Hans-Joachim Woitowitz

Hans-Joachim Woitowitz
Justus-Liebig-Universität Gießen | JLU · occupational and social medicine

Emeritus

About

238
Publications
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2,144
Citations

Publications

Publications (238)
Article
Although there is no dispute among independent scientists about the carcinogenic and fibrogenic effects of chrysotile, the asbestos industry has been continuously and success-fully acting to cast doubts on its harm. Another approach including asbestos insurance entities is to refuse compensa-tion by raising the bar and fight criminal prosecution fo...
Article
Although there is no dispute among independent scientists about the carcinogenic and fibrogenic effects of chrysotile, the asbestos industry has been continuously and successfully acting to cast doubts on its harm. Another approach including asbestos insurance entities is to refuse compensation by raising the bar and fight criminal prosecution for...
Article
Schikowsky et al.conducted a cross-sectional study of 207 selected asbestos workers from a power plant with a mean exposure of 49 (0.1-844.9) fiber-years, mean exposure duration of 21.4 (1-42) years, and a mean latency period of 36.2 (13-60) years. Their results include a statistically significant association of Forced Vital Capacity (FVC), Forced...
Article
Der Lungenkrebs zählt zu den häufigsten Krebsarten. Laut jüngsten WHO-Daten gehen nicht weniger als 10 % dieser Erkrankungen auf arbeitsbedingte Einwirkungen von Kanzerogenen zurück. Dabei nimmt Asbest nach wie vor die dominierende Rolle ein. Außerdem sind Quarz und ionisierende Strahlen (Uranbergbau) häufige Krankheitsauslöser. Nur durch die fachä...
Article
Full-text available
The silicate mineral asbestos is categorized into two main groups based on fiber structure: serpentine asbestos (chrysotile) and amphibole asbestos (crocidolite, amosite, anthophyllite, tremolite, and actinolite). Chrysotile is used in more than 2 000 applications and is especially prevalent in the construction industry. Although its use is banned...
Article
Full-text available
An 81-year-old woman was dying from histologically confirmed pulmonary fibrosis without having had any asbestos exposure in the workplace. The lung dust fibre analysis showed significantly increased "asbestos bodies" (AB) (2,640 AB per gram of wet lung tissue) and asbestos fibre concentrations (8,600,000 amphibole fibres of all lengths and 540,000...
Article
Dosisgrenzwerte mit der Funktion eines ‘Abschneidekriteriums’ konnten im deutschen Berufskrankheitenrecht nur in Einzelfällen als Konventionen legitimiert werden. Dies erfolgte bisher ausschließlich durch den Verordnungsgeber. Grundlage waren drei arbeits- und sozialmedizinisch definierte, jedoch an speziellen, insbesondere krebserzeugenden Noxen o...
Article
Since Ramazzini (1700), central tasks of occupational medicine are the exploration of the causes of work-related diseases and their control in professional groups with high risks at the workplaces. This is true particularly regarding the fatal dangers of newly created man-made carcinogenic chemicals. Such chemical induced cancers were first discove...
Article
Since Ramazzini (1700), central tasks of occupational medicine are the exploration of the causes of work-related diseases and their control in professional groups with high risks at the workplaces. This is true particularly regarding the fatal dangers of newly created man-made carcinogenic chemicals. Such chemical induced cancers were first discove...
Article
Due to the current query whether the predominantly used chrysotile (white) asbestos comprises health risks we performed a literature search including in vitro and animal experiments as well as epidemiological studies.As shown by epidemiological studies chrysotile causes less pleural fibrosis and mesotheliomas when compared with other asbestos types...
Article
In the German Ordinance on occupational diseases dose-limit values of carcinogenic substances that serve as decision criteria for compensation have been exclusively authorized by the legislator. These values were established only in exceptional cases as conventions, and the action itself was limited to well-defined preconditions. These precondition...
Article
Due to latency periods that can last for decades, asbestos-related diseases show 18 years after the enforcement of the prohibition of asbestos application in Germany their highest numbers. In the centre of attention are asbestos-induced pleural fibroses, mesotheliomas, asbestoses, lung and laryngeal cancer. Diagnosing and expertizing these diseases...
Article
This article discusses the development of asbestos-induced malignant mesotheliomas after non-occupational environmental exposure to asbestos through contact with occupationally exposed household members. In our policlinic, we have seen six fatal pleural mesothelioma cases (five wives and one son of asbestos-industry workers) with no history of occu...
Article
Obstructive pulmonary disease and emphysema are recognized as occupational diseases in miners working in black coal mines (BK No. 4111 BKV). A case of a uranium miner suffering from an obstructive pulmonary disease and emphysema is described; toxicological data have demonstrated that this disease can be caused at least in part by exposure to high c...
Article
Full-text available
The aim of this study was to evaluate the diagnostic power of a fuzzy classifier and a marker panel (CYFRA 21-1, NSE, CRP) for the detection of lung cancers in comparison to asbestosis patients at high-risk of developing lung cancer. A panel of four tumour markers, i.e. CEA, CYFRA 21-1, NSE, SCC and CRP, was measured in newly diagnosed lung cancer...
Article
Full-text available
Ataxia-telangiectasia is an autosomal recessive disease characterized by neurological and immunological symptoms, radiosensitivity and cancer predisposition. Heterozygous carriers of an ataxia-telangiectasia gene mutation are predisposed to epithelial cancers. We initiated a study to elucidate the frequency and clinical relevance of ATM gene mutati...
Chapter
Bei den in der Bundesrepublik jährlich neu anerkannten Berufskrebserkrankungen ist ein Anstieg von 95 Fällen im Jahre 1978 auf 530 im Jahre 1988 und auf 1785 im Jahre 2000 zu verzeichnen, in der ehemaligen DDR stieg die Zahl von 137 im Jahre 1978 auf 327 (ohne Wismut AG) im Jahre 1988. Seit Mitte der 90er Jahre bewegen sich die Zahlen im vereinigte...
Article
Full-text available
Despite an extensive literature, the relationship between asbestos exposure and lung cancer remains the subject of controversy, related to the fact that most asbestos-associated lung cancers occur in those who are also cigarette smokers: because smoking represents the strongest identifiable lung cancer risk factor among many others, and lung cancer...
Article
The impact of genetic polymorphisms in GSTM1, GSTP1 or GSTT1 on susceptibility to lung cancer has received particular interest since these enzymes play a central role in detoxification of major classes of tobacco carcinogens. In the current German study we investigated the role of GSTM1, GSTT1 and GSTP1 polymorphisms as a genetic modifier of risk f...
Article
Full-text available
Background: The impact of genetic polymorphisms in CYP1A1 or CYP1B1 on susceptibility to lung cancer has received particular attention since these enzymes play a central role in the activation of major classes of tobacco carcinogens. Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population fre...
Article
The ILO (1980) Classification has been revised during recent years. The new version is now available as the International Classification of Radiographs of Pneumoconioses (Revised edition 2000). The Guidelines booklet is currently available only in English. Those involved felt it was important to maintain continuity with the ILO (1980) edition, in p...
Article
Pulmonary siderosis is a well established disorder in welders. Internationally more than 150 cases of interstitial pulmonary siderofibrosis are associated with long-standing and heavy exposure to welding fumes at poorly ventilated working places. Characteristic job histories, lung function analyses and histological examinations as well as elemental...
Article
Hintergrund: Über Siderosen bei Schweißern wird seit Jahrzehnten berichtet. Darüber hinaus wurden mehr als 150 Fallberichte über fibrosierende interstitielle Lungenerkrankungen („Siderofibrosen”) mit langjähriger Schweißraucheinwirkung unter unzureichenden arbeitshygienischen Bedingungen mitgeteilt. Patienten: Am Beispiel charakteristischer Biograf...
Article
Findings in the areas of preventive medicine, toxicology and oncology indicate that benzene is an exceptional carcinogen. In individual cases of litigation it has become obvious that particular legal restrictions for compensation must be overcome. Apart from a few cases with an extremely high lifetime exposure to benzene the following impediments l...
Article
Aim. The risk of lung cancer which is observed in rodents after inhalation or instillation of granular insoluble dust has to be discussed for granular bio-durable particles without essential specific toxicity. In this context increased biological effects of ultrafine particles <100 nm in diameter should be considered not only for free primary parti...
Article
The Precautionary Principle (PP) provides a means of acting in the face of uncertainty, although the full extent of the legal implications is still under discussion. Recent reports of the European Commission, on how to apply the PP, and of the European Environment Agency, on how the concept of precaution has been applied - or not - over the past ce...
Article
Interstitial pulmonary fibrosis (IPF) is reported after long term, severe exposure to welding fumes in poorly ventilated workplaces. Fifteen welders with IPF were examined--13 in our outpatient clinic--from 1990 to 1997. Occupational histories and examinations, lung function analyses, symptoms and clinical findings, histological analyses in 13 pati...
Article
Quartz is used widely in industry. The levels of quartz in various types of stones differ greatly. The pathomechanism of exposure to quartz dust plausibly explain pathogenesis. There is evidence from animal experiments that quartz dust is carcinogenic. Respirable quartz dust was international classified as carcinogene. Epidemilogical studies reveal...
Article
Rounded atelectases as pseudotumours of the lung represent a special kind of asbestosis that has so far only been paid little attention to. They can rarely be recognised in the conventional X-ray of the thorax, but can always be detected by computed tomography. Due to the lack of malignity surgical measures are usually not indicated. In the course...
Article
Over the last 50 years the scientific evidence for synergistic effects in carcinogenicity has increased considerably as the result of animal experiments and epidemiological studies. Of particular importance are synergisms which amplify the carcinogenic effects of exposure to carcinogens ("synergistic syncarcinogenicity") not only in an additive, bu...
Article
To ascertain the lung burden of asbestos fibres in Hungarian lung cancer patients in comparison with the cumulative asbestos exposure estimated from the occupational history. For 25 Hungarian lung cancer patients, lung tissue fibre analysis was performed by scanning transmission electron microscopy (STEM) and counting of ferruginous bodies (FBs) by...
Article
Since 1977 the diffuse malignant mesothelioma of the pleura and peritoneum caused by asbestos represents one of the most often compensated occupational cancers in Germany. Because of the probability of an asbestos-related etiology, it is considered as a "signal tumour", mainly indicating exposure to asbestos dust at the workplace. Two cases of hist...
Article
This study examines the role of occupational factors in the development of diffuse malignant mesothelioma with special emphasis on the dose-response relationship for asbestos and on the exposure to man-made vitreous fibers (MMVFs). One hundred and twenty-five male cases, diagnosed by a panel of pathologists, were personally interviewed concerning t...
Article
This case report concerns a 46-year-old woman, dying from histologically confirmed diffuse malignant mesothelioma after asbestos exposure, which was only caused by indoor pollution from crocidolite-containing spray asbestos in building materials. There was no other known occupational or environmental asbestos exposure during her life. The lung tiss...
Article
Background This study examines the role of occupational factors in the development of diffuse malignant mesothelioma with special emphasis on the dose-response relationship for asbestos and on the exposure to man-made vitreous fibers (MMVFs). Methods One hundred and twenty-Jive male cases, diagnosed by a panel of pathologists, were personally inter...
Article
The assessment form VA3-G1 which is used in the second judgement of the preventive examination in occupational medicine according to the Principle G 1.2 of the professional associations on "Asbestos fibres dust" was brought into line with current questions by the group of second judges. The experiences of the past years have shown that the so-calle...
Article
Yearly rising rejection quotas of submitted occupational diseases reflect the existence of system-inherent hurdles as - among others - the list principle with its limiting conditions, the requirements for "general appropriateness" and "group typicality" as well as the insufficient consideration of synergistic combination effects. To prove the "gene...
Article
The aim of this study was to obtain toxicokinetic data on the absorption and elimination of monochlorobenzene (MCB) in blood and its main metabolite 4-chlorocatechol (4-ClCat) as well as on the isomeric chlorophenols (o-ClPh, m-ClPh, and especially p-CIPh as the main ClPh metabolite) in urine for reevaluation of the biological tolerance (BAT) value...
Article
What is the frequency of occupational asbestos exposure among patients suffering from malignant respiratory tumours and how many of these tumours are associated with asbestos in Hungary? An internationally established questionnaire with 29 questions, covering the most characteristic activities of asbestos exposure at the workplace was completed for...
Article
Former East German uranium miners who are known to have been exposed to radon are estimated to be at high risk for lung carcinogenesis. Among these miners over 200 occupationally caused lung cancer cases are expected to occur each year, resulting in a total of 7,000–24,000 excess lung cancer cases in the coming years. It is still unknown whether th...
Article
Certain subsets of the population are especially sensitive to carcinogens, and this can be determined using molecular biological methods. In the literature there has been evidence presented for the use of p21ras (ras) as a tumor marker for human carcinogenic substances such as asbestos, polycyclic aromatic hydrocarbons, and vinyl chloride in the wo...
Article
The results of standardized 8 h lasting exposures of n=18 volunteers to ethylbenzene (EthBz) at levels of 25 and 100% of the maximum allowable concentrations at the workplace (MAK) value of 100 ppm as well as the results of field studies are considered to evaluate a biological tolerance (BAT) value for EthBz. On the basis of the relationship betwee...
Article
Ultrafine aerosol particles D < 100 nm with low solubility in the workplace atmosphere generally are present not as single free particles but composed as aggregates and agglomerates (U-fraction). It has been proposed that temporary these aerosols should be characterized by the particle concentration between D = 5 and D = 200 nm together with an ana...
Article
The oncogene product EGF-receptor (EGF-R), the tumor suppressor gene product p53, and anti-p53 antibodies are detectable in serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure, after exposure to polycyclic aromatic hydrocarbons or vinyl chloride. Thi...
Article
Since 1985 124 clinical courses of patients with non-Hodgkin's lymphomas (NHL) including chronic lymphocytic leukaemias (CLL) or plasmacytomas (PLC) following long-lasting asbestos exposure could be accumulated from various areas of West Germany and from Uppsala. Additional 90 of such cases were found in the literature of the United States and of o...
Article
The results of standardized analyses of commercial bitumen should make a contribution to improve the knowledge about the carcinogenic contents and to the temperature-dependent behaviour in generating aerosols and vapours. There were not found any nitrogen containing heterocyclics in the bitumen samples of HB 90/100; B 45; B 65; B 80; B 200 as well...
Article
Full-text available
The oncogene product epidermal growth factor receptor (EGF-R), the tumour suppressor gene product p53 and anti-p53 antibodies are detectable in the serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure and after exposure to polycyclic aromatic hydrocar...
Article
In a mesothelioma case-control study, asbestos and other mineral fibers from lung burden were examined as causal factors. Diagnosis was confirmed by a panel of pathologists. For 66 cases and 66 controls from hospitals in five German towns, lung tissue fiber analysis by transmission electron microscopy was available. Control patients were treated by...
Article
The evaluation of occupational diseases has to consider cause and effect as well as the amount of impairment to estimate the degree of compensation. We present a case study of a 54-year-old male with hypertension, chronic obstructive lung disease and pulmonary fibrosis after long-term exposure to welding fumes predominantly in confined-spaces. Lung...
Article
The determination of the locality when dealing with the problem of the fraction of quartz dust able to enter the alveoli can be summarized from an occupational medical point of view as follows: Quartz is used widely in trade and industry. The levels of quartz found in the various types of stone used differ greatly. Between 1997 and 1999 the substan...
Article
The mesothelioma of the pleura, the peritoneum and the pericardium is a 'signal-tumor' of previous asbestos inhalation at the work place. Employees in asbestos mines, in the asbestos cement industry, in the asbestos textile industry as well as in the production of gas-mask filters are at a higher risk suffering from this malignant disease. Also env...
Article
Lung cancer due to PAHs can now be compensated as an occupational disease when there is evidence of exposure to a cumulative dose of at least 100 benzo[a]pyrene (BaP) years. The practicability of estimating the cumulative BaP dose, was investigated using the new BK report on occupational diseases on the basis of n = 35 cases of lung cancer after lo...
Article
This report concerns two Turkish immigrant workers, aged 50 and 59, who developed histologically confirmed diffuse malignant mesothelioma in the absence of obvious occupational exposure to asbestos in Germany. Both patients had spent their childhood in central Anatolia, Turkey, where the presence of tremolite asbestos in the environment has been de...
Article
To the Editor: A 51 yr old, nonsmoking female suffered from relaps- ing progressive pneumonia for several years. The patient had worked for 16 yrs in the nuclear industry and was exposed to grinding particles and welding fumes working with zirkaloy, an alloy containing tin, iron, chromium and zirconium. During an exacerbation of the pneumonia radi-...
Chapter
In den letzten Jahren hat sieh das Umweltbewußtsein der Bevölkerung deutlich intensiviert und in der Öffentlichkeit zunehmende Bedeutung erlangt. Unter den vielfältigen Gefährdungen und Schädigungsmöglichkeiten durch exogene Umweltnoxen interessieren besonders auch die Erkrankungsrisiken am Arbeitsplatz (Valentin 1994). So stellen Berufskrankheiten...
Article
For more than 100 years, correlations between severe exposure to dust at the workplace and the occurrence of catarrhal infections of the tracheobronchial region and emphysema have been described, especially in coal miners working underground. The evidence on this causal relationship has recently become so specific as to allow a new occupational dis...
Article
In limit value (MAK-value) setting, long-term limit values are assigned to general dust exposure as well as to exposure to respirable quartz dust and quartziferous respirable dust because of the slow effect these agents have. Therefore, the averaging time for the assessment period was defined as one year or as five years for the documentation of in...
Article
In a cross-sectional study from the point of view of occupational medicine, 58 employees of water-works having been exposed to asbestos fibre dust for many years were submitted to radiological examinations in order to study the effects of asbestos inhalation on the lung and pleura. The workers were exposed to asbestos fibre dust when piping and rep...
Article
Occupational lung cancers are caused by physical and chemistry factors. As demonstrated in 4 patients syncarcinogen risks are a common reality at work place, in general environment and in lifestyle factors. Synergistic effects for lung cancer after interaction of carcinogenes such as asbestos, tar, nitrosamines and cigarette smoking can be seen in...
Article
In an interdisciplinary, multicentre case control study of the causal factors of the diffuse malignant mesothelioma (DMM) standardised histories where taken from n = 324 Patients suffering from DMM, n = 315 hospital control patients (KK) and n = 182 population controls (PK). For 66 DMM, 149 KK and 107 PK a risk from asbestos fibre dust at the workp...
Article
A case-control study was performed to assess various nonoccupational factors (smoking, eating and drinking habits, intake of analgesics) that may be aetiological factors in the development of tumours of the lower urinary tract, while vitamins may be protective. 150 patients (125 men, mean age 66.4 years; 25 women, mean age 68.2 years) with histolog...
Article
Members of the households of former asbestos workers are at a higher risk of dying from mesothelioma resulting from asbestos exposure from cleaning asbestos-contaminated working clothes of their relatives at home. The lung fibre burdens of some of those who develop mesothelioma are similar even to those of former asbestos workers. Such people are s...
Article
Grundproblematik und Fragestellung: Rauchen, unterschiedliche Eß- und Trinkgewohnheiten sowie die Einnahme von Schmerzmitteln scheinen ätiologische Faktoren in der Entstehung von Tumoren der ableitenden Harnwege darzustellen. Vitamine dagegen schützen möglicherweise vor solchen Tumoren. Diese Zusammenhänge wurden im Rahmen einer krankenhausbezogene...
Article
Results of a case-control study into factors affecting the development of diffusive malignant mesothelioma (DMM) showed health risks due to outdoor and indoor exposure to asbestos. It has to be investigated whether or not these findings are confirmed by international indoor and outdoor measurements of asbestos concentrations and our own and interna...