Guy John-Malcolm CameronThe University of Newcastle & Hunter Medical Research Institute · Priority Research Centre GrowUpWell School of Biomedical Sciences and Pharmacy
Guy John-Malcolm Cameron
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February 2018 - February 2021
The University of Newcastle & Hunter Medical Research Institute
- PhD Student
Background Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap (ACO). Patients characterized with ACO have increased disease severity, however the mechanisms driving this have not been widely studied. Objective To characteri...
Innate lymphoid cells (ILC) are resident in the lung and are involved in both the maintenance of homeostasis and the pathogenesis of respiratory diseases. In this study, murine lung ILC were characterised using flow cytometry and the impact of mouse age, sex and strain were assessed. Lung ILC were found as early as postnatal day 4 and numbers peake...
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of morbidity and death globally. The lack of effective treatments results from an incomplete understanding of the underlying mechanisms driving COPD pathogenesis. Interleukin (IL)-22 has been implicated in airway inflammation and is increased in COPD patients. However, its role...
Supplementary Fig. 2: T‐bet+ ILC1s and Rorγt+ ILC3s are increased and GATA3+ ILC2s are decreased in WT mice exposed to CS. Flow cytometric analysis of single cell suspensions from whole lungs of normal air‐ or CS‐exposed WT mice. (A) Flow cytometry gating of ILC1s, ILC2s and ILC3s. Quantification of (B) total ILCs, (C) ILC1s, (D) ILC2s, and (E) ILC...
Supplementary Fig. 1: Top 5 differentially expressed genes identified from RT2 ECM PCR array in WT, Rag1−/− and Rorafl/flIL7RCre mice exposed to CS. Relative abundance of the top 5 genes compared to the geometric mean of Actb, B2m, Gapdh, for normal air‐ and CS‐exposed A) Rag1−/− mice and B) Rorafl/flIL7RCre mice compared to WT controls. cDNA was p...