Harrison W Lin

Harrison W Lin
University of California, Irvine | UCI · Department of Otolaryngology/Head and Neck Surgery

MD

About

150
Publications
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3,178
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Publications

Publications (150)
Article
Objective: To determine the implications of obesity on postoperative adverse events following skull base surgery. Methods: The 2005-2017 American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried for adverse events in skull base surgery cases. Patients were stratified by body mass index (BMI) into...
Article
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Animal studies have discovered that noise, even at levels that produce no permanent threshold shift, may cause cochlear damage and selective nerve degeneration. A hallmark of such damage, or synaptopathy, is recovered threshold but reduced suprathreshold amplitude for the auditory brainstem response (ABR) wave I. The objective of the present study...
Article
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While noninvasive brain stimulation is convenient and cost effective, its utility is limited by the substantial distance between scalp electrodes and their intended neural targets in the head. The tympanic membrane, or eardrum, is a thin flap of skin deep in an orifice of the head that may serve as a port for improved efficiency of noninvasive stim...
Article
Background: The National Ambulatory Medical Care Survey (NAMCS) is a collection of publicly available and deidentified patient data gathered from participating tertiary medical centers. With it, this study attempts to describe and quantify distribution of patients presenting with a rhinologic reason for visit (RFV) in the ambulatory setting, as wel...
Article
The objective of this study is to evaluate the impact of preoperative frailty on short-term outcomes following intradural resection of skull base lesions. The 2005–2017 ACS-NSQIP database was queried for 30-day post-operative outcomes of patients undergoing intradural resection of the skull base, extracted by CPT codes 61601, 61606, 61608, and 6161...
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Objective To examine neurotologists' 2013 to 2016 Medicare Part-D data and evaluate commonly prescribed medications, longitudinal changes in prescribing patterns, presumed associated pathologies, and cost distribution across United States. Methods Comprehensive prescription data of Part-D-participating neurotologists was quiered from the 2013 to 2...
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Objectives: Facial paralysis is a debilitating condition with substantial functional and psychological consequences. This feline-model study evaluates whether facial muscles can be selectively activated in acute and chronic implantation of 16-channel multichannel cuff electrodes (MCE). Methods: Two cats underwent acute terminal MCE implantation...
Article
Objectives: To develop a multiclass-classifier deep learning model and website for distinguishing tympanic membrane (TM) pathologies based on otoscopic images. Methods: An otoscopic image database developed by utilizing publicly available online images and open databases was assessed by convolutional neural network (CNN) models including ResNet-...
Article
Objective To assess the ability of Google Translate (GT) to accurately interpret single sentences and series of sentences commonly used in healthcare encounters from English to Spanish. Design English-speaking volunteers used GT to interpret a list of 83 commonly used sentences and series of sentences of different lengths containing both medical a...
Article
Objectives: To investigate the clinical presentation, treatment breakdown, and overall survival (OS) outcomes of patients with neurofibromatosis type 2 (NF2)-associated bilateral vestibular schwannoma (NVS). Methods: The 2004 to 2016 National Cancer Database was queried for patients with a diagnosis of VS. The "Laterality" code was used to strat...
Article
Objectives/hypothesis: To determine the food security status of patients with a history of head and neck cancer and compare to other types of cancer. Study deign: A retrospective analysis using the National Health Interview Series. Methods: The National Health Interview Series (NHIS) for the calendar years 2014 to 18 was used to elicit food se...
Article
Objectives: To determine the relationship between vestibular migraine (VM) and motion sickness (MoS) susceptibility and their comorbidity in a large student population, and to assess whether experiencing MoS is associated with higher susceptibility for VM. Methods: Surveys including Motion Sickness Susceptibility Questionnaire (MSSQ) and questio...
Article
Objectives/Hypothesis To examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment. Our hypothesis was that adjuvant migraine medications may improve outcomes in SSNHL. Methods A retrospective chart review at a ter...
Article
Objectives: To investigate false-positive findings on non-echoplanar (non-EPI) diffusion-weighted magnetic resonance imaging (DWI) in patients under surveillance post-cholesteatoma surgery. Study design, setting, subjects, and methods: A retrospective review was performed on patients diagnosed with cholesteatoma who underwent surgical resection...
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Objectives: To compare two statistical models, namely logistic regression and artificial neural network (ANN), in prediction of vestibular schwannoma (VS) recurrence. Methods: Seven hundred eighty-nine patients with VS diagnosis completed an online survey. Potential predictors for recurrence were derived from univariate analysis by reaching the...
Article
Objectives To evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis. Methods In a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modific...
Article
Between 2016 and 2017, several U.S. Diplomats in Havana, Cuba, experienced perplexing vestibular and neurological symptoms attributed to an unknown source. They presented with significant vestibular and headache symptoms similar to individuals who experience vestibular migraine (VM). As such, we hypothesize that VM may be a possible explanation for...
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Objectives: To evaluate if patients with a diagnosis of vestibular migraine (VM) by the International Classification of Headache Disorders (ICHD) criteria have meaningful differences in symptomatology and disease characteristics when compared to patients with concurrent vestibular symptoms and migraine that do not meet ICHD criteria. Methods: Pa...
Article
Meniere's disease (MD) is a chronic condition affecting the inner ear whose precise etiology is currently unknown. We propose the hypothesis that MD is a migraine-related phenomenon which may have implications for future treatment options for both diseases. The association between MD and migraine is both an epidemiological and a mechanistic one, wi...
Article
Objectives: Determine rates and reasons for unplanned revisits after ambulatory otologic surgery. Methods: Cross-sectional analysis of State Ambulatory Surgery Databases of California, Florida, Iowa, and New York was performed for years 2010 and 2011. Ambulatory adult otology surgical procedures were linked to ambulatory, emergency, and inpatien...
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The aim of this study is to discuss the state of the art with regard to established or promising bioelectric therapies meant to alter or control neurologic function. We present recent reports on bioelectric technologies that interface with the nervous system at three potential sites—(1) the end organ, (2) the peripheral nervous system, and (3) the...
Article
Objective We aim to identify contemporary noise exposures and hearing protection use among U.S. children in a large, population‐based study. Methods Cross‐sectional analysis of the 2014 National Health Interview Series was performed. Results from in‐person interviews of families with children under 18 years of age in all 50 states were queried. Po...
Article
Objectives To assess the current state of the diagnosis and management of vestibular schwannoma (VS) as well as treatment trends, and to evaluate the role of treatment setting and various specialists in treatment plan. Methods Patients diagnosed with VS completed a voluntary and anonymous survey. The questionnaires were distributed through Acousti...
Article
Objectives: To characterize the progression of mid-frequency sensorineural hearing loss (MFSNHL) over time. Methods: A retrospective chart review spanning 2012 to 2017 was performed at a tertiary care audiology and neurotology center. Our cohort included 37 patients met the criteria for MFSNHL also known as "cookie bite hearing loss." It was def...
Article
Objective: To assess the risk recall of complications among patients who underwent different vestibular schwannoma (VS) treatments. Study design: Patients with VS completed a voluntary and anonymous survey. Setting: Survey links were distributed via the Acoustic Neuroma Association (ANA) website, Facebook, and email list. Subjects and methods...
Article
Objective:: Investigate whether hearing difficulty has an influence on the risk of mortality. Methods:: A nationally representative sample of individuals 18 years or older with data available for hearing and mortality status was selected from the National Health Interview Surveys (NHIS) 2005-2009. Self-perceived hearing status was regrouped as e...
Article
This brief communication regards the indications and complications for and rates of readmission following lingual tonsillectomy. The National Readmissions Database (NRD) 2013-2014 was queried for all cases of lingual tonsillectomy occurring from 2013 to 2014. Among 602 lingual tonsillectomies (mean age 36.5 years, 58.2% male), the common indication...
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Noninvasive transcranial or minimally invasive transtympanic electric stimulation may offer a desirable treatment option for tinnitus because it can activate the deafferented auditory nerve fibers while posing little to no risk to hearing. Here, we built a flexible research interface to generate and control accurately charge-balanced current stimul...
Article
Objectives: To assess and characterize patients' online ratings and comments of neurotologists and determine factors that correlate with higher ratings. Methods: All the American Neurotology Society members were queried on Healthgrades, Vitals, RateMDs, Yelp, and Google from March to June 2018. All ratings were normalized for comparison on a fiv...
Article
Objective:: To describe a case series of previously undiagnosed granulomatosis with polyangiitis (GPA) patients who presented primarily with otological manifestations. Method:: We report a series of patients visited at a neurotology clinic who were eventually diagnosed with GPA based on their otologic complaints and had no prior knowledge of hav...
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Objective: To evaluate the change in quality of life (QOL) of patients with Meniere's disease (MD) after treatment with migraine prophylaxis therapy. Methods: Patients with definite MD were given the Meniere's Disease Outcomes Questionnaire-Retrospective (MDOQ-R) after migraine prophylactic therapy to assess QOL. Changes in physical, emotional,...
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Episodic dizziness is a highly prevalent symptom that has historically been a challenge for primary care physicians, neurologists, and otolaryngologists to accurately diagnosis and properly treat. With an array of diagnoses to consider, including benign positional vertigo, vestibular migraine, Ménière disease, vertebrobasilar syndrome, and vestibul...
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Objective: To improve the existing manually-assembled cochlear implant electrode arrays, a thin film electrode array (TFEA) was micro-fabricated to have a maximum electrode density of 15 sites along an 8-mm length, with each site having a 75 1.8-μm (diameter - height) disk electrode. Methods: The micro-fabrication method adopted a sequence of ph...
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The micro-fabricated thin film electrode array (TFEA) has been a promising design for cochlear implants (CIs) because of its cost-effectiveness and fabrication precision. The latest polymer-based cochlear TFEAs have faced difficulties for cochlear insertion due to the lack of structural stiffness. To stiffen the TFEA, dissolvable stiffening materia...
Conference Paper
Full-text available
Permanent facial paralysis and paresis (FP) results from damage to the facial nerve (FN), and is a debilitating condition with substantial functional and psychological consequences for the patient. Unfortunately, surgeons have few tools with which they can satisfactorily reanimate the face. Current strategies employ static (e.g., implantation of no...
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Objective: 1) Perform a meta-analysis of the available data on the outcomes of stereotactic radiosurgery (SRS) for the treatment of temporal bone glomus tumors (GT), and 2) evaluate the collective outcomes of SRS treatment with respect to tumor control. Data sources: A thorough literature search of the published English-language literature from...
Article
Importance Accidental injuries are a leading cause of morbidity and mortality in the United States. Hearing problems may be associated with an increased risk for such injuries. Objective To investigate associations between hearing difficulty and risk of accidental injuries among US adults. Design, Setting, and Participants Cross-sectional analysi...
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Objective To assess the decision-making process of patients with vestibular schwannoma (VS). Study Design Patients with VS completed a voluntary survey over a 3-month period. Setting Surveys were distributed online through email, Facebook, and member website. Subjects and Methods All patients had a diagnosis of VS and were members of the Acoustic N...
Article
Objectives: Aneurysmal bone cysts (ABC) are benign, rapidly growing osteolytic lesions. Solid variant of ABC (SVABC) is a rare subtype of ABC that has not been reported in the temporal bone. Methods: We report the case of a 6-year-old boy presenting with a slowly enlarging bony protuberance over the right zygomatic/malar eminence region. Compute...
Article
Since the introduction of the Sunshine Act in 2010 and Open Payments Database (OPD) in 2013, a significant amount of data has been collected on physicians and the payments received through ties with pharmaceutical and medical device companies. To date, a study within the field of otology and neurotology using data from the 2015 OPD has not been con...
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In this case series, we set out to describe the clinical entity of isolated, prolonged aural fullness (AF) and its relationship with migraine. Patients with isolated, persistent AF for 6 months or more were included with all possible etiologies ruled out. Migraine dietary and lifestyle changes and medical migraine prophylactic therapy were prescrib...
Article
Importance Hearing loss is one of the most prevalent chronic conditions in the United States and has been associated with negative physical, social, cognitive, economic, and emotional consequences. Despite the high prevalence of hearing loss, substantial gaps in the utilization of amplification options, including hearing aids and cochlear implants...
Article
Objectives/hypothesis: Laryngeal muscles (LMs) are controlled by the recurrent laryngeal nerve (RLN), injury of which can result in vocal fold (VF) paralysis (VFP). We aimed to introduce a bioelectric approach to selective stimulation of LMs and graded muscle contraction responses. Study design: Acute experiments in cats. Methods: The study in...
Article
Objective: To describe persistent post-stapedotomy vertigo (PSV) and its treatment using migraine prophylaxis. Patients: A retrospective review of all patients with persistent PSV spanning 10 years at a tertiary academic hospital was performed. Patients who experienced persistent vertigo for a minimum of 3 months after surgery were included. Tho...
Article
Objective: To report findings from a cohort of vestibular schwannoma (VS) patients presenting with vertigo from a secondary comorbid vestibular disorder; and to discuss management strategies for this subset of patients presenting with both episodic vertigo and VS. Patients: All VS patients who presented with vertigo as the primary symptom from 2...
Article
Background: Our group has previously shown that activation of specific facial nerve (FN) fiber populations and selective activation of facial musculature can be achieved through acute intraneural multichannel microelectrode array (MEA) implantation in the feline model. Hypothesis: Selective stimulation of facial muscles will be maintained in the...
Article
A modified lateral temporal bone resection (mLTBR) is a unique technique that spares the tympanic membrane (TM) and ossicles in select patients with squamous cell carcinoma (SCCa). The records of 5 patients with SCCa of the temporal bone with negative frozen-section biopsy at the tympanic annulus were reviewed. The mean follow-up time for the patie...
Article
Objectives (1) Perform a meta-analysis of the available data on the outcomes of CyberKnife radiosurgery for treatment of vestibular schwannomas (VSs) in the published English-language literature and (2) evaluate the collective outcomes of CyberKnife treatment with respect to tumor control and hearing preservation. Data Sources A thorough literatur...
Article
Objective: Identify contemporary noise exposures and hearing protection use among adults. Study design: Cross-sectional analysis of national health survey. Methods: Adult respondents in the 2014 National Health Interview Series hearing survey module were analyzed. Potentially harmful exposures to occupational and recreational noises in the pas...
Article
Objectives: To determine the optimal postoperative magnetic resonance imaging (MRI) schedule and length of follow-up for patients undergoing microsurgical excision of vestibular schwannoma (VS). Study design: A retrospective review of patients who underwent microsurgical excision of VS at a single tertiary care center between January 1993 and Ma...
Article
Objective The implementation of a universal surgical safety protocol in 2004 was intended to minimize the prevalence of wrong-site surgery (WSS). However, complete elimination of WSS in the operating room continues to be a challenge. The purpose of this study is to evaluate the prevalence and etiology of WSS in the state of California. Study Desig...
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Objectives Permanent injury to the cranial nerves can often result in a substantial reduction in quality of life. Novel and innovative interventions can help restore form and function in nerve paralysis, with bioelectric interfaces among the more promising of these approaches. The foreign body response is an important consideration for any bioelect...
Article
Objective A smartphone-enabled otoscope (SEO) can capture tympanic membrane (TM) images. We sought to compare a SEO to microscopic otoscopy in the detection and evaluation of TM pathology in an otology/neurotology practice. Study Design Prospective single-site study in adults presenting over a 3-month period. Setting Neurotology clinic within a t...
Article
Objectives/hypothesis: To evaluate the variability and discrepancies among the most commonly prescribed ear drops sold at pharmacies in southern California. Study design: Prospective study evaluating 11 commonly used ear drops to treat otologic disorders. Methods: Randomly selected drug stores in three major counties in Southern California (Lo...
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Introduction: Physicians in the ambulatory setting face challenges in adequately educating patients in a brief office encounter. Objective: To evaluate the efficacy of an iPad-based interactive educational module (iBook) in various otologic pathologies. Methods: Patients presenting with symptoms of tinnitus, dizziness, hearing loss, or cochlea...
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Objective: Mal de debarquement syndrome (MdDS) is a balance disorder that typically starts after an extended exposure to passive motion, such as a boat or plane ride. Management is typically supportive (e.g. physical therapy), and symptoms that persist beyond 6 months have been described as unlikely to remit. This study was conducted to evaluate t...
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Split-thickness skin graft (STSG) continues to be the preferred means of external auditory canal (EAC) reconstruction. We thus sought to describe our experience using skin from the posterior aspect of the auricle (SPAA) as a donor site in EAC reconstruction. Grafts were, on average, 5 × 10 mm in size and obtained with a No. 10 blade after tumescenc...
Article
Objective: To investigate the 30-day postoperative complication, readmission, and reoperation rates following surgery for cerebellopontine angle (CPA) schwannomas. Study design: Cross-sectional analysis. Setting: National surgical quality improvement program dataset (NSQIP) 2009 through 2013. Patients: All surgical cases with an Internationa...
Article
Importance: Tinnitus is a common problem for millions of individuals and can cause substantial negative effects on their quality of life. A large epidemiologic study of tinnitus and its management patterns in the US adult population is lacking. Objectives: To quantify the epidemiologic features and effect of tinnitus and to analyze the managemen...
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Objective: To describe a novel approach for excision of exostoses and evaluate the outcomes of transcanal excision of exostoses using ultrasonic serrated knife-assistance versus microosteotomes only. Study design: Retrospective analysis. Setting: Academic Tertiary Care Center. Patients/interventions: Patients receiving a transcanal excision...
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Objectives: In evaluating the historical context of the first description of Menière's disease, its association with migraine headaches is compelling. We have outlined the events and observations of Prosper Menière, which led him to establish a link between migraine headaches and his eponymous disease. Study design: Prosper Menière's original Fr...
Article
Objectives/hypothesis: Quantify the relationships between tinnitus, and anxiety and depression among adults. Study design: Cross-sectional analysis of a national health survey. Methods: Adult respondents in the 2007 Integrated Health Interview Series tinnitus module were analyzed. Data for tinnitus symptoms and severity and reported anxiety an...
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Objectives/hypothesis: Permanent facial nerve injury is a difficult challenge for both patients and physicians given its potential for debilitating functional, cosmetic, and psychological sequelae. Although current surgical interventions have provided considerable advancements in facial nerve rehabilitation, they often fail to fully address all im...
Article
Ganglioneuromas are rare, benign neoplasms derived from sympathetic neural crest progenitor cells. In the pediatric population, ganglioneuromas usually develop in the mediastinum or retroperitoneum. We report the case of a 3-year-old boy who presented with a painless enlarging neck mass, which was found to be a parapharyngeal space ganglioneuroma t...
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Importance Surgical repair of congenital aural atresia and hypoplasia (CAAH) is technically challenging. Long-term surgical and audiologic outcomes of atresiaplasty are incompletely understood.Objectives To review the surgical outcomes for CAAH and analyze the hearing results.Design, Setting, and Participants A retrospective medical record revie...