Harry van Lenthe

Harry van Lenthe
KU Leuven | ku leuven · Section of Biomechanics

About

217
Publications
23,861
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Introduction
Harry van Lenthe currently works at the Section of Biomechanics, University of Leuven. Harry does research in Mechanical Engineering, Biomedical Engineering and Bioengineering.
Additional affiliations
January 2007 - present
KU Leuven
March 2002 - present
ETH Zurich
January 1997 - January 2002
Radboud University

Publications

Publications (217)
Article
Full-text available
Femoroplasty is a procedure where bone cement is injected percutaneously into a weakened proximal femur. Uncertainty exists whether femoroplasty provides sufficient mechanical strengthening to prevent fractures in patients with femoral bone metastases. Finite element models are promising tools to evaluate the mechanical effectiveness of femoroplast...
Article
The goal of this study was twofold. First, we aimed to evaluate the accuracy of a finite element (FE) model to predict bone fracture in cancer patients with proximal femoral bone metastases. Second, we evaluated whether femoroplasty could effectively reduce fracture risk. A total of 89 patients were included, with 101 proximal femurs affected with...
Article
This study aims to evaluate the mechanical performance of a unique, state-of-the-art, patient-specific alloplastic total replacement system for the temporomandibular joint that allows for enthesis reconstruction developed by CADskills BV (Ghent, Belgium), and its influence on the remaining adjacent healthy tissue, by looking into the magnitude and...
Article
Full-text available
Background: Pedicle screw fixation devices are the predominant stabilization systems adopted for a wide variety of spinal defects. Accordingly, both pedicle screw design and bone quality are known as the main parameters affecting the fixation strength as measured by the pull-out force and insertion torque. The pull-out test method, which is recomme...
Preprint
Full-text available
Femoroplasty is a procedure where bone cement is injected percutaneously into a weakened proximal femur. Uncertainty exists whether femoroplasty provides sufficient mechanical strengthening to prevent fractures in patients with femoral bone metastases. Finite element models are promising tools to evaluate the mechanical effectiveness of femoroplast...
Article
High-resolution peripheral quantitative computed tomography (HR-pQCT) devices can scan extremities at bone microstructural level in vivo and are used mainly in research of bone diseases. Two HR-pQCT scanners are commercially available to date: XtremeCT (first generation) and XtremeCT-II (second generation) from Scanco Medical AG (Switzerland). Rece...
Article
Full-text available
The primate thumb plays a central role in grasping and the basal trapeziometacarpal (TMC) joint is critical to its function. The TMC joint morphology varies across primates, yet little is known about form-function interaction within in the TMC joint. The purpose of this study was to investigate how stress distributions within the joint differ betwe...
Article
Full-text available
The enthesis allows the insertion of tendon into bone thanks to several remarkable strategies. This complex and clinically relevant location often features a thin layer of fibrocartilage sandwiched between tendon and bone to cope with a highly heterogeneous mechanical environment. The main purpose of this study was to investigate whether mineralize...
Article
Osteocytes are capable of remodeling their perilacunar bone matrix, which causes considerable variations in the shape and size of their lacunae. If these variations in lacunar morphology cause changes in the mechanical environment of the osteocytes, in particular local strains, they would subsequently affect bone mechanotransduction, since osteocyt...
Preprint
Full-text available
Background context: Acoustic modal analysis (AMA) method has been gained interest in the fixation stability measurement of dental and orthopedic implants which can be adopted as a new fixation measurement technique for spinal pedicle screws.
Conference Paper
Full-text available
Pilot hole preparation, in particular pilot hole diameter is one of the most remarkable pretreatments which affects bone screw stability [1]. Pull-out tests are considered the gold standard to assess screw stability but tests are limited due to their destructiveness. Non-destructive acoustic modal analysis is being used to evaluate the primary and...
Conference Paper
Full-text available
Bone screw fixation can be quantified with several test methods such as insertion torque, pull-out, push-in and bending tests [1-2]; yet, these are all destructive methods. Non-destructive modal analysis is being used to evaluate the mechanical primary and secondary stability of dental implants, and it has recently been proposed for orthopedic and...
Article
Edentulism with associated severe bone loss is a widespread condition that hinders the use of common dental implants. An additively manufactured subperiosteal jaw implant (AMSJI) was designed as an alternative solution for edentulous patients with Cawood and Howell class V–VIII bone atrophy. A biomechanical evaluation of this AMSJI for the maxilla...
Article
PurposePostero-anterior (PA) mobilization is widely used to manage low back pain by physiotherapists. The PA load is applied through the spinous process of a vertebra. Low bone density is a counter-indication of PA mobilization, whether PA mobilization may cause fractures in fragile vertebrae is unclear. Therefore, the aim of this study was to quan...
Article
PMMA bone cement has gained an important place in a variety of orthopaedic applications in the femur. However, appropriate data on the mechanical properties of bone-cement composites from the human femur are lacking. Therefore, the goal of this study was to determine the morphological and quasi-static compressive properties of proximal femoral bone...
Article
Full-text available
Obtaining high-resolution scans of bones and joints for clinical applications is challenging. HR-pQCT is considered the best technology to acquire high-resolution images of the peripheral skeleton in vivo, but a breakthrough for widespread clinical applications is still lacking. Recently, we showed on trapezia that CBCT is a promising alternative p...
Article
Background and Objective: Bone screw fixation can be estimated with several test methods such as insertion torque, pull-out, push-in and bending tests. A basic understanding of the relationship between screw fixation and bone microstructure is still lacking. Computational models can help clarify this relationship. The objective of the paper is to e...
Article
Over the last decades, the use of high-resolution imaging systems to assess bone microstructural parameters has grown immensely. Yet, no standard defining the quantification of these parameters exists. It has been reported that different voxel size and/or segmentation techniques lead to different results. However, the effect of the evaluation softw...
Article
Short-stems are becoming increasingly popular in total hip arthroplasty since they preserve the bone stock and simplify the implantation process. Short-stems are advised mainly for patients with good bone stock. The clinical use of short-stems could be enlarged to patients with poor bone stock if a cemented alternative would be available. Therefore...
Conference Paper
Full-text available
Adequate deltoid and rotator cuff lengthening in total shoulder arthroplasty (TSA) is crucial to maximize the postoperative functional outcome and to avoid complications. Hence surgeons and patients could benefit from including muscle length information in preoperative planning software. Although different methods have been introduced to automatica...
Article
Full-text available
Custom reverse shoulder implants represent a valuable solution for patients with large bone defects. Since each implant has unique patient-specific features, finite element (FE) analysis has the potential to guide the design process by virtually comparing the stability of multiple configurations without the need of a mechanical test. The aim of thi...
Article
Full-text available
Background Adequate deltoid and rotator cuff elongation in reverse shoulder arthroplasty (RSA) is crucial to maximize the postoperative functional outcome and to avoid complications. Measurements of deltoid and rotator cuff elongation during preoperative planning can support surgeons in selecting a suitable implant design and position. Therefore, t...
Article
Full-text available
Knowledge about bone morphology and bone quality of the scapula throughout the population is fundamental in the design of shoulder implants. In particular, regions with the best bone stock (cortical bone) are taken into account when planning the supporting screws, aiming for an optimal fixation. As an alternative to manual measurements, statistical...
Article
Full-text available
Patients with bone metastases have an increased risk to sustain a pathological fracture as lytic metastatic lesions damage and weaken the bone. In order to prevent fractures, prophylactic treatment is advised for patients with a high fracture risk. Mechanical stabilization of the femur can be provided through femoroplasty, a minimally invasive proc...
Article
Full-text available
Aims and Objectives Inexplicable pain to the medial proximal tibia is a frequent finding leading to revision after unicondylar knee arthroplasty (UKA). This study is an effort to find out, if there are any differences between mobile (MB) and fixed bearing (FB) UKA designs in terms of resulting strain in the medial proximal tibia as measured in an i...
Article
Full-text available
Sexually dimorphic bone structure emerges largely during puberty. Sex steroids are critical for peak bone mass acquisition in both genders. In particular, the biphasic effects of estrogens mediate the skeletal sexual dimorphism. However, so far the stimulatory vs inhibitory actions of estrogens on bone mass are not fully explained by direct effects...
Article
Prophylactic treatment is advised for metastatic bone disease patients with a high risk for fracture. Femoroplasty provides a minimally invasive procedure to stabilize the femur by injecting bone cement into the lesion. However, uncertainty remains whether it provides sufficient mechanical strength to the weight-bearing femur. The goal of this stud...
Article
Full-text available
Nonlinear finite element (FE) models can accurately quantify bone strength in healthy and metastatic femurs. However, their use in clinical practice is limited since state-of-the-art implementations using tetrahedral meshes involve a lot of manual work for which specific modelling software and engineering knowledge are required. Voxel-based meshes...
Article
Background Unexplained pain in the medial proximal tibia frequently leads to revision after unicondylar knee arthroplasty (UKA). As one of the most important factors for osteogenic adaptive response, increased bone strain following UKA has been suggested as a possible cause. Questions/purposes In this study we: (1) performed a cadaver-based kin...
Conference Paper
Full-text available
Pedicle screw instrumentation is widely used to obtain rigid internal fixation of the spine for treatment of several severe spinal deformities. Screw loosening is a major failure mode [1]. Pull-out tests are widely used in biomechanical evaluation of the stability of pedicle screws. It has been shown that peak pullout force depends on several para...
Article
Reliable computer models are needed for a better understanding of the physical mechanisms of skull fracture in accidental hits, falls, bicycle - motor vehicle & car accidents and assaults. The performance and biofidelity of these models depend on the correct anatomical representation and material description of these structures. In literature, a st...
Article
High‐resolution peripheral quantitative computed tomography (HR‐pQCT) is considered as the best technique to measure bone microarchitecture in vivo. However, a breakthrough for medical applications is inhibited because of the restricted field of view (∼9 mm) and a relatively long acquisition time (∼3 minutes). The goal of this study was to compare...
Article
Short stem hip implants are becoming increasingly popular since they preserve bone stock and presumably reduce stress‐shielding. However, concerns remain whether they are suitable for a wide range of patients with varying anatomy. The aim of this study was to investigate how femoral anatomy influences stress‐shielding induced by a short calcar‐guid...
Article
Full-text available
Hormonal changes during lactation are associated with profound changes in bone cell biology, such as osteocytic osteolysis, resulting in larger lacunae. Larger lacuna shape theoretically enhances the transmission of mechanical signals to osteocytes. We aimed to provide experimental evidence supporting this theory by comparing the mechanoresponse of...
Article
Androgens via the androgen receptor (AR) are required for optimal male bone health. The target cell(s) for the effects of androgens on cortical bone remain(s) incompletely understood. In females, estrogen receptor alpha in neurons is a negative regulator of cortical and trabecular bone. Whether neuronal AR regulates bone mass in males remains unexp...
Article
The human thumb is specialized for manual tasks as it is no longer typically involved in locomotion. However, members of the genus Pan – the closest extant relatives of modern humans – also have a highly mobile thumb, which allows complex manual tasks such as tool-crafting and use. Here, we investigate the thumb kinematics of bonobos (Pan paniscus)...
Article
Nutrition of articular cartilage relies mainly on diffusion and convection of solutes through the interstitial fluid due to the lack of blood vessels. The diffusion is controlled by two factors: steric hindrance and electrostatic interactions between the solutes and the matrix components. Aging comes with changes in the cartilage structure and comp...
Article
Objectives: To develop and validate an automated classification method that determines the trabecular bone pattern at implant site based on 3D bone morphometric parameters derived from CBCT images. Methods: Twenty-five human cadaver mandibles were scanned using CBCT clinical scanning protocol. Volumes-of-interest comprising only the trabecular b...
Article
Objective: Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical prop...
Conference Paper
Full-text available
Introduction Unexplained pain in the anteromedial region of the proximal tibia is a common challenge following unicondylar knee arthroplasty (UKA), which may even lead to revisions. Although abnormal strain distribution and bone-implant motion have been suggested as potential factors, the specific reason is not yet clear [1]. Therefore, this study...
Article
Due to the rising life expectancy, bone diseases (e.g. osteoporosis, osteoarthritis) and trauma (e.g. fracture) have become an important socio-economic burden. Accurate visualization and quantification of the bone microstructure in vivo is seen as an important step to enhance diagnosis and treatment. Micro-computed tomography (microCT) has become t...
Article
Osteocyte lacunae are small cavities within the bone matrix. Their dimensions and spatial arrangement affect bone mechanical properties. Furthermore, their size and shape affect the strain in bone tissue close to the lacunae; hence, they are supposed to affect the mechanosensory function of the osteocytes residing in the lacunae. It was the purpose...
Article
Full-text available
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are linked to increased skeletal fragility, though the exact mechanisms are poorly understood. Our aim was to characterize the struc...
Article
Full-text available
Voxel-based micro-finite-element (μFE) models are used extensively in bone mechanics research. A major disadvantage of voxel-based μFE models is that voxel surface jaggedness causes distortion of contact-induced stresses. Past efforts in resolving this problem have only been partially successful; i.e., mesh smoothing failed to preserve uniformity o...
Chapter
Bone is probably the most frequently investigated biological material and finite element analysis (FEA) is the computational tool most commonly used for the analysis of bone biomechanical function. FEA has been used in bone research for more than 30 years and has had a substantial impact on our understanding of the complex behavior of bone. Bone is...
Article
Full-text available
Abstract Objective Aging is accompanied by a series of changes in mature tissues that influence their properties and functions. Collagen, as one of the main extracellular components of cartilage, becomes highly crosslinked during aging. In this study, the aim was to examine whether a correlation exists between collagen crosslinking induced by artif...
Preprint
Voxel-based micro-finite-element (μFE) models are used extensively in bone mechanics research. A major disadvantage of voxel-based μFE models is that voxel surface jaggedness causes distortion of contact-induced stresses. Past efforts in resolving this problem have only been partially successful; i.e., mesh smoothing failed to preserve uniformity o...
Article
Full-text available
Purpose of review: The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechan...
Article
Secure implant fixation is challenging in osteoporotic bone. Due to the high variability in inter- and intra-patient bone quality, ex vivo mechanical testing of implants in bone is very material- and time-consuming. Alternatively, in silico models could substantially reduce costs and speed up the design of novel implants if they had the capability...
Article
Full-text available
Bone's microporosity plays important roles in bone biology and bone mechanical quality. In this study, we explored the accuracy and reproducibility of nondestructive desktop μCT for 3D visualization and subsequent morphometric analysis of mouse cortical bone microporosity including the vascular canal network and osteocyte lacunae. The accuracy of m...
Data
Reproducibility data. Data used to evaluate reproducibility. (XLSX)
Data
Accuracy data. Data used to evaluate accuracy. (XLSX)
Article
It has been hypothesized that the interprosthetic gap between ipsilateral hip and knee replacements acts as a stress riser affecting bone fracture behaviour. The aim of this study was to quantify femoral strength and fracture morphology for a wide range of interprosthetic gaps. Seven interprosthetic gaps (0-20cm) were created in artificial femora (...
Article
Statement of significance: Calcium-phosphate scaffolds are being increasingly used to repair critical bone defects. Methods for the accurate characterization of the repair process are still lacking. The present study introduced and validated a novel image-processing technique, using micro-computed tomography (mCT) datasets, to investigate material...
Article
Insufficient primary stability of screws in bone leads to screw loosening and failure. Unlike conventional continuum finite-element models, micro-CT based finite-element analysis (micro-FE) is capable of capturing the patient-specific bone micro-architecture, providing accurate estimates of bone stiffness. However, such in silico models for screws...
Article
Articular cartilage covers the temporomandibular joint (TMJ) and provides smooth and nearly frictionless articulation while distributing mechanical loads to the subchondral bone. The thickness of the cartilage is considered to be an indicator of the stage of development, maturation, aging, loading history, and disease. The aim of our study was to d...
Article
Current motion capture techniques all have shortcomings when applied to the 3D quantitative evaluation of thumb base motion. Dynamic CT might overcome these shortcomings but, so far, robustness of this technique in more than one specimen has not yet been demonstrated.The aim of the current study is to further evaluate the use of dynamic CT for quan...
Article
Purpose: Cortical thickness and density are critical components in determining the strength of bony structures. Computed tomography(CT) is one possible modality for analyzing the cortex in 3D. In this paper, a model-based approach for measuring the cortical bone thickness and density from clinical CTimages is proposed.
Article
Ultrasound propagation is widely used in the diagnosis of osteoporosis by providing information on bone mechanical quality. When it loses calcium, the tissue properties will first decrease. However, limited research about the influence of tissue properties on ultrasound propagation have been done due to the cumbersome experiment. The goal of this s...
Article
Secure fracture fixation is still a major challenge in orthopedic surgery, especially in osteoporotic bone. While numerous studies have investigated the effect of implant loading on the peri-implant bone after screw insertion, less focus has been put on bone damage that may occur due to the screw insertion process itself. Therefore, the aim of this...