Guy Vandenhoven

Guy Vandenhoven
Haute Ecole Paul-Henri Spaak · Integrative Physiology

About

47
Publications
3,087
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,485
Citations
Introduction
Guy Vandenhoven currently works at the Integrative Physiology, Haute Ecole Bruxelles Brabant. Guy does research in Internal Medicine (General Medicine), Diabetology, Cardiology, Sports Medicine and Hyperbaric Medicine. Their most recent publication is 'Assessment of lipid-lowering treatment in Bulgaria — The CEPHEUS study'.

Publications

Publications (47)
Article
Full-text available
This is a multicenter cross-sectional survey of 2,500 Bulgarian adult patients taking lipid-lowering drugs (LLDs) for at least 3 months with no dose change for a minimum of 6 weeks. The primary objective was to establish the proportion of patients who are on LDL-C target, according to the Fourth Joint European Task Force (FJETF) guidelines. The sec...
Conference Paper
Full-text available
Objectives: The control of risk factors and hyperlipidemia in developing nations is largely unknown, and this is particularly evident in a paucity of data regarding patients of African-ancestry. The Centralized Pan-South African survey on the under-treatment of hypercholesterolemia in patients using lipid-lowering drugs (CEPHEUS) evaluated what pro...
Conference Paper
117- BLACK AFRICANS WITH HYPERLIPIDAEMIA HAVE A HIGH PREVALENCE OF TYPE 2 DIABETES AND THE METABOLIC SYNDROME BUT ARE BEING INADEQUATELY TREATED FOR THEIR HYPERLIPIDAEMIA - RESULTS FROM THE CEPHEUS SA STUDY Frederick Raal1; Colin Schamroth2; Guy Vandenhoven3; Anne-Marie Temmerman3 1Carbohydrate & Lipid Metabolism Research Unit, University of the Wi...
Article
Full-text available
To study the effectiveness and safety of budesonide/formoterol (Symbicort) Maintenance And Reliever Therapy (Symbicort SMART, AstraZeneca, Södertalje, Sweden), a simplified management approach with one inhaler compared with conventional best practice (CBP) with multiple inhalers in patients with persistent asthma. Open-label randomised controlled p...
Article
Objective. Rapid dose escalation of quetiapine could offer prompt and effective therapy to patients requiring hospitalization for schizophrenia or schizoaffective disorder. This study evaluated the safety, tolerability, and efficacy of a rapid dose escalation of quetiapine to 800 mg/day over 4 days in patients with severe psychotic symptoms diagnos...
Article
Objective: The FATIMA study (FAst TItration of quetiapine fumarate in bipolar I MAnia) evaluated the safety, tolerability and efficacy of a rapid dose escalation of quetiapine in acutely ill bipolar I patients experiencing a manic episode. Methods: In an open-label, phase II pilot study, 29 patients aged 18 years or older, hospitalised with a bipol...
Article
The CEntralized Pan-European survey on tHE Under-treatment of hypercholeSterolaemia (CEPHEUS) was initiated to quantify the degree of under-treatment of hypercholesterolaemia in Europe. Its primary objective was to establish the proportion of treated patients reaching the LDL-C goals according to the Third Joint European Task Force guidelines. Seco...
Article
Full-text available
Gastroesophageal reflux disease (GERD) is a common chronic disease that is primarily diagnosed based on symptom severity and frequency. This study gathered epidemiological data in a population of GERD patients and evaluated the added-value of the GERD Impact Scale (GIS), a novel, validated patient questionnaire, as a tool for initial and long-term...
Article
Discovery Belux is an open-label, multicentre, randomised, phase IIIb, parallel group study comparing the efficacy of rosuvastatin (RSV) and atorvastatin (ATV) on changes in lipid levels and the achievement of European Atherosclerosis Society (EAS) lipid goals. Patients (> or = 18 years) with primary hypercholesterolaemia, with a low-density lipopr...
Article
Full-text available
Fulvestrant (Faslodex) is a new estrogen receptor (ER) antagonist with no agonist effects that is licensed for the treatment of postmenopausal women with hormone-sensitive advanced breast cancer (ABC) who have progressed/recurred on prior antiestrogen therapy. The Faslodex Compassionate Use Program (CUP) provides expanded access to fulvestrant in c...
Article
The possible improvement of efficacy and tolerability of a 7-day dual antibiotherapy amoxicillin-clarithromycin (AC) on the eradication of Helicobacter pylori (H. pylori) gastritis in children by the adjunction of omeprazole (OAC) was studied. Forty-six children presenting with H. pylori gastritis, assessed at inclusion by endoscopy, H. pylori urea...
Article
Full-text available
Epidermal growth factor receptor tyrosine kinase inhibitors represent a new treatment option for patients with advanced nonsmall cell lung cancer (NSCLC). This retrospective study examined to what extent previous clinical trial experience matches large-scale Western community implementation of this treatment. In the Belgian expanded access programm...
Article
Nasal polyposis is a model for the study of inflammatory processes. We analyzed the expression of galectin-7, a growth regulator, in surface epithelium, glandular epithelium, and connective tissue in human nasal polyps, and examined the effect of the glucocorticoid budesonide on its expression in human nasal polyps ex vivo. Using quantitative, comp...
Article
Objetivos Comparar la utilidad de la medida de la presión arterial (PA) en la consulta y en el domicilio, en el tratamiento de la hipertensión arterial. Diseño, ámbito y participantes Ensayo clínico aleatorizado y controlado, realizado entre marzo de 1997 y abril de 2002, en 56 centros de atención primaria y 3 consultas externas de hospitales de B...
Article
The present multicenter study aimed to survey the patients' experiences in relation to the diagnosis and non-surgical treatment of periodontitis according to current treatment routine. Patients (N = 268) treated for plaque-related periodontitis were enrolled in two groups: group 1 received primary probing of pocket depths (PD 1) and/or primary scal...
Article
In this randomized clinical trial, conducted in 400 hypertensive patients [sitting diastolic blood pressure (DBP) >95 mmHg], blood pressure-lowering therapy was adjusted in a stepwise manner, either on the basis of the self-measured DBP at home or on the basis of conventional DBP measured at the doctor's office. Therapy guided by home blood pressur...
Article
Macrophage migration inhibitory factor (MIF) is a counterregulatory lymphokine for glucocorticoid action within the immune system. To provide further insights into the way expression of pleiotropically acting MIF is modulated by glucocorticoids, we investigated the influence of the glucocorticoid budesonide on the level of expression of MIF in a mo...
Article
Full-text available
Self-measurement of blood pressure is increasingly used in clinical practice, but how it affects the treatment of hypertension requires further study. To compare use of blood pressure (BP) measurements taken in physicians' offices and at home in the treatment of patients with hypertension. Blinded randomized controlled trial conducted from March 19...
Article
Full-text available
Vandenhoven G, Collard F, Schamp E. Children and diving: medical aspects. Eight years' sports medical follow-up of the first scuba diving club for children in Belgium. SPUMS J 2003; 33: 70-73) Evaluation of prospective paediatric divers has been based largely on opinion, with limited data. Two hundred and thirty four children aged six to 13 years w...
Article
Background: The hypothesis that self-measurement of BP at home (HBP) compared with conventional clinic measurement (CBP) would improve the management of hypertension was tested in a multicenter trial.
Article
We examined to what extent self-measurement of blood pressure at home (HBP) can be an alternative to ambulatory monitoring (ABP) to diagnose white-coat hypertension. In 247 untreated patients, we compared the white-coat effects obtained by HBP and ABP. The thresholds to diagnose hypertension were > or = 140/> or = 90 mmHg for conventional blood pre...
Article
Gender, age, smoking, race, and body mass index have been reported to determine the ambulatory white-coat effect (WCE) and white-coat hypertension (WCH). Baseline conventional, day-time ambulatory and self-measured home blood pressure measurements from the THOP trial were used to study the effect of gender, age, body mass index, smoking habits and...
Article
We characterized the anti-inflammatory effects of budesonide on the expression of adhesion molecules involving Lewis(a) (Le(a)) epitope, its sialylated derivative (sLe(a)), and their respective binding sites in human nasal polyposis. By computer-assisted microscopy, we quantitatively characterized the level of histochemical expression of L- and P-s...
Article
Full-text available
Because of the importance of galectins for various cellular activities, the influence of the glucocorticoid budesonide on the level of expression of galectins-1 and -3 was investigated in human nasal polyposis. Ten nasal polyps obtained from surgical resection were maintained for 24 hours in the presence of various concentrations of budesonide. As...
Article
Compared with conventional blood pressure (CBP) measurements, automated techniques are more reproducible, not subject to digit preference or observer bias and are increasingly being used to diagnose white-coat hypertension. Self-measurement of the blood pressure at home (HBP) is less expensive than ambulatory blood pressure monitoring (ABP), but ne...
Article
Full-text available
Am J Hypertens (2001) 14, 106A–106A; doi:10.1016/S0895-7061(01)01423-6 P-233: Comparison of the antihypertensive efficacy and tolerability of candesartan cilexetil and angiotensin-converting enzymze inhibitor therapy in primary hypertension : The champion study Robert Lins1,2,3, Jean-Marie Krzesinski1,2,3, Guy Vandenhoven1,2,3 and Christophe J. Gi...
Article
Full-text available
Background. Metoprolol can improve haemodynamics in chronic heart failure, but survival benefit has, not been proven. We investigated whether metoprolol controlled release/extended release (CR/XL) once daily, in addition to standard therapy, would lower mortality in patients with decreased ejection fraction and symptoms of heart failure. Methods. W...
Article
A double-blind, randomized, parallel, comparative study was designed to evaluate the long-term safety and efficacy of subgingivally administered minocycline ointment versus a vehicle control. One hundred four patients (104) with moderate to severe adult periodontitis (34 to 64 years of age; mean 46 years) were enrolled in the study. Following scali...
Article
The comparative activities of piperacillin/tazobactam and other antibiotics against 5625 Gram-negative and Gram-positive bacteria freshly isolated from hospitalized patients was examined. The percentage of Enterobacteriaceae susceptible to piperacillin/tazobactam, ceftazidime, imipenem and ciprofloxacin was very similar and varied from 81% to 84% i...
Article
Full-text available
The comparative activities of piperacillin/tazobactam and other antibiotics against 5625 Gram-negative and Gram-positive bactena freshly isolated from hospitalized patients was examined. The percentage of Enterobacteriaceae susceptible to piperacillin/tazobactam, ceftazidime, imipenem and ciprofloxacin was very similar and varied from 81% to 84% in...
Article
3,192 hospitalized patients with severe infections were treated with piperacillin alone (6-16 g daily) when urological, gynaecological or abdominal infections were diagnosed, or with a combination therapy of piperacillin and the preferred aminoglycoside within the hospital in case of pulmonary infections. The susceptibility to piperacillin of all G...
Article
The acute and short-term responses to bisoprolol and to atenolol on systemic and renal hemodynamics and on ambulatory blood pressure (BP) were compared in a randomized double-blind cross-over study including 14 patients with mild to moderate essential hypertension. After a 4-week placebo period, the patients received either bisoprolol (10 mg once d...
Article
A method was developed for the determination of (6R)- and (6S)-leucovorin and 5-fluorouracil in plasma. As leucovorin diastereoisomers cannot be separated on a classical reversed-phase column, it was necessary to use a chiral stationary phase. The method presented is based on the same principle as the method described by Wainer and Stiffin [J. Chro...

Network

Cited By

Projects

Projects (2)
Archived project
Archived project