Hadi Kuncoro

Hadi Kuncoro
Universitas Mulawarman · Faculty of Pharmacy

Dr (Doctor of Chemistry), Master of Pharmacy (M.Farm), Apoteker (Apt)

About

70
Publications
47,108
Reads
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111
Citations
Citations since 2016
56 Research Items
109 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Additional affiliations
July 2007 - January 2022
Universitas Mulawarman
Position
  • Researcher
Description
  • Assoc. Prof.
Education
September 2013 - July 2017
Universitas Padjadjaran
Field of study
  • Organic chemistry of Natural Product
September 2008 - February 2010
Airlangga University
Field of study
  • Pharmacy
September 2000 - July 2004
Universitas Islam Indonesia
Field of study
  • Pharmacy

Publications

Publications (70)
Article
Full-text available
Cytotoxic and antioxidant activities from a compound has potency as a cancer drug, cytotoxic activities can cause death cancer cells and antioxidants as regeneration function of damaged cells due to the death of these cells. Forest betel (P. acre) plants a wild plant from East Kalimantan, Indonesia could potentially as sources of compounds for canc...
Article
Full-text available
A steroid, stigma-5(6)-en-3β-ol or β-sitosterol (1) had been isolated from a n-hexane extract of the Krokot plant herb (Lygodium microphyllum). The chemical structure of 1 was identified on the basis of spectroscopic evidences and by comparison with those of spectra data previously reported. The investigation of steroid, stigma-5(6)-en-3β-ol was fr...
Article
Full-text available
Analytical HPLC is a compounds separation tool that have better performances. The ability of the separation was not able to separate isomered saponins with physicochemical properties are very similar. It has been found two isomered saponins of an amorphous crystalline pure seed Kolowe (C. excelsus). The saponin separation using preparative HPLC col...
Conference Paper
Full-text available
Turunan Mangostin dari genus Garcinia telah banyak dilaporkan memiliki aktifitas sebagai antimalaria Dua dari delapan turunan mangostin yang dilaporkan dari penelitian sebelumnya dalam G.tetranda Pierre diketahui memiliki potensi dalam menghambat pertumbuhan parasit P.falciparum jika dibandingkan dengan obat antimalaria yang biasa digunakan yakni k...
Article
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Abstrak Upaya proteksi terhadap infeksi pada kondisi pandemik virus salah satunya adalah dengan cara meningkatkan imunitas tubuh. Upaya tersebut dapat dilakukan dengan memanfaatkan tanaman obat yang diolah dengan baik. Penelitian ini bertujuan untuk mengetahui aktivitas hemaglutinasi dan karakteristik ekstrak dari akar Tapak Dara (Vinca rosea) dan...
Article
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Betasianin merupakan pigmen yang masuk dalam golongan betalain. Stabilitas dari betasianin dapat dipengaruhi oleh suhu, pH dan kondisi penyimpanan. Kulit buah naga merah (Hylocereus polyrhizus) merupakan salah satu tumbuhan yang memiliki senyawa betasianin yang sudah banyak diteliti dan memberikan manfaat. Penelitian ini bertujuan melakukan penguji...
Article
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Two undescribed sesquiterpenoids, namely dysoticans A and B, and three undescribed sesquiterpenoid dimers, namely dysoticans C-E, together with six analogs, were isolated from the stem bark of Dysoxylum parasiticum (Osbeck) Kosterm. (Meliaceae), growing in West Java, Indonesia. Their structures were elucidated based on extensive spectroscopic analy...
Article
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Three new dammarane-type triterpenoids, namely elliptaglin A-C (1–3) were isolated from the stem bark of Aglaia elliptica (C.DC.) Blume along with three known derivatives, namely (20S)-hydroxydammar-24-en-3-on (4), cabralealactone (5), and E-25-hydroperoxydammar-23-en-20-ol-3-one (6). Subsequently, their chemical structures were determined using HR...
Article
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The present study examines the potential activity prediction based on free binding energy (ΔG) and interaction confirmation of phytocompounds from Artocarpus champeden (Lour.) Stokes with macromolecule protein receptor of dipeptidyl peptidase IV (DPP-IV) using in silico molecular docking studies and physicochemical and pharmacokinetic properties (A...
Article
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Tahongai (Kleinhovia hospita Linn) is a medicinal plant that has various properties. This study aims to determine standardization parameters the tahongai aqueous extract. The research method was carried out by macroscopic and microscopic observations on Tahongai powder, then extracted by infusion method. The aqueous extract was then subjected to or...
Article
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Kokang (L. amoena (Hassk) Leenh.) merupakan tanaman lokal Kalimantan Timur dan digunakan sebagai alternatif pengobatan oleh suku dayak untuk mengatasi berbagai masalah kulit, diantaranya menghilangkan noda hitam di wajah, menyembuhkan bekas luka cacar, bekas jerawat dan perawatan kulit (skincare). Penelitian ini bertujuan untuk memperoleh isolat se...
Conference Paper
Full-text available
Abstrak Daun jeruk nipis memiliki aktivitas farmakologi seperti antibakteri dan antioksidan. Tujuan penelitian ini yaitu untuk mengetahui aktivitas antioksidan dan mendapatkan formula gel terbaik dengan dari ekstrak etanol daun jeruk nipis. Ekstrak daun jeruk nipis dengan berbagai variasi konsentrasi yaitu FI, FII, FIII, FIV, dan FV dilakukan pengu...
Conference Paper
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Abstrak Antibiotik merupakan terapi efektif yang baik dalam penyembuhan penyakit yang di sebabkan oleh bakteri sehingga pasien ataupun masyarakat kadang menggunakannya sebagai obat swamedikasi. Karena kurangnya pengetahuan maupun perilaku masyarakat ini dapat menimbulkan kasus resitensi antibiotik. Tujuan dari penelitian ini yaitu untuk mengetahui...
Conference Paper
Full-text available
Vaccination is an effective prevention of disease transmission and an obligation to ensure the availability of vaccines, especially during this COVID-19 pandemic where the availability of vaccines has an Emergency Use Approvel (EUA) permit so that further research is needed on the effects. This study aims to see the effect of using the COVID-19 vac...
Article
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Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation. Mitragyna speciosa (Korth.) Havil. is a controversial plant from this genus, known under the trading name "kratom", and contains mor...
Article
Full-text available
Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation. Mitragyna speciosa (Korth.) Havil. is a controversial plant from this genus, known under the trading name “kratom”, and contains mor...
Conference Paper
Full-text available
Red guava (Psidium guajava) fruits contain lots of vitamin C with 183,5 mg/ 100g. Vitamin C has been researched to have an antioxidant activity that can lower total cholesterol levels. This study aims to analyze meat guava juice's effect in reducing total cholesterol levels in hypercholesterolemia patients in Samarinda. The research method is quasi...
Conference Paper
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Noni (Morinda citrifolia L.) and cucumber (Cucumis sativus L.) fruit are plants that have antihypertensive activity. The active ingredient scopoletin, anthosianin, xeronin in noni and high potassium in cucumber can lower blood pressure. This study aims to determine the characteristic description, hedonic quality test and the effect of giving a comb...
Conference Paper
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Abstrak Diabetes melitus ialah penyakit yang ditandai dengan peningkatan kadar glukosa darah, yang prevalensinya di Kalimantan Timur tahun 2018 diposisi ketiga tertinggi di Indonesia. Daun kersen dan buah naga dipercaya dapat mengatur kadar glukosa darah pada penderita diabetes melitus tipe 2 dan dapat digunakan sebagai terapi komplementer. Penelit...
Conference Paper
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Black Betel Leaf (Piper betle L. var Nigra) contains compounds that act as antibacterials, namely alkaloids, flavonoids, saponins, tannins, steroids and phenolic compounds. Acne or acne vulgaris is an inflammatory reaction in the sebaceous follicles, which is caused by the Propionibacterium acnes bacteria. This study aims to prove that black betel...
Conference Paper
Full-text available
Kokang Leaf (Lepisanthes amoena) as a traditional cosmetic for the Dayak Benuaq and Tunjung tribe is very important to be developed in medicine because it is contain secondary metabolites as antioxidants. This research was conducted with the aim of knowing the yield of kokang leaves (Lepisanthes amoena), the profile of TLC, and knowing the fraction...
Conference Paper
Full-text available
The kokang leaves Lepisanthes amoena (Hassk.) Leenh) is a family of Sapindaceae which has been widely used as a traditional medicine, even now there are many formulas for the preparation of kokang leaves. The purpose of this study was to determine non-specific parameters, profile of TLC and to determine the acute toxicity of ethanol extract of koka...
Conference Paper
Full-text available
Avocado and bay leaves contain flavonoids which can have an effect on lowering blood pressure. This study aims to determine the characteristics of hypertension patient respondents including age, gender, education, occupation, family history and antihypertensive drugs consumed and to determine the effect of giving a combination of avocado juice and...
Article
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Phytoestrogens are plant-derived chemical substances that have estrogen-like structures or estrogenic functions. Deficiency of estrogen in human brain causes neuroinflammation characterized by increase of major histocompatibility complex class II (MHC II) expression as a marker of M1 phenotype in microglia. Recent research found phytoestrogen compo...
Article
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The development of the separation method has an essential role in developing science and technology for the separation and purification of an element or compound from other mixtures based on differences in physical and chemical properties. This research is more focused on the selection parameters of polystyrene-based resin production using diethyle...
Conference Paper
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Lygodium microphyllum is one of the plants that have the potential as an agent hepatoprotective because known of these plants have been used as the chinese traditional medicine. They use it to treat hepatitis diseases with drink a stew of the plant. The purpose of this study is to study the effects of a ethyl acetate fraction as hepatoprotective fr...
Article
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Two fatty acid derivatives, 2-octenoic acid and 2-hexenoic acid were isolated from the extract of n-hexane of the Piper betle L. Var. Nigra (Piperaceae). The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant.
Article
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Piper betle var. nigra is a tropical plant closely related to the common piper. P. betle has also been dubbed a promising source of natural antioxidants in herbal health products, antibacterial, antifungal, antimalarial, cytotoxic activity against the cancer cell lines K562 and HL-60, and antileishmanial. The aim of this study to observation Antimi...
Article
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The objective of the study was to determine the effect of herb formula consisting of Syzygium polianthum leaves, Centella asiatica leaves, Imperata cylindrica roots, Myristica fragrans seeds, Curcuma xanthorizza rhizomes, Curcuma longa rhizomes and Phyllanthus niruri herbson serum uric acid levels of patients with mild hypertension. This research m...
Article
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Tarap (Artocarpus odoratissimus Blanco) is one of the plants in the tropics that are consumed by dayak tribe in East Kalimantan. Toxicity tests on seeds and bark have been done but there is no data regarding the acute toxicity of Artocarpus odoratissimus Blanco seeds and flesh of fruit causing the need for acute toxicity tests. This Research to kno...
Conference Paper
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Sepsis is a medical condition characterized by inflammation throughout the body in response to infections caused by SIRS (Systemic Inflammatory Response Syndrome). To support the treatment of successful treatment of sepsis antibiotic therapy is used. In the selection of antibiotics, several things need to be considered in order to avoid resistance...
Article
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Green grass jelly (Cyclea barbata Miers.) is a plant from Indonesia that is believed to have anti-inflammatory activity. This study aims to find the optimum condition in grass jelly extraction using the ionic liquid-microwave assisted extraction toward total flavonoid content (TFC) and lipoxygenase activity (LIA). The experimental design was perfor...
Article
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Tenebrio molitor Linn. is used by Indonesian people as a drug to reduce blood sugar levels. This study aims to examine the activity of Tenebrio molitor powder as antidiabetic. This research method used male mice with bodyweight 25-25 g, ages 2-3 months and divided into five groups with five male mice for each group. One group as negative control us...
Article
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Objective: Phytoestrogen is a group of compounds that can replace the estrogen function in the body. One of its roles was as neuroprotective with anti-neuroinflammatory mechanism, by inhibiting classical pathway activation of microglia cell. Marsilea crenata Presl. is a plant that is suspected to contain phytoestrogens. The aim of this research was...
Article
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Pyrazoline is an alkaloid class rarely found in nature. The pyrazoline possesses biological activities such as anti-inflammatory, antibacterial, antioxidant and antidiabetic. Pyrazoline has potential as candidate of new drug molecules in pharmacy. This study aims to synthesize new pyrazoline derivative and with the preliminary test through their to...
Article
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Kenaf (Hibiscus cannabinus L.) is an environmentally friendly natural fiber-producing plant that can produce diversified products, such as paper, wallcover, car interior, geotextile, soil safer, fiber drain, particle board, and plastic reinforcement as well as biofuel industry raw materials. Kenaf plant is a plant that has been only part of the fib...
Article
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ABSTRAK Dalam upaya pencarian sumber obat baru dari tumbuhan sebagai antimalaria berbasis pengetahuan etnobotani secara turun temurun, maka dilakukan pengujian penghambatan polimerisasi heme dari ekstrak etanol 70% daun Pepaya (Carica papaya) dan daun Jambu Biji (Psidium guajava). Data yang diperoleh dihitung IC50 dengan menggunakan SPSS 22 diperol...
Article
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Tanaman kerokot (Lygodium microphylum) menunjukan adanya aktivitas antioksidan dengan nilai IC50 65 µ.g/ml. Tujuan penelitian ini untuk mengetahui senyawa metabolit sekunder yang terkandung dalam daun kerokot dan mengetahui pengaruh pemberian infusa daun kerokot terhadap malondialdehida (MDA) pada hewan coba yang telah dipaparkan asap rokok. Diguna...
Article
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This study designed to determine the antidiabetic profile ethanol extracts of leaf extract from three types of mangroves; Avicennia sp., Rhizopora sp, and Sonneratia sp. Extraction process used maceration with ethanol solvent. The phytochemical assayis carried out qualitatively including assay of alkaloids, flavonoids, steroids, terpenoids, phenoli...
Article
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Snakefruit (Salacca zalacca) is one of Indonesian native plant that the pericarp of snakefruit can be used because it has activity as an antimicrobial. This study aims to identify the metabolite content of snakefruit pericarp and to investigate the potential of snakefruit pericarp extracts in inhibiting the growth of Streptococcus mutans and Candid...
Article
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A known naphthalene, isoeleutherol (1), was isolated from the herb of Lygodium microphyllum. The chemical structure of 1 was determined on the basis of spectroscopic data mainly UV, IR, HRTOFMS, 1D-and 2D-NMR spectroscopy, as well as by comparing with compounds previously reported. Isoeleutherol was isolated from this plant for the first time and s...
Article
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Six flavonoid compounds, kaempferol (1), quercetin (2), acacetin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), and isorhamnetin-3-O-β-D-glucopyranoside (6), were isolated from the methanol extract of the Lygodium microphyllum herb. The chemical structures of compounds 1-6 were identified on the basis of spectro...
Article
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Biaya pelayanan kesehatan, khususnya biaya obat, telah meningkat beberapa tahun terakhir, salah satunya adalah obat gastritis. Tingkat kejadian penyakit gastritis di Indonesia adalah 40, 8%, dan angka kejadian gastritis di beberapa daerah di Indonesia cukup tinggi dengan prevalensi 274.396 kasus dari 238.452.952 jiwa penduduk. Banyak masyarakat mem...
Article
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Sepsis merupakan kondisi medis yang ditandai dengan adanya peradangan di seluruh tubuh sebagai respon terhadap infeksi yang disebabkan oleh keadaan SIRS (Systemic Inflammatory Response Syndrome). Untuk menunjang terapi keberhasilan pengobatan penyakit sepsis digunakan terapi antibiotik. Dalam pemilihan antibiotik perlu diperhatikan beberapa hal gun...
Article
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Gonore merupakan penyakit menular seksual yang disebakan oleh bakteri Neisseria gonorrhoeae yang dapat diobati dengan antibiotik. Penelitian ini bertujuan untuk mengetahui gambaran dan kuantitas penggunaan antibiotik pada penyakit gonore. Penelitian ini merupakan penelitian deskriptif dengan studi retrospektif yang diambil dari catatan medik untuk...
Article
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a--Mangostin is a widely reported group of Xanthone compounds from the Clusiaceae family of 40 genera and over 1000 species spread across the tropics and subtropics area. The Objective for determine effect of a-mangostin from Garcinia tetrandra Pierre stem bark against development stadium inhibition and globin accumulation of Plasmodium falciparum....
Article
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p>This study aims to determine the yield, toxicity, and toxic concentration of crude extracts of ethanol, n-hexane fraction extract, ethyl acetate fraction extract and n-butanol fractions extract pare leaf (Momordica charantiaL.) larvae Culex pipiens. The method used to determine the toxicity of extract larvasida test larvae Culex pipiens to obtain...
Article
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Two steroids, stigma-5(6)-en-3β-ol or β-sitosterol (1) and Stigmast-4-en-3-one (2) and quercetin 3-O-β-D-glucopyranoside or Isoquercetin (3) has been isolated from an extract of n-hexane and ethyl acetate from the leaves of plants Lygodium microphyllum. The chemical structures of compounds 1, 2 and 3 identified based on spectroscopic data and compa...
Article
Full-text available
Secondary metabolites's profiles from stem bark of Kolowe (C. excelsus) are steroidal saponin and glycoside's flavonoids, which consists of five kinds of steroidal saponins and eight types of flavonoids glycoside's compounds. Both these classes of compounds in the chemical identification and analysis on the results by LC-MS/MS. Pharmaceutical poten...
Article
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Lygodium microphyllum is an invasive climbing fern weed that has become aggressive in humid habitats in tropical regions. We studied its cytotoxic activity of methanol extract, n-hexane, Ethyl acetate, and n-butanol fraction. Various extract tested for cytotoxic activity on murine P388 leukemia cells using the MTT assay method. The results of the w...
Article
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Secondary metabolites from Kolowe leaf (C. excelsus) with chemical screening are saponins and flavonoids, spread in fraction methanol, ethyl acetate, and a water fraction. Profile secondary metabolites of methanol and ethyl acetate extract from an analysis of LC-MS/MS indicated twenty compounds with molecular masses ranging from 226-1064 for fracti...
Article
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Flavonol compounds, quercetin (1) and quercetin-3-O-β-D-glucopyranoside (2) have been isolated from the ethyl acetate extract of Lygodium microphyllum leaves. The chemical structures of flavonol compounds were identified based on spectroscopic data and by comparison of spectral data obtained previously. The discovery of flavonol compounds in Lygodi...
Data
Full-text available
Cytotoxic and antioxidant activities from a compound has potency as a cancer drug, cytotoxic activities can cause death cancer cells and antioxidants as regeneration function of damaged cells due to the death of these cells. Forest betel (P. acre) plants a wild plant from East Kalimantan, Indonesia could potentially as sources of compounds for canc...
Article
Full-text available
Telah dilakukan penelitian yang berjudul Uji Aktivitas Larvasida Ekstrak Daun Keladi Birah (Alocasia indica Schott) Terhadap Larva Nyamuk Culex sp. Penelitian ini bertujuan untuk mengetahui aktivitas larvasida terhadap larva nyamuk Culex sp. Aktivitas larvasida daun keladi birah dilihat dari kematian larva nyamuk Culex sp. dengan parameter LC50 dan...
Article
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ABSTRAK Penelitian potensi sitotoksik ekstrak air daun sirih hitam (Piper sp.) dilakukan berdasarkan hasil penelitian kandungan metabolit sekunder dan bioaktivitas terhadap Artemia salina Leach ekstrak daun sirih hitam (Piper sp.). Uji bioaktivitas dilakukan dengan metode Brine Shrimp Lethality Test (BSLT) terhadap Artemia salina Leach. Ekstrak dau...
Article
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The research is The Hemostatic Effect of Sisik Naga Leaves (Drymoglossum Piloselloides Presl.) Metanol Extract of Rat (Rattus norvegicus L.) has been done. This reseach’s purposes to determine the hemostatic effect, optimum dose and optimum measured time of Sisik Naga Leaves extract with bleeding time as its parameter used tail bleeding. Dose of Si...
Article
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Has done research on larvacide activity Mara Tunggal leaves (Clausena excavata BURM.F) and Zodia leaves (Euodia ridleyi HOCHR) against larvae of the mosquito Culex sp. The study was conducted to see the massive concentration of Mara Tunggal leaves extracts and leaves Zodia can killed mosquito larvae Culex sp. The method used is a test using larvae...
Article
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A research which identification of secondary metabolites and antibacterial activity test from methanol exstract of leaf Sungkai (Peronema canencens Jack) to several pathogens bacterial, which aims to identification of secondary methabolites and determine the antibacterial activity from crude methanol extract of leaf Sungkai (P. canencens Jack). aga...
Article
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Endhophytes microbes are microbes that live in colonies formed in plant tissues without harming its host plant. Endhophytes was first reported in 1904. Each higher plants may contain some Endhophytes microbes that produce secondary metabolites as a product of coevolution or genetic transfer occurred (genetic recombination) from its host plants to m...