Harry Kissileff

Harry Kissileff
Columbia University | CU · Department of Medicine

Ph.D.

About

148
Publications
6,373
Reads
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7,278
Citations
Citations since 2017
22 Research Items
1140 Citations
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2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Introduction
Skills and Expertise
Additional affiliations
January 1976 - present
Columbia University College of Physicians and Surgeons
Position
  • Adjunct Associate Research Scientist and Director NYNORC Ingestive Behavior Core Laboratory

Publications

Publications (148)
Article
Full-text available
Equivocal findings regarding the influence of overweight/obesity on exercise lipid-oxidizing capacity (EX-LIPOX) might reflect inadequate control of: 1.) acute energy balance/macronutrient composition of diet; 2.) intensity/duration of exercise; and/or 3.) insulin sensitivity (IS) of participant. To assess independent/combined influences of IS and...
Article
Full-text available
The Universal Eating Monitor was a term used to describe a device used in a laboratory setting that enabled investigators to measure, with the same instrument, the rate of eating either solids or liquids, hence the term “universal”. It consisted of an electronic balance placed in a false panel under a table cloth on which could be placed a food res...
Article
Group data means from individuals who self-assess as emotional eaters do not reliably show increased food intake in response to stress or negative emotions. This inconsistency in predictive validity of self-reported emotional eating (EE) could be attributable to unconsidered moderation of the relationship between self-reported EE and behavioral mea...
Article
Virtual portion tasks have been used to predict food intake in healthy individuals, severity of illness in individuals with anorexia nervosa, and weight loss in bariatric surgery patients. Whether portion creation in response to a recalled interpersonal stress ("recalled stress portions") could be used as a proxy for ad lib intake, after a stressor...
Preprint
Virtual portion tasks have been used to predict food intake in healthy individuals, severity of illness in individuals with anorexia nervosa, and weight loss in bariatric surgery patients. Whether portion creation in response to a recalled interpersonal stress (“recalled stress portions”) could be used as a proxy for ad lib intake, after a stressor...
Article
Full-text available
The Eating Disorder Examination Interview Bariatric Surgery Version (EDE-BSV) assesses eating pathology after bariatric surgery but requires significant training and time to administer. Consequently, we developed a questionnaire format called the Eating Disorders After Bariatric Surgery Questionnaire (EDABS-Q). This study evaluates the consistency...
Chapter
The goal of this chapter is to describe measures of emotions as influences on eating behavior and weight control. We begin with the measurement of eating behavior in response to negative emotions or stress (i.e., emotional eating). Next, we show how the measures of emotions can test theoretical models that underlie emotional eating along with the t...
Article
Full-text available
Patients who receive Roux-en-Y gastric bypass (RYGB) lose more weight than those who receive vertical sleeve gastrectomy (VSG). RYGB and VSG alter hedonic responses to sweet flavor, but whether baseline differences in hedonic responses modulate weight loss after RYGB or VSG remains untested. Male and female candidates (n = 66) for RYGB or VSG were...
Article
Food portion size influences energy intake, and sustained high-energy intake often leads to obesity. Virtual portion creation tasks (VPCTs), in which a participant creates portions of food on a computer screen, predict intake in healthy individuals. The objective of this study was to determine whether portions created in VPCTs are stable over time...
Article
Introduction: It is not clear whether impaired exercise lipid oxidation is associated with excess body-fat or changes in metabolic health often associated with the overweight/obese state. Mixed findings may reflect lack of control for key variables including: 1) acute energy balance and macronutrient composition of the diet; 2) intensity and durati...
Article
Perceived life stress (PLS) and cognitive restraint are associated with increased comfort food intake under stress and lead to weight gain and obesity, but the mechanisms by which they do so remain unclear. Stress and negative affect (NA) are associated with increased reward-driven comfort food intake as a means to 'feel better', particularly for i...
Article
In a previous study (Kissileff HR, Carretta JC, Geliebter A, Pi-Sunyer FX. Am J Physiol Regul Integr Comp Physiol 285: R992-R998, 2003), when subthreshold gastric distension (300 ml) and a low dose of cholecystokinin octapeptide (CCK-8) (112 ng/min for 21 min) were concurrently administered to human participants, intake of a test meal was significa...
Article
This paper honors the contributions made by Anthony (Tony) Sclafani and Karen Ackroff to both the Columbia University Seminar on Appetitive Behavior and to the field of ingestive behavior in general. We review their use of the progressive ratio (PR) licking paradigm, to determine whether the taste of sucrose, independent of its post-ingestive effec...
Article
A study in which adolescent patients with anorexia nervosa (n = 24) rated their expected food-anxiety in response to images of portions of food (potatoes, rice pizza, and M&Ms) showed that lower energy-dense foods elicited higher expected anxiety per kilocalorie than higher energy-dense foods. However, the area of the portion sizes could be an unme...
Article
New methods, derived from animal work, for measuring food reward value, i.e. reinforcing value of food, and motivation (i.e. strength of desire) to consume, in humans are described and validated. A sipping device (sipometer) was developed that permits access to a liquid food or beverage on two reward schedules: continuous reinforcement (CR) and pro...
Article
The size of portions that people select is an indicator of underlying mechanisms controlling food intake. Fears of eating excessive portions drive down the sizes of portions patients with anorexia nervosa (AN) can tolerate eating significantly below those of healthy controls (HC) (Kissileff, et al., 2016). To determine whether patients with AN will...
Article
Full-text available
Background Medium chain triglycerides (MCT) enhance thermogenesis and may reduce food intake relative to long chain triglycerides (LCT). The goal of this study was to establish the effects of MCT on appetite and food intake and determine whether differences were due to differences in hormone concentrations. Methods Two randomized, crossover studie...
Article
This review summarizes the formation of the Society for the Study of Ingestive Behavior (SSIB), highlighting the many people whose commitment and perseverance brought together a wide range of disciplines for the common goal of investigating ingestive behavior and providing communication via scientific meetings. The goals and philosophy of the Socie...
Article
Previous studies have suggested that delayed gastric emptying and abnormal postprandial release of hormones that influence satiation, particularly cholecystokinin (CCK), may play an important role in the pathophysiology of bulimia nervosa (BN). This study was designed to test these hypotheses as well as the efficacy of the prokinetic agent erythrom...
Article
Full-text available
Individuals who are weight-reduced or leptin deficient have a lower energy expenditure coupled with higher hunger and disinhibition and/or delayed satiation compared with never-weight-reduced control subjects. Because exogenous leptin inhibits feeding in congenitally leptin-deficient humans, reduced leptin signaling may reduce the expression of fee...
Article
Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition changes. This disproportionate declin...
Article
Bulimia nervosa (BN) is characterized by the recurrent consumption of excessive amounts of food (binge eating) followed by inappropriate compensatory behaviors. A leading hypothesis is that the persistence of BN may be due, in part, to a disturbance in the development of satiation. Because patients with BN consume larger meals than controls, previo...
Article
Previous studies have shown that inherited taste blindness to bitter compounds like 6-n-propylthiouracil (PROP) may be a risk factor for obesity, but this literature has been highly controversial. The objectives of this study were (i) to confirm findings that show an interaction between PROP status and sex on BMI z-score, and (ii) to determine if s...
Article
This study aimed to test the hypothesis that, compared to similarly obese participants without BED, individuals with BED have a disturbance in the development of fullness and reduction of hunger during the course of a standard meal of large size. Thirteen patients with BED and 14 obese control participants consumed 975 g of a milkshake. Participant...
Article
Bulimia Nervosa (BN) is an eating disorder characterized by recurrent episodes of binge eating. During binge eating episodes, patients often describe the rapid consumption of food, and laboratory studies have shown that during binges patients with BN eat faster than normal controls (NC), but the hypothesis that a rapid rate of eating contributes to...
Article
The purpose of the study was to measure test meal consumption and the changes in hunger and fullness during a test meal in obese individuals with and without binge eating disorder (BED) and normal-weight controls. Twelve women with BED, 12 obese control participants, and 12 normal-weight control participants participated in two single-item test mea...
Article
The purpose of this study was to develop a methodology for measuring the reward value of food. Potentially, this methodology may help determine why people tend to regain weight after stopping a diet program. Human subjects were given aspartame-sweetened yogurt shake and non-sweet yogurt shake on continuous, or uninhibited, and progressive ratio, or...
Article
Woledge: I will start this session by showing some diagrams describing energy conversion in a manner similar to the description in Dr Tawada’s presentation (this volume, p. 363). I think these diagrams can help us to understand under what conditions we can expect to see a high efficiency of energy conversion, and therefore to understand why in musc...
Article
Improving children's abilities to recognize when they are full is one strategy to prevent overweight, but currently, there are few validated instruments to assist this process. In the present study, we developed and tested the potential of an analog scaling device for quantifying sensations such as fullness in 4-5 year old children. The device was...
Article
Bulimia nervosa (BN) is a psychiatric illness characterized by eating binges followed by inappropriate behavioral attempts to compensate for the binges, usually vomiting or laxative abuse. Patients with BN have disturbances in the development of satiety during a meal as well as disturbances in functions of the upper gastrointestinal tract such as s...
Article
the classical methods for studying the inhibitory controls of food intake involve the manipulation of tissues hypothesized to signal sites in the brain which in turn remove or reduce excitatory influences on the muscles involved in eating ([4][1]). It is not yet possible to study all the links in
Article
The first 30 years of Columbia's Appetitive Seminar were celebrated by speakers extrapolating from the past to the future for six areas of research on appetite. This editorial introduces reviews of three of the selected topics and briefly summarizes the other three presentations-on the sensing of glucose utilization, gastrointestinal controls of sa...
Article
The aim of this study was to test the hypothesis that gastric distension can enhance the effect of cholecystokinin (CCK) on reduction of food intake in men and women. Eight normal-weight subjects of each gender were tested four times each with either CCK or saline infusion crossed with gastric distension or no distension. Intravenous infusion of a...
Article
Because the stomach plays an important role in the development of satiety, gastric function was examined in bulimia nervosa (BN). Sixteen patients with BN and 16 controls swallowed an inflatable bag, which was positioned in the proximal stomach. Minimal distending pressure (MDP), the pressure needed to overcome intraabdominal pressure, was determin...
Article
Full-text available
This study had two objectives. The first was to evaluate the possibility that, in a previous study, a soup preload augmented the reduction of food intake in a test meal induced by an exogenous infusion of cholecystokinin (CCK) because the soup also endogenously released CCK. The second was to compare CCK release by soup between men and women to det...
Article
Full-text available
To determine whether meal size is related to body mass index (BMI) in obese subjects with binge-eating disorder (BED). Five groups of subjects each consumed two laboratory-test meals on nonconsecutive days. Forty-two women, categorized by BMI and BED diagnosis, were instructed to "binge" during one meal and to eat "normally" during another. Eightee...
Article
The purpose of this study was to determine whether young children are capable of using pictorial silhouettes to quantify feelings of satiety and provide preliminary data on the validity of this method. Subjects were 20 children, 4-6 years old, recruited from a preschool. We hypothesized that subjects would be able to use the silhouettes to communic...
Article
Full-text available
Epidemiological evidence suggests a potential role for vitamin D in colon cancer prevention. Vitamin D, absorbed from the intestine or derived from solar ultraviolet light, is metabolized in the liver to 25-hydroxyvitamin D (25-OH D(3)). Previous studies examining effects of vitamin D upon carcinogenesis have focused upon the active metabolite 1,25...
Article
The benefit of spreading energy intake over many small meals ('nibbling') rather than few large ones ('gorging') for control of blood glucose, serum lipids and body fat accretion has been known for 60 y, but the mechanisms are poorly understood. Men exhibit more of a gorging eating pattern than women and are also more prone to the metabolic complic...
Article
Recent studies with rat taste cells treated with polyunsaturated fatty acids suggest that fatty acids may play a role in dietary fat perception. In humans, sensitivity to the textural properties of fat is associated with the genetic ability to taste the bitter compound 6-N-2-propylthiouracil (PROP). However, it has not been shown that PROP tasters...
Conference Paper
[Society for Neuroscience Abstracts (2000), volume 26, page 1340]
Conference Paper
Full-text available
Ratings of hunger and sickness were reliably higher in those diagnosed with bulimia nervosa than in controls.
Conference Paper
Full-text available
Some appetite-related words were distinctive to the situations tested, implying that the conditions for being motivated to eat can sometimes be dissociated.
Article
Continuous automated weighing of food while subjects ate was used to test the hypothesis that failure to slow eating rate during a meal indicated a deficient response to satiety signals in obese patients. Cumulative intake curves were fitted to a quadratic equation. The physical form of the food and its palatability were a greater influence on the...
Article
Objective The aim of this study was to determine whether temporal patterns of food selection during binges in obese subjects with binge eating disorder (BED) differ from those of patients with bulimia nervosa (BN). Method: Ten obese women with BED and 10 weight-matched women without BED each consumed a multiple-item meal identical to that used in p...
Article
A workshop entitled "Obesity Solutions" was held on January 11, 1996, at St. Luke's-Roosevelt Hospital in New York City and was jointly sponsored by the St. Luke's-Roosevelt Obesity Research Center and the Nestlé R&D Center, Inc., of New Milford, Connecticut. The purpose of the workshop was to bring together experts from the research community and...
Article
A workshop entitled “Obesity Solutions” was held on January 11, 1996, at St. Luke's-Roosevelt Hospital in New York City and was jointly sponsored by the St. Luke's-Roosevelt Obesity Research Center and the Nestlé R&D Center, Inc., of New Milford, Connecticut. The purpose of the workshop was to bring together experts from the research community and...
Article
Full-text available
This study was designed to investigate the biological underpinnings of the observed deficit in satiety in patients with bulimia nervosa. Eight women with bulimia nervosa and 10 age- and weight-matched control subjects consumed three laboratory meals consisting of 200, 400, and 600 g of a radiolabeled liquid meal. For 1 h after each meal, blood samp...
Article
To determine whether patients with bulimia nervosa (BN) experience the development of satiety during a meal differently than control subjects, a novel laboratory meal procedure was employed. Eleven women with BN and 11 women without eating disorders consumed a yogurt shake meal after being instructed to binge. After each 75-g increment consumed, th...
Article
To determine the effect of a social setting on the physiological controls of eating, four pairs of subjects consumed a 15% and a 1% glucose (sweetened with aspartame to match the 15%) preload drink, preceding a test lunch meal, individually in a laboratory, and as a pair in a cafeteria. Compared with the 1% glucose preload, the 15% glucose preload...
Chapter
Full-text available
The thesis of this chapter is that understanding of the control of eating in animals is essential for understanding control of eating in humans. Animal research has provided four tools for the study of human eating, each of which will be a focus of this paper: (a) the methods, both strategic and practical (b) the observed phenomena (c) the theoreti...
Article
A new technique has been developed to study the changes in feelings of satiety during food consumption. Five non obese women were interrupted after eating 75 g increments of a tomato soup test meal served on an eating monitor to complete rating scales of hunger, satiety, fullness, sickness, and pleasantness of the meal. They were instructed to eat...
Article
The differential effects of fructose and glucose on food intake were studied by giving two concentrations (1 and 10%) of glucose and fructose solutions (500 ml) to one group of women 30 min, and to another 135 min, before a meal of macaroni and beef. The 1% solutions of each sugar were sweetened to match 10% fructose by selective additions of aspar...
Article
The purpose of this study was to determine whether the objectively observed binge eating behavior of obese subjects meeting the proposed DSM-IV criteria for binge eating disorder would be similar to that observed in patients with bulimia nervosa. Non-obese patients with bulimia nervosa (BN), obese subjects with binge eating disorder (BED), obese an...
Article
In order to examine the eating behavior of individuals with the newly proposed diagnosis, binge eating disorder (BED), standardized meals were served to 20 obese women, 10 with BED and 10 without BED. When asked to binge eat from a multiple-item array of foods, obese subjects with BED consumed significantly more calories than did obese subjects wit...
Article
Infusion of bombesin into healthy young men at two dosages (1.33 and 4.0 ng.kg-1.min-1) resulted in a significant 135-g reduction in intake of a yogurt and fruit blend, compared with saline infusions, at the higher dose, but only a 20-g (nonsignificant) reduction at the lower dose. There were no overt side effects, although half of the subjects rep...
Article
Full-text available
We studied food selection and intake of 19 women [body mass index (in kg/m2) > 30] [corrected], 10 of whom met proposed DSM-IV criteria for binge-eating disorder (BED). All subjects ate two multicourse meals in the laboratory, and were given tape-recorded instructions at each meal either to binge or eat in a normal fashion. Subjects with BED consum...
Article
Cholecystokinin (CCK) may affect food intake by augmenting neural activity from the distended stomach, thereby amplifying satiety signals. To test the hypothesis that subjects would report more fullness and less hunger with gastric distension when CCK-8 (112 ng/min) was infused than when saline was infused, a gastric balloon was inflated in the sto...
Article
Meiselman's (1992) proposal for redirection of research on human eating behavior towards eating in real settings is misdirected, because it does not take into consideration the questions being addressed by laboratory studies. In fact many of the studies for which he has called have in fact been done and will be cited. There is no compelling scienti...
Article
Pancreatic glucagon and cholecystokinin octapeptide (CCK-8) were intravenously infused (1 ml/min for 10 min) alone or in combination beginning 15 min after normal-weight men had eaten a 500-ml tomato soup preload and 5 min before they were served a lunch of macaroni and beef with tomato sauce. Infusion of approximately 3 ng.kg-1.min-1 glucagon or a...
Article
The abnormalities in eating behavior associated with bulimia nervosa suggest that patients with this illness may have a disturbance in satiety. The present study employed a six-meal protocol to assess satiety in both binge and non-binge eating episodes in women with bulimia nervosa and normal controls by examining whether an increase in the size of...
Article
The accuracy of 24-hour dietary recall of patients with bulimia nervosa was examined by comparing the actual intake of subjects in a laboratory meal with their reported intake in a 24-hour dietary recall interview. The mean caloric intake of the 15 patients who participated in the study was 1,088 (SD 1,335) kilocalories. There were significant posi...
Article
To determine whether the characteristics of binge eating could be observed in a single-item meal, in a laboratory, patients with bulimia nervosa and controls ate two single-item meals and two multiple-item meals. When they were instructed to binge eat, the patients ate significantly more and for a longer time on both single- and multiple-item meals...
Article
A combination of psyllium fiber with nutrients in a commercially available wafer (Fiberall-Ciba Consumer Pharmaceutical) was evaluated for its effectiveness in reducing food intake and appetite. Each of 15 nonobese healthy women received no wafers and four different amounts (39, 104, 169, and 234 kcal) of the fiber wafer with water, in a ratio of 1...
Article
This paper begins with the paradox of invariants arising out of random events, and its title is based on the resolution of that paradox in Monod's book Chance and Necessity. In ingestive behavior this paradox arises particularly in the emergence of constancies in intakes from small bouts of behavior. I point out that one resolution of the paradox c...
Article
Cholecystokinin octapeptide (CCK-8) or saline was intravenously infused for 5 min before and 5 min during a meal of macaroni and beef, served 20 min after a preload of either 100 or 500 g of soup to 12 nonobese men. Intake of the test meal was significantly lower when CCK-8 was given, following the larger preload, than after any of the other treatm...
Article
Full-text available
The animal model of exercise-induced anorexia was employed in humans to develop a laboratory paradigm for studying the acute effect of exercise on food intake. Each of nine obese and nine nonobese women exercised either strenuously (90 W) or moderately (30 W) on a cycle ergometer for 40 min or rested in the laboratory on each of 3 nonconsecutive da...
Article
The understanding of the word "palatability" is explained within a research context consisting of four components: an ingestor, an ingestant, a response measure, and an observer. Within this context a solution is proposed to the circularity of an observer measuring palatability by the amount of ingestive activity and in turn attributing the amount...
Article
Eating behavior of women with bulimia was compared with that of control subjects who had no eating disorders. Both groups were presented with two buffet-style multiple-item meals. In one meal subjects were instructed to eat normally and in the other they were instructed to eat as much as they could. The eating patterns of patients differed from con...
Article
Eating behavior of women with bulimia was compared with that of control subjects who had no eating disorders. Both groups were presented with two buffet-style multiple-item meals. In one meal subjects were instructed to eat normally and in the other they were instructed to eat as much as they could. The eating patterns of patients differed from con...