Halil Senol

Bezmialem Vakıf Universty · Department of Pharmaceutical Chemistry

Introduction This study explores the cytotoxic activity‐guided isolation of the underground parts of Laserpitium hispidum M. Bieb and Laserpitium petrophilum Boiss. & Heldr., which have not been previously investigated. Objectives The aim is to isolate and evaluate bioactive compounds from Laserpitium L. species with anticancer potential. Materia...

In this study, pyrrole-based heterocyclic compounds (2a-k) were synthesized and characterized by elemental analysis, IR and NMR spectra. 11 representatives of the pyrrole derivatives were chosen as objects for the studying biological activity. Among them were the ensembles of pyrroles with other pharmacologically active heterocycles, such as pyridi...

This study explores the antioxidant, anti-inflammatory, and anticholinesterase properties of extracts from the natural plant Scorzonera ketzkhowelii for the first time. Additionally, it focuses on isolating phenolic compounds from the ethyl acetate sub-extract, elucidating their structures, and investigating their in-silico bioactivities. Twelve ph...

This study investigated the fatty acid (FA) compositions and proteins’ molecular weight profiles (MWP) of eight macroalgae species collected from the Antalya and Çanakkale in Turkiye: three red (Liagora viscida , Laurencia obtusa , Palisada perforata ), three brown ( Stypopodium schimperi , Cladostephus spongiosus , Halopteris scoparia ), and two g...

Adulteration of sports supplements poses significant health risks, necessitating stringent regulatory oversight. This study investigates deceptive practices by manufacturers, including concealment of formulations and manipulation of label information, impacting a wide demographic beyond elite athletes. Cinnarizine (CIN), and its degradation produc...

In this study, we synthesized and characterized sixteen new polymethoxy-substituted hydrazone derivatives. These compounds were evaluated for their in vitro cytotoxic activity against human prostate cancer (PC3) and human umbilical vein endothelial (HUVEC) cell lines. Compounds 5, 6, 7, and 11 exhibited significant cytotoxic effects with high selec...

In this study, we synthesized 15 novel quinazoline-morpholinobenzylideneamino hybrid compounds from methyl anthranilate and we assessed their cytotoxicity via in vitro assays against A549 and BEAS-2B cell lines. Molecular docking studies were conducted to evaluate the protein-ligand interactions and inhibition mechanisms on nine different molecular...

In this comprehensive screening study, the chemical composition, and cytotoxic, antimicrobial, and anticholinergic activities of the green algae Penicillus capitatus, collected from Antalya‐Türkiye, were determined as in vitro and in silico. GC‐MS analysis of the hexane extract revealed a high content of fatty acids, with hexadecanoic acid constitu...

In the presented work, it was reported about the synthesis procedure of new isoquinoline derivatives starting from chalcones and acetoacetanilide, a multi-step synthesis pathway yielded four isoquinoline derivatives (5a-d). At the first stage of our research, corresponding cyclohexanone derivatives are synthesized from the Michael addition reaction...

Sorafenib, a multiple kinase inhibitor, is widely used as a first-line treatment for hepatocellular carcinoma. However, there is a need for more effective alternatives when sorafenib proves insufficient. In this study, we aimed to design a structure that surpasses sorafenib's efficacy, leading us to synthesize sorafenib− ruthenium complexes for the...

This study focused on the synthesis and evaluation of the biological activity of ten novel acetohydrazide hybrid derivatives, having furfuryloxy‐1,2,3‐triazole ring. All the target compounds were tested in vitro and in silico for their inhibitory potential against key enzymes: hAChE, hBChE, hCAI, and hCAII, all involved in significant physiological...

The use of medicinal plants for treating various diseases dates back thousands of years and has been a part of many cultures around the world. Various parts of plants, including roots, leaves, and flowers, and their extracts have been used to develop remedies to cure different ailments like fever, pain, inflammation, infections, among others. In th...

In this study, starting from 3‐amino‐thiophene‐2‐carboxylic acid methyl ester, eighteen new arylidenehydrazide derivatives (4–21) were synthesized. To determine cytotoxic activity of target compounds they were tested against human colon cancer and human umbilical vein endothelial cell lines. To determine prospective inhibition mechanism, binding af...

In this study, new quinazoline–chromene hybrid compounds were synthesized. The cytotoxic effects on cell viability of the hybrid compounds were tested against A549 human lung adenocarcinoma and BEAS-2B healthy bronchial epithelial cell lines in vitro. In addition, the ability of the active compounds to inhibit cell migration was tested. Molecular d...

Herein, new derivatives of α,β-unsaturated ketones based on oleanolic acid (4a-i) were designed, synthesized, characterized, and tested against human prostate cancer (PC3). According to the in vitro cytotoxic study, title compounds (4a-i) showed significantly lower toxicity toward healthy cells (HUVEC) in comparison with the reference drug doxorubi...

In this study, imines bearing quinazolin‐4(3H)‐one were synthesized and their inhibitory properties were investigated against some metabolic enzymes including Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), α‐Glycosidase (α‐Gly), and human Carbonic Anhydrase I–II (hCA I–II). All compounds had inhibitory strength with Ki values in the ran...

In this study, twenty new anthranilic acid hydrazones 6-9 (a-e) were synthesized and their structures were characterized by Fourier-transform Infrared (FTIR), Nuclear Magnetic Resonance (1H NMR - 13C NMR), and High-resolution Mass Spectroscopy (HRMS). The inhibitory effects of the compounds against COX-II were evaluated. IC50 values of the compound...

In this study, 16 new compounds were synthesized starting from methylparaben. These new compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin‐4‐on derivatives. All compounds were tested against MCF‐7 breast cancer cells and MCF10A breast healthy tissue to determine their anti‐cancer activity. Molecular docking studies were...

Günümüzde kansere ve diğer mikroorganizmalara karşı kullanılan ilaçların pek çoğunun biyoyararlanımının düşük olması ve başta toksisite gibi yan etkilerinden dolayı tedavide yeni ilaçların varlığına ihtiyaç duyulmaktadır. Her gün artan sayıda anti-kanser veya antibiyotik ilaç geliştirilmesine rağmen, bu ilaçların seçiciliklerinin düşük olması ve ço...

In this study, a total of 13 compounds (5–17) were synthesized starting from oleanolic acid (OA), a natural triterpenoid. Five new compounds (10, 11, 12, 15 and 17), are the main targets of the study, which were synthesized for the first time in this work as oxime, imine and hydrazone derivatives of OA. Other compounds were previously obtained as n...

Cancer is one of the most common and lethal disease in the world therefore, patients need to new and potent anti-cancer agents to treatment. In this study, starting from vanillin, 24 new compounds, which are 12 thiosemicarbazone (4a-h, 5i-j, 6k) and 12 thiazolidin-4-one (7a-h, 8i-j and 9k) derivatives, were synthesized and characterized by NMR, HRM...

Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate (OPCA) on a preclinical model of MS. First, OPCA was synthesized semisynthetically and characterized. Then, the mice with MOG35-55-induced experimental autoimmune/all...

In this study, 13 new hybrid compounds (7a-m) were synthesised starting from ursolic acid, and their cytotoxic activities were investigated on the BEAS-2B and A549 cell lines. In addition, the synthesised compounds were tested against Staphylococcus aureus, Escherichia coli, and Candida albicans to determine their anti-microbial properties. The hyb...

In this study, 13 new hybrid compounds were synthesized starting from the natural product oleanolic acid and their in vitro cytotoxic activities were investigated on BEAS-2B and A549 cell lines. For this purpose, initially, the secondary OH group at the C3 position of oleanolic acid was protected as methoxy and the carboxyl group was converted to a...

The latex of the Euphorbia plant was used in this study to find an effective and natural new insecticide in combating Dentroctonus micans (Kug.), Which causes great damage to Picea orientalis forests. For this purpose; Euphorbia plant was collected from Erzurum and species identification was made. According to the species identification, the spurge...

Coronaviruses (CoVs) are causative agents of the last three epidemics/pandemic; severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome-CoV (MERSCoV) and the last one SARS-CoV-2. Although meta-analysis of treatment studies against these three CoVs found no clear benefit of any spesific regimen, currently, remdesivir and f...

Reactions of benzyne with ester derivatives of spiro[2.4]hepta-4,6-dien-1-ylmethanol were performed. By rearrangement reaction of cyclopropyl methanol units of ((1s*,1′R*,2R*,4′S*)-1′,4′-dihydrospiro[cyclopropane-1,9’-[1,4]methanonaphthalen]-2-yl) methyl 3,5- dinitrobenzoate (13) and its isomer (14), corresponding allyl chlorides were obtained. Two...

Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by 1H- and 13C NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were...

Introduction: The Tissue factor (TF), also known as thromboplastin, Factor III and CD 142 is a membrane glycoprotein responsible for initiating the clotting system. Phospholipids that activate the activation of the coagulation system in the molecular structure are important. TF is used has always been an important tool in the monitoring of the coag...

Salvia (sage) species are grown world-wide, mainly in the three regions; South-East Asia, South Europe to Central and South America with approximately 1000 species. The genus Salvia is represented by over 100 species in Turkey. Since ancient times, they have been used in folk medicine for many purposes in the world, for more than sixty different ai...

Reaction of spiro[2.4]hepta-4,6-dien-1-ylmethanol (3) with phenyltriazolinedione (PTAD) gave 4-phenyl-1-[(3aR(S),6S(R))-1a, 2,3a, 6-tetrahydro-1H-cyclopenta[b]cyclopropa[c]furan-6-yl]-1,2,4-triazolidine-3,5-dione (7) via a novel rearrangement. The structure of this rearranged product was determined by spectroscopic methods and by experimentation. I...