Hanna Damasio

University of Southern California | USC · Brain and Creativity Institute

Living organisms achieve homeostasis by using distinct mechanisms tailored to their physiological complexity. Unicellular organisms as well as plants, which are devoid of nervous systems, rely on covert sensing/detecting and equally covert responding mechanisms. Organisms with nervous systems rely on overt consciousness which is based on homeostati...

In this article, we summarize our views on the problem of consciousness and outline the current version of a novel hypothesis for how conscious minds can be generated in mammalian organisms. We propose that a mind can be considered conscious when three processes are in place: the first is a continuous generation of interoceptive feelings, which res...

In this view, we address the problem of consciousness, and although we focus on its human presentation, we note that the phenomenon is present in numerous nonhuman species and use findings from a variety of animal studies to explain our hypothesis for how consciousness is made. Consciousness occurs when mind contents, such as perceptions and though...

In a new theory of consciousness, Antonio and Hanna Damasio argue that interoception and the generation of homeostatic feelings are crucial to understanding how conscious states emerge. Consciousness occurs when mind contents, such as perceptions and thoughts, are ‘spontaneously identified as belonging to a specific organism/owner’. The identificat...

This kaleidoscopic collection reflects on the multifaceted world of classical music as it advances through the twenty-first century. With insights drawn from leading composers, performers, academics, journalists, and arts administrators, special focus is placed on classical music’s defining traditions, challenges and contemporary scope. Innovative...

Evidence is accumulating to suggest that music training is associated with structural brain differences in children and in adults. We used magnetic resonance imagining in two studies to investigate neuroanatomical correlates of music training in children. In study 1, we cross-sectionally compared a group of child musician (ages 9-11) matched to non...

We present a new high-quality, single-subject atlas with sub-millimeter voxel resolution, high SNR, and excellent grey-white tissue contrast to resolve fine anatomical details. The atlas is labeled into two parcellation schemes: 1) the anatomical BCI-DNI atlas, which is manually labeled based on known morphological and anatomical features, and 2) t...

Background Increased activity in the lesioned hemisphere has been related to improved poststroke motor recovery. However, the role of the dominant hemisphere—and its relationship to activity in the lesioned hemisphere—has not been widely explored. Objective Here, we examined whether the dominant hemisphere drives the lateralization of brain activi...

Figure S1: Example from video stimuli during fMRI. Figure S2: Whole brain activity contrasted between right and left action observation compared between stroke and control groups at a more lenient threshold. Figure S3: Lesion overlap heat map (whole group). Figure S4: Lesion overlap heat map for cortical left hemisphere strokes (n = 6). Figure S5:...

Evidence suggests that learning to play music enhances musical processing skills and benefits other cognitive abilities. Furthermore, studies of children and adults indicate that the brains of musicians and nonmusicians are different. It has not been determined, however, whether such differences result from pre-existing traits, musical training, or...

Music is an important facet of and practice in human cultures, significantly related to its capacity to induce a range of intense and complex emotions. Studying the psychological and neurophysiological responses to music allows us to examine and uncover the neural mechanisms underlying the emotional impact of music. We provide an overview of differ...

Several studies comparing adult musicians and nonmusicians have shown that music training is associated with structural brain differences. It is not been established, however, whether such differences result from pre-existing biological traits, lengthy musical training, or an interaction of the two factors, or if comparable changes can be found in...

Broca's area has long been implicated in sentence comprehension. Damage to this region is thought to be the central source of "agrammatic comprehension" in which performance is substantially worse (and near chance) on sentences with noncanonical word orders compared with canonical word order sentences (in English). This claim is supported by functi...

Broca’s area has long been implicated in sentence comprehension. Damage to this region is thought to be the central source of “agrammatic comprehension” in which performance is substantially worse (and near chance) on sentences with noncanonical word orders compared to canonical word order sentences (in English). This claim is supported by function...

Date Presented 4/1/2017 This poster presents an fMRI study on the role of the action observation network in stroke recovery by examining brain activity differences after left hemisphere stroke and right hemisphere stroke. Our findings suggest that the side of stroke may impact responsiveness to treatment. Primary Author and Speaker: Kaori L. Ito Co...

Gratitude is a complex emotional feeling associated with universally desirable positive effects in personal, social, and physiological domains. Why or how gratitude achieves these functional outcomes is not clear. Toward the goal of identifying its' underlying physiological processes, we recently investigated the neural correlates of gratitude. In...

Intensity variations over time in resting BOLD fMRI exhibit spatial correlation patterns consistent with a set of large scale cortical networks. However, visualizations of this data on the brain surface, even after extensive preprocessing, are dominated by local intensity fluctuations that obscure larger scale behavior. Our novel adaptation of non-...

Supplemental Material. Appendices and additional detailed results. (PDF)

tNLM filtered rfMRI data. Movie of temporal non-local means (tNLM) filtered (h = 0.72) BOLD signal intensities on the cortical surface for a subject from HCP dataset, played back at a real-time rate. The time series associated with each cortical vertex were normalized to zero mean and unit variance. The signal intensities are visualized on a smooth...

Unfiltered rfMRI data. Movie of unfiltered (minimally processed using HCP pipeline) BOLD signal intensities on the cortical surface for the same subject as S1 Video, played back at a real-time rate. The signal intensities are visualized on a smoothed cortical surface using a colormap with transitions from blue (negative) to white (zero) to red (pos...

LB filtered rfMRI data. Movie of Laplace-Beltrami filtered (t = 4) BOLD signal intensities on the cortical surface for the same subject as S1 Video, played back at a real-time rate. The signal intensities are visualized on a smoothed cortical surface using a colormap with transitions from blue (negative) to white (zero) to red (positive). Movie Par...

The brain’s mapping of bodily responses during emotion contributes to emotional experiences, or feelings. Culture influences emotional expressiveness, that is, the magnitude of individuals’ bodily responses during emotion. So, are cultural influences on behavioral expressiveness associated with differences in how individuals experience emotion? Chi...

Automatic computation of surface correspondence via harmonic map is an active research field in computer vision, computer graphics and computational geometry. It may help document and understand physical and biological phenomena and also has broad applications in biometrics, medical imaging and motion capture inducstries. Although numerous studies...

Several studies comparing adult musicians and non-musicians have shown that music training is associated with functional and anatomical brain differences. It is unknown, however, whether those differences result from lengthy musical training, from pre-existing biological traits, or from social factors favoring musicality. As part of an ongoing 5-ye...

Developmental research in music has typically centered on the study of single musical skills (e.g., singing, listening) and has been conducted with middle class children who learn music in schools and conservatories. Information on the musical development of children from different social strata, who are enrolled in community-based music programs,...

Narratives are an important component of culture and play a central role in transmitting social values. Little is known, however, about how the brain of a listener/reader processes narratives. A receiver's response to narration is influenced by the narrator's framing and appeal to values. Narratives that appeal to “protected values,” including core...

In its standard format, the concept of homeostasis refers to the ability, present in all living organisms, of continuously maintaining certain functional variables within a range of values compatible with survival. The mechanisms of homeostasis were originally conceived as strictly automatic and as pertaining only to the state of an organism's inte...

This study evaluated the consequences of damage to the parietal lobe for learning a visuomotor tracking skill. Thirty subjects with a single unilateral brain lesion (13 with and 17 without parietal damage) and 23 demographically comparable healthy subjects performed the Rotary Pursuit task. For each group, time on target increased significantly acr...

Lesion-deficit studies support the hypothesis that the left anterior temporal lobe (ATL) plays a critical role in retrieving names of concrete entities. They further suggest that different regions of the left ATL process different conceptual categories. Here we test the specificity of these relationships and whether the anatomical segregation is re...

Figure S1. Experimental conditions versus baseline. Figure S2. Facts and traits compared with core self conditions. Figure S3. Facts minus core self (interoception and exteroception). Figure S4. Traits minus core self (interoception and exteroception). Figure S5. Interoception and exteroception compared with autobiographical self conditions. F...

Introduction: The neural substrates of states devoted to processing self-related information ("self-related states") remain not fully elucidated. Besides the complexity of the problem, there is evidence suggesting that self-related states vary according to the information domain being considered. Here, we investigated brain correlates for self-rel...

Gratitude is an important aspect of human sociality, and is valued by religions and moral philosophies. It has been established that gratitude leads to benefits for both mental health and interpersonal relationships. It is thus important to elucidate the neurobiological correlates of gratitude, which are only now beginning to be investigated. To th...

Functional magnetic resonance imaging (fMRI) has significant potential in the study and treatment of neurological disorders and stroke. Region of interest (ROI) analysis in such studies allows for testing of strong a priori clinical hypotheses with improved statistical power. A commonly used automated approach to ROI analysis is to spatially normal...

The anterior insula (AI) maps visceral states and is active during emotional experiences, a functional confluence that is central to neurobiological accounts of feelings. Yet, it is unclear how AI activity correlates with feelings during social emotions, and whether this correlation may be influenced by culture, as studies correlating real-time AI...

Several studies comparing adult musicians and non-musicians have provided compelling evidence for functional and anatomical differences in the brain systems engaged by musical training. It is not known, however, whether those differences result from long-term musical training or from pre-existing traits favoring musicality. In an attempt to begin a...

The term autobiographical self has been used to refer to a mental state that permits reflection on self-identity and personality and the answer to related questions (Damasio, 1998). It requires the retrieval and integrated assembly of memories of facts and events that define an individual's biography. The neural mechanisms behind this state have no...

A development essential for understanding the neural basis of complex behavior and cognition is the description, during the last quarter of the twentieth century, of detailed patterns of neuronal circuitry in the mammalian cerebral cortex. This effort established that sensory pathways exhibit successive levels of convergence, from the early sensory...

The neural basis of action understanding is a hotly debated issue. The mirror neuron account holds that motor simulation in fronto-parietal circuits is critical to action understanding including speech comprehension, while others emphasize the ventral stream in the temporal lobe. Evidence from speech strongly supports the ventral stream account, bu...

WE INVESTIGATED EFFECTS OF SIGN LANGUAGE USE AND AUDITORY DEPRIVATION FROM BIRTH ON THE VOLUMES OF THREE CORTICAL REGIONS OF THE HUMAN BRAIN: the visual cortex surrounding the calcarine sulcus in the occipital lobe; the language-related cortex in the inferior frontal gyrus (pars triangularis and pars opercularis); and the motor hand region in the p...

Background / Purpose: Sulcal landmarks have been used extensively for cortical registration, and we have recently seen increasing interest in analyzing the geometry of sulcal anatomy in the study of disease progression, aging, brain asymmetry and various studies of differences in neuropsychological groupings. We present a method for automated gen...

Brain Cortical surface registration is required for inter-subject studies of functional and anatomical data. Harmonic mapping has been applied for brain mapping, due to its existence, uniqueness, regularity and numerical stability. In order to improve the registration accuracy, sculcal landmarks are usually used as constraints for brain registratio...

Automatic computation of surface correspondence via harmonic map is an active research field in computer vision, computer graphics and computational geometry. It may help document and understand physical and biological phenomena and also has broad applications in biometrics, medical imaging and motion capture. Although numerous studies have been de...

Purpose: To correct distortions caused by eddy currents induced by large diffusion gradients during high angular resolution diffusion imaging without any auxiliary reference scans. Materials and methods: Image distortion parameters were obtained by image coregistration, performed only between diffusion-weighted images with close diffusion gradie...

Preterm infants (∼10% of all births) are at high-risk for long-term neurodevelopmental disabilities, most often resulting from white matter injury sustained during the neonatal period. Glutamate excitotoxicity is hypothesized to be a key mechanism in the pathogenesis of white matter injury; however, there has been no demonstration of glutamate exci...

Guidelines for DEHSI ratings. Wnl = Within normal limits. See Figure 2 for examples. (DOCX)

Mean metabolite concentration for pWML cases and non-pWML cases expressed as a ratio relative to creatine. Consistent with the results from the MANCOVA contrasting absolute concentration for the six metabolites, the overall multivariate F contrasting between the pWML cases and the non-pWML, controlling for PCA, was significant (F[5,101] = 4.502, p...

Analyzing geometry of sulcal curves on the human cortical surface requires a shape representation invariant to Euclidean motion. We present a novel shape representation that characterizes the shape of a curve in terms of a coordinate system based on the eigensystem of the anisotropic Helmholtz equation. This representation has many desirable proper...

A considerable body of previous research on the prefrontal cortex (PFC) has helped characterize the regional specificity of various cognitive functions, such as cognitive control and decision making. Here we provide definitive findings on this topic, using a neuropsychological approach that takes advantage of a unique dataset accrued over several d...

The overall volume of the brain has been found to be under relatively strong genetic control, but the relative strength of genetic and environmental factors on between-person variations in regional cortical thickness in adolescence is still not well understood. Here, we analyzed structural MRI data from 108 14-year-old healthy twins (54 females/54...

Sulcal folds (sulci) on the cortical surface are important landmarks of interest for investigating brain development and disease. Accurate and automatic delineation of the sulci is a challenging problem due to substantial variability in their shapes across populations. We present a geodesic curvature flow method for an automatic and accurate deline...

It has been convincingly established, over the past decade, that the human insular cortices are involved in processing both body feelings (such as pain) and feelings of emotion. Recently, however, an interpretation of this finding has emerged suggesting that the insular cortices are the necessary and sufficient platform for human feelings, in effec...

PURPOSE Studies in stroke patients often use functional MRI to assess changes in brain function after stroke and relate these changes to behavioral information, to improve clinical outcomes and reduce disability. A key step in group fMRI analysis is spatial normalization, or image registration to a standard template. After stroke, structural brain...

Some older adults without neurological disease exhibit impaired decision-making in risky, nontransparent situations, like the Iowa Gambling Task (IGT). The prefrontal cortices are particularly vulnerable to age-related decline, and numerous studies implicate the ventromedial prefrontal cortex (VMPFC) in successful IGT performance. However, the rela...

There is increasing evidence to suggest that primary sensory cortices can become active in the absence of external stimulation in their respective modalities. This occurs, for example, when stimuli processed via one sensory modality imply features characteristic of a different modality; for instance, visual stimuli that imply touch have been observ...

Acquisition of new perceptual-motor skills depends on multiple brain areas, including the striatum. However, the specific contribution of each structure to this type of learning is still poorly understood. Focusing on the striatum, we proposed (a) to replicate the finding of impaired rotary pursuit (RP) and preserved mirror tracing (MT) in Huntingt...

This chapter introduces the budding field of mind-brain education and features some of the early advances made in the area of brain research related to education. It provides an overview of how the brain processes information, how it learns, and how the mind relates to the brain and body, while underlining the possibilities for neuroscience to cont...

Using multivariate pattern analysis of functional magnetic resonance imaging data, we found that the subjective experience of sound, in the absence of auditory stimulation, was associated with content-specific activity in early auditory cortices in humans. As subjects viewed sound-implying, but silent, visual stimuli, activity in auditory cortex di...

Flat mapping based cortical surface registration constrained by manually traced sulcal curves has been widely used for inter subject comparisons of neuroanatomical data. Even for an experienced neuroanatomist, manual sulcal tracing can be quite time consuming, with the cost increasing with the number of sulcal curves used for registration. We prese...

Moral judgments, whether delivered in ordinary experience or in the courtroom, depend on our ability to infer intentions. We forgive unintentional or accidental harms and condemn failed attempts to harm. Prior work demonstrates that patients with damage to the ventromedial prefrontal cortex (VMPC) deliver abnormal judgments in response to moral dil...

Group analysis of structure or function in cerebral cortex typically involves, as a first step, the alignment of cortices. A surface-based approach to this problem treats the cortex as a convoluted surface and coregisters across subjects so that cortical landmarks or features are aligned. This registration can be performed using curves representing...

In an fMRI experiment, participants were exposed to narratives based on true stories designed to evoke admiration and compassion in 4 distinct categories: admiration for virtue (AV), admiration for skill (AS), compassion for social/psychological pain (CSP), and compassion for physical pain (CPP). The goal was to test hypotheses about recruitment of...

Manually labeled landmark sets are often required as inputs for landmark-based image registration. Identifying an optimal subset of landmarks from a training dataset may be useful in reducing the labor intensive task of manual labeling. In this paper, we present a new problem and a method to solve it: given a set of N landmarks, find the k(< N) bes...

The Wechsler Adult Intelligence Scale (WAIS) assesses a wide range of cognitive abilities and impairments. Factor analyses have documented four underlying indices that jointly comprise intelligence as assessed with the WAIS: verbal comprehension (VCI), perceptual organization (POI), working memory (WMI), and processing speed (PSI). We used nonparam...

The consistency of neuropsychological outcome following circumscribed damage to the prefrontal cortex (PFC) in the first years of life has not been systematically investigated. On the basis of a single well-studied case, Ackerly and Benton (1948)2. Ackerly , S. S. and Benton , A. L. Report of a case of bilateral frontal lobe defect. Proceedings o...

Two of the most successful and widely used tests developed by Arthur Benton and colleagues are the Facial Recognition Test (FRT) and Judgment of Line Orientation Test (JLO), which probe visuoperceptual and visuospatial functions typically associated with right hemisphere structures, especially parietal, occipitoparietal, and occipitotemporal struct...

We investigated whether auditory deprivation and/or sign language exposure during development alters the macroscopic neuroanatomy of the human insula. Volumetric analyses were based on MRI data from 25 congenitally deaf subjects who were native users of American Sign Language (ASL), 25 hearing subjects with no knowledge of ASL, and 16 hearing subje...

In a MEG experiment, we imaged the early dynamics of the human cerebral cortex during the induction of emotion by visual stimuli. We tested the hypothesis that early cortical responses would correlate with the emotional competence of visual stimuli and subsequent subjective ratings of feeling in a set of specific target regions important for somato...

The Clock Drawing Test (CDT) is widely used in clinical neuropsychological practice. The CDT has been used traditionally as a "parietal lobe" test (e.g., Kaplan, 1988), but most empirical work has focused on its sensitivity and specificity for detecting and differentiating subtypes of dementia. There are surprisingly few studies of its neuroanatomi...