Hafsa Ahmad

Hafsa Ahmad
NITI Aayog · Health

PhD

About

52
Publications
34,389
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699
Citations
Introduction
Additional affiliations
April 2019 - present
Biotechnology Industry Research Assistance Council
Biotechnology Industry Research Assistance Council
Position
  • Consultant
April 2018 - April 2019
National Botanical Research Institute - India
Position
  • SERB-NPDF
November 2017 - March 2018
Babasaheb Bhimrao Ambedkar University
Position
  • Faculty Member

Publications

Publications (52)
Article
Ethnopharmacological relevance Withanone (WN), an active constituent of Withania somnifera commonly called Ashwagandha has remarkable pharmacological responses along with neurological activities. However, for a better understanding of the pharmacokinetic and pharmacodynamic behavior of WN, a comprehensive in-vitro ADME (absorption, distribution, m...
Chapter
Lipid solubility and molecular size are the major limiting factors for any molecule to get absorbed across biological membrane systems. Formulation strategies that address these concerns are of enormous benefit in eliciting the intended response from a therapy. Liposomes and phytosomes are two very versatile lipid-based delivery systems that cater...
Chapter
Full-text available
Withania somnifera Dunal (Solanaceae), populaly known as Ashwagandha or Indian ginseng has been used in the traditional systems of medicine since several thousand years. CSIR-India has developed several chemotypes of this plant (NMITLI-101, NMITLI-118, NMITLI-128). The one currently being explored is NMITLI118R which is characterized by high root y...
Article
The histamine 3 receptor (H3R) is a presynaptic receptor, which modulates several neurotransmitters including histamine and various essential physiological processes, such as feeding, arousal, cognition and pain. The H3R is considered as a drug target for the treatment of several central nervous system disorders. We have synthesized and identified...
Chapter
Poly(lactide-co-glycolide) (PLGA) is a synthetic linear copolymer approved by the USFDA. It provides versatile biodegradable interventions such as 3D scaffolds for tissue engineering. PLGA systems are biocompatible and can be surface modified for intracellular interactions. Its biodegradation rate can be controlled and it is suitable for clinical a...
Article
Full-text available
The hexane soluble extract of Curcuma longa (Turmeric) [herbal medicament (HM)] developed by Central Drug Research Institute, India, as a new antistroke agent. It contains carbonyl as well as non‐carbonyl compounds. To see the activity of non‐carbonyl compounds, HM was reacted with semicarbazide hydrochloride to remove the carbonyl compounds. This...
Article
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Background: This study aimed to evaluate the efficacy of local drug delivery system of zoledronate (ZLN) gel as an adjunct to scaling and root planing (SRP) for the treatment of human periodontal intrabony defects clinically and radiographically. Materials and methods: Forty intrabony defects (three walled and combined defects without involving...
Chapter
Ischemic stroke is a leading cause of mortality worldwide with limited treatment options. Since its pathophysiology involves free radical production, excitotoxicity, and stimulated inflammatory processes, therapeutic agents that can counter oxidative stress and associated inflammation could provide neuroprotection in the advent of cerebral stroke....
Article
Full-text available
A synthetic molecule S006-830, belonging to the class of thiophene-containing trisubstituted methanes, had shown good in vitro and in vivo bactericidal activity against drug-sensitive and drug-resistant Mycobacterium tuberculosis (Mtb). The molecule had also shown good druglike pharmacokinetic properties. However, S006-830 is a racemic mixture of t...
Article
Lapatinib (LPT) is an orally administered drug for the treatment of metastatic breast cancer. For expanding its therapeutic horizon, we have prepared its nanocrystals (LPT-NCs) that were subsequently coated with hyaluronic acid (HA) to produce LPT-HA-NCs. The detailed in-vitro and in-vivo investigation of LPT-HA-NCs showed the superior anticancer a...
Article
Full-text available
A novel 4-aminoquinoline derivative ((S)-7-chloro-N-(4-methyl-1-(4-methylpiperazin-1-yl)pentan-2-yl)-quinolin-4-amine triphosphate) exhibiting curative activity against chloroquine resistant malaria parasite has been identified for preclinical development as a blood schizonticidal agent. The lead molecule selected after detailed SAR studies, has go...
Article
In the present study, we designed Bicalutamide (BCT) and Hesperetin (HSP) co-loaded self nano-emulsifying drug delivery system (SNEDDS) to encounter the problem of BCT induced toxicity, low solubility, and bioavailability. Optimized BCT-HSP SNEDDS would produce an emulsion of globule size 30.84 ± 1.24 nm with a high encapsulation efficiency of BCT...
Article
Rutin, a natural flavonol glycoside is known to possess significant radical scavenging properties which might have beneficial effects in cerebral ischemia. However its oral administration and pharmaceutical use is limited due to its poor aqueous solubility and bioavailability. The current investigation aimed at development of rutin–phospholipid com...
Article
Full-text available
Withania somnifera Dunal (Solanaceae) known as Ashwagandha, a popular plant of Indian origin is known to possess tremedous medicinal potential, often used as anti-inflammatory, anti-platelet, antihypertensive, hypoglycemic, hypolipidemic and adaptogenic candidate. Some of its chemotypes developed by CSIR, India includes NMITLI-101, NMITLI-118, NMIT...
Article
Aim: Development and optimization of ormeloxifene-loaded PEGylated chitosan nanoparticles (CNPs) for enhancing its literature profound therapeutic activity against breast cancer. Methods: CNPs were prepared by ionotropic gelation method and characterized. Results: Optimized formulation (CNPs10) had average 304 nm particle size with 0.247 polyd...
Article
Full-text available
The TLR/IL-1R pathway is a critical signaling module that is misregulated in pathologies like inflammation and cancer. Extracts from turmeric (Curcuma longa L.) enriched in curcumin and carbonyls like turmerones have been shown to exert potent anti-inflammatory effects. The present study evaluated the anti-inflammatory activity, cytotoxic effect an...
Article
Withania somnifera Dunal (Ashwagandha), is an Indian medicinal plant with significant pharmacological properties. Withanolides (steroidal lactones) are the chief constituents potentially responsible for its activity. Some of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates the optimization and development of a...
Article
In this research, we reported the co-delivery of anti-androgen drug Bicalutamide (BCT) with Hesperetin (HSP) in chitosan (CS) coated polycaprolactone (PCL) nanoparticles (NPs) to increase their therapeutic efficacy against an androgen independent prostate cancer cell line. The PCL-BCT-HSP-CS NPs were prepared by anti-solvent precipitation followed...
Article
Endothelial cell mediated inflammation flags and mediates the progression of pre and post myocardial infarction. The present study evaluated the effect of NCCL (a fraction of curcuma oil) in MI/RP injury. Using myocardial left coronary artery ligation and the reperfusion model, here, we show that NCCL-100 mg kg-1 possessed a better salutary effect...
Article
Ormeloxifene hydrochloride (Centchroman) is once-a-week non-steroidal oral contraceptive agent marketed in India and other countries. In this study, we report a validated isocratic high-performance liquid chromatographic (HPLC) method for chiral separation of d- and l-ormeloxifene hydrochloride. This method is capable of baseline separation of its...
Article
Morinda citrifolia L. (NONI) fruits have been used for thousands of years for the treatment of many health problems including cancer, cold, diabetes, flu, hypertension, and pain. Plant extracts have reported several therapeutic benefits, but extraction of individual compound from the extract often exhibits limited clinical utility as the synergisti...
Article
Full-text available
Bicalutamide is a non-steroidal anti-androgen drug used for the treatment of androgen-dependent prostate cancer. Hesperetin is a natural bioflavonoid that can be used in combination with bicalutamide to improve efficacy and decrease tolerance. The aim of the present work was to develop and validate a simple, sensitive, rapid reverse phase-high perf...
Article
Full-text available
In the present study turmerone enriched curcuma oil (C.oil) obtained from Curcuma longa L. was evaluated in lipopolysaccharide (LPS) induced inflammation in THP-1 human monocytes, J774.2 murine macrophages and Swiss mice. THP-1, J774.2 and mice or human whole blood pre-treated with C.oil (1–30 µg/ml; 14 h) and stimulated with LPS (50 ng/ml–1 µg/ml)...
Article
Full-text available
Withania somnifera Dunal is an Indian medicinal plant with significant pharmacological properties, such as adaptogenic, anti-inflammatory, anti-oxidant, anti-platelet, anti-hypertensive, hypoglycemic and hypolipidemic effects. Several chemotypes of W. somnifera include NMITLI-101, NMITLI-118 and NMITLI-128. The present work elaborates the optimizat...
Article
Full-text available
S002-333, a novel anti-thrombotic agent, exhibits excellent platelet mediated antithrombotic action and subsequently has no effect on coagulation cascade. However, its oral bioavailability is hampered due to inherent low aqueous solubility. In order to circumvent this issue, chitosan coated liposomes were prepared by ethanol injection method. S002-...
Article
Full-text available
A substituted 5-(piperidine-1-carbonyl) pyrrolidin-2-one (CDRI compound S007-867) is a potent antithrombotic candidate drug under development at our Institute. An HPLC method for determination of S007-867 with its intermediates has been developed and validated for in process quality control and stability studies. The analytical performance paramete...
Article
Full-text available
Clarithromycin is a semi-synthetic macrolide anti-biotic exhibiting good antimicrobial activity over erythromycin and mefloquine is an anti-malarial agent against falciparum malaria. Clarithromycin, a cytochrome P450 inhibitor, can reportedly cause reversal of mefloquine resistance in Plasmodium strains. Hence a simple, sensitive, selective and rep...
Article
Background: Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant of great medicinal value; used in many clinically proven conditions. NMITLI-118RT+ is a candidate drug under a Council of Scientific and Industrial Research (CSIR) networking project. It is a chemotype of W. somnifera's root extract, which has been used for the present...
Article
Abstract This research aims at the development of controlled release contraceptive transdermal patches of centchroman using ethylcellulose (EC) as film-forming polymer, polydimethylsiloxane (PDMS) as pressure sensitive adhesive with propylene glycol and Di-n-butyl-phthalate for their penetration enhancer and plasticizing properties, respectively. T...
Article
Context: Centchroman (Ormeloxifene) is a nonsteroidal SERM; popularly used as a contraceptive; hence controlled delivery systems become a favorable choice for its administration. Objective: The present work aimed at preparing depot injectable microspheres of centchroman by using ethyl cellulose and evaluating it on various parameters. Materials and...
Article
Full-text available
In the present study, for the first time, HPLC method of CDRI compound S-001-469 is reported, S-001-469 is a new potential substituted chalcone based antidiabetic candidate drug under preclinical development phase. The current study illustrates comprehensive stress testing of S-001-469 under different prescribed ICH stress conditions. A reverse pha...
Article
Objective: Ficus carica Linn. (Moraceae) commonly known as the fig plant, a native of Carica in Asia is grown in nearly all tropical and sub-tropical countries. Phytochemical screening of the hexane extract confirmed the presence of flavonoids (quercetin) which have been associated with C.N.S. effects and also claimed to be the responsible C.N.S. a...
Article
Full-text available
Mimosa pudica L. (Mimosaceae) also referred to as touch me not, live and die, shame plant and humble plant is a prostrate or semi-erect subshrub of tropical America and Australia, also found in India heavily armed with recurved thorns and having sensitive soft grey green leaflets that fold and droop at night or when touched and cooled. These unique...
Article
Full-text available
Introduction:Michelia champaca L. (Magnoliaceae) is an ancient Indian medicinal plant a native of the Indian subcontinent and possessing numerous traditional uses. β-sitosterol is an important plant sterol present in Michelia which is reported to posses' chemopreventive and adaptogenic properties. In the present study, High Performance Thin Layer C...
Chapter
Tannins are a diverse group of poly-phenolic secondary compounds in plants which are redox active, water soluble with sufficiently high molecular weights. Tannins account for a significant proportion of biomass in terrestrial plants and their potential to affect biogeochemical processes is widely appreciated. Michelia champaca L. an Indian medicina...
Article
Full-text available
Introduction: Michelia champaca (Magnoliaceae), commonly known as Svarna champa is a glorious ancient Indian medicinal plant, rich in flavonoids and possessing several folkloric uses, traditionally claimed of having CNS effects. This study was undertaken to ascertain the nootropic potential (memory enhancing effects) of the hexane extracts of the l...
Article
Diospyros montana Roxb. is a medicinally valued herb in the Ayurvedic and traditional systems of medicine. s-sitosterol is an important plant sterol present in Diospyros which is reported to posses anti-cancer and adaptogenic properties. In the present study High Performance Thin Layer Chromatography has been developed for detection and quantificat...
Article
Background: Michelia champaca L. (Magnoliaceae) popularly known as champa is a reservoir of numerous bio-markers, assuming great significance in view of its rich chemistry. Objective: In the present study a High Performance Thin Layer Chromatography method has been used for detection, and quantification of quercetin in Michelia champaca (leaves and...
Article
Diospyros montana R. commonly known as Bistendu, is one of the medicinally important plant, widely distributed throughout India. Almost all parts of Diospyros montana R. possess good therapeutic value in traditional system of medicine. Method: The present investigation deals with the pharmacognostic investigation of the fresh leaves, stem bark, roo...
Article
Background: Michelia champaca L. (Magnoliaceae) popularly known as Champa is a reservoir of numerous bio-markers, and assumes greater significance in view of its rich chemistry. Objective: In the present study a High Performance Thin Layer Chromatography method has been used for detection, and quantification of gallic acid in Michelia champaca (lea...
Article
Full-text available
Crocus sativus L. belonging to the family Iridaceae (syn - kesar) comprises the dried red stigma and is widely cultivated in Iran and other countries such as India and Greece. Saffron contains more than 150 volatile and aroma-yielding compounds mainly terpenes, terpene alcohol, and their esters. The bitter taste and an iodoform or hay-like fragranc...
Article
Full-text available
Objective: To ascertain the diuretic potential of the leaves and stem bark of Michelia champaca L. an Indian medicinal plant widely used for the purpose in traditional systems of medicine. Methods: Aqueous extracts of Michelia champaca leaves and stem bark dosed at 250 and 500 mg/kg each were administered to adult Swiss albino Wistar rats previousl...

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