Haiko Sprott- Prof. Dr. med.
- Professor at University of Zurich
Haiko Sprott
- Prof. Dr. med.
- Professor at University of Zurich
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183
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Introduction
Current institution
Additional affiliations
September 1989 - February 1999
January 2002 - present
March 1999 - February 2012
Education
September 1983 - August 1989
Publications
Publications (183)
The therapeutic response of patients with psoriatic arthritis (PsA) varies greatly and is often unsatisfactory. Accordingly, it is essential to individualise treatment selection to minimise long-term complications. This study aimed to identify factors that might predict treatment response to biological and targeted synthetic disease-modifying antir...
Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 million Dalton (Da), equivalent to roughly 20,000 d...
Background and objectives:
Chronic pain is frequently associated with depression and anxiety disorders. A relationship between affects and pain intensity in everyday life has been previously documented using Ecological momentary assessment technique (EMA) with a particular focus on the exacerbating effect of stress and depressive symptomatology on...
Background
Fibromyalgia (FM) is a very prevalent and debilitating chronic pain disorder that is difficult to treat. Mindfulness-based techniques are regarded as a very promising approach for the treatment of chronic pain and in particular FM. The Mindfulness-Oriented Recovery Enhancement (MORE) intervention, a mindfulness-based group intervention,...
Background: (FM). Fibromyalgia (FM) is a very prevalent and debilitating chronic pain disorder that is difficult to treat. Mindfulness-based techniques are regarded as a very promising approach for the treatment of chronic pain and in particular FM. The Mindfulness-Oriented Recovery Enhancement (MORE) intervention, a mindfulness-based group interve...
Background: Chronic pain is a complex, multidimensional experience. Spirituality is hypothesized to impact pain experience in various ways. Nevertheless, the role that spirituality plays in multimodal pain therapy remains controversial and, to date, quantitative data on whether and for which patients spiritual aspects should be considered in the tr...
Context
Valid instruments for assessing spiritual resources and distress in pain therapy are scarce. The Spiritual Distress and Resources Questionnaire (SDRQ) was developed to fill this gap.
Goals
The objective of this study was to investigate the SDRQ's psychometric properties.
Methods
We presented the SDRQ to 219 patients with chronic pain cond...
Background: (FM). Fibromyalgia (FM) is a very prevalent and debilitating chronic pain disorder that is difficult to treat. Mindfulness-based techniques are regarded as a very promising approach for the treatment of chronic pain and in particular FM. The Mindfulness-Oriented Recovery Enhancement (MORE) intervention, a mindfulness-based group interve...
![Significant interaction in the right putamen with lower [¹¹C]Raclopride...](publication/338136222/figure/fig1/AS:11431281472880037@1748533355221/Significant-interaction-in-the-right-putamen-with-lower-CRaclopride-binding-potential_Q320.jpg)
Background
Extensive literature has investigated the role of serotonin (5‐HT) in the control of the central dopamine (DA) systems, and their dysfunction in the pathological conditions. 5‐HT stimulates the local DA release in striatal regions via activation of various receptors including serotonin receptor‐3 (5‐HT3). Several studies have related pol...
This literature review deals with the question whether neck pain (NP) constitutes a symptom or a trigger of migraine. Firstly, a short survey about some techniques for measuring NP in association and relation with migraine is presented. Secondly, the arguments about NP as a symptom or a trigger of migraine are being reviewed and compared. The main...
Joint pain causes significant morbidity in osteoarthritis (OA). The aetiology of joint pain in OA is not well understood. The synovial membrane as an innervated joint structure represents a potential source of peripheral pain in OA. Here we analyse, using a hypothesis-free next generation RNA sequencing, the differences in protein-coding and non-co...
Einleitung: Die Beteiligung des Dopamin-Systems (DA) bei der Schmerzverarbeitung und bei Belohnungsprozessen wurde beschrieben. Das Fibromyalgie-Syndrom (FMS), welches durch Schmerzen in verschiedenen Körperarealen charakterisiert ist, kann mit depressiven Episoden assoziiert sein. Ein gestörter DA-Stoffwechsel und verminderte Reaktionen auf Belohn...
Der «Hexenschuss» (Lumbago) ist meist harmlos und löst sich selbst innerhalb von wenigen Stunden/Tagen. Akute Schmerzen sollten möglichst schnell terminiert werden, um Chronifizierung zu vermeiden. Weiterführende Diagnostik ist nur bei protrahiertem Verlauf oder häufigen Rezidiven notwendig.
Received: May 10, 2016
Accepted: January 08, 2017
Published online: May 11, 2017
Issue release date: May 2017
Hintergrund: Bis zu 80% der Patienten berichten von leichten bis starken Kopfschmerzen
nach erfolgter Kraniotomie. Bei einem Viertel der Patienten kommt es zur Chronifizierung
der Beschwerden. Kann trotz optimalen Therapiemethoden keine Schmerzlinderung
erzielt werden, gelten die Kopfschmerzen als therapierefraktär. Dies stellt für die
betroffene P...
Objectives:
Widespread sensory deficits resembling hemihypoaesthesia occur in 20-40% of chronic pain patients on the side of pain, independent of pain aetiology, and have been termed nondermatomal sensory deficits (NDSD). Sensory profiles have rarely been investigated in NDSD.
Methods:
Quantitative sensory testing (QST) according to the protocol...
Schmerzen erkennen, diagnostizieren und interpretieren sind unabdingbare Voraussetzungen für eine
potente Therapie. Die Art, die Form und die anatomische Korrespondenz des Schmerzes sowie der Schmerzentstehung, -modulation
und -fortleitung sind zur Erstellung des Behandlungskonzeptes zu beachten. In den meisten Fällen geht es bei chronischen
Schmer...
The effects of pulsed radiofrequency treatment in low back pain was evaluated in a Routine clinical setting and compared with thermal neurotomy of nerve structures of the facet joint. The treatment of 19 patients with lumbar facet joint pain was prospectively evaluated. Follow-ups were recorded at 6 weeks and 6 months after intervention. Patients w...
Dopamine D2/D3 receptor availability at rest and its association with individual pain perception was investigated using the [(11)C] raclopride PET-method in 24 female Fibromyalgia (FMS) participants with (FMS+, N=11) and without (FMS-, N=13) comorbid depression and in 17 healthy women. Thermal pain thresholds (TPT) and pain responses were assessed...
Objectives: Widespread sensory deficits occur in 20–40% of chronic pain patients on the side of
pain, independent of pain aetiology, and are known as nondermatomal sensory deficits (NDSDs).
NDSDs can occur in absence of central or peripheral nervous system lesions. We hypothesised that
NDSDs were associated with cerebral grey matter changes in the...
The application of pulsed radiofrequency to the lumbar sympathetic chain to relief sympatheti-cally maintained pain in the complex therapy of chronic regional pain syndrome (CRPS) is a promising treatment option. Although it is frequently used in clinical practice, there is almost no evidence available. The treatment of 15 patients with lower limb...
Unfassbare Präsentation einer real existierenden Heterogenität Fibromyalgie – wie erkennen, wie vorgehen? Gibt es sie oder gibt es sie nicht – die Fibromyalgie-PatientIn-nen? Und wenn es sie gibt – wie häufi g ist dieses Erkran-kungsbild? Heikle Fragen und kontroverse Antworten: Dieser Artikel möchte Ihnen einen Überblick geben, welche Relevanz die...
Sympathisch unterhaltener Schmerz muss diagnostiziert werden, da es von therapeutischer Wichtigkeit ist, diese Art der Schmerzunterhaltung im Gesamtkontext mitzubehandeln. Medikamentöse und nicht medikamentöse, lokale wie auch systemische Massnahmen und Verfahren stehen hierzu zur Verfügung. Wer Schmerzen behandeln will, muss sie zuerst verstehen.[...
Für die tägliche Praxis ist es relevant, zwischen Art, Form und anatomischer Korrespondenz des individuellen Schmerzes zu unterscheiden. Für den schmerzbehandelnden Spezialisten ist es von entscheidender Bedeutung, den Schmerzcharakter zu erkennen und die korrekte therapeutische Konsequenz daraus abzuleiten. Für den Kliniker ist es wichtig, eine pe...
Hatten Sie in den vergangenen 4 Wochen Rücken-schmerzen?» – Auf diese Frage antwortet jeder 10. Mensch in der Schweiz mit «Ja». In Europa leidet ungefähr jeder fünfte Mensch unter chronischen Schmerzen am Bewegungsapparat, die meisten von ihnen länger als zwei Jahre. Schmerzen gehören somit zu den häufigsten körperlichen Beschwerden in der Bevölker...
Ist Kopfweh Rheuma? Der sogenannte primäre Kopfschmerz nach der aktuellen Klassifikation 1 ist sicher kein "Rheuma". Wir sprechen von "rheumatisch bedingten Kopfschmerzen" am ehesten im Rahmen des sogenannten "sekundären Kopfschmerzes". Neben den osteologischen Entitäten unterscheidet der Rheumatologe im Wesentlichen entzündliche (autoim-mune und p...
ejd.2013.2136 Auteur(s) : Mosab Mohanna1 mohanna.mosabtariq@usz.ch, Oliver Distler2, Haiko Sprott2, Thomas Kundig1, Lars E. French1, Gunther Hofbauer1 1 Department of Dermatology, 2 Department of Rheumatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland Overlap syndrome comprises at least two connective tissue diseases. A...
Background:
Fibromyalgia syndrome (FMS) is frequently associated with psychiatric conditions, particularly anxiety. Deficits in contingency learning during fear conditioning have been hypothesized to increase anxiety and, consequently, pain sensation in susceptible individuals. The goal of this study was to examine the relationship between conting...
The treatment of chronic, non-malignant low-back pain is based on the patients' history and the clinical examination. It can be assumed that half of the cases present with a neuropathic pain component which needs to be treated with antidepressive and antiepileptic drugs instead of "pure" analgesics. Opioids should be considered with extreme caution...
The objective of this paper is to investigate whether there were differences in pain and psychological health status in chronic pain patients with and without migration background before and after an 8-week interdisciplinary outpatient pain programme (IOPP). One hundred eighteen consecutively assessed patients were included. Pain and psychological...
Brain-derived neurotrophic factor (BDNF), a neuromodulator involved in nociceptive hypersensitivity in the central nervous system, is also expressed in synoviocytes of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. We investigated the role of P2 purinoreceptors in the induction of BDNF expression in synovial fibroblasts (SF) of OA and...
cAMP-responsive element-binding protein (CREB) is not involved in the ATP-induced regulation of BDNF expression.
A. OASF were stimulated with ATP (100 µM) for 10 minutes, 2 h, 5 h and 24 h. Western blot analysis of p38 and p44/42 MAPK, phosphorylated p-p38 and p-p44/42 MAPK, as well as phosphorylated p-CREB showed kinase and CREB activation after 1...
Cyclooxygenase (COX) is not involved in the
ATP-induced regulation of BDNF expression. OASF (n = 6) were stimulated with the COX inhibitor sc-560 (100 nM) and ATP (100 µM) for 2 h. The ATP-mediated increase in BDNF expression was not changed by COX-inhibitor treatment. Data are shown as means ± standard deviations. N.s., not significant; *, p<0.05,...
Self-rated activity limitations in patients with non-specific chronic low back pain (cLBP) do not correlate well with performance in traditional tests of impairment (e.g. back strength, ROM, etc.). Tests using more "functional activities" have therefore been recommended as alternative "objective" outcome measures. We examined the relationship betwe...
Various studies have shown that spine stabilisation exercise therapy elicits improvements in symptoms/disability in patients with chronic non-specific low back pain (cLBP). However, few have corroborated the intended mechanism of action by examining whether clinical improvements (1) are greater in patients with functional deficits of the targeted m...
The Rheumatologic Interdisciplinary pain assessment (RIPA) was evaluated for the time period between February 2002 and December 2005 by Scascighini and Sprott in 2007. The objective behind this quality control (performed for the time period from January 2006 through June 2010) was to analyse differences between employed and unemployed patients. Pat...
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Percutaneous radiofrequency procedures are frequently used in the management of chronic pain. Continuous radiofrequency (CRF) has been established as a safe and effective treatment for pain originating from facet and sacroiliac joints through the coagula-tion of their nerve supply. Different methods have been proposed to account for the complex ner...
Zusammenfassung Sind Viren verantwortlich für den Schmerz bei Patienten mit Fibromyalgie? Sind Viren der Auslöser der rheumatoiden Arthritis?
Ist das „chronic fatigue syndrome“ eine Viruserkrankung? Viele offene Fragen – wenig oder kontroverse Antworten. Nach derzeitiger
Kenntnis über die Entstehung des Schmerzes bei der Fibromyalgie lösen sowohl p...
Background / Purpose:
The literature on the influence of migration on physical as well as psychological health and functioning are ambiguous. As part of the quality process and to optimise treatment modules, we looked at the available long-term data of patients with and without migration backgrounds who took part in an 8-week outpatient pain prog...
Are viruses responsible for the pain in patients with fibromyalgia? Are viruses the trigger for rheumatoid arthritis? Is chronic fatigue syndrome a viral disease? There are many open questions with few or controversial answers. According to the current state of knowledge on the origin of the pain in fibromyalgia the varied symptomatic of fibromyalg...
Short- and long-term effects of an interdisciplinary outpatient pain program (IOPP) in terms of quality of life, coping strategies, experiencing of pain and pain intensity as well as the influence of age, gender, or migration background.
Single, prospective cohort with assessments at baseline, posttreatment, and at 3, 6, 12 months follow-up.
A tota...
Spine stabilisation exercises, in which patients are taught to preferentially activate the transversus abdominus (TrA) during "abdominal hollowing" (AH), are a popular treatment for chronic low back pain (cLBP). The present study investigated whether performance during AH differed between cLBP patients and controls to an extent that would render it...
Percutaneous radiofrequency procedures are frequently used in the management of chronic pain. Continuous radiofrequency (CRF) has been established as a safe and effective treatment for pain originating from facet and sacroiliac joints through the coagula-tion of their nerve supply. Different methods have been proposed to account for the complex ner...
Objective
Pain is a complex experience that normally signals actual or potential tissue damage. Anticipatory anxiety to an unpredictable danger increases pain intensity and unpleasantness in healthy subjects. This study addressed the impact of anticipatory anxiety on pain perception in patients with chronic pain conditions for the first time.
Meth...
In some chronic conditions, patient-specific tools with individualized items have proved to be more sensitive outcome instruments than fixed-item tools; their use has not yet been investigated in chronic low back pain (cLBP).
Eleven males and 21 females [mean age 44.0 (12.3) years] with cLBP, undergoing a spine-stabilization physiotherapy programme...
In addition to general health and pain, sleep is highly relevant to judging the well-being of an individual. Of these three important outcome variables, however, sleep is neglected in most outcome studies.Sleep is a very important resource for recovery from daily stresses and strains, and any alteration of sleep will likely affect mental and physic...
Cross-sectional study.
Comparison of the timing of onset of lateral abdominal muscle activity during rapid arm movements in patients with nonspecific chronic low back pain (cLBP) and back-pain-free controls.
Rapid movements of the arm are normally associated with prior activation of trunk-stabilizing muscles in readiness for the impending postural...
Extraartikuläre oder weichteilrheumatische Erkrankungen umfassen ca. ein Viertel aller Erkrankungen des rheumatischen Formenkreises. Dazu gehören generalisierte Phänomene (wie z.B. Fibromyalgie) sowie lokalisierte Schmerzmechanismen im Bereich der Wirbelsäule und der Gelenke. Erkrankungen des subcutanen Binde- und Fettgewebes gehören genauso zu die...
Catastrophizing plays an important role in models of pain chronicity, showing a consistent correlation with both pain intensity and disability. It is conceivable that these associations are mediated or confounded by other psychological attributes.
To examine the relative influence of catastrophizing and other psychological variables on pain and dis...
Exercise rehabilitation is one of the few evidence-based treatments for chronic non-specific low back pain (cLBP), but individual success is notoriously variable and may depend on the patient's adherence to the prescribed exercise regime. This prospective study examined factors associated with adherence and the relationship between adherence and ou...
Assessment of hand strength is used in a wide range of clinical settings especially during treatment of diseases affecting the function of the hand. This investigation aimed to determine age- and gender-specific reference values for grip and pinch strength in a normal Swiss population with special regard to old and very old subjects as well as to d...
Joint pain is one of the most common forms of pain and is experienced by almost a third of the population at some time. To date, it has not been possible to treat joint pain effectively and side effects of commonly prescribed drugs are often hazardous. Therefore, improvements in our understanding of causes and mechanisms associated with joint pain...
Gelenkschmerz ist eine der am häufigsten auftretenden Schmerzformen. Etwa ein Drittel der Bevölkerung hat bereits einmal Gelenkschmerz erfahren. Bis heute ist diese Schmerzform nicht effektiv behandelbar, und Nebenwirkungen der verwendeten Medikamente sind häufig gefährlich. Es ist deshalb sehr wichtig, unser Verständnis über die Ursachen und die M...
The symmetry of, and physical characteristics influencing, the thickness of the lateral abdominal muscles at rest and during abdominal exercises were examined in 57 healthy subjects (20 men, 37 women; aged 22-62 years). M-mode ultrasound images were recorded from the abdominal muscles at rest and during abdominal hollowing exercises in hook-lying....
The aim of the present study was to examine the in-depth application of the Short-Form-(SF)-36 Health Survey to score the general well-being in fibromyalgia syndrome (FS) patients. Quality of life was evaluated in 12 patients with FS. With respect to mental well-being (social functioning, role limitation due to emotional health problems, and mental...
The endogenous pain-relieving system depends in part on the regulation of nociceptive signals through binding of opioids to the corresponding opioid receptor. Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might...
In patients with chronic pain, catastrophizing is a significant determinant of self-rated pain intensity and disability. The Pain Catastrophizing Scale (PCS) was developed to assist with both treatment planning and outcome assessment; to date, no German version has been validated.
A cross-cultural adaptation of the PCS into German was carried out,...
To provide an overview of the effectiveness of multidisciplinary treatments of chronic pain and investigate about their differential effects on outcome in various pain conditions and of different multidisciplinary treatments, settings or durations.
In this article, the authors performed a systematic review of all currently available randomized cont...
Spine stabilization exercises, in which patients are taught to perform isolated contractions of the transverses abdominus (TrA) during "abdominal hollowing", are a popular physiotherapeutic treatment for low back pain (LBP). Successful performance is typically judged by the relative increase in TrA thickness compared with that of the internal (OI)...
Rapid arm movements elicit anticipatory activation of the deep-lying abdominal muscles; this appears modified in back pain, but the invasive technique used for its assessment [fine-wire electromyography (EMG)] has precluded its widespread investigation. We examined whether tissue-velocity changes recorded with ultrasound (M-mode) tissue Doppler ima...
Chronic pain is widely regarded as a condition that is triggered by various factors, including physical, socio-cultural and psychological deficiencies (that is, maladaptive beliefs). These factors are important in the development and maintenance of this unpleasant experience, which consequently requires a biopsychosocial treatment approach. Pain is...
INTRODUCTION: The endogenous pain-relieving system depends in part on the regulation of nociceptive signals through binding of opioids to the corresponding opioid receptor. Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pd...
Altered concentrations of circulating serotonin have been implicated in several pathological conditions such as fibromyalgia,1–4 rheumatoid arthritis2,4,5 and major depression.6 In fibromyalgia in particular, several investigators have reported low serum serotonin levels as compared to the general population.1,3
We analysed sera from 20 patients w...
The transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel, which is mainly expressed by nociceptive neurons in dorsal root and trigeminal ganglia. However, there is increasing evidence that TRPV1 expression is not limited to primary afferent neurons but that the receptor is expressed in various cell types throughout the...
The aim of this quality assessment was to evaluate the specific satisfaction issues of the referring physician and of the patient after the rheumatological interdisciplinary pain assessment (RIPA). The prevalence of chronic pain disorders appear to grow worldwide. In the daily routine we are confronted with the problem, that the waiting list for su...
Das Ziel dieser Qualitätssicherungskontrolle bestand darin, die Zuweiser- und Patientenzufriedenheit nach der Rheumatologischen Interdisziplinären Schmerz-Sprechstunde (RISS) zu evaluieren. Die Prävalenz an chronischen, muskuloskelettalen Beschwerden ist weltweit zunehmend. Im klinischen Alltag stellen wir fest, dass die Wartezeiten für diagnostisc...
