H. Schipper

H. Schipper
Wageningen University & Research | WUR · Department of Experimental Zoology

About

65
Publications
4,426
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635
Citations
Additional affiliations
September 1990 - present
Wageningen University & Research
Position
  • Senior research technician

Publications

Publications (65)
Article
Full-text available
Background: Mucus and mucus glands are important features of the amphibian cutis. In tree frogs, the mucus glands and their secretions are crucial components of the adhesive digital pads of these animals. Despite a variety of hypothesised functions of these components in tree frog attachment, the functional morphology of the digital mucus glands an...
Article
Full-text available
There are indications that lighting schedules applied during incubation can affect leg health at hatching and during rearing. The current experiment studied effects of lighting schedule: continuous light (24L), 12 hours of light, followed by 12 hours of darkness (12L:12D), or continuous darkness (24D) throughout incubation of broiler chicken eggs o...
Data
Data for embryonic ossification (“Cartilage” tab), embryonic plasma melatonin (“Melatonin” tab), growth hormone and IFG-1 at hatching (“GH&IGF-1” tab), post hatch bone dimensions (“BoneData” tab), and CT scan data (“CT-scans” tab). (XLSX)
Data
Appendix S1. Symbols and abbreviations. Appendix S2. Housing conditions. Appendix S3. μ‐CT image analysis. Appendix S4. Histochemical protocols. Appendix S5. Immunohistochemical protocols. Appendix S6. Interdigital, interlimbal, interindividual and intermethodological comparision of the internal pad morphology. Appendix S7. Intermediate topol...
Data
Video S1. The digital tip and internal structures of Hyla cinerea (Frog 3, digit HV) in dorsolateral view rotated by 360° around the dorsal‐ventral pad axis. Colour coding of the structures as in Fig. 5.
Data
Video S2. The digital tip and internal structures of Hyla cinerea (Frog 3, digit HV) in ventrolateral view rotated by 360° around the dorsal‐ventral pad axis. Colour coding of the structures as in Fig. 5.
Article
Full-text available
The morphology of the digital pads of tree frogs is adapted towards attachment, allowing these animals to attach to various substrates and to explore their arboreal habitat. Previous descriptions and functional interpretations of the pad morphology mostly focussed on the surface of the ventral epidermis, and little is known about the internal pad m...
Article
Full-text available
Background: Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent mechanical properties, important for the functions of adult AC. Collagen is the most...
Data
Full-text available
Constant azimuth in the deep zone. Illustration of the constant azimuth in the deep zone for a 72 week old animal. Left: azimuth PLM image with ROI. The articular surface is on top of the image. Right: corresponding orientation pattern. The azimuth is fairly constant in the deep zone up until the last 3% of the total depth.
Data
Full-text available
Illustration of split lines. Left: lateral side of a left hind leg in a 2 week old lamb. Right: medial side of a left hind leg in a 72 week old lamb.
Data
Full-text available
Orientation patterns for caudal/distal/rostral sites. Average orientation patterns for all ten ages divided in caudal, distal and rostral samples.
Data
Orientation patterns for lateral/medial sites. Average orientation patterns for all ten ages divided in lateral and medial samples.
Data
Full-text available
Examples of PLM images for all ten age points. Top: azimuth results. Bottom: retardance results.
Data
Full-text available
Slaughter mass. Slaughter mass together with the exponential fit. The mass at 36 weeks is an estimate from the butcher, because these animals were not weighed prior to sacrifice.
Article
Full-text available
Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Across species, adult AC shows an arcade-like structure with collagen predominantly perpendicular to the subchondral bone near the bone, and collagen predominantly parallel to the articular surface near the articular surface. Recen...
Article
The orientation and organisation of collagen fibrils play an important role in the mechanical functioning of the articular cartilage (AC) that covers the surfaces in the diarthrodial joints. In the adult animal, typically an arcade like 'Benninghoff structure' is found. Because the remodelling capacity of the collagen network in the adult animal is...
Article
The fast muscle fibres in the anterior trunk of teleost fish are primarily responsible for large amplitude undulatory swimming motions. Previous theoretical studies suggested that the near-helical arrangement of these fibres results in a (fairly) uniform distribution of fibre strain and work output during swimming. However, the underlying simplific...
Article
Full-text available
Mechanical load is an important factor in the differentiation of cells and tissues. To investigate the effects of increased mechanical load on development of muscle and bone, zebrafish were subjected to endurance swim training for 6 h/day for 10 wk starting at 14 days after fertilization. During the first 3 wk of training, trained fish showed trans...
Article
The fast muscle fibres that form the bulk of muscle tissue in teleost fish are used in fast escape and attack responses. In adult fish, the fast fibres are arranged in a pseudo-helical pattern that is thought to optimise the work output of the fibres during movement. During development, the muscle fast fibres are initially arranged in parallel with...
Article
The skeleton of the acanthopterygian sea bass (Dicentrarchus labrax L.) normally consists of acellular bone. Individuals with a spinal deformity called lordosis, however, display chondroid bone at the articular surfaces of the affected vertebrae. Chondroid bone is well known in teleosts from sites subjected to mechanical stress. This skeletal tissu...
Article
Full-text available
In contrast to human phonation, the virtuoso vocalizations of most birds are modulated at the level of the sound generator, the syrinx. We address the hypothesis that syringeal muscles are physiologically capable of controlling the sound-generating syringeal membranes in the ring dove (Streptopelia risoria) syrinx. We establish the role of the trac...
Article
Full-text available
The present paper discusses the effects of decreased muscle activity (DMA) on embryonic development in the zebrafish. Wild-type zebrafish embryos become mobile around 18 h post-fertilisation, long before the axial musculature is fully differentiated. As a model for DMA, the nic(b107) mutant was used. In nic(b107) mutant embryos, muscle fibres are m...
Article
Full-text available
Mammalian bone is an active tissue in which osteoblasts and osteoclasts balance bone mass. This process of adaptive modelling and remodelling is probably regulated by strain-sensing osteocytes. Bone of advanced teleosts is acellular yet, despite the lack of osteocytes, it is capable of an adaptive response to physical stimuli. Strenuous exercise is...
Article
Genome and gene duplications are considered to be the impetus to generate new genes, as the presence of multiple copies of a gene allows for paralogues to adopt novel function. After at least two rounds of genome/gene duplication, the Runt gene family consists of three members in vertebrates, instead of one in invertebrates. One of the family membe...
Article
The gene TTP, encoding a C3H zinc finger protein of the TIS11 family, is expressed in growing mouse oocytes. The gene is downregulated in Graafian follicles shortly before ovulation. This corresponds to a possible function in regulation of maternal mRNA translation, a function attributed to related C3H class genes in Caenorhabditis elegans, zebrafi...
Article
The intron-exon organisation of the carp IL-1beta gene consists of 2455bp and comprises seven exons. Three IL-1beta RNA transcripts have been found in carp: (1) a fully spliced product; (2) exon 1-7 with introns 5 and 6; and (3) exon 1-7 with intron 5 only. The intron-containing products probably represent partially spliced transcripts. IL-1beta mR...
Article
Full-text available
During early embryonic development, pig and chicken embryos share striking morphological similarities. In the present study, the timing and location of expression of mRNA for goosecoid (gsc), a gene classically expressed in the nodal region of developing embryos, was examined and compared in preprimitive streak and gastrulating pig and chicken embr...
Article
Next to a prominent nutritional role during larval growth the teleost yolk cell may function during early developmental processes as a source of inducing signals. In Xenopus mesoderm-inducing signals reside in the vegetal cells of the blastula and exert their function on the more animal located cells in the margin. Because of its position reminisce...
Article
The Zfcth1 gene is, as the previously cloned carp cth1 gene, related to the mammalian TIS 11 family of primary response genes and encodes a protein with two putative CCCH zinc fingers. This report describes the RNA expression of this gene during oogenesis and early embryogenesis up to gastrulation in the zebrafish (Danio rerio). Maternal cth1 messa...
Article
The homeobox gene Carp-Ovx1 shows similarity to vertebrate and invertebrate Ovx genes and to Drosophila unplugged. Its expression pattern was studied by in situ hybridization in carp embryos and juveniles. During segmentation, expression becomes gradually limited to the neural tube. In juveniles up to 9 weeks old, cells in the ventral telencephalon...
Article
Full-text available
The carp cth1 gene, related to the mammalian TIS11 family of primary response genes, encodes a novel fish protein with two putative CCCH zinc fingers. This report describes the RNA expression of this gene during cleavage, blastula and gastrula stages of carp embryos. Cth1 mRNA is present in all cleavage stage blastomeres as a maternal message. Afte...
Article
Two strains of carp (Cyprinus carpio L.), a heterogenic and an all male isogeneic, were used as experimental models to assess the effects of low doses of L-thyroxine (T4) on testicular development in juvenile fish. In four experiments (two with each strain) precocious onset of spermatogenesis was induced following exposure to 15 micrograms T4 l-1,...
Article
Full-text available
This report describes the cDNA sequence and embryonic RNA expression pattern of carp Hoxb-1. Carp Hoxb-1 is a labial-like, homeobox-containing gene of the 3' end of the Hox gene cluster. The expression pattern in carp is compared to that of homologs in other vertebrates. As holds for other Hox genes, carp Hoxb-1 is expressed with highest intensity...
Article
A subtractive-hybridization technique, combined with differential screenings and subsequent whole mount in situ hybridization (ISH) reactions, was used to isolate novel cDNA clones representing developmentally-regulated genes of carp. Small-scale differential screenings of an oocyte and a segmentation-stage cDNA library using oocyte-specific and se...
Article
A carp caudal cDNA of 1.3 kb was cloned after screening an early segmentation stage cDNA library with a probe produced by PCR using conserved homeobox sequences as primers and genomic DNA as template. The homeobox gene was called carp-cdxl. The gene appears highly similar to other vertebrate caudal homologs, especially the zebrafish gene cdx(Zf-cad...
Article
The present report firstly describes a pilot study in which, during early development of embryos of the common carp, Cyprinus carpio, the cellular adhesion to fibronectin (FN) was blocked by administration of GRGDS peptide (which binds to the FN-receptor). As this treatment resulted in developmental aberrations, suggesting a functional role for FN,...
Article
The presence, location and morphology of cells containing nuage, an ultrastructural characteristic of primordial germ cells (PGCs), is described from the moment of first morphological recognition of PGC (around 100% epiboly) in embryos of the teleost fish Barbus conchonius. Thus characterized cells were studied in relation to their cellular contact...
Article
With electron microscopy, the presence of peritubular cells has been demonstrated in the interstitial tissue of carp testis. They are long flattened cells, often occupying nearly the whole space between neighbouring tubules. Their ultrastructural characteristics in mature carp, i.e. microfilaments and dense bodies, indicate myoid properties, probab...
Article
During early embryonic development, pig and chicken embryos share striking morphological similarities. In the present study, the timing and location of expression of mRNA for goosecoid (gsc), a gene classically expressed in the nodal region of developing embryos, was examined and compared in preprimitive streak and gastrulating pig and chicken embr...
Article
Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent mechanical properties, important for the functions of adult AC. Collagen is the most abundant soli...

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