Harald Abele

Harald Abele
University of Tuebingen | EKU Tübingen · Department of Gynecology and Obstetrics

Prof. Dr.

About

284
Publications
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2,503
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Publications

Publications (284)
Article
Mit der Neuformulierung des Hebammengesetzes ist die Verpflichtung zu evidenzbasiertem Handeln im Beruf explizit festgelegt. In der Folge befindet sich die Hebammenkunde momentan in einem Transformationsprozess. Was bedeutet das für die aktuelle Hebammenarbeit?
Article
Objective: The objective of the study was to study the effect of preimplantation genetic testing for aneuploidies (PGT-A) performed at blastocyst stage on the levels of first trimester biomarkers. Methods: This is an observational, collaborative, retrospective study. Seven hundred and twenty-eight patients were included in the study. Patients we...
Article
Die Zunahme des maternalen Alters bei der Geburt und die Entwicklung der personalisierten Medizin in der Geburtshilfe erfordern eine ständige Reflexion der Beratung zum Geburtsmodus. Dabei steht die Förderung einer physiologischen Geburt im Mittelpunkt. Die Beratung darf jedoch nicht einseitig erfolgen, sondern muss auch auf Fragen der postpartalen...
Article
Ausbildung im Umbruch Die durchgeführte Vollakademisierung des Hebammenberufs birgt Chancen und Risiken zugleich. Am Beispiel des primärqualifizierenden Studiengangs Hebammenwissenschaft in Tübingen zeigt sich, warum Studiengänge im Bereich Hebammenkunde vor allem an Medizinischen Fakultäten verortet werden sollten.
Conference Paper
Zielsetzung Bei einem erhöhten Frühgeburtsrisiko vor der 34. Woche werden Cortikosteroide zur fetalen Lungenreife verabreicht, durch welche ein Infant Respiratory Distress Syndrom verhindern werden soll. Die Wirkung von Corticosteroid (ACS) kann jedoch nur entfaltet werden, wenn das Anwendungsintervall zwischen Gabe und Geburt mindestens 24 Stunde...
Article
Full-text available
The academization of the midwifery profession poses greatchallenges for Germany, especially due to the tight timelines:Corresponding courses of study can in principle be offered at both universities and technical colleges–although contraryt o the recommendations of the Science Council. This means that there is a heterogeneity in midwifery qualifica...
Article
Zusammenfassung Die jetzt auch in Deutschland einsetzende Vollakademisierung der bisher fachschulisch verorteten Hebammenausbildung stellt sowohl die Länder als auch die Hochschulen vor große Herausforderungen. Ziel dieses Artikels ist vor diesem Hintergrund, mögliche Risiken, die sich aus der Vollakademisierung und der Neufassung des Hebammengeset...
Article
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Die Neufassung des Hebammengesetzes setzt in Deutschland die Richtlinie 2013/55/EU um. Diese legt als Voraussetzung für die Aufnahme einer Ausbildung zur Hebamme eine mindestens 12-jährige Schulbildung fest. Die Akademisierung des Hebammenberufes geschieht vor dem Hintergrund, dass in Deutschland derzeit noch mehr als 70% aller Ausbildungsplätze fü...
Article
Premature birth makes a substantial contribution to the perinatal morbidity and mortality and is one of the main risk factors for disability-adjusted life years (DALYs). Since 2008 the incidence in Germany has been stable at slightly over 8 %. Germany therefore occupies one of the lowest places in Europe. The condition after premature birth is the...
Article
Zusammenfassung Ziel Offizielle Leitlinie der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG), der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (ÖGGG) und der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe (SGGG). Ziel der Leitlinie ist es, die Prädiktion, die Prävention und das Management der Frühgeb...
Article
Aims This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of this guideline is to improve the prediction, prevention and management of preterm birth based on evidence obtained from recent...
Article
Aims This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of this guideline is to improve the prediction, prevention and management of preterm birth based on evidence obtained from recent...
Article
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Objective To examine the blood flow in the splenic artery as marker for materno-fetal transmission at about 20 weeks following a maternal first-trimester primary CMV infection. Methods This is a retrospective study at the prenatal medicine unit at University of Tuebingen, Germany. Women were included who underwent an amniocentesis to examine the f...
Article
Objective: To examine the effectiveness of the first and second cervical length measurement in the prediction of preterm delivery in symptomatic women with twin pregnancies. Methods: Retrospective study at the perinatal unit at the University Hospital of Tuebingen, Germany which included women with twin gestations with painful and regular uterin...
Article
Frage - Antwort Die Risiken von Rauchen in der Schwangerschaft sind bekannt. Wie ist die Situation derzeit insbesondere der Einflüsse auf die Frühgeburtlichkeit und Entwicklung der Kinder?
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Objective To compare several strategies for second trimester labor induction for termination of pregnancy (TOP) using misoprostol and mifepristone and to determine which one is more effective in accelerating the time to delivery. Method This was a retrospective study in which pregnancies that underwent second and third trimester TOP due to fetal a...
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Purpose To characterize and understand the demographics (age and body mass index, BMI) of a cohort of women who delivered at a single institution over an 11-year period. The purpose of this analysis is to look for effects over time of demographic characteristics on mode of delivery. Methods Retrospective analysis of singleton deliveries between 20...
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Purpose It was the aim to evaluate the personal preference of mode of delivery and to analyze differences between medical professionals and non-medical professionals. Interest in participating in a risk stratification system was evaluated. We hypothesized that gaining information about risk stratification provided in the survey could potentially ch...
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Purpose To determine the false-positive rates (FPR) associated with screening for trisomy 18/13 using first-trimester combined screening (FTCS) and an ultrasound plus cfDNA-based approach (US-cfDNA), which includes a detailed ultrasound examination, a cfDNA analysis and a FTCS reflex backup test for cases with uninformative results. Methods This i...
Article
Objective: Hysterectomy is a frequently used therapeutic option for benign gynecological conditions. The purpose of this study was to investigate the incidence and characteristics of unforeseen malignant pathologies of the uterine corpus in a large population-based, single center cohort. Methods: Patients who underwent hysterectomy for presumed ben...
Article
Introduction This study investigates whether the time of diagnosis of foetal trisomy 21/18/13 and the frequency of termination of pregnancy have changed in the past 10 years. Material and Methods Retrospective study at the Tübingen University Centre for Womenʼs Health in which the cases with ante- and postnatal diagnosis of trisomy were investigate...
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Purpose: Pregnancy-associated breast cancer (PABC) is considered the second most common malignancy affecting pregnancy. The limited knowledge as to long-term survival is nonuniform. This retrospective study aims to contribute by a follow-up of pregnancies of breast cancer patients treated at a single university centre with focus on maternal long-t...
Article
Objective: To determine whether screening for trisomy 21 based on first-trimester combined screening (FTCS) with assessment of nasal bone (NB), tricuspid flow (TCF), and ductus venosus flow (DVF) results in similar false-positive rates compared to ultrasound and cell-free DNA (cfDNA) screening. Methods: This is a subanalysis of a prospective ran...
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Purpose Recently, alterations of maternal lipid metabolism were shown to associate with gestational diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for placenta and fetal metabolism are currently not understood. Methods Maternal and placental lipid profiles were characterized in GDM and normal glucose tolerant...
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Rhabdomyolysis is a rare clinical condition resulting from severe muscle damage that can cause potentially life-threatening complications. Amongst other causes, muscle compression due to patient positioning during prolonged surgery may result in extensive skeletal muscle breakdown. We report on a 39-year-old nulligravida who developed rhabdomyolysi...
Chapter
Die Plazenta im Spannungsfeld zwischen Mutter und Kind nimmt entscheidend Einfluss auf die Entwicklung des ungeborenen Kindes und den Gesundheitszustand der Mutter. Allzu oft wird der Rolle der Plazenta keine besondere Beachtung geschenkt. Doch gerade plazentabedingte Veränderungen, Variationen in der Anlage oder Erkrankungen und damit verbundene K...
Article
The human fetal auditory system is functional around the 25th week of gestational age when the thalamocortical connections are established. Fetal magnetoencephalography (fMEG) provides evidence for fetal auditory brain responses to pure tones and syllables. Fifty-five pregnant women between 31 and 40 weeks of gestation were included in the study. F...
Article
Objective: To examine whether in fetuses with trisomy 21 (T21), the ductus venosus (DV) flow differs in presence of a major cardiac defect (CHD) and whether this affects the risk distribution in first trimester screening for T21. Methods: Retrospective study involving pregnant women who underwent first trimester screening. This involves an exami...
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The number of pregnancies complicated by gestational diabetes (GDM) is increasing worldwide. To identify novel characteristics of GDM, we studied miRNA profiles of maternal and fetal whole blood cells (WBCs) from GDM and normal glucose tolerant (NGT) pregnant women matched for body mass index and maternal age. After adjustment for maternal weight g...
Chapter
Das Ersttrimesterscreening hat sich in den vergangenen Jahren dramatisch verändert. War es zu Beginn nur als Screeningtest für Trisomie 21 gedacht, ist es heute eine umfassende Risikoanalyse für zahlreiche Komplikationen in der Schwangerschaft. So können heute im Rahmen des Ersttrimesterscreenings etwa die Hälfte aller Fehlbildungen erkannt und die...
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Introduction Currently, almost every third child in Germany is delivered by caesarean section. Apart from straightforward and clear indications for caesarean section which account for approx. 10%, the large proportion of relative indications in particular needs to be critically reviewed if the current C-section rate is to be effectively lowered. It...
Poster
The potential of eHealth and mHealth solutions is increasingly unfolding, considering the rapidly evolving technical opportunities for healthcare providers to integrate information technology. Pregnant women are using the Internet, social media and smartphone apps in record numbers for seeking information online and sharing their knowledge. We anal...
Article
Objective: Prospective randomized trial to compare the performance of first trimester combined screening (FTCS) with an approach that uses the combination of a detailed ultrasound examination and cfDNA analysis. Methods: Pregnant women with a normal first-trimester ultrasound examination at 11 to 13 weeks' gestation (fetal NT ≤3.5 mm and no feta...
Chapter
Die Entbindung Frühgeborener setzt eine optimale perinatalmedizinische und neonatologische Versorgung voraus. Viele Faktoren müssen zusammenwirken, um ein optimales Outcome der Kinder und Mütter zu erzielen. Es geht dabei nicht nur um den günstigsten Entbindungszeitpunkt, sondern vor allem um die dann zur Verfügung stehende Logistik und fachliche K...
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We present a rare case of non-invasive papillary urothelial carcinoma of the vagina as the initial presentation of a multicentric urothelial carcinoma also involving bladder and renal pelvis and report for the first time in the literature the molecular alterations observed in the vaginal urothelial lesion and the synchronous lesions of the urinary...
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Objective To compare the effectiveness of contemporary treatment of preterm labor to a historical cohort. Study designRetrospective matched case–control study to compare the outcomes of patients that were treated for preterm labor at the University Hospital of Tuebingen, Germany in 2014/2015 (current treatment cohort) and 2006/2007 (historical coho...
Article
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Background With growing demand for medical information and health applications in pregnancy, the potential of electronic health (eHealth) and mobile health (mHealth) solutions in clinical care is increasingly unfolding. However, we still do not know how pregnant women engage with mobile apps, how such apps impact routine medical care, and whether b...
Article
Objective: To examine whether combining the dichotomous assessment of the a-wave and the Ductus venosus (DV) PIV measurement improves first-trimester-screening performance. Methods: Retrospective study performed at the University Hospital of Tuebingen based on singleton pregnancies that underwent first-trimester-screening including DV flow asses...
Article
Objective The main objectives of our study were to demonstrate that laparoscopic supracervical hysterectomy (LSH) or total laparoscopic hysterectomy (TLH) can be performed safely even in patients with a uterine weight ≥ 500 g, to analyze the rate of conversions to laparotomy due to uterine size and to estimate the incidence and type of intraoperati...
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Pelvic floor protection is an issue of increasing relevance. This article sought to summarize the session at last year's annual meeting of the German Society of Gynecology and Obstetrics (DGGG) in Stuttgart (10/2016) called "Urogynecology 2020-what is the optimal rate of cesarean section-does urogynecology have to deal with Obstetrics?". The main f...
Article
Background: Based on a non-randomized study of Nigro et al. (2005) the intravenous administration of hyperimmunoglobulins (HIGs) is applied frequently to women with primary CMV-infection as "off-label use" in Germany. Objectives: In order to describe their CMV-specific neutralization-capacity in vitro, we analyzed the HIG preparations Cytotect(?...
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Full-text available
PurposeTo examine the maxillary length of euploid and aneuploid fetuses in the second and third trimester. Methods Retrospective study utilizing stored 2D images of second and third trimester fetal profiles obtained at the University of Tuebingen, Germany. The length of the maxilla was measured as a straight line between the anterior ventral and po...
Article
Zusammenfassung: Alkohol- oder Tabakkonsum in der Schwangerschaft kann das Ungeborene schädigen. Die Beratung Schwangerer zu diesem Thema ist daher von großer Bedeutung. Ziel der vorgestellten Studie war neben der Entwicklung einer internetbasierten, professionell durch E-Mail begleiteten Plattform für alkohol- oder tabakkonsumierende Schwangere („...
Article
Issue: The estimation of foetal weight is an integral part of prenatal care and obstetric routine. In spite of its known susceptibility to errors in cases of underweight or overweight babies, important obstetric decisions depend on it. In the present contribution we have examined the accuracy and error distribution of 35 weight estimation formulae...