) were used to elicit changes in cognitive/emotional states in seated, healthy volunteers. These stimuli did not require the use of a mouse, so movements were assumed to be non- instrumental. Stimuli included films, games, quizzes and music. Moti...
Conference Paper
Full-text available
We have developed an interactive, three-dimensional visualisation that plots individual motion capture data streams so they can be visually inspected concurrently to yield a unified, multimodal view of a complex problem. The primary objective in this study is to facilitate analysis of groups of putatively correlated time series with large numbers o...
Conference Paper
Full-text available
The Inputs-Outputs interdisciplinary conference on engagement (and related terms) was structured to cross-fertilise the relevant researchers from the arts, sciences and engineering on the causes, consequences and assessment of engagement. The goal of the conference was to encourage interdisciplinary research and collaboration on engagement, presenc...
Conference Paper
Full-text available
“Sounding Brighton” is a collaborative project exploring practical approaches towards better soundscapes focusing on soundscape issues related to health, quality of life and restorative functions of the environment. The project is part of a citywide engagement process working to provide opportunities to demonstrate how an applied soundscape approac...
Article
Full-text available
Many academic fields would benefit from an aggregation of technologies that could objectively measure engagement on a moment-by-moment basis. To develop this methodology, subjective responses to stimuli must be shown to correlate with the component technologies, such as motion capture or psychophysiology. Subjective scales for engagement often fail...
Conference Paper
Full-text available
Objective metrics of engagement are valuable for estimating user experience or progression through interactional narratives. Postural micromovements of seated individuals during computer engagement have been previously measured with magnetic field sensors and chair-mounted force matrix detection mats. Here we compare readings from a head-mounted ac...
Conference Paper
Full-text available
"Sounding Brighton" is a collaborative project exploring practical approaches towards better soundscapes focusing on soundscape issues related to health, quality of life and restorative functions of the environment. The project provides the opportunity to raise awareness and promote communication on soundscapes among the general public, stakeholder...
Data
N588K reentry in realistic 2D geometry. Re-entrant spiral waves generated by the application of a premature S2 stimulus into the refractory and partially recovered region of an excitation wave after a delay of 241 ms rom the initial wave stimulus under the N588K (SQT1 mutant) condition. The induced spiral waves transition from transmural re-entry w...
Data
N588K reentry in idealised 2D geometry. Initiation and conduction of re-entry in a 2D idealised model of the transmural ventricle under the N588K (SQT1 mutant) condition. A planar conditioning wave generated by an S1 stimulus at the ENDO end propagates towards the EPI end. An S2 stimulus is applied to the EPI part during the vulnerable window of th...
Data
WT reentry in realistic 2D geometry. Re-entrant spiral waves generated by the application of a premature S2 stimulus into the refractory and partially recovered region of an excitation wave after a delay of 400 ms rom the initial wave stimulus under the wild type (control) condition. The induced spiral waves transition from transmural re-entry with...
Data
WT reentry in realistic 3D geometry (anterior view). Anterior view of the ventricles showing re-entrant scroll waves generated by the application of a premature S2 stimulus in a local refractory region of a previous conditioning excitation wave after a time delay of 380 ms from the initial conditioning wave stimulus under the wild type (control) co...
Data
N588K reentry in realistic 3D geometry (left ventricular view). Left ventricular view of the ventricles showing re-entrant scroll waves generated by the application of a premature S2 stimulus in a local refractory region of a previous conditioning excitation wave after a time delay of 245 ms from the initial conditioning wave stimulus under the N58...
Data
Appendix. Appendix showing the: (i) IKr Markov model equations for WT and N588K conditions (ii) concordance between simulations and experimental currents elicited by action potential waveforms (iii) steady state APD rate dependence for the full Markov Chain model and (iv) model independence of the functional consequences of the N588K mutation for c...
Data
WT reentry in idealised 2D geometry. Initiation and conduction of re-entry in a 2D idealised model of the transmural ventricle under the wild type (control) condition. A planar conditioning wave generated by an S1 stimulus at the ENDO end propagates towards the EPI end. An S2 stimulus is applied to the EPI part during the vulnerable window of the l...
Data
WT reentry in realistic 3D geometry (left ventricular view). Left ventricular view of the ventricles showing re-entrant scroll waves generated by the application of a premature S2 stimulus in a local refractory region of a previous conditioning excitation wave after a time delay of 380 ms from the initial conditioning wave stimulus under the wild t...
Data
N588K reentry in realistic 3D geometry (anterior view). Anterior view of the ventricles showing re-entrant scroll waves generated by the application of a premature S2 stimulus in a local refractory region of a previous conditioning excitation wave after a time delay of 245 ms from the initial conditioning wave stimulus under the N588K (SQT1 mutatio...
Article
Full-text available
The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death. This simulation study identifies arrhythmogenic mechanisms in the rapid-delayed rectifier K(+) current (I(Kr))-linked SQT1 variant of the SQTS. Markov chain (MC) models were...
Article
Full-text available
The field of automated patch-clamp electrophysiology has emerged from the tension between the pharmaceutical industry's need for high-throughput compound screening versus its need to be conservative due to regulatory requirements. On the one hand, hERG channel screening was increasingly requested for new chemical entities, as the correlation betwee...
Article
Not all metals taste equally metallic when placed in the mouth. While much work has been done to examine the metallic taste sensations arising from metal ions in solutions, there is comparatively less known about the taste of solid metals. In this study seven metals in the form of spoons were used to compare the perception of taste arising from sol...