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Hakan Leblebicioglu

Hakan Leblebicioglu
VM Medicalpark Samsun Hospital · Infectious Diseases

Prof, ESCMID fellow
Department of Infectious Diseases VM Medicalpark Samsun Hospital, Samsun, Turkey

About

270
Publications
61,646
Reads
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8,906
Citations
Citations since 2016
72 Research Items
4891 Citations
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20162017201820192020202120220200400600
Introduction
Prof. Hakan Leblebicioglu, MD, FESCMID Samsun VM Medicalpark Hospital, Infectious Diseases Clinic, Samsun, Turkey He have been worked at the Infectious Diseases & Clinical Microbiology, Ondokuz Mayis University for 25 years. His current research interests are Crimean Congo Hemorrhagic Fever and viral hepatitis.
Additional affiliations
July 2020 - November 2020
Medical Park Samsun Hospital
Position
  • Professor
December 2018 - July 2020
Liv Hospital
Position
  • Professor
July 1991 - July 2016
Ondokuz Mayıs Üniversitesi
Position
  • Head of Department

Publications

Publications (270)
Article
Full-text available
The monkeypox outbreak has emerged in 13 countries and increased alarmingly since the first confirmed case in the UK on May 7, 2022 [1]. The WHO has reported 28 suspected and 92 confirmed cases of monkeypox in 12 non-endemic countries as of May 21 [2]. Monkeypox represents a possible public health problem that needs appropriate attention to prevent...
Article
Full-text available
The Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally, becoming a long-lasting pandemic [1,2,3]. As is so often the case for infectious diseases, vulnerable communities are likely to demonstrate the worse effects and this holds true for COVID-19 in Latin America [4]....
Article
Objectives In pandemic conditions, patients with febrile neutropenia are also at risk of COVID-19. Aim of this systematic review is to evaluate COVID-19 cases presented with febrile neutropenia and provide information regarding incidence, clinical course and prognosis. Methods We systematically searched on COVID-19 and febrile neutropenia cases in...
Article
COVID-19 is a severe acute respiratory syndrome. Recent reports showed that autoimmune thyroiditis might occur following COVID-19 infection. We aimed to review the literature to assess the prevalence, clinical features and outcome of autoimmune thyroid disorders triggered by COVID-19. We reviewed case reports, case series, and observational studies...
Article
Background: Increasing number of patients with COVID-19-associated mucormycosis have been reported, especially from India recently. We have described a patient with COVID-19-associated mucormycosis and, searched and analyzed current medical literature to delineate the characteristics of COVID-19-associated mucormycosis. Method: We reported a patie...
Article
Full-text available
A novel coronavirus (SARS-CoV-2), causing an emerging coronavirus disease (COVID-19), first detected in Wuhan City, Hubei Province, China, which has taken a catastrophic turn with high toll rates in China and subsequently spreading across the globe. The rapid spread of this virus to more than 210 countries while affecting more than 25 million peopl...
Article
In their study, Yue et al. reported influenza co‐infection among COVID‐19 patients as 57.3%. The study included a period of January 12‐February 21, 2020 in Wuhan, China. We have recently detected this rate as 0.54% in Turkey. This difference between rates of co‐infection can be explained by the seasonality of the influenza virus. Our study included...
Article
Full-text available
The recent report by Caly et al., describing the antiviral potential of ivermectin against SARS-CoV-2 in vitro arrive to the agenda potential candidates for COVID-19 treatment [1]. This discovery gave hope to the researchers who are screening for drugs that can be repurposed for treating COVID-19. Ivermectin, is a member of the avermectin family (F...
Article
Full-text available
Background Short-term peripheral venous catheters-related bloodstream infections (PVCR-BSIs) rates have not been systematically studied, and data on their incidence by number of device-days is not available. Methods Prospective, surveillance study on PVCR-BSI conducted from September 1st, 2013 to 31st Mays, 2019 in 246 intensive care units (ICUs),...
Article
Full-text available
Background Short-term peripheral venous catheter–related bloodstream infection (PVCR-BSI) rates have not been systematically studied in resource-limited countries, and data on their incidence by number of device days are not available. Methods Prospective, surveillance study on PVCR-BSI conducted from September 1, 2013, to May 31, 2019, in 727 int...
Article
Remaining co-authors of this study: Bahrain: Saeed, N.K.; Abdul-Aziz, S.; ALSayegh, S.; Humood, M.Z., Mohamed-Ali, K.; Swar, S., Magray, T.A.S. Egypt: Bayani, V.; Ahmed, S.A.; Alansary, A.M.; Hassan, A.R.; Abdullorziz-Ghazi, I.; El-Fattah, M.A.; Hala, A.; Ahmed-Fouad, H.; Mounir-Agha, H.; Hamza, H.S.; Salah, Z.; Abdel-Aziz, D.M.; Ibrahim, S.B.; Hel...
Article
Remaining co-authors of this study: Bahrain: Saeed, N.K.; Abdul-Aziz, S.; ALSayegh, S.; Humood, M.Z., Mohamed-Ali, K.; Swar, S., Magray, T.A.S. Egypt: Bayani, V.; Ahmed, S.A.; Alansary, A.M.; Hassan, A.R.; Abdullorziz-Ghazi, I.; El-Fattah, M.A.; Hala, A.; Ahmed-Fouad, H.; Mounir-Agha, H.; Hamza, H.S.; Salah, Z.; Abdel-Aziz, D.M.; Ibrahim, S.B.; Hel...
Article
Full-text available
Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2012 to December 2017 in 523 intensive care units (ICUs) in 45 countries from Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, prospective da...
Chapter
Hepatitis C virus (HCV) causes acute and chronic infection and is a global health problem. It leads to cirrhosis and hepatocellular carcinoma and causes several extrahepatic manifestations. Global prevalence of chronic HCV infection is estimated at around 1%. However the epidemiology of HCV infection changes according to the region. The estimated a...
Article
Full-text available
Background: Data describing the coagulopathy of Crimean-Congo haemorrhagic fever are scarce. We did rotational thromboelastometry (ROTEM) and conventional coagulation testing in patients with Crimean-Congo haemorrhagic fever to increase our understanding of the coagulopathy of this infectious disease. Methods: We did a prospective observational...
Article
Background: Migrants may be underimmunised and at higher risk of vaccine-preventable diseases, yet there has been no comprehensive examination of what policies are currently implemented across Europe targeting child and adult migrants. We analysed vaccination policies for migrants in 32 EU/EEA countries and Switzerland. Methods: Using framework ana...
Article
Background Migrants within the European Union and European Economic Area (EU/EEA) may be underimmunised and lack documentation on previous vaccinations. We investigated approaches to vaccination in recently arrived adult and child migrants, and guideline availability and implementation. Methods: Between March and May 2017, a national vaccination ex...
Article
Background Migrants may be underimmunised and at higher risk of vaccine-preventable diseases, yet there has been no comprehensive examination of what policies are currently implemented across Europe targeting child and adult migrants. We analysed vaccination policies for migrants in 32 EU/EEA countries and Switzerland. Methods Using framework anal...
Chapter
Hepatitis B virus classification into serological subtypes based on the antigenic properties of HBsAg and genotypes/subgenotypes based on genetic sequence heterogeneity is described. Current criteria for assignment of HBV strains to genotype and subgenotype, recent findings and discrepancies of subgenotype identification are discussed. Characterist...
Chapter
Full-text available
In this chapter the global distribution and contemporary trends of the prevalence of hepatitis B in the different regions of the world were described. Analysis of the relationship between HBV prevalence and income, also vaccination campaign of infants and children under 5 years old, is presented. Specific attention was paid on the distribution of h...
Article
Full-text available
Background/aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure. We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers, separately and in combinations, on liver fibrosis in tr...
Article
Full-text available
Hepatitis E virus (HEV), a non-enveloped single stranded RNA virus causes sporadic cases of hepatitis or outbreaks. The disease is generally self-limited although it may cause fulminant hepatitis in pregnant women, elderly, those with underlying chronic hepatitis, immunosuppressed, and transplant recipients. It is transmitted through fecal–oral rou...
Article
Full-text available
The Recommendations for Management of Endemic Diseases and Travel Medicine in Solid-Organ Transplant Recipients and Donors: Latin America clinical practice guideline is intended to guide clinicians caring for solid-organ transplant (SOT) donors, candidates and recipients regarding infectious diseases (ID) issues related to this geographical region,...
Article
Full-text available
Objective: Occupational exposures, can lead to decreased employee productivity, increased cost of health expenses and temporary or permanent suspension from working life. The most common cause of illness and death due to occupational exposures are blood-borne infections. In this study, it was aimed to evaluate the occupational exposures among resid...
Article
Background: Treatment with direct acting antiviral agents (DAAs) has provided sustained virological response rates in >95% of patients with chronic hepatitis C virus (HCV) infection. However treatment is costly and market access, reimbursement and governmental restrictions differ among countries. We aimed to analyze these differences among Europea...
Article
Full-text available
Background Crimean Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection that presents significant risk of nosocomial transmission to healthcare workers. Aim Evaluation of CCHF infection prevention and control (IP&C) practices in healthcare facilities that routinely manage CCHF cases in Eurasia. Methods A cross-sectional CCHF...
Article
Full-text available
Crimean-Congo hemorrhagic fever (CCHF) is the most wide-spread, tick-borne viral disease affecting humans. The disease is endemic in many regions such as Africa, Asia, Eastern and Southern Europe, and Central Asia. Recently, the incidence of CCHF has increased rapidly in the countries of the Eastern Mediterranean Region of the World Health Organiza...
Article
Full-text available
Background: Crimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4–30%. The natural history of disease and outcomes of CCHF in pregnant women is poorly understood. Objectives: To sy...
Article
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has been known as a nosocomial pathogen, both for the last 10 years in Turkey and for 20 years worldwide. Due to limited treatment options and high mortality rates, despite improvements in the field of medicine at the present time, CRKP is still a big threat for public health. This study was carried...
Technical Report
Full-text available
There are available comprehensive and detailed evidence-based recommendations for preventing catheter-related bloodstream infection (CRBSI) previously edited and published by organizations from high income industrialized countries, such as the Centers for Disease Control and Prevention (CDC) in 2011,1 Joint Commission International (JCI) in 2012,2...
Article
Full-text available
Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, using Centers for Disease Control a...
Article
in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Health-care Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected pr...
Article
Infective endocarditis (IE) is life-threatening condition with a highly variable clinical presentation. We report a case of acute IE with delayed diagnosis which resulted due to an initial misdiagnosis of Crimean Congo Hemorrhagic Fever (CCHF) in an endemic area. A case was due to Staphylococcus aureus and requiring valve replacement. They serve to...
Article
Crimean–Congo hemorrhagic fever (CCHF) is a potentially fatal tick-borne viral infection that is widely distributed worldwide. The diagnosis is frequently missed due to the non-specific initial symptoms and the differential diagnosis included many infectious and non-infectious causes. This retrospective study describes the clinical features and fin...
Article
Crimean-Congo hemorrhagic fever (CCHF) is a geographically widespread tick-borne zoonosis. The clinical spectrum of the illness varies from mild infection to severe disease and death. In severe cases, hemorrhagic manifestations develop, with fatality rates of 4–20%, depending on the geographic region and quality of the health care. Although vast ma...
Article
Introduction: The information of discharge criteria in patients with Crimean-Congo Hemorrhagic Fever (CCHF) is limited. In this study, we aimed to determine the clinical and laboratory parameters used in discharging the patients by the experienced centers. Materials and methods: The study was done in 9 reference centers of CCHF from May 1, 2015...
Chapter
http://www.uptodate.com/contents/crimean-congo-hemorrhagic-fever
Article
Full-text available
Crimean-Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection characterized by fever, bleeding, leukopenia and thrombocytopenia. It is a major emerging infectious diseases threat, but its pathogenesis remains poorly understood and few data exist for the role of apoptosis in acute infection. We aimed to assess apoptotic gene exp...
Data
Participant SGS groups. (XLS)
Data
Participant epidemiological and baseline clinical data. (XLS)
Article
Full-text available
A case of infective endocarditis caused by an uncommon agent _Abiotrophia defectiva_ with atypical manifestations is presented. A 42-year-old female had previously rheumatic heart disease, presented with the symptoms of fever and chills resolved within three days under antibiotherapy. She was diagnosed with endocarditis due to _A. defectiva_. Despi...
Article
Full-text available
Hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. Only 1%-30% of patients in need of treatment may get it. In recent years, the availability of direct-acting antiviral agents (DAA) has been an important advancement in treating HCV infection. However, due to cost, it is not possible to receive these drugs in many countries...
Article
The conflict in Syria is a big humanitarian emergency. More than 200,000 Syrians have been killed, with more than half of the population either having been displaced or having immigrated. Healthcare has been interrupted due to the destruction of facilities, a lack of medical staff, and a critical shortage of life-saving medications. It produced sui...
Article
Full-text available
This position paper is the second ESCMID Consensus Document on this subject and aims to provide intensivists, infectious disease specialists and emergency physicians with a standardized approach to the management of serious travel-related infections in ICU or the emergency department. This document was cooperative effort between members of two ESCM...
Article
Full-text available
Depending on their destinations and activities, international travelers are at a significant risk of contracting both communicable and non-communicable diseases. On their return to their home countries, many require intensive care. The emergence of Severe Acute Respiratory Syndrome Corononavirus (SARS-CoV) and Middle East Syndrome Coronavirus (MERS...
Article
Background: The recent Ebola epidemic has increased public awareness of the risk of travel associated VHF and international preparedness to manage imported cases was inadequate, highlighted by cases of nosocomial transmission. Crimean-Congo haemorrhagic fever (CCHF) is a re-emerging tick-borne VHF centred in the Eurasian region, affecting a large...
Article
Full-text available
Background Staphylococcus aureus is one of the causes of both community and healthcare-associated bacteremia. The attributable mortality of S. aureus bacteremia (SAB) is still higher and predictors for mortality and clinical outcomes of this condition are need to be clarified. In this prospective observational study, we aimed to examine the predict...
Article
Corresponding author. Department of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University Medical School, Samsun, Turkey. Tel.: +90 362 3121919/2480; fax: +90 362 4576029.
Article
Full-text available
Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognised hazard. We report a multi-centre retrospective cross-sectional study undertaken in Turkey in 2014 in 9 hospitals which are regional reference centres for CCHF, covering years 2002-2014 inclusive. Data were systematically extracted from charts of all pers...
Article
Crimean-Congo hemorrhagic fever (CCHF) is endemic in Turkey, with peak incidence of hospital admissions in the summer months. The aim of this pilot study was to evaluate the role of the severity grading score (SGS) in predicting length of hospital stay, laboratory usage, need for blood products, and hence total costs of patients. Thirty-five patien...