Haitham Qaralleh

Haitham Qaralleh
Mu’tah University · Department of medical laboratory sciences

PhD in biomedical sciences

About

75
Publications
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Introduction

Publications

Publications (75)
Article
Full-text available
Diabetes is one of the most common chronic diseases worldwide. This study aims to evaluate the hypoglycemic and hypolipidemic effects of Crataegus aronia (C. aronia) ethanolic extract and Crataegus aronia phytosome (C. aronia-p) in streptozotocin (STZ)-induced diabetic rats. The phytochemical content of C. aronia was identified. The C. aronia ethan...
Article
Sex hormones have a large influence on the structure and function of vaginal microbiota. A delicate balance between the vaginal microbiota and the host is one of the most important health reasons for women. The purpose of this study was to see if there were any links between female sex hormone levels and vaginal microbial diversity. A total of 100...
Article
Full-text available
Background and Objectives: Nanoscience is one of the most important branches of modern science, which deals with the knowledge, structure, and properties of nanoparticles. This study aimed to investigate the ability of an airborne fungus (Aspergillus flavus) to synthesize silver nanoparticles (AgNPs) and to test the antibacterial activity of the sy...
Article
Full-text available
Microbial antibiotic resistance is rapidly increasing as a result of overuse or misuse of antibiotics, as well as a lack of new, effective antibiotics. Alternative antimicrobial treatments, such as nanoparticles, and their potential for stronger synergetic effect when paired with other active chemicals, could be a viable option. This study is prepa...
Article
Full-text available
Introduction: A cost-effective and ecologically friendly method of generating silver nanoparticles (AgNPs) includes pathways that utilize a variety of biological sources to decrease metal ions. This study was designed to synthesize AgNPs using a fungus strain Aspergillus flavus and evaluate its antibacterial activities alone or in combination with...
Article
Full-text available
One of the most important roles for nanotechnology concerns is the development of optimizable experimental protocols for nanomaterials synthesis. The formation of silver nanoparticles (AgNPs) was supported by Rhizopus stolonifer MR11, which was isolated from olive oil mill soil samples. The ability of R. stolonifer MR11 to biosynthesize silver nano...
Article
Full-text available
Background: Ephedra foeminea is known in Jordan as Alanda and traditionally. It is used to treat respiratory symptoms such as asthma and skin rashes as an infusion in boiling water. The purpose of this study was to determine the antidiabetic property of Ephedra foeminea aqueous extract in streptozotocin-induced diabetic rats. Methods: The aqueou...
Article
A paucity of local information concerning the chemical profiles and biological activities of extracts obtained from less‐studied P. granatum peel of Jordanian origin was considered in this study for the first time. Fractionation of the crude ethanol extracts was performed because of their higher phenolic and flavonoid contents compared to the water...
Article
Full-text available
Echinococcosis is a common and endemic disease that affects both humans and animals. In this study, the in vitro activities of methanolic extracts of Ruta graveolens, Peganum harmala aerial parts, and Citrullus colocynthis seeds against protoscolosis and isolated bacterial strains from hydatid cysts were assessed using disc diffusion methods and Mi...
Article
Full-text available
Phenol is a severe pollutant that harms the environment and, potentially, human health. This study aimed to investigate the biodegradability of phenol by the plant growth-promoting bacterium R. nepotum. That included studying the growth kinetics and the effects of growth conditions such as incubation temperature, pH, and the use of different substr...
Article
Full-text available
Introduction: Fungi are one of the main approaches for synthesis of metallic nanoparticles (NPs), which can have medical and biotechnological applications such as their role in anti-bacterial, anti-cancer and various industrial activities. Objective: The current research focused on the biosynthesis of silver nanoparticles (AgNPs) using airborne fun...
Article
Full-text available
Phenol is one of the main pollutants that have a serious impact on the environment and can even be very critical to human health. The biodegradation of phenol can be considered an increasingly important pollution control process. In this study, the degradation of phenol by Bacillus simplex was investigated for the first time under different growth...
Article
Full-text available
Phenol is one of the main pollutants that have a serious impact on the environment and can even be very critical to human health. The biodegradation of phenol can be considered an increasingly important pollution control process. In this study, the degradation of phenol by Pseudomonas fredriksbergsis was investigated for the first time under differ...
Article
Full-text available
Phenol is one of the most important environmental pollutants that are found in sewage and industrial water from which agricultural lands are irrigated. In this study Curtobacterium flaccumfaciens bacterium was isolated in pure culture from phenol-uncontaminated farmland soil. Its ability to biodegrade phenol was examined. C. flaccumfaciens demonstr...
Article
The Jordanian endemic medicinal plant, Cupressus sempervirens was obtained from Dhana Natural Reserve, Al-Tafilah, Jordan to investigate its antibacterial and antioxidant activities. The procuring of essential oil was made by processing of dry leaves of C. sempervirens using steam-distillation method giving 0.26% (w/w) yield. The analysis of obtain...
Article
Full-text available
Globally, multidrug-resistant bacteria affects wound infections, both hospital-acquired infections and community-acquired infections. The main isolates cultured from 607 subjects with wound infections were methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter spp. [multidrug resistant (MDR)]...
Article
Full-text available
Background and aims: Branched chain amino acids (BCAAs) can be tightly connected to metabolism syndrome (MetS) which can be counted as a metabolic indicator in the case of insulin resistance (IR). The aim of this study was to assess the potential role of these acids under oxidative stress. Material and Methods: the in vitro antioxidant activity of...
Preprint
Full-text available
The medical usage of honey has become popular as an alternative and complementary treatment in recent time. This study was aimed at determining the inhibitory effect of honey and propolis against various species of Gram-positive and Gram-negative bacteria. The antibacterial activity was assessed using the disc diffusion and macro-dilution methods....
Article
Full-text available
Flavonoids and branched chain amino acids (BCAAs) have been recognized as attractive agents for research due to their role in diabetes and cancer. The present study investigates the antiglycation effect of BCAAs and flavonoid compounds and their cytotoxic effect on different colorectal cancer cell lines individually and in combination. This study w...
Preprint
Full-text available
The plants, Althaea officinalis, Tilia cordata and Psidium guaja have been used traditionally to treat respiratory infection symptoms. Flowers of A. officinalis and leaves of T. cordata and P. guaja have been used to treat cough, sore throat, catarrh, oral and pharyngeal mucosa irritation. Therefore, this study was designed to examine the antibacte...
Article
Full-text available
Juniperus phoenicea from five natural populations in southern Jordan were collected and their genetic variations using inter simple sequence repeats (ISSR) were studied. The hydro-distilled essential oils (EOs) from three geographical regions were characterized by their chemical composition and antibacterial activity. ISSR data analysis for the two...
Article
Full-text available
Excessive consumption of coffee and caffeine containing products may increase the likelihood of adverse effects. Therefore, this study designed to evaluate the roasted date and roasted barley beans as an alternative's coffee beverages. The micronutrient (Fe, Zn and Cu) and caffeine contents were measured atomic absorption spectrophotometer. The ant...
Article
Full-text available
Excessive consumption of coffee and caffeine containing products may increase the likelihood of adverse effects. Therefore, this study designed to evaluate the roasted date and roasted barley beans as an alternative's coffee beverages. The micronutrient (Fe, Zn and Cu) and caffeine contents were measured atomic absorption spectrophotometer. The ant...
Article
Full-text available
Many medicinal herbs are widely used in traditional folk medicine in most countries of the world, including Jordan, to treat many human diseases including microbial infections, diabetes and cancer. This study was conducted to evaluate the anti-cancer and antibacterial effects of essential oil (EO) of Varthemia Iphionoides, as well as the synergisti...
Article
Full-text available
Coved-19 pandemic is spreading fear among the world in several aspects such as health, economic, international relations, political stability, and social stability. It emerged suddenly and attacked the world in a short period without warning. Details about the virus such as the source, symptoms, transmission, diagnosis and treatment are still incom...
Article
Full-text available
Abstract: Brevibacterium spp.that was already isolated from wastewater treatment plant of Petra City, Jordan. While 1 and 2 mM of 3,4-dichloro benzoic acid (3,4-DCBA) were used, the biodegradation rate was 14.5 and 21.25 µM/h, respectively, and the remaining was 58% for both. The remaining ratio to the quantity of 3,4-DCBA used was taken in conside...
Preprint
Full-text available
Neopetrosia exigua has received great attention in natural product chemistry. The diversity of N. exigua constituents has been demonstrated by the continued discovery of novel bioactive metabolites such as antimicrobial metabolites. In this study, in order to localise the active component of N. exigua biomass according to the polarity, a sequential...
Article
Full-text available
Bacterium Aeromonas hydrophila (A. hydrophila) was isolated from the Petra Wastewater Treatment Plant effluent in southern Jordan. It was identified by using morphological and biochemical characteristics. A. hydrophila was found to be able of using chlorobenzoate compounds as carbon and energy source. These capabilities were with different biodegra...
Article
Full-text available
Brevibacterium spp.that was already isolated from wastewater treatment plant of Petra City, Jordan. While 1 and 2 mM of 3,4-dichloro benzoic acid (3,4-DCBA) were used, the biodegradation rate was 14.5 and 21.25 µM/h, respectively, and the remaining was 58% for both. The remaining ratio to the quantity of 3,4-DCBA used was taken in consideration, as...
Conference Paper
Full-text available
Centaurea damascena a member of Asteraceae family was investigated for its aerial part essential oil composition and antibacterial activities. A total of 35 Components were characterized with the presence of oxygenated terpenes that represents more than 86 % of the total essential oil components. The composition was dominated by 11.45 % fokienol, 8...
Conference Paper
Full-text available
The family Asteraceae include large number of Centaurea species which have been applied in folk medicine. One of the family Asteraceae members is the Centaurea damascena which authentically been tested for its antibacterial and antioxidant activity as well as its toxicity. The aims of the study were to determine the antimicrobial and antioxidant ac...
Conference Paper
Full-text available
Centaurea damascena a member of Asteraceae family was investigated for its aerial part essential oil composition and antibacterial activities. A total of 35 Components were characterized with the presence of oxygenated terpenes that represents more than 86 % of the total essential oil components. The composition was dominated by 11.45 % fokienol, 8...
Article
Full-text available
Purpose: To carry out eco-friendly biosynthesis of fungi-derived silver nanoparticles (AgNPs) and investigate their antibacterial synergies with essential oils (EOs) of Asteriscus graveolens (Forssk.) Less. and Cupressus sempervirens. Methods: Biosynthesis of AgNPs was carried out using a cell-free filtrate of Tritirachium oryzae. The biosynthesize...
Preprint
Full-text available
The main object of this investigation was to shed light on the information on the level of Cu uptake by Pseudomonas aeruginosa that has been previously isolated from patients using Gram-negative E. aerogenes ans a Gram-positive Bacillus thuringiensis as a control for Cu uptake measurements. Cu uptake data showed that maximum Cu uptake was obtained...
Article
Full-text available
The main object of this investigation was to shed light on the information on the level of Cu uptake by Pseudomonas aeruginosa that has been previously isolated from patients using Gram-negative E. aerogenes ans a Gram-positive Bacillus thuringiensis as a control for Cu uptake measurements. Cu uptake data showed that maximum Cu uptake was obtained...
Preprint
Full-text available
The family Asteraceae include large number of Centaurea species which have been applied in folk medicine. One of the family Asteraceae members is the Centaurea damascena which authentically been tested for its antibacterial activity. The aim of the study was to discuss antibacterial activities of essential oil composition and methanolic extract of...
Preprint
Antibactrial activity of Asteriscus graveolens methanolic extract and its synergy effect with fungal mediated silver nanoparticles (AgNPs) against some enteric bacterial human pathogen was conducted. Silver nanoparticles were synthesized by the fungal strain namely Tritirachium oryzae W5H as reported early. In this study, MICs of AgNPs against E. a...
Preprint
Full-text available
The family Asteraceae include large number of Centaurea species which have been applied in folk medicine. One of the family Asteraceae members is the Centaurea damascena which authentically been tested for its antibacterial and antioxidant activity as well as its toxicity. The aims of the study were to determine the antimicrobial and antioxidant ac...
Preprint
Full-text available
It is worth mentioning that the high output of different physiological responses under the expression of vgb, may have a considerable effect on the enzyme productivity, dairy industry, heavy metal uptake, biodegradation of different organic pollutants and other applications. The expression of bacterial haemoglobin is useful in lessening the load of...
Article
The family Asteraceae include large number of Centaurea species which have been applied in folk medicine. One of the family Asteraceae members is the Centaurea damascena which authentically been tested for its antibacterial activity. The aim of the study was to discuss antibacterial activities of essential oil composition and methanolic extract of...
Article
Antibactrial activity of Asteriscus graveolens methanolic extract and its synergy effect with fungal mediated silver nanoparticles (AgNPs) against some enteric bacterial human pathogen was conducted. Silver nanoparticles were synthesized by the fungal strain namely Tritirachium oryzae W5H as reported early. In this study, MICs of AgNPs against E. a...
Article
Full-text available
The family Asteraceae include large number of Centaurea species which have been applied in folk medicine. One of the family Asteraceae members is the Centaurea damascena which authentically been tested for its antibacterial and antioxidant activity as well as its toxicity. The aims of the study were to determine the antimicrobial and antioxidant ac...
Article
It is worth mentioning that the high output of different physiological responses under the expression of vgb, may have a considerable effect on the enzyme productivity, dairy industry, heavy metal uptake, biodegradation of different organic pollutants and other applications. The expression of bacterial haemoglobin is useful in lessening the load of...
Article
The family Asteraceae include large number of Centaurea species which have been applied in folk medicine. One of the family Asteraceae members is the Centaurea damascena which authentically been tested for its antibacterial and antioxidant activity as well as its toxicity. The aims of the study were to determine the antimicrobial and antioxidant ac...
Article
Description A major focus of nanotechnology concerns is the expansion of the optimization of nanomaterials in purity, size and dispersity. Method In the current work, a two-step AgNP synthesis process was optimized at the mycelia-DI water suspension and AgNP formation reaction levels. Results Biomass filtrate from the fungal strain Tritirachium o...
Article
The aims of this study are to synthesis silver nanoparticles (AgNPs) using the culture supernatant of the fungal strain Tritirachium oryzae W5H and to investigate the antibacterial activity of AgNPs individually and in combination with some antibiotics and essential oil of the plant Centaurea damascena. The colour of the filtrate with silver nitrat...
Article
Full-text available
Centaurea damascena a member of Asteraceae family was investigated for its aerial part essential oil composition and antibacterial activities. A total of 35 components were characterized with the presence of oxygenated terpenes that represents more than 86 % of the total essential oil components. The composition was dominated by 11.45 % fokienol, 8...
Article
Infections with Pseudomonas aeruginosa are difficult to treat not only because it is often associated with multidrug-resistant infections but also it is able to form biofilm. The aim of this study was to evaluate the antibiofilm and anti-Quorum Sensing (QS) activities of Thymbra capitata essential oils (EOs) against Beta Lactamase (BL) producing P....
Article
Full-text available
The substrate range of 2,4-dinitrotoluene (DNT) dioxygenase was investigated by measuring substrate-dependent O2 uptake and maximum growth (expressed in A600) on substrate-containing minimal medium. The control for each strain had no added particular substrate. The following aromatic compounds: catechol, α-naphthalene acetic acid, β-dimethylaminobe...
Article
The extracellular lipase produced by Acinetobacter sp. K5b4 was purified to homogeneity using ultrafiltration (cutoff 30 KDa) followed by gel filtration chromatography on Sephadex G-50. The enzyme was purified to homogeneity with an apparent molecular mass of 133 KDa by SDS-PAGE. This purification resulted on 10.24 fold with 18.3% recovery. The Km...
Article
Full-text available
p class="Abstract">The aim of this study was to evaluate the antibacterial activity of Origanum ramonense essential oil extracted from the air-dried leaves against β-lactamase and extended-spectrum β-lactamase obtained from the patients with urinary tract infection. The essential oil was extracted by hydrodistillation and analyzed by GC–MS. In vitr...
Article
Full-text available
World health organization reported cardiovascular disease as the first cause of mortality for five consecutive years of 2010-2014. Smoking is an exogenous source of metals contamination in the human body and attributed to 12% of all deaths among adults aged over 30 years. This is the first study carried out to elucidate the contribution of the pers...
Article
Full-text available
This study was conducted to assess the in vivo and ex vivo immunomodulatory effect of the ethanol leaves extract of Moringa peregrina in Balb/c mice. For this study, five groups of 5 Balb/c mice were given a single acute subtoxic oral dose of the ethanolic extract at 1.13, 11.30, 23.40 and 113.4 mg/kg and the immunomodulatory effect was assessed on...
Article
Full-text available
p class="Abstract">The marine sponge Neopetrosia contains about 27 species that is highly distributed in Indian Ocean, Atlantic Ocean (Caribbean Sea) and Pacific Ocean. It has proven to be valuable to the discovery of medicinal products due to the presence of various types of compounds with variable bio-activities. More than 85 compounds including...
Thesis
Full-text available
This study was designed to evaluate the antibacterial activity of Thymus capitatus and two of its major components namely thymol and carvacrol. The dried leaves were extracted using soxhlet apparatus. Thymol and carvacrol were isolated using normal phase column chromatography. The antibacterial activity of the leaves extract, thymol and carvacrol w...
Article
Full-text available
This study was designed to evaluate the antibacterial activity of Thymus capitatus and two of its major components namely thymol and carvacrol. The dried leaves were extracted using soxhlet apparatus. Thymol and carvacrol were isolated using normal phase column chromatography. The antibacterial activity of the leaves extract, thymol and carvacrol w...
Article
Full-text available
The antibacterial effect of Moringa peregrina (leaves, roots and seeds) ethanolic extracts were investigated. The effect of plant extracts were tested against three bacterial species: Escherichia coli (E. coli ATCC25922), Staphylococcus aureus (S. aureus ATCC 43300) and Klebsiella pneumoniae (K. pneumoniae ATCC 13883). M. peregrina ethanolic extrac...