Hamzah H.Kzar

• PhD in clinical biochemistry
• Principal Investigator at Al-Qasim Green University

This study investigated newly synthesized of chitosan-St-TPGS-NPs and chitosan-Sd-TPGS-NPs (CStNPs and CSdNPs) produced by a combination of sonication and emulsification/solvent evaporation method and in combination with the ionic gelation method with slight modifications. The newly synthesized CStNPs and CSdNPs were characterized by several techni...

Lung cancer is the second most prevalent cancer and ranks first in cancer-related death worldwide. Due to the resistance development to conventional cancer therapy strategies, including chemotherapy, radiotherapy, targeted therapy, and immunother-apy, various natural products and their extracts have been revealed as alternatives. Berberine (BBR), w...

The Pseudomonas aeruginosa bacterium, which is considered a nosocomial infectious agent, changes its structure due to exposure to various antibiotics and becomes relatively resistant to them, which makes it difficult to treat diseases caused by this bacterium. This study can identify the main genes that make biofilm and allow researchers to inhibit...

Small extracellular (EV) particles known as exosomes are released by a variety of cell types, including immune system cells, stem cells, and tumor cells. They are regarded as a subgroup of EVs and have a diameter that ranges from 30 to 150 nm. Proteins, lipids, nucleic acids (including RNA and DNA), and different bioactive compounds are among the w...

Breast cancer (BC) is developing from cells of breast tissue and is caused by the presence of malignant cells, which are characterized by uncontrolled cell division, leading to abnormal growth (in situ carcinoma), and their ability to invade normal tissue locally. BC's diagnosis and treatment strategies have recently improved, but the incidence rat...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the same sequence as SARS-CoV and has been reported with clinical symptoms similar to those of SARS-CoV and MERS-CoV. This study reviewed the neuro-invasive potential of SARS-CoV2 reported in various studies. We searched keywords containing COVID-19, coronavirus, respiratory infec...

In this study, aluminium alloy 1050 strips were bonded together using the electrically assisted roll bonding process (EARB) atelectric current levels from 0 A up to 300 A. The effect of electric current level and plastic strain as the two main EARB parametershave been investigated on bonding strength by using the peel test. Results showed that by i...

This study focused on the recent synthesis of new compounds from aryl propionic acid derivatives compared to naproxen. The present study aimed to investigate the safety and efficiency of the new derivatives in improving analgesic effects and reducing adverse effects via modifying its chemical structure by adding new functional groups. The new compo...

The liver, kidney, and thyroid glands are main vital in biochemical and physiological activities in animals and humans. In this study, we examined the effects of adding selenium supplementation on the improvement activity of many glands such as the liver, kidney, and thyroid after cadmium chloride administration (induced toxicity) in male rabbits....

Objective: The chronic autoimmune disease affecting the joints that are characterized by a progressive symmetric inflammation of affected joints resulting in cartilage destruction, bone erosion, and disability has been called Rheumatoid arthritis (RA). The aim of this study is to the assessment of FAS and lipid profiles in Iraqi patients with RA. M...

ARTICLE DETAILS Objective: The chronic autoimmune disease affecting the joints that are characterized by a progressive symmetric inflammation of affected joints resulting in cartilage destruction, bone erosion, and disability has been called Rheumatoid arthritis (RA). The aim of this study is to the assessment of FAS and lipid profiles in Iraqi pat...

Background: The diseases that involve the myocardium directly and are not the result of hypertension, congenital, vascular, coronary, or pericardial abnormalities are called cardiomyopathy (CM). It is known that interleukin-1 (IL-1) family cytokines involve in inflammation and immune regulation and act as an important role in innate and adaptive im...

microRNAs (miRNAs) play a crucial role in various biological processes, including immune system regulation, such as cell proliferation, tolerance (central and peripheral), and T helper cell development. Dysregulation of miRNA expression and activity can disrupt immune responses and increase susceptibility to neuroimmune disorders. Conversely, miRNA...

Ulcerative colitis (UC) is a type of inflammatory bowel disease with a high recurrence rate. In this regard, sulfasalazine and immunosuppressive medications are often used for an extended period in clinical practice, but their effectiveness is limited, and they are prone to side effects. Modern research has shown that herbal active ingredients of T...

Most gas emissions by motor automobiles include unburned hydrocarbons, carbon monoxide, and other oxides (N x O y , SO x , etc.). There are many hydrocarbon compounds in car exhaust, such as benzopyran, formalde-hyde, butadiene, and so on. In this study, anatase titanium dioxide nano-particles (aTiO 2-NPs) filters are investigated to prevent the en...

Body mass index (BMI) more than 30 kg/m 2 is considered obese. Obesity is a pathophysiologic component of type 2 diabetes, and there is a common relationship between insulin resistance (IR) and obesity (T2D). The aim of this study was to investigation of the PON1 (C>T rs705379) SNP and its correlation with adiponectin (ADNT) levels in insulin resis...

An odontogenic infection is an infection that originates within a tooth or in the closely surrounding tissues. In vitro quantitative evaluation of. IL-6, INF-gamma and CD4 and. CD8 molecules during odontogenic infection and control. group. In vitro quantitative determination of, IL-6,INF-gamma and CD4 and CD8 molecules in serum using Sandwich-ELISA...

Background: Recognizing and strengthening emotional intelligence is useful in all members of society, especially students. By recognizing emotional intelligence and applying it, students can achieve more success in their career. The aim of this study was to investigate the relationship between emotional intelligence and academic achievement among s...

Background: Urtica dioica (UD), as a natural antioxidant, has positive effects on oocyte maturation. This study aimed to investigate the effects of hydro-alcoholic UD extract and retinoic acid on follicular development in an in vitro fertilization (IVF) condition. Methods: A total of 40 female Wistar rats were randomly divided into 5 groups: group...

In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and...

Wound dressing is one of the most well-known and challenging issues all over the world. Recently, in the field of biological applications, polymeric scaffold incorporating metal oxide nanoparticles has been extremely important, especially in focusing on wound healing. In this project, we have successfully fabricated nano-fibrous scaffold using the...

In this paper, activated carbon (AC) was utilized to eliminate formaldehyde from synthetic sewage. To this end, three kinds of activated carbon were used, which were commercial AC (CAC), AC derived from walnut shell (ACWS), and AC derived from lotus leaves (ACLL). Also, the influence of sorption time, formaldehyde concentration, and adsorbent dose...

This study was conducted to assess the omentin-1 (OME-1) V109D gene SNP in women with PCOS and healthy control and to investigate the possible relationship between this adipokine and metabolic profile. This study includes 50 women in the range of age (19-43 Y) who have been diagnosed with PCOC as a patient group and 40 healthy women in age (17-45 Y...

Background The detrimental role of advanced glycation end products (AGEs) against cardio-metabolic health has been revealed in several previous reports. However, the results of studies regarding the association between AGEs and obesity measurements are inconsistent. In the current meta-analysis, we aimed to quantitatively summarize the results of s...

Cu (OAc)2 was immobilized on the surface of magnetic nanoparticles modified by Imine-Thiazole acting as a ligand. This immobilization is done to fabricate a new and green magnetically recoverable copper catalyst [Fe3O4@SiO2-(Imine-Thiazole)-Cu (OAc)2]. Techniques such as ICP-OES, TEM, FT-IR, EDX, SEM, TGA, VSM, and XRD were used to characterize the...

Background: According to World Health Organization (WHO) estimates, there are currently 1.1 billion tobacco smokers worldwide. This study follows the need for change in the increasing trend of lifestyle-related diseases and the lack of extensive studies on the pattern of smoking. Methods: In the current study, an electronic database search was con...

Abstract: In this study, we examined the berberine-chitosan nanoparticles (BCNP) action as a natural polymer used to enhance liver and kidney damage induced by phenylhydrazine in male rats. Healthy 20 male Sprague-Dawley rats weighed 150 - 200 g were used in this study and the animals were randomly divided into four groups, G1: (CON), G2: chitosan...

Noise pollution is one of the environmental factors that severely threaten humans’ mental, emotional, and physical health. One of the most significant sources of this pollution is the noise generated by traffic and urban transportation, mainly the urban railway. This paper assessed noise pollution at stations, passenger cars, and the train operator...

Cancer is now one of the major causes of death across the globe. The imbalance of cytokine and chemokine secretion has been reported to be involved in cancer development. Meanwhile, CC chemokines have received considerable interest in cancer research. CCR10, as the latest identified CC chemokine receptor (CCR), has been implicated in the recruitmen...

Chemical vapor deposition (CVD) is a vacuum deposition method used to produce high quality, and high-performance, solid materials. The process is often used in the semiconductor industry to produce thin films. Microfabrication processes widely use CVD to deposit materials in various forms, including monocrystalline, polycrystalline, amorphous, and...

Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological functions, including the regulation of sphingolipid metabolism, platelet aggregation, and apoptosis. However, it has been found that metabolites derived from cholesterol...

In this study, we examined the berberine-chitosan nanoparticles (BCNP) action as a natural polymer used to enhance liver and kidney damage induced by phenylhydrazine in male rats. Healthy 20 male Sprague-Dawley rats weighed 150-200 g were used in this study and the animals were randomly divided into four groups, G1: (CON), G2: chitosan (CHS), G3: b...

In this work, applications of pure and doped boron nitride (B16N16, SiB15N16, and AlB15N16) nanoclusters to find an efficient sensor for sulfasalazine (SSZ) drug detection were investigated using density functional theory (DFT). The adsorption energy of B16N16, SiB15N16, and AlB15N16 in the most stable complexes were calculated at -24.58, -30.39, a...

The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the im...

Background: Infertility in men has increased in recent years. Numerous physical, chemical, biological, and social factors are known to play a role in reducing semen quality, in between, there are high-risk behaviors that affect the quality of semen. In this paper, the effects of three factors: smoking, alcohol consumption, and drugs have been inves...

Novel Yttrium-metal–organic framework (Y-MOF) was synthesized under optimal conditions of microwave with a power of 20 W, the temperature of 30 degrees of centigrade, and time duration of 10 min. The products were characterized by SEM (morphology and size distribution), TGA (thermal stability), BET technique (surface area), and FTIR (characterizati...

Traumatic injuries to skeletal muscles caused by accidents, surgeries, and strains result in a significant disability. Currently, the golden standard of treatment for skeletal muscle injuries is tissue grafting. However, this treatment strategy is associated with several challenges. Therefore, developing alternative strategies is highly demanded. I...

Background: Headaches are a major focus of public health efforts. Because stress and emotional disturbances play a role in various forms of headaches, emotion regulation can be thought of as a factor in adaptation and successful control of this illness. The effectiveness of cognitive emotion management strategies in women and men with migraine head...

Nanofluids are liquid suspensions of hard nanometer-sized particles suspended in a base fluid. The suspension of small solid particles in energy transmission fluids enhances their thermal conductivity and provides an inexpensive and creative way to greatly boost their heat transfer (HT) properties. It is possible to add nanofluids to various indust...

Surface modifications of polysaccharide filter papers can alter their catalytic properties significantly. In particular, polysaccharides have gained increasing interest in the development of heterogeneous catalysts. This wok introduces a new approach to the heterogeneous/ sustainable catalytic system preparation based on a catalytic filter paper mo...

The efficient detection and removal of noxious chemicals is essential for human health and environmental security. Here, we have explored the sensitivity and selectivity of aluminum phosphide nanosheet (AlPNS) toward toxic phosgene (Ph), thiophosgene (ThP), and formaldehyde (FD) gases, using density functional theory simulations. The interaction is...

It has been approved that the normal physiology of skin can be adversely affected by acne vulgaris (AV). This disorder leads to impairment of stratum corneum hydration and causes trans epidermal water loss. The normal physiology of the males’ skin is different from the normal physiology of females’ skin. Therefore, in case of any skin disorder, cho...

Background Elevated lipids in umbilical cord blood affect fetal programming, leading to a higher risk of developing cardiovascular disease in later life. However, the causes of changes in the lipid profile of umbilical cord blood are not clear yet. This study aimed for the first time to determine the association of asprosin concentration with TAG,...

It has been approved that the normal physiology of skin can be adversely affected by acne vulgaris (AV). This disorder leads to impairment of stratum corneum hydration and causes trans epidermal water loss. The normal physiology of the males’ skin is different from the normal physiology of females’ skin. Therefore, in case of any skin disorder, cho...

Aims: Quality of life is especially important in patients with diabetes. This study aimed to investigate the quality of life model in patients with type 2 diabetes based on awareness and mediated disease management behaviors. Materials & Methods: In this study, 300 patients with type 2 diabetes in Indonesia, Iraq, Iran, and India were studied. Rese...

Background and objective: The mortality cases of breast cancer (BC) are probably caused by inadequate of the benefits of treatment and early detection, moreover the lack of appropriate facilities for diagnosis and detection, also high cost effectiveness of the treatment. The preparation of Everolimus (EV) loaded PLGA-TPGS NPs (nano-EV) targeting wi...

Summary Background and aims Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of tomato intake on inflammatory biomarkers; however, the results are equivocal. Therefore, the present study aimed to systematically review and analyses randomized clinical trials (RCTs) assessing the effects of tomato intak...

Background: A multi-gene inherited metabolic illness in which the body is unable to produce enough insulin and is characterized by abnormal glucose homeostasis has been now called Type 2 diabetes mellitus (T2DM). Objectives: This study aimed to evaluate the effect of CAT-21 A/T (rs7943316) gene polymorphism and antioxidant index (AOI) in the Iraqi...

Bimetallic nanoparticles offer unique chemical, physical and optical properties that are not available for monometallic nanoparticles. Bimetallic nanoparticles play a major role in various therapeutic, industrial and energy fields. Recently, nanoparticles of Copper/Zinc bimetallic nanoparticles have attracted attention in various fields, especially...

A simple, rapid, and low-cost method for preparation of Co 3 O 4 nanoparticles (Co 3 O 4-1 and Co 3 O 4-2) using solid-state calcination of mixture of Co(NO 3) 2 Á6H 2 O and salicylic acid (1:1 weight ratio) at two different temperatures of 500 and 600 C is reported. The morphologies and structure of the as-prepared Co 3 O 4 nanoparticles were char...

Background and objective: The mortality cases of breast cancer (BC) are probably caused by inadequate of the benefits of treatment and early detection, moreover the lack of appropriate facilities for diagnosis and detection, also high cost effective of the treatment. The preparation of Everolimus (EV) loaded PLGA-TPGS NPs (nano-EV) targeting with f...

Porous hematite a-Fe 2 O 3 nanoparticles (NPs) were synthesized using plant extract. The physicochemical characteristics of resulting porous particles were determined using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), energy dispersive X-ray (EDS), High-Resolution Transmission Electron Microscopy (HR-TEM), vibrating sample magnetome...

Quantum chemical density functional theory (DFT) calculations were performed to investigate the adsorption of arsine (AsH3) gaseous substance at the surface of representative models of boron nitride (B16N16), aluminum nitride (Al16N16), and silicon carbide (Si16C16) fullerene-like nanocages. The results indicated that the adsorption processes of As...

As a new nanostructure, a graphene is a compound of carbon atoms with a two-dimensional structure that has attracted the attention of many nanoscale researchers due to its novel physical and chemical properties. The presence of all graphene atoms in the surface and its unique electrical properties, as well as the ability to functionalize and combin...

omentin-1 level in women with PCOS

Water contamination has negative effects on people's quality of life and the environment in recent decades as a result of increased agricultural and industrial activities. Using new advanced nanomaterials can be helpful for the removal of water contamination. In this study, novel hydroxyapatite/zinc Oxide nanocomposites was prepared via a simple ci...

Background: Acne in adult female may start during adolescence and persist or have an onset in adulthood. Acne has various psychosocial effects that impact patients' quality of life. Treatment of acne in adult women. This study aimed to evaluate the effect the of some trace element levels such as Zinc, Copper, Manganese, and iron (Zn, Cu, Mn, and Fe...

Breast cancer (BC) is a one of highly prevalent and mortality type of cancers among women worldwide. The overexpression of certain proteins such as HIF-1A in blood of breast cancer tumors may be useful to investigate the prognosis and selecting therapies. Many genes are now known to be regulation by HIF-1A through transcription activation. HIF-1A p...

BREAST CANCER

Background and Objective: The mortality dramatically increases in breast cancer are caused by inadequate benefits of different types of therapies. mTOR is an atypical serine/threonine-protein kinase that belongs to the phosphoinositide 3-kinase (PI3K)-a related kinase family. The aim of this study to investigate of the ability of EV to inhibiting b...

Background: One of the most important agents that must be found in all dividing cells is folate. Aim: Assessment of human folate receptor-1 gene expression and correlation with leptin hormone in obese and non-obese subjects of Babylon province, Iraq. Subjects and Method: This study included 60 obese subjects (OS) in the range of age (10-45 years) a...

Background and objective: The mortality cases of breast cancer (BC) are probably caused by inadequate of the benefits of treatment and early detection, moreover the lack of appropriate facilities for diagnosis and detection, also high-cost effectiveness of the treatment. The preparation of Everolimus (EV) loaded PLGA-TPGS NPs (nano-EV) targeting wi...

Background and objective: The mortality dramatically increase in breast cancer are caused by inadequate of the benefits of different types of therapies. mTOR is an atypical serine/ threonine protein kinase that belongs to the phosphoinositide 3-kinase (PI3K)-related kinase family. The aim of this study to investigate the ability of EV to inhibiting...

Abstract Background and objective: The cluster of differentiation 44 (CD44) is a transmembrane cell adhesion molecule involved in cell-to-cell and cell-to-matrix interactions by binding with hyaluronan, extracellular matrix proteins, and growth factors. CD44 plays role in cellular signaling cascades by participating in signal transduction processe...

Breast cancer (BC) is developing from cells of breast tissue and caused by the presence of malignant cells, which are characterized by uncontrolled cell division, leading to abnormal growth (in situ carcinoma), and their ability to invade normal tissue locally. The diagnosis and treatment strategies of BC are recently improved, but the incidence ra...

Background: Breast cancer (BC) is one of the highly prevalent and mortality type of cancers among women worldwide. The overexpression of certain proteins such as HIF-1A in the blood of breast cancer tumors may be useful to investigate the prognosis and selecting therapies. Many genes are now known to be regulation by HIF-1A through transcription ac...

The chronic autoimmune disorder that characterized by systemic features and joint involvement which affects 1% of the world's adults is Rheumatoid Arthritis. The steroid like hormone involve in bone and calcium metabolism is vitamin D. This study aim to investigate the relationship between serum vitamin D3/VDR ratio and levels of rheumatoid factor...

Background and objective: The highly prevalent and mortality type of cancer among women worldwide is breast cancer (BC). The mortality cases of BC are probably incidence by inadequate benefits of treatment and early detection, moreover the lack of appropriate facilities for diagnosis and detection. The aim of this work is to assess of use of ROC of...

Molecular Types of Breast Cancer

Protein-ligand docking study

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. Both T and B lymphocytes are involved in the pathogenesis of the disease. Rheumatoid Arthritis (RA) is the most prevalent rheumatic chronic inflammatory disease worldwide; though characterized by the development of peripheral synovitis, it is considered a systemic disease linke...

Assessment of Vitamin D3/VDR Ratio and its Correlation with Physiological Rheumatoid Factor in Iraqi Patients with Rheumatoid Arthritis

Rigid docking : In rigid docking the molecules are rigid, in 3D space of one of the molecule which brings it to an optimal fit with other molecule in terms of scoring function. Also the internal geometry of both the receptor and ligand are rigid. Flexible docking : In this type of docking the molecules are flexible, conformations of the receptor an...

Western blotting, also known as immunoblotting or protein blotting, is a technique used to detect the presence of a specific protein in a complex protein mixture It is a core technique in cell biology, molecular biology, virology and others Western blots have become one of the most common analytical tools for the Detection the expression of speci...

This presentation will cover the following topics: - What is Real Time- PCR ? - How does real-time PCR work ? - Real time- PCR Vs. Traditional PCR -Real time- PCR instruments? - Detection Chemistry - Real time- PCR data analysis

Breast cancer constitutes the most common type of cancer Breast cancers are conventionally classified into different types by morphological feature, histological features, tumor grade, proliferation status, lymphovascular invasion – prognostic variables

Background: The chronic inflammatory skin disease with a strong genetic predisposition and autoimmune pathogenic traits is called Psoriasis. Aim: Study the IL6 (C174G) promoter polymorphisms and correlation with growth factor and TNFA activity in patients with psoriasis in Iraqi population. Subjects and Methods: This study is included 40 subjects (...

Background: Glucose transporting into cells, angiogenesis, and apoptosis are the main factors that inducing the progression of many types of cancers including breast cancer. BC progression was seen as a multi-step process involving progressive changes from normal to hyperplasia with and without atypia, carcinoma in situ, invasive carcinoma, and met...

Abstract: Background: Breast cancer (BC) is a heterogeneous disease witch produce from a number of genetic and epigenetic risks that lead to dysregulation of cell growth, circumvention of apoptosis, and development of the ability to invade the underlining tissue through the basement membrane. Aim: To assessment the association of BMI and age with p...

Background: A peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals is called growth hormone. In human, growth hormone gene is encoded the protein growth hormone receptor that located on chromosome number 5. Obesity is a condition in which excess fat has accumulated in the body, such that it ca...

Okra (Abelmoschus esculentus) is a flowering plant in the mallow family. Okra is important for its edible green and dry seed pods. The plant is cultivated in tropical, subtropical and warm temperate regions around the world. The geographical source of okra now is very available in Iraq. The rabbit rapidly develops severe hypercholesterolemia and de...

Background Oxidative stress has the critical role in the initiation and progression of any type of cancers through cellular damage. Malignant lungs tumor characterized by uncontrolled cell growth in tissues of the one or both lungs. The tumor growth is transfer from one or both lung to separating to other parts in human body. Peroxidation of membr...

Background: Diabetes mellitus (DM) can be describing as a metabolic changes that characterizing by chronic hyperglycaemia and imbalance of carbohydrates, fats and proteins metabolism resulting from disorders in pancreatic secretion of insulin, action of insulin, or both. Development of T2DM can be attributing to the both effects , the genetic an en...

Colorectal cancer is one of the most frequent malignant diseases in the developed countries. It was reported that total antioxidant status is being play a very important roles in development of carcinogenesis. The aim of this study to assess of some risk factors such as age, gender, obesity, and smoking status on total antioxidant status in patient...

One of most frequent malignant disease in the developed countries is colorectal cancer and it is the seventh most common cancers among Babylon population /Iraq. It was reported that oxidative stress status is being play a very important roles in development of carcinogenesis. The purpose from this study was assessment of antioxidant status in diffe...

KRAS gene is involved in G protein-mediated signal transduction pathway and has constitutive GTPase activity, which is a loss when the gene is mutated. It was reported that mutation in KRAS codons 12 and 13 are the most frequently detected mutation (hot spots) in human colorectal cancers. SOD-1 is an enzyme that in humans is encoded by the SOD1 gen...

The hypoglycemic effect of orally administered boiling aqueous extract of a heart of palm (HP) against alloxan-induced diabetes rabbits was investigated in this study. Rabbits were treated daily with 0.5 g/kg HP boiling aqueous extract alone, or 10 U/Kg body weight insulin alone, or a combination of 0.5 g/kg HP boiling aqueous extract and 10 U/Kg b...