Haider Faisal Ghazi

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Verified

Haider verified their affiliation via an institutional email.

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• Ph.D. Immunology
• Professor at Nahrain University

Objectives: To evaluate the ratio of interleukin18 and interleukin18 binding protein in type 2 diabetes mellitus patients, and its relation with the presence of interleukin18-607C/A and interleukin18-137G/C gene polymorphisms and the type of complications. Method: The case-control study at the endocrinology clinic of the Madinat Al-Imamin Al-Kazemi...

Pregnancy and delivery are physiological conditions that are marked by abrupt alterations to hormones, immunological and molecular characters. The current study aimed to evaluate oxytocin (OT), prolactin (PRL), cortisol and insulin growth factor-2 (IGF-2) levels as physiological biomarkers; programmed cell death protein-1 (PD-1), programmed cell de...

Background: The antibody that crosses transplacentally from mother to fetus is very important origin of protective passive immunity against infection neonatal with enterovirus. Important varieties of coxsackievirus B3 (CVB3) are responsible for infections in newborns. The purpose from this study is to investigate in the prevalence of Coxsackie B v...

A pregnant woman under normal circumstances tends to give birth normally, but when a defect occurs in the physiological, immunological and even genetic factors, this may lead to dystocia labor and consequently undergo to caesarean section (CS) delivery. Thus, the present study is set to evaluate some physiological, immunological and genetic biomark...

Pregnancy and childbirth are physiological states characterized by sudden hormonal and immunologically described changes. The current study aimed to investigate the influence of maternal variables (age, previous abortion, placental position, and fetal position) on some physiological biomarkers, such as oxytocin (OT), prolactin (PRL), cortisol, and...

Background: This study proposes that the glial scar adjacent to the penetrating brain injuries is active in stabilizing the surrounding uninjured tissue by limiting the inflammatory response to the injury site. The study showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-known anti-inflammatory molecule, is present within the...

The aim: Determine the frequency of anti-viral capsid antigen IgM, IgG and IgA in in ammatory bowel disease. Materials and methods: Case controlled study conducted during involved 60 Crohn’s disease, 60 ulcerative colitis and 60 subjects as a control group with negative gastroin- testinal symptoms. Diagnosis and disease classi cation were establish...

Objective: The aim: To identify the relation between EBV infection/reactivation and multiple sclerosis, compared to the normal controls. Patients and methods: Materials and methods: A case-control study conducted in 120 MS patients, aged between 12-42 years, and 120 apparently healthy age- and sex-matched volunteers as controls. Viral DNA was ex...

Cigarette smoking is a lifestyle behavior that causes significant adverse health effects. Cigarette smoke contains chemicals, many of which are lead to the production of reactive oxygen species (ROS), which can lead to apoptosis and autophagy. To estimate the association of Cigarette smoking with the autophagy and immunity, technology of real time...

To determine the association between cigarette smoking and oxidative stress, a study was conducted in the period from The Enzyme-linked immunosorbent assay (ELISA) technique was utilized for measurement the antioxidant enzymes including: Glutathione superoxide (GPX) and catalase (CAT) and the biomarker of lipid peroxidation Malondialdehyde (MDA). A...

In recent years increasing evidence proposed that local immune cells at implantation site have largely contributed to embryo implantation. The intrauterine infusion of activated peripheral blood mononuclear cells culture 2 days before embryo transfer can enhance the implantation. One of the methods used to evaluate the endometrial receptivity is by...

In recent years increasing evidence proposed that local immune cells at implantation site have largely contributed to embryo implantation. The intrauterine infusion of activated peripheral blood mononuclear cells culture 2 days before embryo transfer can enhance the implantation. One of the methods used to evaluate the endometrial receptivity is by...

Background: Epilepsy is a common disorder of brain that is not well controlled via drugs available for it. Gephyrin, a well-known inhibitory synaptic regulator, has a role in epilepsy. Additionally, significant development of oxidative stresses tends to be involved in epileptic seizure pathophysiology that giving rise to neuronal cell death. Zizyph...

Background: The programmed death-1(PD-1) and its ligand (PD-L1), negative regulatory molecule, have an important role in immunoregulatory and critical to terminating immune response and have role in maintaining a normal pregnancy. Aim: The aim of this study was to reveal the expression patterns of PD-1 and PDL-1 placenta tissue. Methods: A total of...

Objectives Inhaled corticosteroids are the most effective controllers of asthma, although asthmatics vary in their response. FKBP51 is a major component of the glucocorticoid receptor which regulates its responses to corticosteroids. Therefore, the present study aims to identify the role of FKBP5 gene polymorphism in asthma susceptibility and corti...

Human peptidoglycan recognition protein-1 (PGLYRP‐1) protein molecule activation in the semen of infertile patients has been suggested to induce a negative impact on seminal fluid analysis. 176 infertile patients included in this study were tested for seminal fluid analysis, Endtz test, and PGLYRP‐1 in seminal plasma using enzyme-linked immunosorbe...

Background: T-helper 17 plays a novel role in inflammation in gastritis by producing IL-17A, IL-17A gene polymorphisms that might be responsible for disease susceptibility and development of different gastric lesions. Objective: The aims of study was to determine the association of IL-17A (G197A) genotype and allele frequency with disease phenot...

Epilepsy is a common brain disorder that is not quite controlled via available antiepileptic drugs. It is distinguished by imbalance between excitatory neurotransmitters and that of inhibitory. Inflammatory events seem to be involved in pathophysiology of epileptic seizures and giving rise to neuronal cell death. Moreover, Ziziphus spina christi, i...

and objective: Tumor Necrosis Factor-Alpha-308 gene Polymorphism have been related to different disease conditions due to increased TNF-. However, its relation with Seminal fluid analysis is not studied in Iraq. Objective: this study aimed to investigate the association of TNF--308 gene Polymorphism and TNF- seminal plasma concentration with of...

Background: Epilepsy is a common brain disorder that is not quite controlled via available antiepileptic drugs. Gephyrin is a scaffolding protein that interacts particularly with GABAA receptor subunits and has a role in epilepsy. Further, the production of massive reactive oxygen species seems to involve in the pathophysiology of epileptic seizure...

Blastomycosis is a rare but important fungal infection cause by dimorphic fungus Blastomyces dermatitidis.Pneumonia is the most common manifestation and the lung is almost always the organ initially infected. The performance of blastomycosis diagnosis using microscopic examination and culture are highly dependent on the quality of the clinical spec...

Inhaled corticosteroids are the most effective controllers of asthma. Asthmatics, however, vary in their response to inhaled corticosteroid. FKBP51 is a major component of the Glucocorticoid receptor which regulates its sensitivity to corticosteroid. No previous study assesses the relationship of FKBP5 polymorphism with corticosteroid resistance in...

Asthma is a chronic inflammatory disease affecting 5% of the world population. Characterized by eosinophilic type2 inflammation. FKBP51 immunophilin, the important modular protein of glucocorticoid receptor (GR). We aimed to evaluate immunocytochemical localization of GR and FKBP51 in induced sputum cells by using immunocytochemical method and immu...

The cellular immune response and apoptotic pathways are closely related dose dependent responses against Echinococcus granulosus antigens. The aim of this study is to evaluate the cellular expression of Bax, Bcl-2 and Caspase-3 in both liver and spleen of experimentally cystic echinococcosis mice treated with Oxfendazole, Oxfendazole +Praziquantel,...

ABSTRACT— Corresponding Author: 2* Inflammasome activation cytokine were associated with bad seminal fluid analysis parameters among infertile men with spinal cord injury suggesting pivotal role of NLRP3 pathway in male infertility. Objective: the present study aims to measurement of NLRP3 inflammasome mRNA expression and their activation cytokines...

Inflammasome activation cytokine were associated with bad seminal fluid analysis parameters among infertile men with spinal cord injury suggesting pivotal role of NLRP3 pathway in male infertility. Objective: the present study aims to measurement of NLRP3 inflammasome mRNA expression and their activation cytokines (IL-1ß and IL-18) mRNA expression...

Background: Measles is a highly contagious viral disease. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine. Measles transmitted via droplets from the nose, mouth or throat of infected persons. Objective: To evaluate the immune response to measles infection among immunized...

Background: Cancer of the urinary bladder is the second most common genitourinary cancer, multiple carcinogenic factors have been attributed including viral infections, a high percentage of human polyomaviruses were found in bladder cancer tissues which might play a role in the process of carcinogenesis.

Background and objective: Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) plays a pivotal role in initiation of inflammation. genetic variation in NLRP3 gene have been proposed to predispose several inflammatory diseases. This study aimed to evaluate the risk of NLRP3 (exon 3) gene polymorphisms and its...

Background: The infection by hepatitis C virus causedliver diseases such as:chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The current study aims to investigate the rate of HCV genotypes, subtypes, viral load and antibody immune response among Iraqi chronic hepatitis patients. Methodology: During 2012-2017 period seventy-hundred a...

Background John Cunningham virus (JCV) is one of the highly sero-prevalent viruses worldwide, and after primary infection it remains latent and then reactivates in immunocompromised patients, high JCV viruria seen in renal transplant recipients (RTR), some of them progress to polyomavirus associated nephropathy (PVAN). The objectives of this study...

Background: Recurrent pregnancy loss (RPL) has been found to be associated with increase in the pro-inflammatory cytokines which cause up-regulation of inflammatory mediators including cell adhesion molecules (CAMs) that might act in aggravation of this pathological process. Objective: To find out whether there is a relation between the pathology o...

Toll like recptor-4 protein level increased due to cellular activation during inflammatory process. This study aimed to measurement of seminal plasma TLR-4 in association with seminal fluid analysis parameters. A total of 170 semen samples were collected from infertile men attending High Institute of Infertility Diagnosis and Assisted Reproductive...

Asthma is a chronic airway inflammatory disease thought to be initiated by interaction between genetic and environmental factors, these factors can increase severity and exacerbation symptoms. The current study was carried out on 60 Iraqi asthmatic patients who referred to Al-Immammian Al-Kadhmian Teaching Hospital respiratory outpatient clinic. Sp...

Asthma is a chronic inflammatory disease affecting 5% of the world population. FKBP51 is an important immunophilin modular protein of the glucocorticoid receptor (GC). The aim of the present study was to evaluate the levels and immunocytochemical distribution of FKBP51 and GR in lymphocyte cells of asthmatic patients, by use of immunocytochemistry...

Human Adenovirus (ADV) is one of highly prevalent viruses worldwide, after primary infection, it remains latent and then might reactivate in immunocompromised patients. High ADV viremia seen in renal transplant recipients (RTR) with clinical presentations range from asymptomatic viremia to respiratory and gastrointestinal disease hemorrhagic cystit...

Aim: Inflammasome pathway has been linked in the pathogenesis of multiple sclerosis (MS) disease and its expression may be linked to the response to treatment. This study aims to evaluate inflammasome protein and mRNA expression and activating cytokines (interleukin [IL] 1B and IL18) in MS patients undergoing the first line and second line of treat...

The complex interplay between H. pylori and autophagy was elucidated in gastritis in term of host defense and survival of microbe. However, H. pylori frequently succeed in their survival and develops more aggressive tissue damage by different ways. A total of 80 gastritis patients undergoing gastroscopy during September, 2013 to August, 2014. Forma...

Methicillin resistant Staphylococcus aureus (MRSA) detection is a challenge to any clinical microbiology laboratory and demands implementation of strict protocols for active screening. This study aims to determine the validity of rapid immunochromotographic (ICT) test for detection compared with the gold standard method. Duplicate swabs were collec...

Epilepsy is a standout amongst the most widely recognized genuine mind issue. Study was performed to investigate the conceivable antiepileptic impact of Ivabradine against pilocarpine incited seizure in male rats. Four gatherings were utilized as a part of this examination. Rats of each gathering (aside from typical gathering) were infused intraper...

Epilepsy is a standout amongst the most well-known genuine cerebrum issue, can happen at all ages. The examination was performed to investigate the conceivable antiepileptic impact of Felodipine against pilocarpine prompted seizure in male rats. The investigation did on forty male Wister rats similarly assigned to four gathering: (1) typical gather...

Uropathogenic Escherichia coli (UPEC) is the major cause of urinary tract infection (UTI), establish quiescent intracellular bacterial reservoirs (QIRs). These latent reservoirs, which persist indefinitely, are resistance to antibiotic therapies and can induce recurrence. Autophagy related 16 like 1 gene (ATG16L1) Thr300Ala genetic variant confer a...

Currently, the evaluation and treatment of chronic inflammatory diseases relies on specific clinical signs accompanied with single or multiple marker(s) for that disease. Despite that, these diseases share a common innate immune mechanism involved upregulation of "Inflammasome" that have been proved in its implication in the pathologic mechanism (s...

Background:inflammasome protein govern the inflammatory process. The ele- vation of NLRP3 inflammasome might be related to bad seminal fluid analysis results. Objectives:This study aimed to evaluate seminal plasma NLRP3 protein and its relation with seminal fluid analysis parameters before and after in vitro sperm activation. Patients and Methods:...

Tonsillopharyngitis among children considered as a major public health problem in the community, because of post-streptococcal complications, cost, time consuming diagnostic tests and un- necessary antibiotics. To determine the validity of Rapid Antigen Detection Test (RADT) in the diagnosis of streptococcal tonsillopharyngitis in comparison with c...

Background Epstein-Barr virus (EBV) is one of the most common latent viruses inside the humans' B

Background: In normal pregnancy around 30% of stromal cells in decidualised endometrium are leucocytes, lymphocyte subtypes may play a role in the pathogenesis of molar pregnancies. The aim of the study is to investigate the pattern of infiltrating lymphocytes in paraffin embedded tissue sections obtained from molar pregnancies. Material and Method...

Background/aim: Diagnosis of Hirschsprung's disease (HD) can be hard and requires good experience, principally for pathologists who infrequently encounter the disease. However, diagnosis is not always possible with hematoxylin and eosin (H and E) because staining has limitations in the identification of immature ganglion cells in neonates and the...

BACKGROUND: Abnormal lymphocyte activation status have been described in rheumatoid arthritis. Suggesting an increased need for iron as a source of energy. OBJECTIVE: To evaluate the cellularexpression pattern ofTransferrin receptor(CD71)proteinin the peripheral blood lymphocytes, PATIENTS &METHODS: This study involved forty-six rheumatoid arthriti...

We have evaluated IL-2; IL-10 and IFN-ɣ protein expression in both liver and spleen of BALB/c mice experimentally induced secondary hydatidosis and treated with different drugs. Following Intraperitonial inoculation of Echinococcus granulosus-protoscolices, following the infection, mice were treated for 6 months with different drugs. The sera of th...

Helicobacter pylori persistence may develop atrophic gastritis, gastric ulcer or cancer. To determine the association between the presence of autophagy related gene 16 like 1 and thrionin 300 alanine mutation and H. pylori infection among atrophic gastritis patients. Gastric biopsy was taken from eighty patients and tested for urease, and blood sam...

Background: Peripheral blood lymphocytes (PBL)of Rheumatoid arthritis (RA)patients have a property of phenotypic and functional activation. Glutathione S- transferase pi (GSTπ) has been implicated in playing an important role in the initiation and progression of cellular activation. Objectives: To determine the percentage of cellular expression of...

Background: Peripheral blood lymphocytes (PBL)of Rheumatoid arthritis (RA)patients have a property of phenotypic and functional activation. Glutathione S-transferase pi (GSTπ) has been implicated in playing an important role in the initiation and progression of cellular activation. Objectives: To determine the percentage of cellular expression of G...

Background: Rheumatoid arthritis is a chronic inflammatory disease of the synovium with uncertain pathogenesis. A number of phenotypic and functional T-cell defects have been described in rheumatoid arthritis. Objective: To evaluate the cellular expression L-selectin (CD62-L) protein in the peripheral blood lymphocytes, L-selectin cellular expressi...

Glioma is one of the most aggressive and most common tumors of the central nervous system (CNS) in humans. The exact causes of glioma are not well known, but evidence suggests the involvement of genetic factors in addition to environmental risk factors. The present study aimed to determine whether polymorphisms in IL-10-1082A/G, IL-12p40 1188C/A, a...

In Crohn’s disease, the interaction between ATG16L1 genetic variant and Murine Norovirus infection has been proposed. This study aims to estimate the association of Human Norovirus infection with ATG16L1 genetic variant among inflammatory bowel disease patients. This Case- control study involves 35 Crohn’s disease (CD) and 40 ulcerative colitis (UC...

Autophagy related 16 like 1 gene (ATG16L1) Thr300Ala genetic variant confer an increased risk for the development of Crohn s disease. According to Montreal disease classification, this study aims to determine the clinical significance of ATG16L1 T300A genetic variant among those patients. This case control study involved 35 CD, 40 UC and 35 HC. Aft...

Background: Hodgkin's lymphoma (HL) and Non-Hodgkin's lymphoma(NHL) are characterized by a profound disturbance of the cell cycle and apoptosis regulation., Ki-67 and P53 expression has been shown to be associated with adverse clinical outcome in a variety of malignant hematological disorders, including HL and NHL. Aim: This study aimed to clarify...

Background: there are different procedures for the diagnosis of females suspected with toxoplasmosis. However, time, cost, and accuracy of the test should meet patient’s needs.Material and methods: one hundred and eleven female with suspected toxoplasmosis were under go three different procedures for the diagnosis of Toxoplasma gondii infection. La...

Background: there are different procedures for the diagnosis of females suspected with toxoplasmosis. However, time, cost, and accuracy of the test should meet patient’s needs. Material and methods: one hundred and eleven female with suspected toxoplasmosis were under go three different procedures for the diagnosis of Toxoplasma gondii infection. L...