Hany Akeel- Ph.D. candidate
- lecturer at Bilad Alrafidain university
Hany Akeel
- Ph.D. candidate
- lecturer at Bilad Alrafidain university
Looking for potential collaboration In cancer research
About
75
Publications
18,004
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Introduction
Hany Akeel currently works at the Department of pharmacology, Al-Mustansiriya University. Hany does research in Toxicology, Public Health and Primary Care. Their current project is 'Beta receptor blocking effect of non beta blocker drug'.
Current institution
Bilad Alrafidain university
Current position
- lecturer
Publications
Publications (75)
Background: Worldwide, cancer is the primary cause of mortality. Research indicates that around half of all cancer types are caused by p53 mutations or downregulation. Alternative or complementary therapy methods are, therefore, desperately needed. The relationship between p53 and the proto-oncoprotein MDM2, a ubiquitin ligase frequently overexpres...
Background: beta-blockers have been used several times to treat various cardiovascular and non-cardiovascular diseases. However, there is some time limited by side effects and contraindications. Recently, several studies suggest that several medications (not belonging to beta-blocker classes) may have a beta-blocking impact or bind to beta receptor...
Background: Marine ecosystems are a vast reservoir of bioactive compounds with immense pharmacological potential.
Objectives: This review explores the molecular mechanisms of action, potential therapeutic applications, and challenges in the clinical translation of marine-derived bioactive molecules targeting immune pathways.
Methods: A comprehensiv...
This study explores novel therapeutic avenues for diabetes, a global health concern marked by elevated blood glucose levels. We investigated the anti‐diabetic potential of Gymnema Sylvestre's bioactive compounds, including Gymnemic acid I, Stigmasterol, Deacylgymnemic acid, Beta‐Amyrin acetate, Longispinogenin, Gymnemic acid II, Gymnemic acid, Gymn...
Introduction: Disposal of heavy metals into the water as a result of industrial development might cause a threat Health and the environment. aim of this study was to assess the uptake of Co2+ from aqueous solutions via NiO/ γ-Al2O3 nano catalysts. Methods: The main variables that affect the percentage of metal removal were assessed. It took about 5...
Background: Acute myeloid leukemia (AML) is a heterogeneous malignancy principally affecting the elderly population. Despite advances regarding molecular dissection of the disease, prognosis remains poor, with an overall survival of less than 30%. Current treatment for patients with newly diagnosed AML usually includes intensive chemotherapy treatm...
Background: Breast cancer, the world's most prevalent cancerous disease that threatens women, is mainly dependent upon ovarian endocrine secretion for its growth and development. Telomerase inhibitors have been widely studied for their use to treat various tumors. BIBR1591 is the first highly effective small molecule telomerase inhibitor that could...
Background: Uncontrolled hypertension increases the risk of cardiovascular illnesses and death, among other serious health problems. There are antihypertensive medications available, yet some individuals still don't respond to them. Because of the critical function that adrenaline neurons play in blood pressure control, inhibiting these neurons may...
Chemotherapy used for the treatment of cancer has many troubling side effects besides its known harmful effect on the immune system. For example, its toxic collateral effects and the associated inflammation significantly impact the patient's quality of life. This hypothesis and theory article describes strategies for reducing chemotherapy collatera...
Background
Thymidine kinase 2 (TK2) is a crucial enzyme in the mitochondrial pyrimidine salvage pathway, strongly associated with several mitochondrial diseases. Current treatments frequently damage mitochondria, leading to a decrease in cellular energy output.
Objective
This study aimed to use computational approaches to identify inhibitors of TK...
Background: Uncontrolled hypertension increases the risk of cardiovascular illnesses and death, among other serious health problems. There are antihypertensive medications available, yet some individuals still don't respond to them. Because of the critical function that adrenaline neurons play in blood pressure control, inhibiting these neurons may...
BACKGROUND: Medical physics plays a crucial role in the diagnosis and treatment of cancer, primarily through the application of advanced imaging and radiation therapy techniques. As cancer treatments evolve, there is an increasing need for precision and efficacy to improve patient outcomes and minimize side effects. AIM: This study aims to explore...
Hemodialysis patients often face challenges related to adherence to medications and psychological well-being, including depression. Understanding the prevalence of depression and adherence patterns among these patients is crucial for optimizing their care and improving outcomes. This study aimed to assess medication adherence and the prevalence of...
Dental infections, which include anything from severe periodontal illnesses and abscess forms to routine tooth caries, are a major public health risk. This review article focuses on the pathophysiology and treatment of dental infections. A narrative review was conducted based on several published articles, relevant journals, and books in Google Sch...
BACKGROUND: Breast cancer is one of the main Cancers affecting patients all over the world; however, till now, there has been no successful treatment without any side effects on patient health, but there are groups of medications similar to MDM2 inhibitors that have promising effects. The aim of this study was to find out whether the use of mdm2 in...
Objective: This study aimed to discover the cytotoxic effect of YH239-EE and YH239 alone and their enantiomer potency in cytotoxic effect on the MCF7 cell line. Methods: We used the cytotoxic study on MDM2 cell lines by detecting the percentage of apoptosis and necrosis by annexin v methods. Result: This result shows that YH239-EE causes more apopt...
Objective:
This study aimed to discover the cytotoxic effect of YH239-EE and YH239 alone and their enantiomer potency in cytotoxic effect on the MCF7 cell line.
Methods:
We used the cytotoxic study on MDM2 cell lines by detecting the percentage of apoptosis and necrosis by annexin v methods.
Result:
This result shows that YH239-EE causes more...
Dementia is a major health problem among the elderly around the world; the number of dementia patients, as well as antidementia drugs, has been increasing in recent years. In this paper, we searched the dementia treatment guidelines, domestic and foreign literature reports in the past five years, summarized the classification of dementia, the selec...
Multiple sclerosis (MS) is a chronic autoimmune disease with demyelination, inflammation, neuronal loss, and gliosis (scarring). Our object to review MS pathophysiology causes and treatment. A Narrative Review article was conducted by searching on Google scholar, PubMed, Research Gate about relevant keywords we exclude any unique cases and case rep...
The histological makeup of the pancreas in immature male and female Iraqi blackbuck (Caprus hircus) has not been well described. We aimed to describe the histological features of the pancreas in immature male and female Iraqi blackbuck. Samples were collected from 20 immature male and female animals' pancreas, obtained from the Al-Najaf slaughterho...
Citation: Jwaid MM, Alwan MJ, Ihsan I, Jwaid MM, Muhsin YF, Al-hussaniy HA, Al iraqi MK (2024) Novel anticoagulants in the management of atrial fibrillation: A comprehensive comparative analysis. Pharmacia 71: 1-6. https://doi. Abstract Background: Atrial fibrillation (AF) stands as the most prevalent cardiac arrhythmia, with associated risks of st...
Background : Atrial fibrillation (AF) stands as the most prevalent cardiac arrhythmia, with associated risks of stroke and systemic thromboembolism. While vitamin K antagonists, specifically warfarin, have historically been the mainstay for stroke prevention in AF, they come with inherent limitations.
Aim : This review seeks to offer a comprehensiv...
Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of current study...
Hemodialysis patients often face challenges related to adherence to medications and psychological well-being, including depression. Understanding the prevalence of depression and adherence patterns among these patients is crucial for optimizing their care and improving outcomes. This study aimed to assess medication adherence and the prevalence of...
Multiple sclerosis (MS) is a neuropathological disease diagnosed by a magnetic resonance imaging device. Early patients affected with MS are named active. This study assessed the difference between active and non-active MS using the region of interest value. Twenty patients with MS included in this study were examined with T1 weighted image (T1W) w...
BACKGROUND: Protein and peptide drugs offer significant promise as therapeutic agents due to their superior efficacy and reduced toxicity compared to conventional chemical drugs. Nevertheless, difficulties with medication delivery techniques impede their practical deployment. Poor absorption limits non-invasive delivery methods such as nasal, pulmo...
BACKGROUND: The presence of acute pain is a serious condition, perhaps, the most terrible negative feeling of a person. Therefore, it is advisable to intraoperatively use means of acute pain control for comfort and to prevent the formation of chronic pain syndrome. Using a multimodal approach to acute pain management allows for better outcomes. The...
Background : Statins have emerged as a vital therapeutic option for dyslipidemia, effectively reducing morbidity and mortality in individuals with various medical conditions. Recent research has shed light on the intricate pathophysiology of atherosclerosis, which involves lipid accumulation and inflammatory mediators. This research was conducted t...
Background : Medicine’s success relies on solubility, which is the process of dissolving a solid substance in a fluid phase to create a uniform molecular dispersion. However, hydrophobic active medicinal components exhibit poor solubility in water, limiting their effectiveness and incorporation into medications.
Aim : This review explores the poten...
A BSTRACT
Background
Clinical pharmacogenetics is a rapidly growing field that focuses on the study of genetic variations and their impact on drug metabolism, efficacy, and safety. Angiotensin II receptor blockers (ARBs) are commonly used to treat hypertension in Iraq but not all patients respond equally to these drugs.
Aim
This article aims to r...
Alzheimer’s disease (AD) is a neurological disorder characterized by mental and behavioral changes that develop progressively with a decline in brain function. Dysfunctions in glutamatergic and cholinergic pathways, along with an increased concentration of beta-amyloid protein (Aβ), lead to synapses that are full of phosphorylated protein. These ch...
Iraq, a country with a rich history and culture, has been plagued by numerous challenges that have hindered the growth and development of its medical and scientific research community. Despite the many obstacles facing the country, there are dedicated healthcare professionals and researchers who are working tirelessly to advance medical knowledge a...
Introduction: The family history of thyroid disease (FHTD), which is either hyper or hypothyroidism, and its effect and the association with other diseases such as autoimmune disease or genetic diseases such as Down syndrome are not well understood, especially in countries in the middle east such as Iraq, which makes studies of this type get some i...
The aim of the present study is to describe the histological features of the eyes of a domestic mallard duck, Anasplatyrhynchus. The eyeballs often adult males and females constituted the material of the study. The cornea histologically consisted of a stroma, a Descemet membrane, a bowman membrane, an external epithelium, and a posterior epithelium...
With the rapid development of modern life science, computational Molecular docking has gradually become one of the core disciplines and methods of modern life science research. Computational docking studies the relationship between the structure and pharmacodynamics of biological macromolecules and the interaction between biological macromolecules...
Cancer is a major public health problem, and chemotherapy plays a significant role in the management of neo-plastic diseases. However, chemotherapy-induced cardiotoxicity is a serious side effect secondary to cardiac damage caused by antineoplastic's direct and indirect toxicity. Currently, there are no reliable and approved methods for preventing...
Age-related macular degeneration (AMD) is a progressive degenerative eye disorder that primarily affects individuals over 50. It causes gradual loss of central vision and can lead to irreversible severe visual loss if left untreated. AMD is a leading cause of blindness in the developed world. This study aimed to investigate the effects of a loading...
The prevalence of juvenile obesity is increasing, reaching epidemic proportions, presenting a link not only to NAFLD (non-alcoholic fatty liver disease) but to abnormal lipid profiles and liver enzyme abnormalities. Liver ultrasonogra-phy is a sensitive and specific tool for the recognition of NAFLD. This study aims to assess the association betwee...
Background. The patient needs from the doctor things such as interest visual contact, empathy, of this and the most important thing is good treatment and diagnosis, However, the patient usually did not receive the level of requirement from their doctors. Objective. Evaluate the expected requirement regarding family history and other doctors and car...
Myopathy is a disease characterized by muscle dysfunction in general and may be associated with genetics, medication such as statins, or inflammation. In 2019, an epidemic viral infection (SARS-CoV-2 virus) that invaded most countries worldwide appeared and caused acute respiratory disease. Consequently, patients had to take a group of drugs for a...
Background: Due to its negative effects on the unborn child and the mother as a consumer, pregnant women's intake of psychoactive substances has become a public health concern. Additionally, consuming these chemicals has been linked to several neurological development changes in children, including behavioral issues (such as attention deficit hyper...
In addition to energy storage, the adipose tissue plays multiple important roles, particularly the secretion of biomolecules such as leptin that participate in the neuroendocrine regulation of appetite. Therefore, this review sought to understand the influence of leptin on the genesis of obesity. A systemic review of the literature was conducted us...
NeuroAid II, a folk Chinese Medicine, is currently used in Asia for the treatment of stroke.An experimental study demonstrated that NeuroAid enables neuronal cells to be more resistantto glutamate toxicity. This research was constructed to evaluate the efficacy of NeuroAid in theprevention of epilepsy (EP). Forty healthy adult male mice were used a...
The various species' male accessory genital glands vary and are intimately related to the pelvic urethra. These glands secrete nutritional substances, buffers, and mucous to increase volume, serve as lubricants, reduce the minor acidity of vaginal contents and make the environment more hospitable to motile sperm. This study aims to study the histol...
Background; panax ginseng is one of the best ayurvedic plant used for treatment of several types of disease such as diabetes, improve the libido and hair-lose and as antioxidant also decrease the side effect and toxicity of several chemotherapy and toxic substances and several studies show that it may have an anticancer effect. Aim: to find out the...
Background : Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of the current...
Nefopam hydrochloride (Acupan) is commonly used to relieve moderate to severe postoperative pain. This drug is generally well tolerated; however, it has been associated with cardiac conduction problems, cerebral edema, fever, and renal failure when taken in excess. The aim is to investigate the effect of toxic doses of nefopam on the liver, heart,...
Background : Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of current stud...
Objective:
Monitoring the result of miR 409 3p and its response to tumor proliferation and its mechanism of action on some types of lung cancer in vitro (A549 cell line).
Methods:
Two A549 cell line group negative control group with oligonucleotide cultured under conventional conditions and transfected with positive control nucleotides. Experime...
Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects of P. ginseng C. A. Mey, febuxostat, and their combination against DOX-induced cardiotoxicity...
Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects of P. ginseng C. A. Mey, febuxostat, and their combination against DOX-induced cardiotoxicity...
The basic concept of Neuroanesthesia & Neuro Critical Care is referred to as the ABCDE of neuroanesthesia. Early Brain Injury (EBI) was formerly known as primary brain injury. In EBI there is a loss of autoregulation and loss of blood-brain barrier integrity. The presence of Cushing's triad indicates the presence of intracranial hypertension. The t...
There is a lot of research and information on drugs and treatments, but a questionnaire was conducted to find out the degree of knowledge of doctors and medical personnel in general about the hormone leptin. It was found that many people do not know what leptin is and what it's a role in the body Leptin is a hormone that plays a key role in energy...
Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of current study...
Methicillin was known as an antibiotic that was used to treat many infections caused by Staphylococcus aureus, but in a short period of time, this antibiotic entered the medical field and eventually led to the emergence of methicillin-resistant strains of bacteria, and it is believed that methicillin resistance resulted from the bacterial acquisiti...
Background & Aims: Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the outer fibrous layer composed of the sclera and cornea. This study is aimed to know the psychosocial and economic impacts of uveitis in Iraq.
Materials and Methods: For this Cross-sectional study, 100 surveys were conducted in p...
Background; Doxorubicin (DOX) is a broad-spectrum anti-cancer drug that is used to treat a variety of cancers, including blood cancers such as leukaemia and solid tissue cancers. But however, its use some time limited because of its cardiotoxicity
Objective; to determine the cardioprotective effect of ginseng in the case of cardiotoxicity caused b...
Diseases of the respiratory system are a common cause of antibiotic prescription in Iraq and worldwide. Technology has been recently used for its diagnosis, such as the Film Array Respiratory Panel. This study aims to identify the correlation between the diagnosis and treatment of respiratory tract infections with the result of polymerase chain rea...
Coronavirus disease 2019 (Covid-19) is a worldwide infectious disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2). In severe SARS-CoV-2 infection, there are severe inflammatory reactions due to neutrophil recruitments and infiltration in the different organs with the formation of neutrophil extracellular traps (NETs), which involv...
Background. The patient needs from the doctor things such as interest visual contact, empathy, of this and the most important thing is good treatment and diagnosis, However, the patient usually did not receive the level of requirement from their doctors. Objective. Evaluate the expected requirement regarding family history and other doctors and car...
Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypothalamus and the feeding center in the ventral tegm...
Currently, cancer is among the leading causes of death in the world. It is the correct diagnosis that gives the patient a better chance of healing. The detection of genetic markers, macromolecules that are produced directly by the tumor or by the host, has the potential to be one of the diagnostic tests. This paper is a review article, with the obj...
Coronavirus is a pathogen that has been known to medicine for a long time with 39 different genotypes, which fall under the broad realm of Riboviria, which mainly targets the human respiratory system. The novel coronavirus disease 2019 is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This virus has an enveloped single-...
Objectives: Doxorubicin is one of the most important and powerful anticancer drugs, the most pronounced limitation for its use is toxicity on normal cells. Mechanism of doxorubicin-induced cardiotoxicity (DIC) is multifactorial and complex, including direct DNA damage, formation of free radicals, interference with DNA repair, and activation of immu...
Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-i...
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I have simple research published on androgen receptors and the difference between normal and mutated receptors
this is my article
please help with revisions
the Journal F1000 research wants a reviewer please help
I had finished docking with MOE molecular operating environment, However, I was faced with docking result, what this result and how to find the affinity, binding and number, and type of binding?
The acceptance rate is the ratio of the number of articles submitted to the number of articles published (or rejection rate). Although like with many journal measures, the raw number does not tell the whole story, it can be used to gauge a publication's selectivity or prestige.
Calculating acceptance rates
Acceptance rates are calculated in a variety of ways. Some journals calculate the rate based on the total number of papers received. Others allow the editor to select which articles are forwarded to reviewers and determine the acceptance rate based on the number of manuscripts examined, which is smaller than the total number of manuscripts received. Furthermore, many editors do not keep accurate records of this information and merely provide a rough estimate.
