Harry Gosker

Harry Gosker
Maastricht University | UM · Department of Respiratory Medicine

PhD

About

138
Publications
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6,558
Citations

Questions

Questions (4)
Question
Within Maastricht University (UM) we have spread the call for junior practical training (JPT) projects (internships/placements) for the Biomedical Sciences master. But we would like to offer our students the opportunity to perform their JPT outside our university too. Students will have interviews and select a project during November-March. The actual JPT takes places in April – March. JPT objectives include participation in an ongoing biomedical research project, exposure to the real-life research environment, gaining experience in setting up experimental research/focused experiments, practical understanding of modern research techniques and methodologies (possibilities and limitations), keeping a laboratory journal, active participation in academic/scientific meetings in professional practice, and the exchange of newly acquired knowledge by reporting to others and writing a report.
If you think your company/institute can offer such a placement please drop me a message via RG and I will tell you how to submit your project proposal (brief & easy).
Question
We need normal or reference values for isometric knee extension at 60° (Biodex system - no weight correction). Does someone know where to find those (Biodex company has none)? Or maybe someone has a large dataset (healthy adults, mainly elderly 50-75 range)?
Question
mATPase staining is based the conversion of ATP into AMP and Pi, the latter being stainded black. Based on differences in acid resistance of type I, IIA, and IIX MyHC isoforms one can distinguish between the fiber types; with an acid pre-incubation (pH ± 4.5)  the mATPase activity of type II fibers is inhibited rendering their staining light(er). The MyHC type I is more resistant to the acid and these fibers stain black. But WHY is it that type I MyHC is more resistant to acid (one would think that this would make more sense for MyHCs in anaerobic fibers?
Question
If your were to buy a DXA scanner to measure body compostion (fat & lean mass), would you go for Hologic or Lunar?

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Projects

Projects (3)
Project
The COPD disease course is positively influenced by a healthy lifestyle. It is however difficult for COPD patients to adapt their lifestyle even after successful completion of a pulmonary rehabilitation programme. Next to regular disease exacerbations, in particular when they require hospitalization, it is known that poor dietary habits and sedentary behaviour, via different mechanisms, not only diminish physical performance but also affect cognitive performance and contribute to depression. These symptoms not only adversely affect quality of life but also preclude susceptibility to behavioural change after pulmonary rehabilitation. In the current proposal we therefore investigate how tailored nutritional intervention as adjunct to state of the art lifestyle counselling can contribute to maintenance or recovery of an active lifestyle. We will focus on recently identified deficiencies in the diet and nutritional status of many Dutch COPD patients as well as on well-established disturbances in muscle metabolism in COPD. We will investigate the consequences of these nutritional and metabolic derangements on the communication between gut, skeletal muscle and brain. We hypothesize that this communication is disturbed by low grade inflammation that flares up during infectious exacerbations. The project comprises a combination of experimental research in mouse models, to unravel the mechanisms, and nutritional intervention studies in patients with COPD to investigate the efficacy of the novel treatment at two crucial moments in the disease course; the maintenance phase after pulmonary rehabilitation and the recovery phase after hospitalization for a COPD exacerbation.
Project
The partners collaborating in the PROOF project bundle the expertise of healthcare actors, (food) companies and knowledge institutions in order to develop food that is tailored to patients’ needs.
Archived project
The goal of this project is to investigate how diet affects cognition through stress-related mechanisms across the lifespanusing preclinical and clinical approaches.