Håkan Ottosson

Håkan Ottosson
Karolinska Institutet | KI · Department of Biosciences and Nutrition

PhD

About

17
Publications
2,983
Reads
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681
Citations
Citations since 2017
5 Research Items
210 Citations
2017201820192020202120222023010203040
2017201820192020202120222023010203040
2017201820192020202120222023010203040
2017201820192020202120222023010203040
Additional affiliations
April 2011 - present
Karolinska Institutet
Position
  • Senior Lab Manager
April 2011 - present
Karolinska Institutet
Position
  • Lecturer
August 2004 - January 2008
IsoSep AB
Position
  • Senior Researcher
Description
  • Chemical synthesis. Synthesis of drug substances, synthesis of carbohydrate derivatives. Writing SOP’s for document handling and laboratory procedures. Supervision of a graduate student. System administration.
Education
August 1981 - September 1989
Stockholm University
Field of study
  • Organic Chemistry

Publications

Publications (17)
Article
Full-text available
Selenocompounds (SeCs) are promising therapeutic agents for a wide range of diseases including cancer. The treatment results are heterogeneous and dependent on both the chemical species and the concentration of SeCs. Moreover, the mechanisms of action are poorly revealed, which most probably is due to the detection methods where the quantification...
Article
N-acetylcysteine amide (NACA) is the amide derivative of N-acetylcysteine (NAC) that is rapidly converted to NAC after systemic administration. It has emerged as a promising thiol antioxidant for multiple indications; however, the pharmacokinetic property is yet unclear due to lack of an accurate quantification method. The present investigation aim...
Article
Full-text available
Aroylated phenylenediamines (APDs) are novel inducers of innate immunity enhancing cathelicidin gene expression in human bronchial epithelial cell lines. Here we present two newly developed APDs and aimed at defining the response and signaling pathways for these compounds with reference to innate immunity and antimicrobial peptide (AMP) expression....
Article
p-Xyleneselenocyanate (p-XSC) is one of the most investigated selenium compounds in cancer-prevention and -therapy. Despite the potent anti-cancer property, there is still no proper method to perform the quantitative analysis of p-XSC in plasma. In this investigation, we aimed at developing a method based on liquid chromatography-mass spectrometry...
Article
Full-text available
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recover...
Article
Full-text available
Bacterial resistance against classical antibiotics is a growing problem and the development of new antibiotics is limited. Thus, novel alternatives to antibiotics are warranted. Antimicrobial peptides (AMPs) are effector molecules of innate immunity that can be induced by several compounds, including vitamin D and phenyl-butyrate (PBA). Utilizing a...
Article
Full-text available
Innate immunity, the front line of our defence against pathogens, relies, to a great extent, on the production of antimicrobial peptides (AMPs). These peptides exhibit antimicrobial activity and immunomodulatory properties. In humans, AMPs include the defensins (α- and β-families) and the cathelicidin, LL-37. Bacterial resistance against antibiotic...
Article
Recent work in our laboratory has shown that n-pentenyl glycosides (NPGs) are excellent substrates for a wide variety of reactions occurring at the anomeric center. They are prepared readily by standard glycoside forming procedures, including Fischer's direct method, and although they are stable to a wide range of reagents, they are readily activat...
Article
Full-text available
A general rationalization for armed/disarmed effects, first recognized in n-pentenyl glycosides but recently extended to a variety of other glycosyl donors, is postulated. Reaction of a glycosyl donor with an appropriate electrophile gives a positively charged intermediate which is less favorable when there is an adjacent electron-withdrawing group...
Article
Full-text available
Reaction of p-trifluoroacetamidophenyl 2,4-di-O-benzyl-α-d-mannopyranoside with 2-O-acetyl-3,4,6-tri-O-benzyl-α-d-mannopyranosyl chloride gave a trisaccharide derivative which was O-deacetylated and then treated with ethyl 2,3,4-tri-O-benzyl-6-O-dibenzyloxyphosphoryl-1-thio-α-d- mannopyranoside. The resulting pentasaccharide derivative was deprotec...
Article
Full-text available
Durch Reaktion des Bromids (I) mit dem Mannosid (II) erhält man nach Deblockierung des Kondensationsprodukts das Oligosaccharid (III).
Article
Full-text available
Condensation of 3,6-di-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-2-deoxy-2- phthalimido-beta-D-glucopyranosyl bromide with p-nitrophenyl 3-O-benzoyl-4,6-di-O-benzylidene-alpha-D-mannopyranoside, p-nitrophenyl 3,6-di-O-benzyl-alpha-D-mannopyranoside and p-nitrophenyl 3,4-di-O-benzyl-alpha-D-mannopyranoside gave protected tri- and...
Article
Das tritylierte und benzylierte Mannosid (Ib) wird mit dem Lactosaminbromid (II) zum blockierten Trisaccharid (III) kondensiert, das zum freien Trisaccharid (IV) entblockiert wird.

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