Hadi Karimkhani

• PhD
• Professor (Assistant) at Okan University

This study aimed to investigate the effects of the calpain inhibitor N-Acetyl-Leu-Leu-norleucinal (ALLN) on neuroapoptotic cell damage caused by Copper Oxide Nanoparticles (CuO-NP) and exacerbation of damage through brain ischemia/reperfusion (I/R) in a rat model. Male Wistar Albino rats (n=80) were divided into eight groups: Control, I/R, CuO-NP,...

Boric acid and omega-3 are used as essential elements for both animal and human health. Many researchers have shown these beneficial effects on cardiac and inflammatory markers. This study aims to evaluate cardiac protective effect of boric acid and omega-3 against MI (myocardial infarction), probably due to the suppression of pro-inflammatory cyto...

Aim: The aim of the present study was to investigate the effect of apoptosis on rat skeletal muscle caused by chronic alcohol and statin consumption with modified liquid diet and to elucidate protective effects of betaine supplementation. Methods: TNF-α (tumor necrosis factor), NF-kB (Nuclear Factor kappa B), cytochrome c and caspase-3 levels wi...

Background Paracetamol is one of the widely used antipyretic and analgesic drug around the world. Many researchers showed that paracetamol caused to hepatotoxicity or nephrotoxicity. Objective In the present study, we aimed to determine whether betaine has protective effects on hepatotoxicity and nephrotoxicity in neonate rats, following to long t...

Aim: Oxidative stress(OS) and lipid peroxidation(LP) occur in a cell due to irreversible damage resulting from incidents such as traumatic brain injury(TBI). The aim of our study was to investigate the possible neuroprotective effect of boric acid (BA) by examining the changes in catalase (CAT) activity and levels of CAT and malondialdehyde (MDA)...

Introduction: Due to irreversible damage following head trauma, many overlapping pathophysiological events occur including excitotoxicity, acidotoxicity, ionic imbalance, edema, oxidative stress inflammation and apoptosis. Material and methods: In this this study, after the rats were separated in to groups theserats were fed throughout fourteen...

Obesity is an energy intake more than the energy consumed and the increase in body fat mass relative to lean body mass. It is a chronic disease causes hormonal disorders together; this makes various diseases in many systems. Obesity has been common in the worldwide increasingly and is associated with adverse health problems such as hypertension, co...

AIM: To investigate the possible neuroprotective effect of boric acid (BA) by examining the changes in catalase (CAT) activity and levels of CAT and malondialdehyde (MDA) in brain tissues from rats with closed head trauma. MATERIAL and METHODS: This experimental study consisted of three groups of rats: control (n=8), traumatic brain injury (TBI) (n...

Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-α (TNF-α) and interleukine-1β...

Background The purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH) Methods In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were divided into 5 groups each consisting of 10 mice. Calcitriol was intraperitoneally administered as low dose, medium dose, medium-high dose and high do...

Pregabalin, a drug used in epilepsy, anxiety, neuropathic pain is reported to have analgesic effects in inflammatory pain. We aimed to investigate whether pregabalin have gastric side effects and to compare with a non steroidal antiinflammatory drug (NSAID) in rats. The effects of pregabalin on antioxidant levels, which are suggested to protect aga...

Oxidative stress occurs in a cell due to irreversible damage resulting from some pathophysiological incidents such as a traumatic brain injury (TBI). Free oxygen radicals, which cause the formation of oxidative stress and lipid peroxidation, also leads to neurotoxicity. Protective role of boric acid on the brain in several animal models except TBI...

S137/P-68, Abant, Turkey

S137/P70, Abant/Turkey, 2017

PS3-72

Pasteurellosis is one of the important economic diseases in ruminants, especially in cows and buffaloes. It is caused by Pasteurella multocida and occasionally by Mannheimia haemolytica. The aim of this study was to isolate Pasteurella multocida from lungs with probable mentioned bacterial agents in cows and buffaloes in Urmia's slaughter house. 24...

Objectives: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. Methods: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatme...

model of acute myocardial infarction

Acetaminophen (APAP) is the most commonly reported toxic ingestion in the world. Severe liver injury resulting from overdose or chronic use of APAP remains a significant clinical problem. In recent years, the mechanisms underlying liver injury caused by APAP have become much better understood. We have studied the protective effect of chitosan suppl...