Habibah A Wahab

Habibah A Wahab
University of Science Malaysia | USM · School of Pharmaceutical Sciences

PhD (King's College London)

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290
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Publications

Publications (290)
Article
Full-text available
Dengue is one of the most prevalent viruses transmitted by the Aedes aegypti mosquitoes. Currently, no specific medication is available to treat dengue diseases. The NS2B–NS3 protease is vital during post-translational processing, which is a key target in this study. Due to methoxy group substitution, methoxyflavones are more bioavailable and metab...
Article
Full-text available
The primary goal was to enhance the stability and bioavailability of chloramphenicol for ophthalmic use without compromising patient comfort, such as causing blurry vision. This study employed a 2-level full factorial design to optimize the formulation, exploring different concentrations of poloxamer 407 and HPMC to achieve this objective.
Article
Full-text available
Background: Memory and cognitive regression are the first symptoms of Alzheimer’s Disease (AD), which may progress to speech and mobility challenges which affecting around 35% of those who over the age of 80 years old. Preliminary study shows THICAPA and Palm Oil Extracted Tocotrienol (POET) is effective in reducing AD symptoms in Dorosophila melag...
Article
Full-text available
Angiotensin-converting enzyme 2 receptors (ACE2R) are requisite to enter the host cells for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). ACE2R is constitutive and functions as a type I transmembrane metallo-carboxypeptidase in the renin-angiotensin system (RAS). On thyroid follicular cells, ACE2R allows SARS-CoV-2 to invade the thy...
Article
Full-text available
The Zingiber zerumbet rhizomes are traditionally used to treat fever, and the in vitro inhibitory effect of ethyl acetate extract from Zingiber zerumbet rhizomes (EAEZZR) against DENV2 NS2B/NS3 (two non-structural proteins, NS2 and NS3 of dengue virus type 2) has been reported earlier. This study was carried out to establish an acute toxicity profi...
Article
Objectives This study aimed to develop, optimize and evaluate glyceryl monooleate (GMO) based cubosomes as a drug delivery system containing cisplatin for treatment of human lung carcinoma.SignificanceThe significance of this research was to successfully incorporate slightly water soluble and potent anticancer drug (cisplatin) into cubosomes, which...
Article
Full-text available
New phenylisoxazole quinoxalin-2-amine hybrids 5a–i were successfully synthesised with yields of 53–85% and characterised with various spectroscopy methods. The synthesised hybrids underwent in vitro α-amylase and α-glucosidase inhibitory assays, with acarbose as the positive control. Through the biological study, compound 5h exhibits the highest α...
Article
Lung cancer is the one of the most prevalent cancer in the world. It kills more people from cancer than any other cause and is especially common in underdeveloped nations. With 1.2 million instances, it is also the most prevalent cancer in men worldwide, making about 16.7% of the total cancer burden. Surgery is the main form of curative treatment f...
Article
Background: Quassinoids are degraded triterpene compounds that can be obtained from various species of the Simaroubaceae plant family, including Eurycoma longifolia. Quassinoids are the major compounds in E. longifolia, and they are known to have various medicinal potentials, such as anticancer and antimalarial properties. Dihydrofolate reductase (...
Article
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A series of new imidazole-phenazine derivatives were synthesized via a two-step process. The condensation of 2,3-diaminophenazine and benzaldehyde derivatives proceeds with intermediate formation of an aniline Schiff base, which undergoes subsequent cyclodehydrogenation in situ. The structures of the synthesized compounds were characterized by 1D a...
Article
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Background: Tuberous sclerosis complex (TSC) is a rare autosomal dominant multisystem disease resulting from hyperactivation of the mammalian target of rapamycin (mTOR) signaling pathway. This study aimed to measure the quantitative impact of publications in TSC. Materials and methods: We analysed TSC literature obtained from the Scopus database us...
Article
Full-text available
Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by the development of benign hamartomas in various organs, including renal angiomyolipoma. The current medical standard treatment for TSC-associated renal angiomyolipoma involves the use of a mammalian target of rapamycin (mTOR) inhibitor. To better understand the molecular b...
Conference Paper
Abstract. In the present, the study on Alzheimer disease is exceptionally important since the number of cases are increasing by almost 10 million every year. According to World Health Organization, Alzheimer disease is one of the major effects of disability and dependency among older people and is currently the seventh leading cause of death among...
Article
Full-text available
Background: Memory and cognitive regression are the first symptoms of Alzheimer’s Disease (AD), which may progress to speech and mobility challenges which affecting around 35% of those who over the age of 80 years old. Preliminary study shows THICAPA and Palm Oil Extracted Tocotrienol (POET) is effective in reducing AD symptoms in Dorosophila melag...
Article
Full-text available
As a continuous effort to discover potential neuraminidase (NA) inhibitors, two series of benzimidazole derivatives consisting of esters, 5(a–g) and carboxylic acid moieties, 6(a–g) were synthesised under conventional and microwave conditions. The efficiency of both methods was compared, and their ability to inhibit the action of NA enzyme was exam...
Article
Full-text available
2023) Evaluation of gamma irradiation on medicinal plants for both qualitative and quantitative analysis of phenolic acid, Analytical Chemistry Letters, 13:4, 369-393, Abstract The aim of this study is to assess how gamma irradiation affects the chemical profiles of medicinal plants. Two different forms; methanol leaf extracts and dried leaves, of...
Article
Objective: Breast cancer affects women globally, regardless of age or location. On the other hand, Tamoxifen (TXN), a class II biopharmaceutical drug is acting as a prophylactic/treating agent for women at risk of and/or with hormone receptor-positive breast cancer. However, its oral administration has life-threatening side effects, which have led...
Article
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In recent years, in situ gel delivery systems have received a great deal of attention among pharmacists. The in situ gelation mechanism has several advantages over ointments, the most notable being the ability to provide regular and continuous drug delivery with no impact on visual clarity. Bioavailability, penetration, duration, and maximum medica...
Article
In our effort to develop potent anti-hyperglycemic compounds with inhibitory activity against α-amylase and α-glucosidase, a series of novel quinoxaline-isoxazole moieties were synthesized. The novel quinoxaline-isoxazole derivatives were assessed in vitro for their anti-hyperglycemic activities on α-amylase and α-glucosidase inhibitions. The resul...
Article
Full-text available
Eurycomanone and eurycomalactone are known quassinoids present in the roots and stems of Eurycoma longifolia. These compounds had been reported to have cytotoxic effects, however, their mechanism of action in a few cancer cell lines have yet to be elucidated. This study was aimed at investigating the anticancer effects and mechanisms of action of e...
Preprint
Full-text available
Eurycomanone and eurycomalactone are known quassinoids present in the roots and stems of Eurycoma longifolia. These compounds had been reported to have cytotoxic effects, however, their mechanism of action in a few cancer cell lines have yet to be elucidated. This study was aimed to investigate the anti-cancer effects and mechanisms of action of eu...
Preprint
Full-text available
Eurycomanone and eurycomalactone are known quassinoids present in the roots and stems of Eurycoma longifolia. These compounds had been reported to have cytotoxic effects, however, their mechanism of action in a few cancer cell lines have yet to be elucidated. This study was aimed to investigate the anti-cancer effects and mechanisms of action of eu...
Preprint
Full-text available
Background The Zingiber zerumbet rhizomes are traditionally used to treat fever, and in vitro inhibitory effect of ethyl acetate extract from Zingiber zerumbet rhizomes (ZZEA) against DENV2 NS2B/NS3 has been reported early. This study was carried out to establish an acute toxicity profile and evaluate the anti-pyretic activities of ZZEA in yeast-in...
Article
Full-text available
Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A growing interest in the medicinal values of P. macrocarpa especially in Asia reflects the usage of diver...
Article
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An increase in the occurrence of viral infectious diseases is a global concern for human health. According to a WHO report, dengue virus (DENV) is one of the most common viral diseases affecting approximately 400 million people annually, with worsening symptoms in nearly 1% of cases. Both academic and industrial researchers have conducted numerous...
Article
Full-text available
Acetylcholinesterase (AChE) inhibitors remain the primary therapeutic drug that can alleviate Alzheimer’s disease’s (AD) symptoms. Several Cassia species have been shown to exert significant anti-AChE activity, which can be an alternative remedy for AD. Cassia timoriensis and Cassia grandis are potential plants with anti-AChE activity, but their ph...
Article
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SARS-CoV-2 is a recently discovered member of coronaviruses (CoVs) family that is very contagious and has a high infectivity rate. Expanding the search for antivirals which act against SARS-CoV-2 would allow more treatment options for the infected patients, accelerate their recovery time, and to avoid some serious adverse effects which can be cause...
Article
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The aging population increases steadily because of a healthy lifestyle and medical advancements in healthcare. However, Alzheimer’s disease (AD) is becoming more common and problematic among older adults. AD-related cases show an increasing trend annually, and the younger age population may also be at risk of developing this disorder. AD constitute...
Preprint
Full-text available
Carica papaya (CP) leaf is long known for its traditional pharmacological effects against dengue virus and malaria. Therefore, CP could also be a potential solution for the treatment of other infectious diseases, such as coronavirus. In this study, we evaluate the potential effect of the ethanolic CP leaf extract in inhibiting the enzymatic activit...
Article
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Fluorescent organic nanoparticles (FONs) are a large family of nanostructures constituted by organic components that emit light in different spectral regions upon excitation, due to the presence of organic fluorophores. FONs are of great interest for numerous biological and medical applications, due to their high tunability in terms of composition,...
Article
Full-text available
According to the World Health Organisation (WHO), as of week 23 of 2022, there were more than 1,311 cases of dengue in Malaysia, with 13 deaths reported. Furthermore, there was an increase of 65.7% during the same period in 2021. Despite the increase in cumulative dengue incidence, there is no effective antiviral drug available for dengue treatment...
Article
Full-text available
The effectiveness of the logic mining approach is strongly correlated to the quality of the induced logical representation that represent the behaviour of the data. Specifically, the optimum induced logical representation indicates the capability of the logic mining approach in generalizing the real datasets of different variants and dimensions. Th...
Conference Paper
Background Dengue is a catastrophic arboviral disease, globally and locally. At present there are no effective antiviral drugs and only a limited approved vaccine available1. The much-needed treatment for dengue has pushed studies to look into strategizing and developing methods to search for prospective inhibitor candidates. Due to the pivotal ro...
Article
Targeting vascular endothelial growth factor receptor (VEFGR) and its co–receptor neuropilin–1 (NRP–1) is an interesting vascular strategy. tLyp–1 is a tumor–homing and penetrating peptide of 7 amino acids (CGNKRTR). It is a truncated form of Lyp–1 (CGNKRTRGC), which is known to target NRP–1 receptor, with high affinity and specificity. It is media...
Article
The current development of the satisfiability logical representation in Discrete Hopfield Neural Network has two prominent perspectives which are systematic and non-systematic logic. In general, systematic logic was reported to provide us with more consistent and very predictable behaviour whereas non-systematic logic provides broader solution spac...
Article
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Background Antirrhinum majus (Snapdragon) is a perennial Mediterranean-native plant that is commonly used for mass display. Few reports acknowledged the traditional use of A. majus for its medicinal and therapeutic effects. Herein, we assess the impact of A. majus’s sample preparation and extraction methods on the plant-aerial parts’ phytochemical...
Article
Dengue virus (DENV) is an arbovirus widespread through tropical and subtropical areas. It is transmitted to humans through Aedes mosquitoes. Infections with DENV can lead to a series of complications, including dengue fever, dengue haemorrhagic fever, or dengue shock syndrome, which might manifest through secondary infections because of a vulnerabl...
Article
Objective To determine the effects of deoxyelephantopin on mTOR and its related target molecules (Akt/mTOR/P70S6K) in the ER-positive breast cancer cell line. Materials and Methods Primary in silico simulations were determined, and the effects of deoxyelephantopin on the phosphorylation of the Akt/mTOR/P70S6K molecules were evaluated using AlphaSc...
Article
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Because of the extraordinary advancements in biomedical nanotechnology over the last few decades, traditional drug delivery systems have been transformed into smart drug delivery systems that respond to stimuli. These well-defined nanoplatforms can boost therapeutic targeting efficacy while reducing the side effects/toxicities of payloads, which ar...
Article
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Despite much interest and studies toward the genus Podocarpus, the anti-malarial evaluation of Podocarpus polystachyus’s phytoconstituents remains lacking. Herein, the phytoconstituents of P. polystachyus leaves and their anti-malarial effect against Plasmodium falciparum were investigated for the first time. One new natural product, 8ß,13ß-kaur-15...
Article
Vascular dementia (VaD) is associated with the loss of cognitive function. The pharmacotherapy for dementia is cholinesterase inhibitor (ChEI). However, currently available ChEIs produce side effects. Therefore, new anticholinesterase agents are required for treating dementia. In vitro assays showed that Syzygium polyanthum leaf extract (SPLE) inhi...
Article
Full-text available
The pathogenic dengue virus (DV) transmitted mainly by the Aedes aegypti mosquito has been the most rapidly spreading mosquito-borne viral disease and became a serious threat to global health issue in tropical and sub-tropical countries. The clinical symptoms ranging from mild to a fatal dengue hemorrhagic fever and dengue shock syndrome, character...
Article
Full-text available
Alzheimer’s disease (AD) causes progressive memory loss and cognitive dysfunction. It is triggered by multifaceted burdens such as cholinergic toxicity, insulin resistance, neuroinflammation, and oxidative stress. Syzygium plants are ethnomedicinally used in treating inflammation, diabetes, as well as memory impairment. They are rich in antioxidant...
Article
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Macaranga tanarius (MT) and Syzygium jambos (SJ) are pharmacologically reported to have anti-oxidant, anti-inflammatory, and anti-diabetic effects, and can be neuroprotective agents. Our previous work revealed that MT and SJ exhibited 76.32% and 93.81% inhibition against acetylcholinesterase (AChE) at 50 μg/mL final concentration in their ethyl ace...
Article
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Recently, new variants of non-systematic satisfiability logic were proposed to govern Discrete Hopfield Neural Network. This new variant of satisfiability logical rule will provide flexibility and enhance the diversity of the neuron states in the Discrete Hopfield Neural Network. However, there is no systematic method to control and optimize the lo...
Article
Full-text available
Creating optimal logic mining is strongly dependent on how the learning data are structured. Without optimal data structure, intelligence systems integrated into logic mining, such as an artificial neural network, tend to converge to suboptimal solution. This paper proposed a novel logic mining that integrates supervised learning via association an...
Article
Full-text available
Neuraminidase (NA) is an enzyme that prevents virions from aggregating within the host cell and promotes cell-to-cell spread by cleaving glycosidic linkages to sialic acid. The best-known neuraminidase is the viral neuraminidase, which present in the influenza virus. Thus, the development of anti-influenza drugs that inhibit NA has emerged as an im...
Article
Full-text available
Breast cancer is women's most prevalent cancer type. The development of chemotherapy drug resistance and adverse effects is a signifiant barrier to breast cancer treatment. Recently, the focus of drug discovery has increased toward a valuable structure known as chalcones due to their extensive bioactivity in cancer treatment. In this study, 11 new...
Article
Full-text available
Objective: The objective of this study was to find the best base mixture composition (poloxamer 407 and HPMC) of chloramphenicol in situ gel formula based on in vitro property (Cumulative amount of drug release). Methods: The in vitro diffusion of chloramphenicol in situ gel study was carried out using franz diffusion cells to know the effect of th...
Article
Global tuberculosis (TB) burden underscores the importance of developing new effective anti-TB drugs. This study was concerned with prospecting for potential anti-TB agents from Malaysian medicinal plants. In our previous study, we have reported that n-hexane fractions of Costus speciosus (C. speciosus) (J. Koening) Sm., Cymbopogon citratus (C. cit...
Article
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Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended...
Article
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The H1N1 pandemic in 2009 and the H5N1 outbreak in 2005 have shocked the world as millions of people were infected and hundreds of thousands died due to the infections by the influenza virus. Oseltamivir, the most common drug to block the viral life cycle by inhibiting neuraminidase (NA) enzyme, has been less effective in some resistant cases due t...
Article
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This present study reports some natural products and one hydroxamic acid synthetic compound which were previously reported as matrix metalloproteinase-9 (MMP-9) inhibitors to be evaluated for their inhibition toward severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) 3-chymotrypsin-like protease (3CLpro). This enzyme is one of the proteins...
Article
Full-text available
Drug targeting is a progressive area of research with folate receptor alpha (FRα) receiving significant attention as a biological marker in cancer drug delivery. The binding affinity of folic acid (FA) to the FRα active site provides a basis for recognition of FRα. In this study, FA was conjugated to beta-cyclodextrin (βCD) and subjected to in sili...
Conference Paper
As of December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged causing the third outbreak of coronavirus that our planet still suffers until today. To date, no effective therapy has been approved for its treatment, which suggests the need to broaden the search scope for an efficient remedy. In the current wo...
Conference Paper
COVID-19 is an ongoing outbreak of viral pneumonia that was first discovered in China by the end of 2019. Since then, COVID-19 has spread out from China across the globe. Therefore, there is an urgent need to find an immediate effective therapy in order to halt the spread of this virus. Many studies have been conducted over the past year focusing o...
Article
Full-text available
Lung cancer (LC) is the leading cause of cancer-related deaths, responsible for approximately 18.4% of all cancer mortalities in both sexes combined. The use of systemic therapeutics remains one of the primary treatments for LC. However, the therapeutic efficacy of these agents is limited due to their associated severe adverse effects, systemic tox...