Hany A. Batakoushy

Menoufia University, College of Pharmacy · Pharmaceutical Analytical Chemistry

Two versatile yet simple methods, colorimetric and spectrofluorimetric, were utilized for the quantitation of nonchromophore neomycin using silver nanoparticles modified with fluorescein. Fluorescein was excited at 485 nm (emission at 515 nm); when it is deposited on the surface of silver nanoparticles, its fluorescence intensity at 515 nm is quenc...

Correction for ‘Cancer treatment approaches within the frame of hyperthermia, drug delivery systems, and biosensors: concepts and future potentials’ by Zeinab S. Sayed et al., RSC Adv., 2024, 14, 39297–39324, https://doi.org/10.1039/D4RA06992G.

Aims: Gastrointestinal stromal tumors (GISTs) account for about 80% of the mesenchymal tumors of the GI tract. About 5000-6000 patients are diagnosed in the United States (US) alone, and up to 14.5 cases per million discovered in Europe annually. Avapritinib (AVP) is a potent selective targeted medication that has been recently approved, by the US...

This work presents a review of the therapeutic modalities and approaches for cancer treatment. A brief overview of the traditional treatment routes is presented in the introduction together with their reported side effects. A combination of the traditional approaches was reported to demonstrate an effective therapy until a few decades ago. With the...

An innovative green synthesized carbon quantum dot was decorated with terbium as new fluorescent nanoprobes (Tb,N@CQDs) and developed as eco-friendliness, water-soluble, cost-effectiveness, and biocompatibility quantum dots for analysis of edoxaban (EDN). A microwave synthesis technique produced environmentally friendly (Tb,N@CQDs) in just 7 min, b...

In the current study, a cadmium-metal organic frameworks (Cd-MOFs) structure was developed using a chemical process. The work comprised two main stages, initially inspection of the physicochemical features of the structure, and secondly, the application of the prepared Cd-MOFs as a turn-off nanosensor for the spectrofluorimetric determination of bi...

In the present study the authors’ main goal is to avoid the corrosive attack of the chloride ions of 3.5% NaCl solution in saline medium on the mild steel (MS), by addition of small amount of a new derivative of the hydrazide called ligand (HL), as a corrosion inhibitor. This study had been achieved by employing different electrochemical measuremen...

Background The proposed research study introduces independent concentration extraction (ICE) as a novel UV–Vis spectrophotometric approach. The approach can be used for extracting the concentration of two analytes with severely overlapped spectra from their binary mixtures. ICE is based on spectral extraction platform involving simple smart success...

Alzheimer’s disease (AD) is a neurodegenerative disease that badly impacts patients and their caregivers. AD is characterized by deposition of amyloid beta (Aβ) and phosphorylated tau protein (pTau) in the brain with underlying neuroinflammation. We aimed to develop a neuroprotective paradigm by loading verapamil (VRH) into hyaluronic acid-modified...

One of the biggest issues affecting the entire world currently is water contamination caused by textile industries’ incapacity to properly dispose their wastewater. The presence of toxic textile dyes in the aquatic environment has attracted significant research interest due to their high environmental stability and their negative effects on human h...

Beryllium (Be2+) is a type of alkaline earth-divalent metal that enters many strategic industries. The work environment limits concentrations of beryllium is in the range of 0.01 – 1.0 μg mL−1 (ppm), where concentrations exceeding 5.0 ppm of Be2+ lead to acute toxicity, causing pulmonary edema and chemical pneumonitis. Herein, Be2+ was measured sel...

Tobacco smoking is becoming one of the major worldwide concerns regarding environmental pollution as well as health threats. In 2005, the World Health Organization (WHO) released the Framework Convention On Tobacco Control (FCTC), which outlined protocols for controlling tobacco products. Oman was one of the leading countries to follow these protoc...

Avapritinib (AVA) is the first medication authorized by the US-FDA in 2020 for the management of gastrointestinal stromal tumours (GISTs) that can't be treated by surgery. Cancer is among the most common causes of death worldwide and is the second most common cause of death after cardiovascular disease. Therefore, a quick, easy, sensitive, and stra...

In the present study, a first validated and green spectrofluorimetric approach for its assessment and evaluation in different matrices was investigated. After using an excitation wavelength of 345 nm, Roxadustat (ROX) demonstrates a highly native fluorescence at an emission of 410 nm. The influences of experimental factors such as pH, diluting solv...

Terbium- and nitrogen-doped carbon quantum dots (Tb,N@CQDs) were greenly created employing microwave synthesis from plum juice with terbium nitrate. The synthesis of Tb,N@CQDs was fast (7 min) with a high quantum yield (35.44%). Tb,N@CQDs were fully characterized using transmission electron microscopy, Zeta potential analysis, fluorescence, and ult...

The present research has established a quick and highly sensitive second‐derivative synchronous fluorometric technique for the simultaneous quantification of a binary mixture of olmesartan medoxomil and rosuvastatin calcium. Simultaneously, the suggested approach was used to detect the synchronous fluorescence intensity of the cited drugs at Δ λ =...

A simple, sensitive, selective, accurate and precise method was developed and fully validated for determination of oxcarbazepine (OXC) in presence of their preservatives and determination of oxcar- bazepine (OXC) in human plasma. A reversed phase liquid chromatography (RP-HPLC) with UV detection techniques were applied for separation and quantifica...

Mono organometallic compounds of Cu(II), Mn(II), Pb(II), Zn(II), Cd(II), Co(II), Ni(II) and Mg(II) of new diethyl 3-((2-aminophenyl)carbamoyl)-3-hydroxypentanedioate ligand have been synthesized and characterized using spectral analyses; (1H-NMR, mass, IR, UV-VIS and ESR) , magnetic moments , conductance, elemental and thermal analysis. Amide ligan...

Water contamination with harmful ions has grown to be a significant environmental issue on a global scale. Therefore, the fabrication of simple, cost-effective, and reliable sensors is essential for identifying these ions. Herein, co-doping of carbon dots with new caffeine and H3BO3-derived boron (B) and nitrogen (N) was performed (BN@CDs). The as-...

Copper (Cu) plays a role in maintaining healthy nerve cells and the immune system. Osteoporosis is a high-risk factor for Cu deficiency. In the proposed research, unique green, fluorescent cysteine-doped MnO 2 quantum dots (Cys@MnO 2 QDs) were synthesized and assessed for the determination of Cu in different food and hair samples. The developed qua...

Avapritinib (AVP) was the first precision drug to be approved by the US FDA in 2020 for patients suffering from metastatic gastrointestinal stromal tumors (GISTs) and progressive systemic mastocytosis. The analysis of AVP in pharmaceutical tablets and human plasma was then carried out using a fast, efficient, sensitive, and simple fluorimetric meth...

A novel modified carbon paste electrode that was based on Epoxide natural rubber 30 phr (electrode V) and Epoxide natural rubber spent coffee 5 phr (electrode X) as a chemical modifier was developed and used to quantify mercuric ions in water samples. The developed electrode exhibits a Nerstian response within ranges of 10-7 – 10-1 and 10-8 – 10-1...

Herein, a sensitive and selective spectrofluorimetric method has been developed for the determination of the ocular local anesthetic benoxinate hydrochloride (BEN-HCl) in eye drops and artificial aqueous humour. The proposed method is based on the interaction of fluorescamine with the primary amino group of BEN-HCl at room temperature. Following th...

A sequential spectrophotometric resolution technique (SSRT) was developed in this study without the use of systematic separation procedures to determine drug of a quaternary combination; caffeine (CAF), pseudoephedrine (PSE), doxylamine succinate (DOX), and paracetamol (PAR). Their presence in a tablet with a gap ratio of 3:3:1:150, respectively, a...

A simple, sensitive, selective, accurate and precise method was developed and fully validated for determination of oxcarbazepine (OXC) in presence of their preservatives and determination of oxcarbazepine (OXC) in human plasma. A reversed phase liquid chromatography (RP-HPLC) with UV detection techniques were applied for separation and quantificati...

Background: Before it spreads to other tissues, mebendazole, a highly effective broad-spectrum anthelmintic, is used to treat worm infestations caused by roundworms, hookworms, whipworms, threadworms (pinworms), and the gastrointestinal form of trichinosis. Objective: The development of new methods for sensitive quantification of mebendazole in...

Mercury (Hg2+) is natural element present in food such as fish, water and soils, exposure to mercury led to severe toxic effect on nervous, digestive, and immune system. Herein, a novel, green and environmentally friendly fluorescent probe decorated cysteine MnO2 quantum dots (Cys@MnO2 QDs) has been synthesized. This synthesis was carried out throu...

The neuro-stimulant anti-narcoleptic drug as modafinil (MOD) is used to treatment neurological conditions caused by COVID-19. MOD was used to treatment narcolepsy, shift-work sleep disorder, and obstructive sleep apnea-related sleepiness. So, an innovative, quick, economical, selective, and ecologically friendly procedure was carried out. A highly...

A brand-new class of anti-infective drugs that work against bacteria, viruses, and protozoan parasites is nitazoxanide and related thiazolides. Thiazolides have also been shown to cause cell cycle arrest and apoptotic cell death in cancer cells in recent years. In this study, an eco-friendly, spectrofluorimetric technique that is verified, easy, an...

Herein, we developed a new pencil graphite ion-selective electrode strategy for the broadly used erectile dysfunction medication, sildenafil citrate (SC, vitamin V), for its automated potentiometry and potentiometric titration profiling in marketed tablets and human urine samples. The method was based on ion-pair complexation between SC and sodium...

An anthelmintic, rafoxanide (RF), is frequently used in veterinary medicine to cure fascioliasis in cattle and sheep. A sensitive, quick, and selective detection of RF in its pharmaceutical preparation and in human urine was achieved through developing a new electrochemical sensor. The suggested method relied on the electro-oxidation of RF that use...

An one-pot hydrothermal method was developed for synthesis of carbon quantum dots co-doped with copper and nitrogen (Cu, N@CQDs). The synthesized Cu, N@CQDs has unique advantages such as high fluorescence quantum yield (39.1%) and high catalytic activity. Oxidative coupling of amoxicillin (AMX) with 4-aminoantipyrine (4-NH2-APE) in the presence of...

Diabetes mellitus is a worldwide disease that requires special and continuous medical care. Many classes of oral hypoglycemic drugs are currently used; however, the treatment strategy depends on the nature of diabetes type, pharmacological properties of the used drugs in addition to the clinical characteristics of the patient. As such, in this lite...

A new and valid method was developed for the quantitative voltammetric analysis of midodrine hydrochloride (MID) in pharmaceutical tablets (Midodrine) and biological samples. The method is based on electro-oxidation of MID supported by both disposable pencil electrode (PE) and glassy carbon electrode (GCE). The analysis was carried out using cyclic...

A novel optical nano‐sensor for the detection of pregabalin (PG) in its pharmaceutical (Lyrica®) capsules and biological samples was reported. For the fabrication of highly fluorescent carbon quantum dots (CQDts), a simple green hydrothermal approach was described, and Ascorbic acid (AA) was used as a carbon source. The obtained CQDts were confirme...

A new, valid method was developed for quantitative spectrofluorimetric analysis of dapagliflozin (DGF) in its pure form and its commercially available tablets (Farxiga®). The proposed analytical method based on measurement of fluorescence intensity for DGF at 303 nm after excitation at 278 nm. Various experimental parameters influencing the fluores...

An efficient, accurate and sensitive spectrofluorimetric method was developed for analysis of empagliflozin (EGF) in pure form, dosage form and human plasma. The proposed procedure was based on formation of yellow fluorescent product between benzofurazan reagent and empagliflozin in slightly alkaline medium that is measured at 521 nm, when excitati...

In recent years, a lot of single-pill combinations (SPC) manufactured and are used as a promising choice in diabetes treatment. However, this trend made a serious challenge to drug analysts because of the difficulty in the analysis of two or more drugs in the presence of each other. In this study, a new validated high performance thin-layer chromat...

A highly accurate, simple and sensitive spectrofluorimetric analytical method for dapagliflozin (DGF) quantitation was developed. The proposed method was successively applied to DGF analysis in both its pure and pharmaceutical dosage forms. This method was developed to investigate DGF stability in its degradation products, as laid out in Internatio...

A new validated spectrofluorimetric method was proposed for dapagliflozin (DGF) analysis in bulk, plexin its commercially available tablets and in spiked human plasma. The proposed spectrofluorimetric method depended on the formation of a fluorescent complex soluble in organic liquids by a substitution reaction between 4‐chloro‐7‐nitrobenzo‐2‐oxa‐1...

A simple colorimetric method for the quantitative detection of two cephalosporins, cefoperazone (CFZ) and cefepime (CPM), has been developed and validated for the application in clinical and quality control laboratories. The method was based on exploiting the reducing properties of cephalosporins due to the 7-aminocephalosporanic acid dihydrothiazi...

Metal complexes of cefixime, cefpodoxime and cefperazone with aluminium, calcium, strontium and zinc have been synthesized and characterized with melting points, UV-Visible and FTIR spectroscopy. The in vitro evaluation of the antimicrobial activity has revealed a significant reduction of the activity for most of the prepared metals complexes. Furt...

The structural information of the pharmaceuticals and insights on the modes of molecular interactions are very important aspects in drug development. In this work, two cephalosporins and antimicrobial combinations, cefepime-metronidazole and cefoperazone-sulbactam, were studied in the solid state using FTIR spectroscopy for the first time. Quantita...