Gustavo Alejandro Orozco

Gustavo Alejandro Orozco
Lund University | LU · Department of Biomedical Engineering

Ph.D.

About

40
Publications
4,348
Reads
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162
Citations
Additional affiliations
June 2020 - March 2021
University of Eastern Finland
Position
  • PostDoc Position
February 2016 - May 2020
University of Eastern Finland
Position
  • PhD Student
July 2015 - January 2016
Universidad Libre Cali
Position
  • Researcher

Publications

Publications (40)
Article
Full-text available
Ligaments of the knee provide stability and prevent excessive motions of the joint. Rupture of the anterior cruciate ligament (ACL), a common sports injury, results in an altered loading environment for other tissues in the joint, likely leading to their mechanical adaptation. In the collateral ligaments, the patterns and mechanisms of biomechanica...
Article
Full-text available
We developed a novel knee joint model in FEBio to simulate walking. Knee cartilage was modeled using a fibril-reinforced biphasic (FRB) formulation with depth-wise collagen architecture and split-lines to account for cartilage structure. Under axial compression, the knee model with FRB cartilage yielded contact pressures, similar to reported experi...
Conference Paper
Full-text available
Introduction: Traumatic knee cartilage injuries trigger chondrocyte death via the release of damage-associated molecular patterns (DAMPs) and reactive oxygen species (ROS) 1-3. Chondrocyte death disrupts cartilage metabolism, with decreased production of matrix constituents and subsequent post-traumatic osteoarthritis 1. A better understanding of b...
Preprint
Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known that proteoglycan (PG) loss, cell dysfunction, and...
Article
Full-text available
Abnormal loading of the knee due to injuries or obesity is thought to contribute to the development of osteoarthritis (OA). Small animal models have been used for studying OA progression mechanisms. However, numerical models to study cartilage responses under dynamic loading in preclinical animal models have not been developed. Here we present a mu...
Article
Full-text available
Severe joint injuries often involve cartilage defects that propagate after mechanical loading. The propagation of these lesions may contribute to the development of post-traumatic osteoarthritis (PTOA). However, the mechanisms behind their propagation remain unknown. Currently, no numerical predictive methods exist for estimating crack propagation...
Article
Full-text available
Osteoarthritis (OA) is a degenerative disease that affects the synovial joints, especially the knee joint, diminishing the ability of patients to perform daily physical activities. Unfortunately, there is no cure for this nearly irreversible musculoskeletal disorder. Nowadays, many researchers aim for in silico-based methods to simulate personalize...
Preprint
Full-text available
Abnormal loading of the knee due to injuries or obesity is thought to contribute to the development of osteoarthritis (OA). Small animal models have been used for studying OA progression mechanisms. However, numerical models to study cartilage responses under dynamic loading in preclinical animal models have not been developed. Here we present a mu...
Article
Full-text available
Excessive tissue deformation near cartilage lesions and acute inflammation within the knee joint after anterior cruciate ligament (ACL) rupture and reconstruction surgery accelerate the loss of fixed charge density (FCD) and subsequent cartilage tissue degeneration. Here, we show how biomechanical and biochemical degradation pathways can predict FC...
Conference Paper
Full-text available
In efforts to predict post-traumatic osteoarthritis (PTOA) progression, contemporary mechanobiological models implement cytokine diffusion-mediated inflammation. However, they lack an important biomechanical factor, the advection of cytokines along with the flow of interstitial fluid during physiological loading. Here, we refine the models predicti...
Article
Convection-enhanced delivery is a technique to bypass the blood–brain barrier and deliver therapeutic drugs into the brain tissue. However, animal investigations and preliminary clinical trials have reported reduced efficacy to transport the infused drug in specific zones, attributed mainly to backflow, in which an annular gap is formed outside the...
Article
Full-text available
The purpose of this proof‐of‐concept study was to develop 3D patient‐specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with ACL reconstructed knees were imaged at 1‐ and 3‐years after surgery. The MRI data was use...
Article
Full-text available
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to result in loss of cartilage proteoglycans, the source...
Article
Convection-enhanced delivery (CED) is a technique to bypass the blood-brain barrier and deliver therapeutic agents into the brain. However, animal studies and preliminary clinical trials have reported reduced efficacy to transport drugs in specific regions, attributed mainly to backflow, in which an annular zone is formed outside the catheter and t...
Article
Full-text available
Cartilage provides low-friction properties and plays an essential role in diarthrodial joints. A hydrated ground substance composed mainly of proteoglycans (PGs) and a fibrillar collagen network are the main constituents of cartilage. Unfortunately, traumatic joint loading can destroy this complex structure and produce lesions in tissue, leading la...
Article
Full-text available
Ligaments provide stability to the human knee joint and play an essential role in restraining motion during daily activities. Compression-tension nonlinearity is a well-known characteristic of ligaments. Moreover, simpler material representations without this feature might give reasonable results because ligaments are primarily in tension during lo...
Article
Full-text available
Purpose: The intervertebral disc supports axial and shear forces generated during tasks such as lifting and carrying weights. The objective of this study was to determine the forces in the lumbar spine of workers carrying a bag on the head, on the shoulder, and on the anterior part of the trunk. Materials and methods: Kinematic measurements were re...
Article
Full-text available
Agarose hydrogels have been extensively used as a phantom material to mimic the mechanical behavior of soft biological tissues, e.g. in studies aimed to analyze needle insertions into the organs producing tissue damage. To better predict the radial stress and damage during needle insertions, this study was aimed to determine the friction coefficien...
Conference Paper
Convection-enhanced delivery (CED) is a technique to deliver controlled amounts of drugs directly into the brain for the treatment of tumors and diseases such as Parkinson’s. Several CED animal studies have shown encouraging results for drug distribution. However, clinical trials have reported low efficacy of CED, primarily due to the poor distribu...
Conference Paper
Introduction Convection enhanced delivery (CED) is a method to deliver controlled amounts of drugs over target zones into the brain and bypass the blood-brain barrier for the treatment of diseases and tumors. However, there is a problem during infusions called backflow that consist the drug flows through the interface needle-tissue. Several experi...
Article
Full-text available
Convection-enhanced delivery as a means to deliver therapeutic drugs directly to the brain has shown limited clinical efficacy, primarily attributed to the phenomena of backflow, in which the infused fluid flows preferentially along the shaft catheter rather than forward into the tissue. We have previously developed a finite element model of backfl...
Article
A previously proposed finite element model that considers geometric and material nonlinearities and the free boundary problems that occur at the catheter tip and in the annular zone around the lateral surface of the catheter was revised and was used to fit a power-law formula to predict backflow length during infusions into brain tissue. Compared t...
Article
The bamboo species Guadua angustifolia is a natural functionally graded material with a high potential to help solving the housing deficit in Latin American countries. Bamboo plantations also play an important role to help reducing the devastation of tropical forests. Many studies have demonstrated the excellent mechanical properties of bamboo alon...
Conference Paper
Full-text available
Después de explorar varias técnicas de modelado, en este estudio se presenta un procedimiento alternativo para obtener una representación geométrica y una malla realista del cerebro y de una vértebra, a partir de imágenes de tomografía. En el proceso se utilizaron programas de dominio público y otros de diseño asistido (CAD), comúnmente disponibles...
Conference Paper
Convection enhanced delivery is a protocol to deliver large volumes of drugs over localized zones of the brain for the treatment of diseases and tumors. Brain infusion experiments at higher flow rates showed backflow, in which an annular zone is formed outside the catheter and the infused drug preferentially flows toward the surface of the brain ra...
Conference Paper
Convection-enhanced delivery is a technique to infuse therapeutic agents into the brain under positive pressure for the treatment of disorders of the central nervous system. Recent clinical trials [1] have shown limited efficacy of this procedure, attributed to poor distribution of the infused agent that may be due to backflow, in which the infused...

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