Gyungah Jun

Gyungah Jun
Boston University | BU · Department of Medicine

PhD

About

135
Publications
12,050
Reads
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9,238
Citations
Introduction
Additional affiliations
June 2010 - present
Case Western Reserve University
Position
  • Research Assistant
August 2009 - present
Boston University
Position
  • Professor (Assistant)
February 2000 - July 2009
Independent Researcher
Position
  • Database Developer and Manager
Education
August 2002 - January 2008
Case Western Reserve University
Field of study
  • Genetic Epidemiology and Statistical Genetics
September 1998 - January 2000
Cleveland State University
Field of study
  • Computer and Information Science

Publications

Publications (135)
Article
Full-text available
Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be protective for risk of a number of conditions, including cardiovascular disease and chronic kidney disease, as well as numerous aut...
Article
Full-text available
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A...
Article
Full-text available
To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes. Association study of AD and CLU, PICALM, CR1, and APOE genotypes. Academic research institutions in the United States, Canada, and Israel. Seven thousan...
Article
Full-text available
Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the genetic basis remains to be elucidated. We report that homozygous deletion of Epha2 in two independent strains of mice developed prog...
Data
Morphological, histochemical and biochemical characterization of wild type and mutant mouse lens. (A) H&E sections of lenses from eight-month- and two-week-old mice. Note abnormal structure of the Epha2 homozygous knockout lens. Scale bars: 1 mm for left two panels; 10 µm for right two panels. (B) Anterior view of an intact Epha2−/− lens stained wi...
Data
Crystallin expression and activation status of Akt and ERK1/2 kinases in wild type and mutant mice. (A) Epha2 deletion did not cause significant changes in crystallin expression until development of mature cataract. Each lens from the indicated age was extracted with RIPA buffer first. After centrifugation, the supernatant was collected as soluble...
Data
Exonic primers and their amplification conditions for EPHA2 gene re-sequencing. (0.05 MB DOC)
Data
Completeness of SNP genotyping and other quality metrics. (0.07 MB DOC)
Data
Association results using PLINK in the BMES unrelated data. (A) P values from single SNP association under the dominant model. (B) P values from single SNP trend test for the severe cases and controls with age at least 70 years in the BMES. (C) Haplotype association for the binary and quantitative cortical cataract trait in BMES. (0.10 MB DOC)
Data
EPHA2 expression in human lens. (A) Lysates were prepared from two 56 and 60 year old human lenses and blotted for EPHA2. (B–D) EPHA2 staining of human lens: Images from sagittal sections at anterior (B) and posterior (C) regions and coronal section near the equator (D) are shown. (E) Negative control without primary antibody. Scale bars: 5 µm. (4....
Data
Single SNP association using ASSOC in the BDES family data. (0.14 MB DOC)
Data
Heterogeneity test and meta-analysis using METAL (A to D). Three genetic models (Add: additive, Dom: dominant, and Rec: recessive) were tested for each SNP. QE-P: P values associated with the Q statistic; Zscore: Z-score from meta-analysis; N: the total number of individuals in the meta-analysis; Meta-P: P values from meta-analysis. (A) Heterogenei...
Data
Retroillumination images of normal human lens vs. lens with cortical cataract. A normal human lens. (A) compared with cortical cataract lens from the Beaver Dams Eye Studies (BDES) (B) and Blue Mountain Eye Studies (BMES) (C). (D) A panel of retroillumination images from UKTS going from normal in the lower right corner to varying degrees of cortica...
Data
Single SNP association using ASSOC in the UKTS family data. (0.14 MB DOC)
Data
Normal Quantile-Quantile (Q-Q) plots from residuals under the dominant model. The first column is the residuals from the initial trait without any transformations (NOTF), the second column is the residuals from the initial trait with the George-Elston transformation (GETF), and the third column is the inverse normal transformed adjusted data with t...
Data
Plots of linkage disequilibrium (LD) for EPHA2. Each LD plot is based on correlation coefficient of LD (r2) in the HapMap CEU (A), BDES (B), UKTS (C), and BMES (D) datasets. (2.84 MB TIF)
Article
Full-text available
Diabetic nephropathy, the most common cause of end-stage renal disease, aggregates in families and specific ethnic groups. Deconstructing diabetic nephropathy into intermediate, quantitative phenotypes may increase feasibility of detecting susceptibility loci by genetic screens. Glomerular filtration rate (GFR), which characterizes diabetic nephrop...
Article
Studies of age-related macular degeneration (AMD) often involve persons with both choroidal neovascularization and geographic atrophy (GA), but few genome-wide scans (GWSs) have discriminated between these two outcomes. To comprehend the role of pigmentary abnormalities (PA) and GA in AMD, the authors analyzed the data from a previous GWS on AMD (F...
Article
Retinal vessels can be observed noninvasively and provide a window to microvascular systems elsewhere in the body. Generalized retinal arteriolar narrowing can represent structural changes resulting from persistent high blood pressure. However, data from recent studies also suggest that generalized retinal arteriolar narrowing might precede hyperte...
Article
Full-text available
We developed a new marker-reordering algorithm to find the best order of fine-mapping markers for multipoint linkage analysis. The algorithm searches for the best order of fine-mapping markers such that the sum of the squared differences in identity-by-descent distribution between neighboring markers is minimized. To test this algorithm, we examine...
Article
Full-text available
To test whether genes for drusen formation are independent of age-related macular degeneration (AMD) pathogenesis. A genome-wide model-free linkage analysis was performed, using two semiquantitative drusen traits, size and type, on two sets of data: (1) 325 individuals (225 sib pairs) from the Beaver Dam Eye Study (BDES), and (2) 297 individuals (3...
Article
Full-text available
Age-related cataracts are one of the leading causes of visual impairment and blindness among the elderly worldwide. Among age-related cataracts, cortical opacities rank as the second most common type; however, little is known about their molecular pathogenesis or genetics. To identify susceptibility loci for cortical cataracts, we genotyped a subse...
Article
To examine the genetic basis of age-related macular degeneration (ARMD), a degenerative disease of the retinal pigment epithelium and neurosensory retina, we conducted a genomewide scan in 34 extended families (297 individuals, 349 sib pairs) ascertained through index cases with neovascular disease or geographic atrophy. Family and medical history...
Article
Full-text available
A genome-wide screen was conducted for type 2 diabetes progression genes using measures of elevated fasting glucose levels as quantitative traits from the offspring enrolled in the Framingham Heart Study. We analyzed young (20-34 years) and old (>or= 35 years) subjects separately, using single-point and multipoint sibpair analysis, because of the p...
Article
Full-text available
The metabolic syndrome is characterized by the clustering of several traits, including obesity, hypertension, decreased levels of HDL cholesterol, and increased levels of glucose and triglycerides. Because these traits cluster, there are likely common genetic factors involved. We used a multivariate structural equation model (SEM) approach to scan...

Projects

Project (1)
Project
Identify genetic variants associated with risk for AD using a large scale of GWAS data (more than 30,000 samples of multi-ethnics including European Americans, African American, Hispanics, and Asians from multiple cohorts/centers)