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Hamed Haghi-Aminjan

Hamed Haghi-Aminjan
Ardabil University of Medical Sciences (ARUMS)

Ph.D

About

94
Publications
12,637
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2,094
Citations
Education
September 2013 - November 2018
October 2010 - September 2013

Publications

Publications (94)
Article
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Background Cancer remains a leading cause of death worldwide. Environmental factors, specifically endocrine-disrupting chemicals (EDCs), like phthalates, are increasingly being linked to cancer development. Phthalates, widely used in consumer products, can activate the aryl hydrocarbon receptor (AhR). This scoping review investigates how phthalate...
Article
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Peripheral neuropathy (PN) is one of the most common disorders characterized by the dysfunction or degeneration of peripheral nerves and has many different causes. PN often causes weakness, numbness, and pain, usually in the hands and feet, which can cause physical disability and a reduced quality of life. The purpose of this study was to conduct a...
Article
Microplastics have emerged as a significant global environmental concern, yet the absence of standardized protocols for assessing their toxicity remains a challenge. To address this gap, we applied the ISO 10,993–5:2009 and ISO 10,993–12:2012 standards for the first time to evaluate the effects of microplastics on cancer progression. Our study util...
Article
Introduction Chemotherapy therapies are effective in treating cancer, but they can have harmful effects on the cardiovascular system. This study explores the possible role of metformin in reducing the cardiac damage caused by chemotherapy. Methods In this scoping review, we conducted a comprehensive literature search on electronic databases (PubMe...
Article
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Patients with breast cancer show altered expression of genes within the pectoralis major skeletal muscle cells of the breast. Through analyses of The Cancer Genome Atlas (TCGA)-breast cancer (BRCA), we identified three previously uncharacterized putative novel tumor suppressor genes expressed in normal muscle cells, whose expression was downregulat...
Article
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Background Exposure to pesticides is of concern to public health officials worldwide. Deltamethrin is a synthetic pyrethroid pesticide which is widely used in agriculture and veterinary medicine. Deltamethrin poisoning is always one of the concerns in medical centers due to the deltamethrin induced hepatotoxicity. This study evaluated the hepato-pr...
Article
Chlorpyrifos (CPF) is a widely used pesticide that can impair body organs. Nonetheless, metformin is known for its protective role against dysfunction at cellular and molecular levels led by inflammatory and oxidative stress. This study aimed to investigate the modulatory impacts of metformin on CPF-induced heart and lung damage. Following the trea...
Article
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Aims: Although chemotherapy agents are used to treating cancers, they have serious side effects, like their harmful effects on the cardiovascular system, limiting the clinical use of these chemotherapy agents. This study aimed to systematically investigate the potential role of ginseng derivatives in the prevention of chemotherapy-induced cardiac...
Article
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Background: As a medical dilemma, gastric cancer will have 7.3 million new cases in 2040. Despite the disease’s high economic and global burden, conventional chemotherapy regimens containing cisplatin have insufficient effectiveness and act non-specifically, leading to several adverse drug reactions To address these issues, the biological efficacy...
Chapter
The toxic effects of chemicals can be affected by many different factors, including dosage, duration, and route of exposure. The term used to determine the severity of the toxicity spectrum, ranging from doses with no toxicologically identifiable and negligible effects to doses with more profound toxicity, including but not limited to no adverse re...
Article
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Background Diabetes-induced reproductive complications can lead to subfertility and infertility, raising the need to protect reproductive organs. There are limited medications used to improve reproductive health in diabetic patients. Melatonin, mainly produced by the pineal gland, may improve diabetes-associated reproductive complications through v...
Article
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Oxidative stress induces cell senescence and aging. Cell senescence is an irreversible cell cycle arrest mechanism responsible for various pathological diseases and aging. Cerium oxide nanoparticles (CeO2 NPs) have been found to have anti-oxidant effects with a capacity to scavenge free radicals. With this background, we aimed to investigate the se...
Article
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Backgrounds: Diabetes can cause diabetic neuropathy (DN), a nerve injury. High blood sugar (glucose) levels can harm nerves all over your body. The nerves in your legs and feet are the most commonly affected by DN. The purpose of this study was to conduct a review of melatonin’s potential neuroprotective properties against DN. Method: A full system...
Article
Aims Recent studies show targeted therapy of new pyrazino[1,2-a]benzimidazole derivatives with COX-II inhibitory effects on different cancer cells. This study aimed to investigate 2D cell culture and 3D spheroid formation of glioblastoma multiforme (GBM) cells using a microfluidic device after exposure to these compounds. Main methods After isolat...
Article
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Gastrointestinal (GI) cancers are responsible for approximately half of cancer-related deaths, highlighting the need for the identification of distinct and common features in their clinicopathological characteristics. Long ncRNA (lncRNAs), which are involved in competitive endogenous RNA (ceRNA) networks with critical roles in biological processes,...
Article
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Aluminum phosphide (AlP) poisoning can be deadly in most cases targeting the heart. To overcome AlP toxicity, exenatide has been studied in the present study due to its pleiotropic effects on cardiac damages. In this study, the rats were exposed to LD 50 of AlP (10 mg/kg) by gavage, and exenatide at doses (0.05, 0.1, and 0.2 mg/kg) injected intrape...
Article
Background Aluminum phosphide (AlP) toxicity is associated with a high risk of death due to heart, liver, and kidney failure as the target organs. Phosphine gas released due to the ingestion is the main factor involved in the multi-organ failure with various mechanisms. Levosimendan (LEV) is a calcium sensitizer with a pleiotropic effect on multipl...
Article
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Arsenic (As) poisoning is widespread due to exposure to pollution. The toxic level of (As) causes oxidative stress-induced aging and tissue damage. Since melatonin (MLT) has anti-oxidant and anti-aging properties, we aimed to evaluate the protective effect of MLT against the toxicity of sodium arsenite (NaAsO2). Healthy male NMRI mice were divided...
Article
Aluminum phosphide (AlP) poisoning is common in many countries responsible for high mortality. The heart is the main target organ in AlP poisoning. Several studies have reported the beneficial effects of cannabidiol (CBD) in reducing heart injuries. This study aimed to investigate the possible protective effect of CBD on cardiac toxicity caused by...
Article
Aims: Glioblastoma multiforme (GBM) is a highly devastating malignant brain tumor with poor pharmacotherapy. Based on COX-2 inhibitory effects in preventing cancer progression, new pyrazino[1,2-a]benzimidazole derivatives were assessed on isolated human GBM cells. Main methods: In this study, firstly, primary culture of astrocytes from human GBM...
Article
Full-text available
Exposure to certain environmental toxins has been shown to be associated with cellular senescence mainly through induction of oxidative stress and impact on cellular systems. Acrylamide (ACR) has raised worldwide concerns regarding the high risk of human dietary exposure to its hazardous effect. Although there is ample evidence about the carcinogen...
Preprint
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Background Renal cell carcinoma (RCC) is the most frequent heterogeneous type of kidney cancer. Although the role of many genes in the development of RCC has been shown, its specific molecular mechanism is still unknown. In this research, we studied the expression profile of two poorly studied genes, PGGHG and ODF3B, with possible role in renal can...
Article
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Botulinum toxin type-A (BoNT/A) application, especially neurological disorders, has been spread nowadays while it may cause side effects. The current study aimed to assess the BoNT/A dose-dependent effect on induction of aging in the Drosophila melanogaster model. The third instar larvae of Drosophila melanogaster were exposed to ¼ LC50, ½ LC50, an...
Article
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Background: Parkin-mediated mitophagy is the dominant mitophagy pathway of neural cells. Its restoration will result in prevention of cognitive decline, including Alzheimer's disease (AD). The role of this mitophagy pathway in neurodegenerative diseases has drawn attention in recent years. The two main pathological proteins in AD, amyloid β (Aβ) an...
Article
Background The rapid-growing population of diabetic patients and the elderly are among the direst challenges that the science of medicine is facing today. Targeting these two challenges can shed light on new means to control and ideally reverse this trend. In this experiment, Vinpocetine’s effect on aged pancreatic beta-cell functions in correlatio...
Article
Aluminum phosphide (AlP) causes serious poisoning in which severe cardiac suppression is the significant lethal consequence. According to evidence, levosimendan can exert outstanding cardiac support and protection in different pathological conditions. This study aimed to investigate the mechanisms by which levosimendan may alleviate cardiovascular...
Article
Background Aluminum phosphide (AlP) causes severe cardiotoxicity. Taurine has been chosen for the present study because of its positive known effects on cardiac injuries. Method To evaluate AlP-induced cardiotoxicity, the animals were divided into seven groups, including the control group, the taurine group (500 mg/kg), AlP with LD50 dose, AlP + t...
Article
The conventional cancer treatment modalities such as radiotherapy and chemotherapy suffer from several limitations; hence, their efficiency needs to be improved with other complementary modalities. Hyperthermia, as an adjuvant therapeutic modality for cancer, can result in a synergistic effect on radiotherapy (radiosensitizer) and chemotherapy (che...
Article
Aims Although chemotherapeutic agents have highly beneficial effects against cancer, they disturb the body's normal homeostasis. One of the critical side effects of chemotherapeutic agents is their deleterious effect on the cardiac system, which causes limitations of their clinical usage. Taurine constitutes more than 50% of the amino acids in the...
Article
P-Coumaric acid (p-CA) is a hydroxycinnamic acid, an organic compound that is a hydroxyl derivative of cinnamic acid. P-CA is the most abundant isomer of the three in nature and can be found in a wide variety of edible plants such as fungi, peanuts, navy beans, tomatoes, carrots, basil, and garlic. Recently, the therapeutic properties of p-CA have...
Article
Aim of the study Sepsis has well-documented inflammatory effects on cardiovascular and blood cells. This study is designed to investigate potential anti-inflammatory effects of metformin on cardiac and blood cells 12 and 24 h following cecal ligation and puncture (CLP)-induced sepsis. Methods For the purpose of this study, 36 male Wistar rats were...
Article
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Gallic acid (GA), a plant-derived ubiquitous secondary polyphenol metabolite, can be a useful dietary supplement. This in vitro study’s primary purpose was to assess the anti-aging properties of GA using rat embryonic fibroblast (REF) cells, antidiabetic effects via pancreatic islet cells, and finally, elucidating the molecular mechanisms of this n...
Article
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Background Purpose of this study was to deliver a report of chest CT findings of COVID-19-infected pediatric and adult patients and to make an age-based comparison. A systematic search was conducted in accordance with PRISMA guidelines to identify relevant studies in the electronic databases of PubMed, Scopus, ProQuest, ScienceDirect, and Web of Sc...
Article
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Resistance of cancer cells to therapy is a challenge for achieving an appropriate therapeutic outcome. Cancer (stem) cells possess several mechanisms for increasing their survival following exposure to toxic agents such as chemotherapy drugs, radiation as well as immunotherapy. Evidences show that apoptosis plays a key role in response of cancer (s...
Article
Aims Chemotherapy is an effective therapeutic modality which is commonly used for battling various cancers. However, several side effects induced by chemotherapeutic drugs would limit their clinical use. The present systematic review aims to evaluate the role of curcumin/curcuminoids co-administration during gastric cancer chemotherapy. Methods Th...
Article
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Objective: Metformin has a potent inhibitory activity against inflammation and oxidative stress, which inevitably occur in sepsis-associated encephalopathy (SAE). The precise mechanisms underlying neuroprotective effects of metformin in SAE, are still unclear. In the present work, the protective effect of metformin on SAE using cecal ligation and...
Article
Aims Cannabinoids are the chemical compounds with a high affinity for cannabinoid receptors affecting the central nervous system through the release of neurotransmitters. However, the current knowledge related to the role of compounds in the regulation of cellular aging is limited. This study aimed to investigate the effect of cannabidiol and tetra...
Article
The cover image is based on the Review* Effect of the Herbal medicines in obesity and metabolic syndrome: A Systematic Review and Meta-analysis of clinical trials by Moloud Payab ** et al., https://doi.org/10.1002/ptr.6547.***
Article
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Lung cancer remains the leading cause of one-quarter of all cancer deaths and it's a major public health problem worldwide. Nanotechnology offers a novel strategy to combat lung cancer. Recently, biologically synthesized silver nanoparticles (AgNPs) has attracted significant attention for their anticancer effects against lung cancer. Thereby, the c...
Article
Obesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its “globesity” still remains a big challenge all over the world. The current systematic review and meta‐analysis...
Article
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Background: Obesity as a developing global challenge can be characterized by increase in adipocyte number and size arising from adipogenesis. Control of adipogenesis, as a potential strategy, can prevent and manage obesity. So far, the effectiveness of herbal medicine and active ingredients therapies for obesity and metabolic syndrome treatment ha...
Article
Background Cardiac disease is accounted as the leading cause of worldwide morbidity and mortality, mainly in association with induction of inflammation and oxidative stress. The disease is characterized by the overproduction of reactive oxygen and/or nitrogen species (ROS/RNS), and reduced antioxidant capacity. Cannabidiol (CBD) is a non-psychoacti...
Article
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Introduction: Some studies are in favor of protective and anti-inflammatory effects of Ocimum basilicum (OB) against renal failure. Objectives: The aim of this study was to explore the protective effects of OB extract against gentamicin (GM)-induced nephrotoxicity in male rat models of acute kidney injury. Materials and Methods: Twenty-seven adult...
Article
Background Chemotherapy, as a systemic therapy, is one of the most effective modalities for cancer treatment. However, the use of chemotherapeutic drugs in patients with breast cancer can lead to thyroid dysfunction. This systematic review summarizes the available data on thyroid function following breast cancer chemotherapy. Methods To illuminate...
Article
French maritime pine bark extract (FMPBE; Oligopin®), a dietary supplement, is rich in procyanidin. The objective of this study was to determine the effects of FMPBE on bone remodeling in postmenopausal osteopenic women. This randomized, double‐blinded, placebo‐controlled clinical trial was conducted on 40 postmenopausal osteopenic women. Individua...
Article
Background Prostate cancer is the second most common malignancy in men in the world, and radiotherapy is used as a standard treatment modality for this cancer. Although this treatment modality effectively kills prostate cancerous cells, it unavoidably irradiates the organs/tissues that are away from the treatment site. In this regard, radiation‐ind...
Article
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Objective: To evaluate the protective effect of Zataria multiflora extract, an antioxidative medicinal plant, against ‎cyclophosphamide (CP)-induced oxidative lung damage in mice. ‎ Methods: Mice were intraperitoneally pre-treated with various doses of Zataria multiflora extract (50, 100, 200, and 400 ‎mg/kg) once daily for 7 consecutive days. Anim...
Article
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Oxidative stress has been involved in the aging process and the pathogenesis of type-2 diabetes, which is a serious health problem worldwide. This study investigates the anti-aging, anti-apoptotic, and antioxidant properties of alpha-lipoic acid (ALA), aiming to improve aged rat pancreatic cells. In this regard, half maximal effective concentration...
Article
Aging contributes to an increased risk of developing a number of neurodegenerative and chronic disorders, predominantly related to oxidative stress (OS) and defects in the antioxidant balance. This study focused on the antisenescence effect of four plant species (Falcaria vulgaris, Ixiolirion tataricum, Ajuga chamaecistus, and Scabiosa flavida) on...
Article
Poisoning with aluminum phosphide (AlP) has been attributed to the high rate of mortality among many Asian countries. It affects several organs, mainly heart and kidney. Numerous literature demonstrated the valuable effect of minocycline in mitigating pathological symptoms of heart and kidney disease. The aim of the present study was to evaluate th...
Article
Introduction: Chemotherapy agents are widely and effectively used for the treatment of different malignant tumors. Nonetheless, their use may lead to different adverse outcomes such as nephrotoxicity which is the main cause of morbidity and hospitalization of patients in intensive care units. Melatonin is a small molecule with pleiotropic healing p...
Article
MicroRNAs (miRNAs, miRs) are small (21-25 nucleotides) endogenous and noncoding RNAs involved in many cellular processes such as apoptosis, development, proliferation, and differentiation via binding to the 3'-untranslated region of the target mRNA and inhibiting its translation. Angiogenesis is a hallmark of cancer, which provides oxygen and nutri...
Article
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Background and purpose: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, impaired insulin secretion or peripheral insulin resistance. Today, many herbal medicines are used in treatment of diabetes. Recently anti-diabetic properties of resveratrol are reported in some studies, but none have evaluated its anti-neuropathy prop...
Article
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Gastric cancer accounts 8% of the total cancer cases leading to 10% of total cancer deaths worldwide. The indoleamine N-acetyl-5-methoxytryptamine, better known as melatonin, is the principal hormone produced by the pineal gland. Recently, it has been well documented some anti-cancer roles of melatonin in some malignancies as breast and colon cance...
Article
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Background and purpose: Gastric cancer is the second most common cause of cancer worldwide and despite huge advances in treatments, the chance of survival is very low even in surgery cases. Having a genetic predisposition plays an important role in cancer development. Polymorphisms in the NQO1(NAD(P)H Quinone dehydrogenase 1) gene could affect the...
Article
Irisin is a hormone-like molecule mainly released by skeletal muscles in response to exercise. Irisin induces browning of the white adipose tissue and has been shown to regulate glucose and lipid homeostasis. Keeping its energy expenditure and metabolic properties in view, numerous studies have focused on its therapeutic potential for the treatment...
Article
Gadolinium (Gd) chelates have been widely used as contrast agent in magnetic resonance imaging (MRI). In addition to using MRI, they are interesting, as a radiosensitizer, in neutron capture therapy (NCT). However, the poor selective tissue labeling and localization provided by conventional molecular Gd chelates have confined success in both MRI an...
Article
Objectives: Reproductive malfunctions after chemotherapy still are a reason of reducing fertility and need specialized intensive care. The aim of this review was to investigate the effect of melatonin on the reproductive system under threatening with chemotherapeutic drugs. Methods: To find the role of melatonin in the reproductive system during...
Article
Full-text available
Aluminum phosphide (AlP), one of the most commonly used pesticides worldwide, has been the leading cause of self-poisoning mortalities among many Asian countries. The heart is the main organ affected in AlP poisoning. Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart. The present study reveals evidence on...
Article
Kidney diseases need specialized health care and still are a reason of death. There is a large body of evidence that indicates minocycline possesses some cytoprotective effects beside of antibacterial properties. In this review, we aimed to explain cytoprotective mechanisms and kidney protection of minocycline. In order to find the effects of minoc...
Article
Full-text available
Melatonin is a neurochemical hormone produced by pineal gland and has an important role in regulating circadian rhythm in human body. In recent years it has revealed some cytoprotection and antimitogenic effect of this neurohormone which was explained in relation to its receptors and accordingly some intracellular signaling pathways. The Role of me...
Article
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Background and purpose: Osteoporosis is a multiple disease that is characterized by decrease in bone mass and bone strength. This decrease is more common in postmenopausal women due to decreased estrogen levels. Vitamin D3 plays a pivotal role in skeletal metabolism by binding to nuclear steroid receptors (receptors for vitamin D (VDR)). This study...
Article
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Background and purpose: Infection caused by hepatitis B virus is a major health problem and the most common known chronic infection. It has an important role in developing cirrhosis and hepatic cancer. Glutathione-s-transferase enzyme is one of the most important metabolic enzymes in cellular protection mechanisms such as: xenobiotic detoxification...
Article
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Background Gastric cancer accounts for 8% of total cancer cases and 10% of total cancer deaths worldwide. Melatonin is the principal hormone produced by the pineal gland. An anti-cancer role for melatonin has been demonstrated in breast and colon cancer. Melatonin has also been shown to have a protective role in the gastrointestinal tract as a free...