Gustavo González-Gaitano

Gustavo González-Gaitano
Universidad de Navarra | UNAV · Department of Chemistry

PhD in Chemistry

About

131
Publications
12,416
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3,299
Citations
Additional affiliations
September 2016 - October 2016
Universidad de Navarra
Position
  • Professor

Publications

Publications (131)
Article
Full-text available
Synthetic hydrogels provide controllable 3D environments, which can be used to study fundamental biological phenomena. The growing body of evidence that cell behavior depends upon hydrogel stress relaxation creates a high demand for hydrogels with tissue‐like viscoelastic properties. Here, a unique platform of synthetic polyethylene glycol (PEG) hy...
Article
Full-text available
Implementing proteins in optoelectronics represents a fresh idea towards a sustainable new class of materials with bio‐functions that can replace environmentally unfriendly and/or toxic components without losing device performance. However, their native activity (fluorescence, catalysis, etc .) is easily lost under device fabrication/operation as n...
Article
Full-text available
In recent years, Solution Blow Spinning (SBS) has emerged as a new technology for the production of polymeric, nanocomposite, and ceramic materials in the form of nano and microfibers, with similar features to those achieved by other procedures. The advantages of SBS over other spinning methods are the fast generation of fibers and the simplicity o...
Article
Full-text available
Many studies have shown the capacity of soil humic substances (HS) to improve plant growth in natural ecosystems. This effect involves the activation of different processes within the plant at different coordinated molecular, biochemical, and physiological levels. However, the first event triggered by plant root-HS interaction remains unclear. Some...
Article
Soil organic matter is considered by soil scientists as the interlayer that connect alive with mineral sides of the soil. In addition, microorganisms have in soil organic matter a source of carbon as well as a source of energy. We can observe a duality that can be analyzed from a biological, physicochemical, or even thermodynamic sense. From this l...
Article
Full-text available
Chitosan‐based hydrogels are prepared via the formation of polypseudorotaxanes (PPR), by selectively threading α‐cyclodextrin (α‐CD) macrocycles onto polymeric chains, which, through the formation of microcrystalline domains, act as junction points for the network. Specifically, host–guest inclusion complexes are formed between α‐CD and PEGylated c...
Article
Full-text available
Variations on the processing conditions of conventional methods for polymeric film preparation may allow tuning certain properties. In this work, different casting surfaces and humidity are presented as variables to consider for cellulose acetate (CA) film preparation using conventional solution casting method. Specifically, borosilicate glass, sod...
Article
Full-text available
Gemfibrozil (GEM) is a hypolipidemic agent, which is effective in reducing serum cholesterol and triglyceride levels. Complexation of GEM with native β-cyclodextrin (β-CD) and with the derivatives hydroxypropyl-β- and randomly methylated β-CD (HPβ-CD and Meβ-CD) was studied in aqueous solution of pH 2.8 and 7.0. The stability constants were determi...
Article
Full-text available
Collagen-based polymers and their blends have attracted considerable interest for new materials development due to their unique combination of biocompatibility, physical and mechanical properties and durability. Leather, a modified natural biopolymer made from animal rawhide and the first synthetic collagen-based polymer known since the dawn of civ...
Preprint
Full-text available
Variations on the processing conditions of conventional methods for polymeric film preparation may allow tuning certain properties. In this work, different casting surfaces and humidity are presented as variables to consider for cellulose acetate (CA) film preparation using conventional solution casting method. Specifically, borosilicate glass (BS)...
Article
Full-text available
The relationship between processing conditions, structure and morphology are key issues to understanding the final properties of materials. For instance, in the case of polymers to be used as scaffolds in tissue engineering, wound dressings and membranes, morphology tuning is essential to control mechanical and wettability behaviors. In this work,...
Preprint
Full-text available
Variations on the processing conditions of conventional methods for polymeric film preparation may allow tuning certain properties of film. Different casting surfaces and humidity during casting are presented in this work, as variables to be considered for cellulose acetate film preparation (CA). Casting surfaces, borosilicate glass, soda-lime glas...
Article
Full-text available
Pseudopolyrotaxanes (PPRs) are supramolecular structures consisting of macrocycles able to thread on a linear polymer chain in a reversible, non-covalent way, often referred to in the literature as “molecular necklaces”. While the synthesis and reaction mechanisms of these structures in solution have been widely described, their solvent-free produc...
Article
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Anti-microbial peptides (AMPs), small biologically active molecules, produced by different organisms through their innate immune system, have become a considerable subject of interest in the request of novel therapeutics. Most of these peptides are cationic-amphipathic, exhibiting two main mechanisms of action, direct lysis and by modulating the im...
Article
Device-Associated Healthcare-Associated Infections (DA-HAI) are a major threat to public health worldwide, since they are associated with increased hospital stays, morbidity, mortality, financial burden, and hospital overload. A strategy to combat DA-HAI involves the use of medical devices endowed with surfaces that can kill or repel pathogens and...
Chapter
Leishmaniasis is a neglected tropical disease caused by intracellular parasites from the genus Leishmania. This neglected tropical disease is responsible for significant morbidity and mortality worldwide. One of the most important challenges for the treatment of leishmaniasis is the oral administration of drugs. Such need combined to the predicted...
Article
The combination of polymeric surfactants with different features into mixed micelles give access to properties that may be superior to the single-component micelles. In this work, we investigated synergistic effects in mixtures of D-α-Tocopheryl polyethylene glycol succinate (TPGS) with poloxamines (also known as Tetronic), pH-responsive and thermo...
Article
Full-text available
Aspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA has greatly increased their anti-tumoral efficacy in CRC compared with the organic counterparts without the Se functionality, suc...
Article
Hypothesis. The combination of polymeric surfactants into mixed micelles is expected to improve properties relevant to their use in drug delivery, such as micellar size, gelation, and toxicity. We investigated synergistic effects in mixtures of D-α-Tocopheryl polyethylene glycol succinate (TPGS), an FDA-approved PEGylated derivative of vitamin E, a...
Article
Photocatalytic properties of titanium dioxide nanoparticles (TiO2 NPs) have encouraged its use as filler in polymer-based nanocomposites with application in food packaging. The surface modification of TiO2 NPs with cyclodextrins (CDs), can improve their functionality in a large extent. Within this purpose, sorbic acid (SA) and benzoic acid (BA), co...
Article
Gram-negative bacteria possess numerous defenses against antibiotics, due to the intrinsic permeability barrier of their outer membrane, explaining the recalcitrance of some common and life-threatening infections. We report the formulation of a new drug, PPA148, which shows promising activity against all Gram-negative bacteria included in the ESKAP...
Article
Miltefosine (MF), an alkylphospholipid originally developed for breast cancer treatment, is a highly active drug for the treatment against leishmaniasis, a neglected tropical disease considered the world's second leading cause of death by a parasitic agent after malaria. MF exhibits dose-limiting gastrointestinal side effects in patients and its pe...
Article
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Nanocomposites based on low density polyethylene filled with carbon nanotubes prepared by high energy ball milling and their potential antibacterial activity. image
Article
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Nanocomposites based on poly(vinylidene fluoride) (PVDF) filled with barium titanate, BaTiO3, (BT) particles, and multiwalled carbon nanotubes (MWCNTs) were prepared by high‐energy ball milling (HEBM) and subsequent hot pressing. This method of materials preparation allowed obtaining uniform dispersions of the nanofillers. The influence of the part...
Article
Pseudo-polyrotaxanes (PPRs) are supramolecular host-guest complexes constituted by the reversible threading of a macrocycle along a polymer chain. The resuting dynamic "molecular necklaces" offer potential applications in nanotechnology, drug delivery, and biomaterials. We report the formation of PPRs by threading of cyclodextrins (CDs), cyclic oli...
Article
The solubilisation of methylparaben (MP), an antimicrobial agent used as a food preservative and in cosmetics and personal-care products, in two poloxamines of different Hydrophilic-Lipophilic Balance (HLB), namely Tetronic® 904 (T904) and 1107 (T1107), has been studied. The influence of the preservative on the aggregation behaviour of both Tetroni...
Article
Full-text available
Fibers of poly(vinylidene fluoride) (PVDF) filled with multiwalled carbon nanotubes (MWCNTs) were prepared by solution blow spinning (SBS). The influence of the MWCNTs on the surface morphology and mechanical behavior of single fibers was studied. The morphology of the materials prepared and the dispersion of the MWCNTs within the polymer were stud...
Article
Full-text available
The modification of the surface of titanium dioxide nanoparticles (TiO₂ NPs) by the incorporation of cyclodextrins (CDs), cyclic oligosaccharides with a hydrophobic cavity, can largely improve the functionality of TiO₂ by lodging molecules of interest in the CD to act directly on the surface of the nanoparticles or for further release. With this ai...
Article
Polypseudorotaxanes are polymer chains threaded by molecular rings that are free to unthread; these ‘pearl-necklace’ can self-assemble further, leading to higher order supramolecular structures with interesting functionalities. In this work, the complexation between α-cyclodextrin (α-CD), a cyclic oligosaccharide of glucopyranose units, and polyeth...
Article
Selenium (Se) incorporated into organic frameworks has demonstrated anticancer activity against several cancer types. One of the drawbacks of most of these constructs is their poor solubility and bioavailability, which can be overcome with the use of suitable nanocarriers. We have synthesized a series of 5-substituted amide selenodiazoles, based on...
Article
Full-text available
Purpose The traditional method to determine humic content (humic and fulvic acids) in commercial fertilizers, biostimulants, and organic materials is based on the oxidation of the organic carbon contained in the basic-soluble but acid-insoluble fraction (humic acids) and the basic-acid soluble fraction (fulvic acids) of their alkaline water extract...
Article
Full-text available
Poly(methyl methacrylate) (PMMA) films filled with titanium oxide (TiO2) nanoparticles were prepared by solution blow spinning (SBS). The influence of the presence of nanoparticles (up to 10% by weight) in the physicochemical properties of the material was studied, focusing on the morphology, structure, and thermal properties, by scanning electron...
Article
Tetronics are X-shaped block-copolymers of polyethylene oxide and polypropylene oxide, which self-assemble into micelles and can undergo a sol-gel transition; these transitions are dependent on temperature, concentration but also pH, due to the central diamine group of the tetrablock. We report the nanoscale morphologies underlying these different...
Article
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In this work, the antimicrobial effect of silver nanoparticles in polyethylene based nanocomposites has been investigated using a non-conventional processing method to produce homogeneous materials. High energy ball milling under cryogenic conditions was used to achieve a powder of well-blended low-density polyethylene and commercial silver nanopar...
Article
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This work describes the feasibility of poly(anhydride) nanoparticles as carriers for the oral administration of glibenclamide (GB) as well as the in vivo evaluation of their hypolipidemic effect in a C. elegans model. For this purpose, and in order to increase the GB payload, the drug was encapsulated in nanoparticles in presence of cyclodextrins (...
Article
Solution blow spinning, SBS, was used to prepare fibrous films of thermoplastic nanocomposites with potential antibacterial properties based on polysulfone, PSF, filled with well dispersed TiO2 nanoparticles. The PSF/TiO2 nanocomposites were produced with different nanoparticles content up to 10% by weight. A wide characterization was carried out f...
Article
Basalt fibers were surface treated with silane coupling agents as a method to enhance the adhesion and durability of fiber-matrix interfaces in concrete based composite materials. In particular, this work has been focused on the study of basalt fibers chemical coatings with aminosilanes and their subsequent characterization. Surface treatments were...
Article
The aggregation and structure of D-α-tocopheryl polyethylene glycol succinate micelles, TPGS-1000, an amphiphilic derivative of vitamin E, were characterized by scattering and spectroscopic methods, and the impact of different cyclodextrins (CDs) on the self-assembly studied, with the view of combining these two versatile pharmaceutical excipients...
Article
Solution blow spinning, SBS, a quite novel processing method, was used to obtain poly (ethylene-co-vinyl acetate), EVA, films with controlled surface properties. The influence of the surface characteristics of EVA films on the adhesion of DH5α Escherichia coli was studied. In particular, the initial concentration of the EVA solution to be blow spun...
Article
Thermoplastic nanocomposite materials with potential bactericide properties were prepared and their surface properties and adhesion to Streptococcus mutans, S. mutans, were characterized. Solution blow spinning was successfully used to prepare films with a fiber-like structure on the surface of nanocomposites based on Polyvinylidene fluoride, PVDF,...
Article
The pharmaceutical applications of cyclodextrins (CDs), cyclic oligosaccharides capable of including hydrophobic molecules inside their cavities, have been known for decades. Besides the solubilising and encapsulating abilities of natural and modified CDs due to the formation of inclusion complexes, there is an increasing interest in organised macr...
Article
Polymeric micelles, in particular PEO-PPO-based Pluronic, have emerged as promising drug carriers, while cyclodextrins, cyclic oligosaccharides with an apolar cavity, have long been used for their capacity to form inclusion complexes with drugs. Dimethylated β-cyclodextrin (CD) has the capacity to fully break-up F127 Pluronic micelles, while this e...
Article
We report the preparation of a nanocomposite hydrogel based on a poloxamine gel matrix (Tetronic T1107) and cyclodextrin (CD)-modified Barium Titanate (BT) nanoparticles. The micellization and sol-gel behaviour of pH-responsive block-copolymer T1107 were fully characterised by small-angle neutron scattering (SANS), dynamic light scattering (DLS), a...
Article
Full-text available
Ceramic nanoparticles with piezoelectric properties, such as BaTiO3 (BT), constitute a promising approach in the fields of nanocomposite materials and biomaterials. In the latter case, to be successful in their preparation, the drawback of their fast aggregation and practically null stability in water has to be overcome. The objective of this inves...
Article
Full-text available
The effect of high energy ball milling, HEBM, and the presence of kaolin on the structure, morphology, and biofilm development of polylactic acid, PLA, were studied. Biofilm development was evaluated in terms of structural and/or morphological variations so as the sole presence of kaolin. Composites based on PLA filled with kaolin were prepared by...
Article
Inclusion complexes between cyclodextrins (CDs) and polymers - so-called pseudopolyrotaxanes (PPR) - are at the origin of fascinating supramolecular structures, which are finding increasing uses in biomedical and technological fields. In this work, we explore the complexation of a range of cyclodextrins with Tetronic T1307, a four-arm block-copolym...
Article
Full-text available
The effect of the presence of silica nanoparticles on the structure, thermal stability and dynamics of low density polyethylene, LDPE, has been studied. Different loads of nanoparticles were dispersed within a LDPE matrix using high energy ball milling (HEBM) as a preliminary processing step to ensure a uniform dispersion of nanofiller to obtain na...
Article
Inclusion complexes between cyclodextrins and polymers - so-called pseudopolyrotaxanes (PPR) - are at the origin of fascinating supramolecular structures, which are finding increasing uses in biomedical and technological fields. Here we explore the impact of both native and a range of modified cyclodextrins (CD) on the self-assembly of X-shaped pol...
Article
The aggregation behaviour of a chiral metallosurfactant, bis(2,2'-bipyridine)(4,4'-ditridecyl-2,2'-bipyridine)ruthenium(II) dichloride (Ru24C13), synthesized as a racemic mixture was characterized by small-angle neutron scattering, light scattering, NMR and electronic spectroscopies. The analysis of the SANS data indicates that micelles are prolate...
Article
We report the effect of native cyclodextrins (α-, β-, and γ-) and selected derivatives in modulating the self-assembly of the non-ionic surfactant polyoxyethylene cholesteryl ether (ChEO10), and its mixtures with triethylene glycol monododecyl ether (C12EO3), which form wormlike micelles. Cyclodextrins (CDs) generally induce micellar break-up throu...
Article
Full-text available
Los medios audiovisuales son herramientas adecuadas hoy en día para ilustrar el desarrollo de las clases magistra-les impartidas por el profesor universitario. El alumno se desenvuelve con soltura en estos soportes, y la utilización de estos medios es un óptimo complemento para una buena comprensión del tema. Particularizando esta acción en estudio...
Article
Composites based on polyvinylidene fluoride filled with barium titanate (PVDF/BT) submicrometric particles were prepared. To uniformly disperse BT particles within PVDF, high-energy ball cryomilling was used. The effect of processing and the presence of BT particles on the structure and morphology of the composites were analyzed by Fourier transfor...
Article
The aim of this investigation has been to define universal parameters that could be extracted in a straightforward way from FTIR-ATR spectra for the quality control (QC) of cork stoppers for paraffin and silicone; i.e., the most common components in surface treatment for lubrication and sealing. Three indicators, namely TC (total coating), SC (sili...
Article
In this work, PVDF–BaTiO3 composites were prepared using cryogenic high-energy ball milling (HEBM) and subsequent hot pressing. PVDF-BaTiO3 mixtures with different weight fractions of submicrometric BaTiO3 particles were subjected to 1 h of active milling. By applying pressure at 200°C the resulting powder was molded in the form of thin discs. This...
Article
Composites based on polystyrene (PS) filled with submicrometre particles of BaTiO3 were prepared making use of high energy ball milling (HEBM) and hot pressing. The effect of processing and the amount of BaTiO3 particles on the morphology and structure of the composites was studied to finally correlate them with their dielectric behaviour. The meth...
Article
Rhodamines B and 6G have been used to evaluate the dispersion of β-Cyclodextrin in a thermoplastic matrix, poly(ethylene-co-vinyl acetate), by high energy ball milling. In a first stage, a study of the binding properties of β-Cyclodextrin with both fluorophores has been carried out, to determine which of them forms the most stable complex with the...
Article
Ethylene vinyl acetate copolymer, a thermoplastic semicrystalline polymer, has been blended with barium titanate submicrometric particles (BaTiO3) by means of high-energy ball milling (HEBM) for obtaining composites in the form of films by hot pressing. Two different milling conditions have been considered: (i) milling at room temperature and (ii)...
Conference Paper
In this work, PVDF-BaTiO3 composites were prepared using cryogenic high-energy ball milling (HEBM). PVDF-BaTiO3 mixtures with different weight fractions of submicrometric BaTiO3 particles were subjected to 1 h of effective milling. By applying pressure at 200 °C the resulting powder was molded in the form of relatively thin discs. Morphological and...
Article
The effect of the presence of alumina microparticles and silica nanoparticles on the coefficient of thermal expansion (CTE) of films of low density polyethylene (LDPE) based composites was investigated. A new method based on the use of an atomic force microscope (AFM) is proposed for measuring nano-thermal expansion of films to finally obtain the C...
Article
The chemiluminescent oxidation of some phthalhydrazide derivatives, luminol (LUM), isoluminol (ISOL), N-(4-aminobutyl)-N-ethylisoluminol (ABEI) and N-(6-aminohexyl)-N-ethylisoluminol (AHEI), has been carried out in micellar media and in the presence of natural cyclodextrins (CDs), using Co(II) as catalyst and H2O2 as oxidant. The cationic cetyltrim...
Article
The purpose of this investigation has been to establish reference pK a values in D2O for the three natural CDs by high-resolution 1H-NMR, according to the recent guidelines provided by the IUPAC for the determination of extreme pK a values. The most alkaline conditions achieved in this study than in previous pH potentiometric assays have made possi...
Article
The purpose of this investigation has been to establish reference pKa values in D2O for the three natural CDs by high-resolution 1H-NMR, according to the recent guidelines provided by the IUPAC for the determination of extreme pKa values. The most alkaline conditions achieved in this study than in previous pH potentiometric assays have made possibl...
Article
The chemiluminescence (CL) yield of two isoluminol derivatives, N-(4-aminobutyl)-N-ethylisoluminol (ABEI) and N-(6-aminohexyl)-N-ethylisoluminol (AHEI), is remarkably increased in the presence of natural cyclodextrins (CDs). The most notable effect is produced by the addition of gamma-CD that produces enhancements up to 15-fold in the light emissio...