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July 2017 - present
University of South Carolina School of Medicine- Columbia, US
- PhD Student
- CB1 receptor signaling activation of G-protein coupled inwardly-rectifying potassium (GIRK) channels. Recording GIRK activation induced changes membrane potential via fluorescent assay, measures of cAMP, and whole-cell, patch clamp electrophysiology.
May 2014 - August 2016
University of South Carolina: School of Medicine - Columbia, South Carolina
- Laboratory Assistant
The cannabinoid CB1 receptor is expressed throughout the central nervous system where it functions to regulate neurotransmitter release and synaptic plasticity. While the CB1 receptor has been identified as a target for both natural and synthetic cannabinoids, the specific downstream signaling pathways activated by these various ligands have not be...
Recreational use of synthetic cannabinoids (SCs) is associated with desirable euphoric and relaxation effects as well as adverse effects including anxiety, agitation and psychosis. These SC-mediated actions represent a combination of potentiated cannabinoid receptor signaling and "off-target" receptor activity. The goal of this study was to compare...
Synthetic cannabinoids (SCs) are a class of new psychoactive substances (NPSs) that exhibit high affinity binding to the cannabinoid CB1 and CB2 receptors and display a pharmacological profile similar to the phytocannabinoid (-)-trans-Δ9-tetrahydrocannabinol (THC). SCs are marketed under brand names such as K2 and Spice and are popular drugs of abu...
Establishing our fluorescent assay to measure G-protein coupled inwardly rectifying potassium (GIRK) channels
Withdrawal from cocaine regulates expression of distinct glutamate re-uptake transporters in the nucleus accumbens (NAc). In this study, we examined the cumulative effect of glutamate re-uptake by multiple excitatory amino acid transporters (EAATs) on drug-seeking at two different stages of withdrawal from self-administered cocaine. Rats were train...