
Haleh VaezTabriz University of Medical Sciences | TBZMED · Department of Pharmacology
Haleh Vaez
Pharm D, PhD of Pharmacology.
About
46
Publications
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419
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Introduction
Additional affiliations
August 2011 - present
pharmacy faculty,Tabriz University of Medical Sciences
Position
- metformin effect in isolated heart
Publications
Publications (46)
It has been attempted to highlight a critical issue affecting the older adult population, namely, polypharmacy and its characteristics, challenges, and approaches to its reduction. Polypharmacy is defined as the use of several medications, or typically, more than 4 chronic medications. It increases healthcare costs (emergency room visits and hospit...
Background
High dose chemotherapy is one of the therapeutic strategies for breast cancer and doxorubicin (DOX) as a chemotherapy agent is widely used. DOX indication is limited due to its dose‐depended cardiotoxicity. Recently, cannabidiol (CBD) shows antitumoral and cardioprotective effects, so we hypothesized that CBD administration with high‐dos...
Background The field of pharmacology is considered a separate pre-clinical field in the standard curriculum of medical sciences. In most cases, it is offered together with other pre-clinical lessons (e.g., anatomy, physiology, and biochemistry). The scientific basis for the rational and safe prescription of drugs is discussed in pharmacology; there...
Background
Breast cancer is one of the world’s most frequently diagnosed malignancy and the second highest cause of all cancers in females. This cancer mortality is mostly due to lung metastasis. High dose chemotherapy is one of therapeutic strategies beside others. Doxorubicin (DOX) is a widely used chemotherapy agent. however, use of DOX is limit...
Background: Effective clinical care and identifying susceptibility to COVID-19-related mortality requires rapid recognition of risk factors and their relations with disease outcomes. This study aimed to cluster and identify various subgroups of COVID-19 patients and examine the relationship between these subgroups and the causes of death. Methods:...
Objectives:
4-Phenyl butyric acid (4-PBA) is a chaperone-mediated autophagy (CMA) inducer, which eliminates unnecessary and damaged cellular components through lysosomal enzymes. It could reduce misfolded and unfolded proteins produced after myocardial infarction (MI) and can improve cardiac function. We aimed to investigate the effect of 4-PBA on...
Background: Eryngium is a genus with 274 species, which belongs to the Umbelliferae family. The nine species of this genus are endemic to Iran. The existence of terpenoids, saponins, flavonoids, and steroid components in most Eryngium species is the reason behind their anti-inflammatory, anti-cancer, and, especially, anti-diabetic effects among the...
Neuropathic pain due to vincristine administration is an important dose limiting adverse effect with no definite efficient treatment. Citrus aurantium possesses multiple therapeutic potentials and is commonly used in traditional medicine. This study investigate the possible effects of the hydroethanolic extract of C. aurantium (CA) leaves and magne...
Purpose 4-phenyl butyric acid (4-PBA) is a chaperone-mediated autophagy (CMA) inducer, which eliminates unnecessary and damaged cellular components through lysosomal enzymes. It could reduce misfolded and unfolded proteins produced after myocardial infarction (MI) and can improve cardiac function. We aimed to investigate the effect of 4-PBA on isop...
Toll-like receptors (TLRs) are essential receptors of the innate immune system, playing a significant role in cardiovascular diseases. TLR4, with the highest expression among TLRs in the heart, has been investigated extensively for its critical role in different myocardial inflammatory conditions. Studies suggest that inhibition of TLR4 signaling p...
Background: STAT3 is an oncogenic signaling pathway found constitutively active in many types of human malignancies and plays a key role in cancer progression. Stattic is a small molecule, which selectively inhibits SH2 domain of STAT3. In most of the studies, stattic has been proposed as a promising strategy for inhibition of STAT3 in cancer cells...
Background: One of the largest plant genera of the Umbelliferae family is Eryngium including 274 species, of which only 9 species are native to Iran and one of the most dominant species is E. billardieri. Numerous pharmacological effects of E. billardieri such as anti-inflammatory, antimicrobial, antioxidant have been reported in several studies.
O...
Immune-induced inflammation plays an important role both in aggravating and healing of post myocardial infarction (MI) injuries. Potent anti-inflammatory and local immunomodulatory activity of infliximab has been suggested to have modulating effects on immune responses after MI. The aim of the present study was to evaluate the efficacy of inflixima...
Background: Type 2 diabetes mellitus is a chronic metabolic disorder with prominent vascular injuries. In this condition, the levels of multiple pro- and anti-angiogenic factors have been shown to change. This study aimed to investigate the possible effect of metformin on proangiogenic factor, endocan levels, via the modulation of p-AMPK/AMPK axis...
Background: Astragaloside IV (AST) is a saponin from the roots of Astragalus plants which has been widely used in traditional medicine to treat cardiovascular diseases. However, the effect of AST on myocardial infarction remains unknown. Thus, we aimed to investigate the cardio protective effects of AST on isoproterenol-induced myocardial infarctio...
Background: Scrophularia atropatana contains chemicals activating the GABA system and inhibiting glutaminergic system. As well as we know, drugs inhibiting glutamate system have analgesic effects and reduce tolerance to the analgesic effects of morphine. In the present study, effect of methanol extract of aerial parts of S. atropatana on tolerance...
Objectives:
Sepsis can result in severe organ injury by provoking inflammatory cascades and oxidative stress. Several studies are currently underway to find a drug with anti-inflammatory effects to prevent mortality and morbidity during sepsis. The present study was undertaken to assess the effects of metformin on oxidative stress and antioxidant...
Scrophularia genus belonging to the family of Scrophulariaceae, is a medicinal plant widely distributed in Iran. In the present study, the anti-malarial activity of different extracts of three Iranian endemic species of Scrophularia including S. frigida, S. subaphylla and S. atropatana, was screened by an in-vitro preliminary assay. The plant mater...
Background: Coronary artery disease is a leading cause of death worldwide. The present
study has been designed to investigate efficacy of methanolic extract of Scrophularia
subuphylla (S. subuphylla) on ischemia and reperfusion-induced myocardial injury in
isolated rat heart.
Methods: The isolated male Wistar rat hearts (n= 5) were perfused by Kreb...
Myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. The present study investigated potential resistance to ischemia-reperfusion (I/R) injuries following administration of methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat heart. Male Wistar rat hearts (n= 8-...
A quantitative structure–mobility relationship (QSMR) is proposed to estimate the electrophoretic mobility of diverse sets of analyses in capillary zone electrophoresis using Abraham solvation parameters of analyses, such as the excess molar refraction, polarizability, hydrogen bond acidity, basicity, and molar volume. QSMR was developed for predic...
Background: Rosmarinic acid is a polyphenolic compound with considerable antioxidant activities. We aimed to investigate its cardioprotective effects against isoproterenol-induced myocardial infarction (MI) in rats.
Methods: Male Wistar rats were assigned to 5 groups of control, isoproterenol, and treatments with 10, 20, 40 mg/kg of rosmarinic aci...
Myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. The present study was investigated potential resistance to ischemia-reperfusion (I/R) injuries following administration of methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat heart. Male Wistar rat hearts (n...
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induced acute injury by inhibitingng TLR4 pathway. Male Wistar rats were randomly divided into 3 groups (...
Toll like receptors (TLRs) are key players in the innate immune responses. The energy sensing enzyme, AMPK, has been implicated in the modulation of immunity. The present study investigated whether AMPK activation by metformin could contribute to the regulation of immune responses in the isolated heart via suppression of TLR4 activity, independent...
Background: Hesperidin is a flavonoid and has strong anti-oxidant and anti-inflammatory activities. The aim of the present study is to investigate the effects of hesperidin on ischemic/reperfusion (I/R) induced injuries and arrhythmias. Methods: Male Wistar rats were anesthetized and then the hearts were removed and cannulated immediately to a lang...
Activation of AMP‑activated protein kinase (AMPK) has been indicated to produce an anti‑inflammatory effect through the suppression of toll‑like receptor (TLR) activity. In the present study, the investigation was designed to identify the effect of A‑769662, a direct activator of AMPK on lipopolysaccharide (LPS)‑induced acute lung and heart inflamm...
Sepsis-induced myocardial dysfunction is a serious organ complication. In the present study, we investigated the effect of metformin on myocardial dysfunction and TLR4 activity in LPS-induced sepsis. Male Wistar rats were randomly divided into 3 groups (n=6): control received normal saline (0.5 ml), LPS group received lipopolysaccharide (0.5 mg/kg;...
Background: Clinical use of Morphine in pain management is a controversial issue and long-term exposure to opiates induces physical dependency and tolerance. The aim of this study was to evaluate the attenuation effects of Magnesium sulfate and Amitriptyline on the development of Morphine-induced dependency and tolerance. Methods: In this study dif...
Background:
The aim of this study was to evaluate the cardioprotective effects of aqueous fraction of Marrubium vulgare hydroalcoholic extract on cardiac parameters in ischaemic-reperfused isolated rat hearts.
Materials and methods:
The aerial parts of the plant were extracted with methanol 70% by maceration. The water-soluble portion of the tot...
Eremostachys laciniata, having rich flavonoid content, is expected to have a considerable antioxidant
effect. In this study We used ACMS (Accelerated cytotoxic or protective mechanism screening technique)
to evaluate the possible antioxidant effect of E. laciniata rhizome against oxidative cell damages
induced by different types of oxidative stress...
Myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression. In many cases of sepsis, the presence of Lipopolysaccharide (LPS) has been established. LPS Binding Protein (LBP) bound endotoxin is recognized by CD14/toll-like...
Introduction:
Tolerance to and dependence on the analgesic effect of opioids is a pharmacological phenomenon that occurs after their prolonged administration.
Objective:
The aim of this study was to evaluate the protective effects of ceftriaxone and amitriptyline on the development of morphine-induced tolerance and dependence.
Methods:
In this...
Background: Methanolic extract of Marrubium crassidens Boiss has potent antioxidative effects and can have cardio-protective effects on Ischemia/Reperfusion (I/R) injuries in heart. Methods: The extract was prepared by maceration. The isolated rat hearts were perfused by Krebs-Henseleit solution enriched with the extract (0, 10, 50, and 100μ/ml), u...
Introduction: Chronic opiate exposure induces tolerance to opiate analgesic effects. Glutamate system
is believed to play a major role in morphine induced tolerance. The inhibitory effects of magnesium
sulfate and bupropion on this system are well-studied. The aim of this study was to evaluate the effects
of magnesium sulfate and bupropion on the p...
Asthma is one of the most common chronic disorders and about 7% of the US population suffers from asthma. Initial response to allergy is associated with mediators like histamine, prostaglandin (PG) D2 and leukotriene (LT) C4. In asthmatic patients, 5-lipo-oxygenase (5-LO) pathway produces more LTC4 than the healthy people. Also, pro-inflammatory fa...
1 / 10 Vol.12, No.1 | 2014 | hypothesisjournal.com HYPOTHESIS HYPOTHESIS ABSTRACT Nowadays plant-based medi-cine or herbal medicine research is be-coming more prevalent all over the world, presumably due to natural acces-sibility and fewer adverse effects. Quince (Cydonia oblonga Miller), a plant in the Rosaceae family, is considered to be a good a...
Purpose:
Prescription of ketotifen as an effective antihistamine in asthma and allergic conditions is associated with side effect of weight gain. Caffeine is an agent which increases thermogenesis and improves energy expenditure and also effective in asthma. The aim of current study was to evaluate caffeine impact in reducing weight gain side effe...
Purpose:
RESULTS of our previous study revealed that preischemic perfusion of honey before zero flow global ischemia had cardioprotective effects in rat. The present study investigated potential resistance to reperfusion injury following short term postischemic administration of natural honey in globally ischemic isolated rat heart.
Methods:
Mal...
Purpose:
In the present study, effects of preischemic administration of natural honey on cardiac arrhythmias and myocardial infarction size during zero flow global ischemia were investigated in isolated rat heart.
Methods:
The isolated hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion then perfused by a mo...
Background and Aims: In the present study, effects of post-ischemic administration of natural honey
on zero flow global ischemia/reperfusion induced myocardial infarct size were investigated in isolated
rat heart.
Methods: Male Wistar rats were divided into five groups (n= 8-15). The rat hearts were isolated
rapidly, mounted on a Langendorff appara...
Objectives: In the present study, effects of hydroalcoholic extract of grape seed (GSE) on ischemia-reperfusion (I/R)-induced infarct size and cardiac arrhythmias were investigated in isolated rat heart. Methods: Isolated rat hearts were divided into four groups and mounted on a Langendorff apparatus at constant pressure, then subjected to 30 min r...
Questions
Questions (4)
after 7 days 80% of our animals show tumor growth. I wonder for that 20% what should we do? does it need more time? Or second injection? or we should put them out of the experiment?
I have 5 groups (n=8), and the values in each group are same so that the mean of each group is the same as the data in that group and the error amount is zero. now I want to compare these five groups. Which test would be the best choice?
Our power supply for western blotting transfer process needs three parameters of watt, voltage and current. In LC3 western blotting in different methods just the voltage or just the current are indicated and so I do not know how I can adjust these three to get the best results
With human kits is referenced but they don't work in rat hearts.