Hai-Feng Pan

Hai-Feng Pan
Anhui Medical University | AHMU · Department of Epidemiology and Biostatistics

M.D

About

509
Publications
34,900
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11,978
Citations
Introduction
Skills and Expertise
Additional affiliations
January 2010 - present
The University of Hong Kong
January 2009 - present
Southern Medical University
January 2008 - December 2012
Anhui Medical University

Publications

Publications (509)
Article
Full-text available
Background Traffic-related air pollution especially in highly socioeconomically developed megacity is usually considered as a severe problem leading to inevitable adverse health outcomes. This study aimed to investigate the associations between traffic-related air pollutants with risk of dry eye disease (DED) outpatient visits in a megacity (Guangz...
Article
Backgrounds Previous studies have suggested the potential links between dioxins or dioxin-like polychlorinated biphenyls (DL-PCBs) and obesity. However, the combined effects of dioxins and DL-PCBs on obesity are still unclear. Methods Nine kinds of dioxins and DL-PCBs were measured among 852 adults using the National Health and Nutrition Examinati...
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To examine the effectiveness and safety of two different B cell activating factor/proliferation-inducing ligand inhibitors, telitacicept and belimumab, in treating patients with active systemic lupus erythematosus (SLE). Patients with active SLE who received belimumab (n = 100) or telitacicept (n = 101) from 2019 to 2023 at multiple centers in Chin...
Article
Background Although earlier observational studies have revealed a connection between human papillomavirus (HPV) infection and several autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), the exact causative mechanism underlying this association is still unknown. Methods This two‐sample bidirectional MR stu...
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There is limited evidence regarding the effects of long‐term exposure to PM2.5 constituents on the risk of arthritis and rheumatoid arthritis, and the interaction between PM2.5 and green space remains unclear. This study examined the relationship between long‐term exposure to PM2.5 constituents and the risk of arthritis and rheumatoid arthritis, wi...
Article
Importance Environmental heat and cold exposure (EHCE) remains the principal preventable cause of morbidity and mortality in children and adolescents globally. Objective To report EHCE-related burden and analyze its temporal trends among children and adolescents from 1990 to 2019. Design, Setting, and Participants This repeated cross-sectional st...
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To evaluate the associations between biological aging, metabolic heterogeneity of obesity, and rheumatoid arthritis (RA). This prospective cohort study analyzed 268,184 individuals from the UK Biobank. Biological age was estimated using phenotypic age (PhenoAge), Klemera-Doubal methods (KDM-BA), and telomere length. We calculated KDM-BA acceleratio...
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Background Sleep and physical activity (PA) are thought to be interconnected with the development of rheumatoid arthritis (RA). However, the precise nature and extent of these relationships have yet to be fully quantified. This study aimed to quantify the longitudinal effects of sleep behaviors, PA, and genetic susceptibility on the incidence of RA...
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Objective The purpose of this study was to assess the diagnostic performance of narrow‐band imaging (NBI) in monitoring patients with head and neck carcinomas posttreatment and to compare it with that of white light endoscopy (WLE). Data Sources PubMed, Embase, Web of Science (WOS), Cochrane Library, China Biology Medicine disc (CBM disc), China N...
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Objectives Emerging research has investigated the potential impact of several modifiable risk factors on the risks of rheumatoid arthritis (RA), but the findings did not yield consistent results. This study aimed to comprehensively explore the genetic causality between modifiable risk factors and the susceptibility of RA risk using the Mendelian ra...
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The study aimed to investigate the pattern and trend of Musculoskeletal (MSK) disorders in people aged 5–19 years from 1990 to 2021. The data was sourced from the Global Burden of Disease study 2021. The Age-standardized DALYs rates (ASDR), age-standardized mortality rate (ASMR), age-standardized prevalence rate (ASPR), and age-standardized inciden...
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Aim To elucidate the effects of sleep parameters and renal function on the risk of developing new‐onset severe metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials and Methods The primary analysis involved a cohort of 305 257 participants. Multivariable Cox models were employed to calculate hazard ratios and 95% confidence i...
Article
Objective To investigate the age‐standardized prevalence rate (ASPR) and temporal trends for hip, knee, hand, and other osteoarthritis (OA) at a global, continental, and national level. Design The estimates and 95% uncertainty intervals (UIs) for case number and ASPR of OA were derived from the Global Burden of Diseases Study (GBD) 2019. The joinp...
Article
Introduction: Systemic Lupus Erythematosus (SLE) is a multi-dimensional autoimmune disease involving numerous tissues throughout the body. The chromatin accessibility landscapes in immune cells play a pivotal role in governing their activation, function, and differentiation. Aberrant modulation of chromatin accessibility in immune cells is intimat...
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Backgrounds A growing body of evidence has highlighted the interactions of lipids metabolism and immune regulation. Nevertheless, there is still a lack of evidence regarding the causality between lipids and autoimmune diseases (ADs), as well as their possibility as drug targets for ADs. Objectives This study was conducted to comprehensively unders...
Article
Backgroud Endoscopic thyroidectomy (ET) and robotic thyroidectomy (RT) yield similar perioperative outcomes. This study investigated how the learning curve (LC) affects perioperative outcomes between ET and RT, identifying factors that influence the LC. Materials and Methods Two researchers individually searched PubMed, EMBASE, Web of Science, and...
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Air pollution can cause disease and has become a major global environmental problem. It is currently believed that air pollution may be related to the progression of SSNHL. As a rapidly developing city in recent years, Hefei has serious air pollution. In order to explore the correlation between meteorological variables and SSNHL admissions, we cond...
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Background Cytokines act a vital role in autoimmune neuroinflammatory diseases (ANDs) with undetermined causal relationships. Mendelian randomization (MR) analysis was performed to estimate the causal effects of circulating levels of cytokines on the risk of ANDs. Methods The causal relationship between 34 circulating cytokines and 4 kinds of ANDs...
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To carry out an in-depth analysis of the scientific research on autoimmunity, we performed the first bibliometric analysis focusing on publications in journals dedicated to autoimmunity (JDTA) indexed by science citation index during the period 2004–2023. Using bibliometric analysis, we quantitatively and qualitatively analyzed the country, institu...
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Introduction Air pollution is speculated to increase the risk of Coronavirus disease-2019 (COVID-19). Nevertheless, the results remain inconsistent and inconclusive. This study aimed to explore the association between ambient air pollution (AAP) and COVID-19 risks using a meta-analysis with meta-regression modelling. Methods The inclusion criteria...
Article
MicroRNAs (miRNAs) are non-coding RNA molecules that bind to mRNAs to regulate gene expression. Since changes in miRNA expression levels have been found in a variety of autoimmune illnesses, miRNAs are important in autoimmune diseases. MiRNAs serve not only as pathogenic factors and biomarkers for autoimmune diseases but also as important targets f...
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Background Fatigue is a relatively prevalent condition among hemodialysis patients, resulting in diminished health-related quality of life and decreased survival rates. The purpose of this study was to investigate the relationship between fatigue and body composition in hemodialysis patients. Methods This cross-sectional study included 92 patients...
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Progranulin (PGRN), a multifunctional growth factor-like protein expressed by a variety of cell types, serves an important function in the physiologic and pathologic processes of fibrotic diseases, including wound healing and the inflammatory response. PGRN was discovered to inhibit pro-inflammation effect by competing with tumor necrosis factor-al...
Preprint
Background: No studies have deeply examined the transmission patterns of H1N1pdm09 in Anhui Province, China. Methods: We conducted a genome-wide analysis of 162 historical epidemic strains in Anhui Province, China to understand the transmission patterns, incoming and outgoing events, and evolutionary dynamics of the strains. Results: Our study show...
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Background and Aims The Oxidative Balance Score (OBS) emerges as a novel index for assessing the state of oxidative stress. Previous studies have reported the possible links between oxidative stress and the development of non-alcoholic fatty liver disease (NAFLD), but the relationship between OBS and NAFLD remains unclear. Methods Data from the Na...
Preprint
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Background There is an explicit link between biological age (BA) and chronic liver disease (CLD). This study aimed to explore the association between clinical biomarker-based BA and potential interaction with genetic risk on incident CLD. Methods This prospectively cohort study was conducted in UK Biobank included 347,917 participants. We quantifi...
Article
Context Previous observational studies have indicated a bidirectional association between metabolic syndrome (MetS) and osteoarthritis (OA). However, it remains unclear whether these bidirectional associations reflect causal relationships or shared genetic factors, and the underlying biological mechanisms of this association are not fully understoo...
Preprint
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Purpose Previous studies have suggested that patients with IgA nephropathy (IgAN) was associated with an increased risk of coronavirus disease 2019 (COVID-19) infection. However, the findings were inconsistent, and whether there was a causality between IgAN and COVID-19 infection remains unknown. This study was performed to estimate the casual effe...
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Background and aims The older people bears a severe burden of disease due to frailty and depressive symptoms, however, the results of association between the two in the older Chinese people have been conflicting. Therefore, this study aimed to investigate the developmental trajectories and interactions of frailty and depressive symptoms in the Chin...
Preprint
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Background Emerging research indicates a potential correlation between frailty, healthy diet and IBD because of overlapping mechanisms. To evaluate the individual and joint effects of frailty and healthy diet on the risk of IBD. Methods Data on frailty and diet were collected from a prospective cohort of 338,716 UK Biobank participants. Cox propor...
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Background Short-term exposure to air pollution may trigger symptoms of drug-resistant tuberculosis (DR-TB) through stimulating lung tissue, damaging tracheobronchial mucosa, the key anti-mycobacterium T cell immune function, and production and release of inflammatory cytokines. Objective To investigate the association between acute exacerbations...
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Objective This study aimed to examine rheumatoid arthritis (RA) risk associated with hormonal and reproductive factors in women from the large cohort of the UK Biobank. Methods Data on hormonal and reproductive factors in women were collected from a prospective cohort of 223 526 UK Biobank participants. The potential relationship between reproduct...
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A number of studies from the literature have suggested that exposure to air pollutants is associated with a declined bone mineral density (BMD), and increased risks of osteoporosis (OP) and bone fractures. This study was performed to systemically assess the genetically causal associations of air pollutants with site-/age-specific BMD and risk of bo...
Article
Background and Aims CKD is one of the most prevalent non-communicable health concerns in children and adolescents worldwide; however, data on its incidence, prevalence, disability-adjusted life years (DALYs), and trends in the population are limited. We aimed to assess the global, regional, and national trends in CKD burden in children and adolesce...
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Objective To examine the efficacy and safety of telitacicept in the treatment of patients with SLE in everyday clinical practice. Methods Seventy-two patients with active SLE who received telitacicept for more than 24 weeks at multiple centres in China between 2019 and 2022 were retrospectively identified. Twenty-one of these patients received 52...
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Objective A high-sodium diet is an important risk factor for hypertension in the Chinese population, which can increase the risk of cardiovascular and cerebrovascular diseases. Although a large number of related studies have been carried out in Anhui province, clear, effective salt reduction interventions and policies that can be widely promoted ha...
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Osteoarthritis (OA) is a threat to public health issue with high morbidity and disability worldwide. However, unequivocal evidence on the link between air pollution and OA remains little, especially in multi-study sites. This study aimed to explore the relationship between short-term exposure to main air pollutants and the risk of OA outpatient vis...
Article
Objectives To provide an overview and in-depth analysis of temporal trends in prevalence of musculoskeletal (MSK) disorders in women of childbearing age (WCBA) at global, regional and national levels over the last 30 years, with a special focus on their associations with age, period and birth cohort. Methods Estimates and 95% uncertainty intervals...
Article
This study aimed to determine if air pollution affected the risk of periodontitis outpatient visits. We collected the records of 56,456 periodontitis outpatient visits in Hefei, China, from January 1,2014 to December 31,2021. The relationship between air pollution and periodontitis outpatient visits was evaluated using distributed lag nonlinear and...
Article
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With the deepening of research on the correlation between meteorological factors and autoimmune diseases, the relationship between climate change and dermatomyositis (DM) has come to our attention. This study aimed to explore the short-term correlation between meteorological factors and DM outpatient visits. Daily records of hospital outpatient vis...
Article
Background The disease burden attributable to chronic obstructive pulmonary disease (COPD) is significant worldwide. Some studies have linked exposure to air pollution to COPD, but there has been little research on this.Methods We aimed to assess the COPD-related disease burden attributable to air pollution from multiple epidemiological perspective...
Preprint
Full-text available
Background and Aims The elderly population bears a severe burden of disease due to frailty and depressive symptoms, however, the results of association between the two in the elderly Chinese population have been conflicting. Therefore, this study aimed to investigate the developmental trajectories and interactions of frailty and depressive symptoms...
Article
Full-text available
Objective The purpose of this study was to precisely evaluate the serum Dickkopf-1 (DKK-1) level in patients with ankylosing spondylitis (AS) relative to that in normal controls and to test the causal relationship between DKK-1 and the risk of AS. Methods Embase, PubMed, Web of Science, WANFANG DATA, VIP, and China National Knowledge Infrastructur...
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Background: Thyroid disease is a common endocrine disorder, and thyroid surgeries and postoperative complications have increased recently. This study aimed to explore the effectiveness of intraoperative nerve monitoring (IONM) in endoscopic thyroid surgery using subgroup analysis and determine confounding factors. Materials and methods: Two rese...
Preprint
Objectives: Previous observational studies have revealed a connection between sarcopenia and COVID-19. To evaluate their causal relationship, we utilized a bidirectional two-sample Mendelian randomization (MR) analysis to study the link of cause and effect between sarcopenia and COVID-19. Methods: Inverse variance weighting (IVW), MR-Egger, weighte...
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Evidence suggests a possible association between ambient air pollutants and oral diseases. Nevertheless, information regarding the relationship between air pollutants and pulpitis is scarce and inconclusive. In view of this, the present study aimed to investigate the relationship between short-term exposure to air pollution and outpatient visits fo...
Article
Full-text available
In recent years, a growing number of studies have found that air pollution plays critical roles in the onset and development of autoimmune diseases, but few studies have shown an association between air pollutants and dermatomyositis (DM). We sought to investigate the relationship between short-term exposure to air pollution and outpatient visits f...
Article
Aim: To describe current situation and analyze temporal trends of prevalence for four autoimmune diseases including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS) and psoriasis, at the global, continental, and national levels. Methods: The estimates and 95% uncertainty interval (UI) for age-standardized prev...
Article
Autoimmune eye diseases (AEDs), a collection of autoimmune inflammatory ocular conditions resulting from the dysregulation of immune system at the ocular level, can target both intraocular and periorbital structures leading to severe visual deficit and blindness globally. The roles of air pollution and meteorological factors in the initiation and d...
Preprint
BACKGROUND Osteoarthritis (OA) is the most common cause of adult activity limitation and a major cause of deformity in aging people, therefore gradually becomes a global public health issue. OBJECTIVE We here provide a comprehensive evaluation of the trends and cross-country inequalities of global OA burden over the last 30 years. METHODS The est...
Article
Aim: To describe burden, and to explore cross-country inequalities across sociodemographic development levels for four autoimmune diseases (ADs) including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS) and psoriasis (PS). Methods: The estimates and their 95% uncertainty interval (UI) for disability-adjusted...
Article
Immunoglobulin A nephropathy (IgAN) is a common primary glomerulonephritis, which is mainly characterized by excessive IgA deposition in the glomerular mesangial area. Although exploring the pathogenesis of IgAN and improving the treatment strategies continuously, the exact pathogenesis of IgAN remains unclear and the disease still leads to high mo...
Preprint
The high prevalence of dialysis-related symptoms in maintenance hemodialysis (MHD) patients severely affect quality of life. Therefore, in this study, we assessed the dialysis symptom index (DSI) of MHD patients during the second wave of COVID-19, which triggered a health crisis, resulting in many cities in China opting for social isolation. A tota...
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Auto-inflammatory and autoimmune diseases of the musculoskeletal system can be perceived as a spectrum of rheumatic diseases, with the joints and connective tissues are eroded severely that progressively develop chronic inflammation and lesion. A wide range of risk factors represented by genetic and environmental factors have been uncovered by popu...
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Objective Emerging evidence has highlighted the possible links of environmental pollution with several cardiovascular diseases (CVDs). The current study aimed to explore the impact of short-term air pollution exposure on CHD hospitalization in Hefei. Methods Data about the daily number of CHD admissions (from 2014 to 2021) were retrieved from the...