Gustavo A. González Aguilar

Gustavo A. González Aguilar
Research Center for Food and Development A.C. | CIAD · Department of Technology of Food of Plant Origin

PhD

About

443
Publications
307,360
Reads
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14,302
Citations
Introduction
Our research is focus on antioxidant and development of functional foods. It is very important to our group to elucidate the possible interactions between bioactive compounds and fiber and how the bioaccesibility and bioaviability is affected during the digestion processes. The biochemical and physicochemical interactions that occur between these molecules are being studied. Nutrigenomic and metabolomic studies of phenolic compounds give good information necessary to elucidate some mechanisms.
Additional affiliations
January 2000 - December 2012
Research Center for Food and Development A.C.
January 1999 - December 1999
United States Department of Agriculture
Position
  • Visiting Scientist
Description
  • Work in the Fresh-cut area in natural antioxidants to prevent deterioration of tropical fruits
January 1999 - December 1999
United States Department of Agriculture
Position
  • Sabbatical
Description
  • Studies on the use of natural antioxidants to prevent deterioration and maintain the nutritional value of fresh-cut fruits

Publications

Publications (443)
Article
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In this work, the ultrasound-assisted extraction (UAE) (operating conditions of sonication amplitude, pulse-cycle, and extraction time) was investigated to obtain an extract rich in biologically active compounds from Annona muricata leaves. In addition, the content of bioactive compounds from the extract by the optimal UAE conditions (UAE extract)...
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Inflammation may negatively impact health, particularly that of the central nervous system. Phenolic compounds are bioactive molecules present in fruits and vegetables with potential anti‐inflammatory effects. The purpose of the present work is to review the immunomodulatory bioactivities of phenolic compounds in the periphery and in the central ne...
Article
Escherichia coli is among the most prevalent food contaminant microorganisms that have evolved, generating variants based on their effects on the host; these include commensals or pathobiont strains. The last classifications of E. coli intestinal pathobionts found in this review are enteroinvasive, enterohemorrhagic, enteropathogenic, enterotoxigen...
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La obesidad es actualmente un problema de salud pública a nivel mundial. Ésta se caracteriza por afectar a múltiples órganos, entre ellos el hígado, desarrollándose enfermedades como la enfermedad de hígado graso no alcohólico (EHGNA), la cual predispone al desarrollo de carcinoma hepatocelular. En esta revisión se discute la asociación entre la ob...
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Sweet potato (SP; Ipomoea batatas (L.) Lam) is an edible tuber native to America and the sixth most important food crop worldwide. China leads its production in a global market of USD 45 trillion. SP domesticated varieties differ in specific phenotypic/genotypic traits, yet all of them are rich in sugars, slow digestible/resistant starch, vitamins,...
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The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic rodents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase)...
Article
Phellinus Quél is one of the largest genera of Hymenochaetaceae; it comprises about 220 species widely distributed on Earth. Most Phellinus species are lignicolous mushrooms that accumulate bioactive compounds. This research studied the phenolic composition of Phellinus spp. and their relationship with antibacterial and antiviral capacity. Phenolic...
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Melatonin (MT) treatment (100 µM, 2 h) was applied to four mango fruit cultivars (‘Langra’, ‘Chaunsa’, ‘Dashehari’, and ‘Gulab Jamun’), before being stored at 5 ± 1 °C for 28 d, in order to alleviate chilling injury (CI). Maximum CI reduction was observed in ‘Langra’ mangoes, and minimum in ‘Gulab Jamun’ mangoes. This positive effect on quality pre...
Article
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Resume The meninges protect the nervous system from various rather damaging stimuli and pathogens from the periphery. This tissue is composed of brain endothelial cells (BECs) that express various ion channels and chemical transmitter receptors also expressed by neurons and glial cells to communicate with each other. However, information on the eff...
Article
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e effects of an exogenous application of various concentrations and dipping duration of melatonin (MT) treatment on postharvest senescence, quality, chilling tolerance, and antioxidant metabolism of mango fruit cv. "Dashehari" were examined. Fruits were treated with three concentrations of MT (50, 100, or 150 µM), each applied for three times (60,...
Article
Guava fruit is rich in phenolic compounds (PCs), whose metabolic fate has not been explored. Non-digestible carbohydrates and PCs in whole guava (WG) and seedless guava (SG) were submitted to an in vitro colonic fermentation, followed by evaluation of the anti-proliferative activity of the fermentation extracts in HT-29 cancer cell lines. The main...
Article
This study aimed to obtain sorghum doughs subjected to two fermentation processes (backslopping and spontaneous fermentation techniques) with enhanced biological properties and to assess their influence on the bioaccessibility of phenolic compounds and Ferulic Acid (FA) of cookies formulated from fermented sorghum doughs. The best contents of Total...
Article
The prevalence of gastritis requires the consumption of functional foods to counteract this disease. The objective of this work was to characterize guava-Aloe vera purees, evaluate their in vitro anti-inflammatory effect and demonstrate the gastroprotective effect in a murine model induced to the gastric lesion. The nutritional composition, physico...
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Avocado cv. ‘Hass’ paste is the main byproduct derived from industrial avocado processing, and contains various bioactive compounds (BCs). Consumption of these compounds from different sources has been associated with positive health effects, although studies of avocado byproducts remain minimal. Avocado paste was analyzed, regarding its physicoche...
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Bacterial diseases and reactive oxygen species can cause dental caries and oral cancer. Therefore, the present review analyzes and discusses the antibacterial and antioxidant properties of synthetic and plant-derived substances and their current and future patents to formulate dental products. The reviewed evidence indicates that chlorhexidine, flu...
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Avocado paste (AP) is a phenolic-rich byproduct of avocado oil extraction. The effects of sub-chronic consumption of diets supplemented with an AP phenolic extract (PE) were analyzed. A standard diet (SD), high-fat diet (HFD), and these supplemented with PE (SD + PE and HFD + PE) were used. Significantly increased satiety was observed in PE-supplem...
Article
Introduction: Fouquieria splendens commonly named "ocotillo", is a native plant from Mexico, used in folk medicine against different illnesses. However, scientific evidence about its biological activities is limited. The objective of this study is to determine phenolic composition, antioxidant and antiproliferative effect of F. splendens. Methods:...
Article
Consumption of tropical fruits is growing around the world, not only due to their flavor and appearance but also for their nutritional value. In addition to the content in macro and micronutrients, tropical fruits contain substantial amounts of bioactive compounds in peels, and seeds which constitute an underexploited source of bioactive compounds...
Article
The blood-brain barrier (BBB) is a physical structure whose main function is to strictly regulate access to circulating compounds into the central nervous system (CNS). Vegetable-derived phenolic compounds have been widely studied, with numerous epidemiologic and interventional studies confirming their health-related bioactivities across multiple c...
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The role of non-energy-yielding nutrients on health has been meticulously studied, and the evidence shows that a compound can exert significant effects on health even if not strictly required by the organism. Phenolic compounds are among the most widely studied molecules that fit this description; they are found in plants as secondary metabolites a...
Article
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Curcumin (CUR) is a phenolic compound that is safe for human consumption. It exhibits chemopreventive, antiproliferative, antiangiogenic, and antimetastatic effects. However, these benefits can be hampered due to the lipophilic nature, rapid metabolism, low bioavailability, and fast elimination of the molecule. Considering this, the present work re...
Article
Exogenous melatonin (100 μM) was applied to four mango fruit cultivars, namely, ‘Langra’, ‘Dashehari’, ‘Chaunsa’, and ‘Gulab Jamun’, and subsequently stored at 5 ± 1 °C for 28 d. ‘Langra’ mangos responded best to melatonin treatment by increasing their chilling tolerance during storage, while ‘Gulab Jamun’ mangos did not experience any significant...
Article
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Con el fin de contribuir al conocimiento sobre la propagación asexual de Rubus idaeus L., se estableció un experimento cuyo objetivo fue conocer, en dos años consecutivos (2017 y 2018), los efectos de tipos de sustratos y ácido indol-3-butírico (IBA), en la propagación de diferentes variedades frambuesa a partir de esquejes de raíz bajo condiciones...
Article
Diabetes induces inflammation in the brain and kidneys; it is also known to be linked with changes in the expression and functionality of Kir channels. Diets rich in antioxidants (e.g., phenolic compounds) tend to reduce diabetes-related oxidative damage in several organs and the expression of K+ channels. We evaluated the effect of a diet suppleme...
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Lactic acid fermentation increases the bioactive properties of shrimp waste. Astaxanthin is the principal carotenoid present in shrimp waste, which can be found esterified in the liquid fraction (liquor) after its lactic acid fermentation. Supercritical CO2 technology has been proposed as a green alternative to obtain astaxanthin from fermented shr...
Article
This study aimed to trap green tea extract (GTE) with maltodextrin (MD) to protect catechins from high temperatures, pH variations, and storage. GTE:MD microparticles (19.35:80.65 % w/w) were obtained by spray drying, producing microparticles (26 μm) with a trapping efficiency of 63%, containing epigallocatechin gallate (EGCG), gallocatechin gallat...
Article
The aim of this study was to determine the effect of roselle (Hibiscus sabdariffa L.) aqueous extracts addition on the chemical, physico‐chemical and sensorial properties of frankfurters‐type sausages. For that, five formulations were prepared: the original mixture was used as control sample (CS). The other samples were formulated added roselle ext...
Article
Neolentinus lepideus is a fungus consumed by rural communities in Central America and Asia due to its rich flavor; however, little information on its chemical composition is available. With this in mind, the objective of this work was to determine the content of vitamin E and C, ergosterol, phenolic compounds of this fungus as well as its antioxida...
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Heterocyclic amines (HCAs) are compounds with carcinogenic potential formed during high-temperature processing of meat and meat products. Vegetables or their extracts with high antioxidant capacity can be incorporated into the meat matrix to reduce their formation, but it is necessary to find the optimal levels to achieve maximum inhibition without...
Article
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Raspberries are important sources of bioactive compounds, whose synthesis is influenced by the fertilization system and the maturity stage. This study evaluated the effect of organic and conventional fertilization systems on raspberries at three maturity stages, pink, ripe, and overripe. Physicochemical characteristics, bioactive compounds (phenoli...
Article
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Avocado peel is a source of bioactive compounds with antioxidant, anti-inflammatory, antiproliferative and antimicrobial capacities, among others. Physical and chemical interactions of phenolic compounds with indigestible polysaccharides could affect their bioaccessibility in the upper gastrointestinal tract, allowing them to reach the colon, where...
Article
The meninges shield the nervous system from diverse, rather harmful stimuli and pathogens from the periphery. This tissue is composed of brain endothelial cells (BECs) that express diverse ion channels and chemical-transmitter receptors also expressed by neurons and glial cells to communicate with each other. However, information about the effects...
Article
Full-text available
Polyphenols are the most important phytochemicals in our diets and have received great attention due to their broad benefits for human health by suppressing oxidative stress and playing a protective role in preventing different pathologies such as cardiovascular disease, cancer, diabetes, and obesity. The stability of polyphenols depends on their e...
Article
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The present work evaluated the influence of extraction method and species on the physicochemical properties, oxidative stability, fatty acid profiles, and rheological behaviour of pumpkin seed oils. The seeds of two pumpkin species (Cucurbita argyrosperma Huber [CA] and Cucurbita moschata Duchesne [CM]) were obtained from small-scale pumpkin proces...
Article
Pineapple (Ananas comosus) is a widely consumed tropical fruit. UV-C irradiation reduces the microbial load of fruits and contributes to the increase their content of phenolic compounds (PCs). Snack-bars were prepared batch using UV-C irradiated pineapple slices (irradiated pineapple bar, IPB) or with non-irradiated pineapple slices (non-irradiated...
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The content of antioxidant compounds varies within fungal species, and the Polyporales order has been recognized for this property. Numerous antioxidant compounds have been identified in Polyporales fungi, including phenolic compounds, β-glucans, ergosterol, ergothioneine, vitamin C, and tocopherols. Each compound contributes differently to the ant...
Article
The effects of phenolic-rich extracts from avocado peels (AP) and seeds (AS) on the colloidal and the lipid oxidative stability of oil-in-water (O/W) emulsions/nanoemulsions were evaluated. For this purpose, the interfacial tension (IFT) of avocado oil droplets in the presence of extracts and surfactants (low methoxyl pectin, LMP; Tween 80, T80), i...
Article
Los déficits nutricionales en la mujer deportista causan numerosos problemas de salud, así como un empeoramiento en el rendimiento deportivo, como consecuencia de estas deficiencias nutricionales. El conocimiento de estos déficits y su prevención deben ser un aspecto principal para cualquier responsable deportivo. Establecer la importancia del estu...
Article
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Agro-industrial processing activities generate by-products that are discarded at high economic and environmental costs; however, many of them still contain high levels of bioactive compounds (BCs) such as dietary fiber (DF) and phenolic compounds (PCs), which, when combined, are known as antioxidant dietary fiber (ADF). These BCs have properties th...
Article
Bacterial food-borne and nosocomial infections are a public health issue around the world that is exacerbated by biofilm formation and acquired resistance to antibiotics. New therapies focusing on the prevention of biofilm formation may help to face these challenges. In this study, the antibiofilm activity of Cu²⁺ and Fe³⁺ complexes formed with an...
Article
In this study, the effect of intense pulsed light (PL) on color, firmness, phytochemicals content and antioxidant activity (AA) of fresh‐cut avocados (FCA) was evaluated for 12 days. In that sense, three different ultraviolet and visible wavelength ranges of PL were compared: 180‐1100nm (UVC‐VIS), 280‐1100nm (UVB‐VIS) and of 400‐1100nm (VIS). Inter...
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Sorghum’s biological potential can be exploited to formulate healthy foods. The objective of this work was to optimize the germination process of sorghum to maximize the content of free phenolic compounds and antioxidant activity. According to the response surface methodology, the maximum content of total phenols and ferulic acid was obtained at 35...
Article
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This study aimed to characterize the quality and bioactive compounds from five cultivars grown in Mexico´s northern region: Heritage, Summit, Harvest, and red and yellow Autumn. The physicochemical characteristics, DPPH anti-radical capacity, total phenolics, flavonoid and anthocyanins, polyphenolic profile, and ascorbic acid levels of the raspberr...
Chapter
Fruit by-products and the importance of their valorization to reduce their negative environmental impacts have gained attention as a form of sustainable management that can generate profits for the producing areas. These materials constitute an unexplored and underexploited source of health benefits. This chapter focuses on tropical fruits consumed...
Article
Background Curcumin is a natural phenolic compound exhibiting multiple bioactivities that have been evaluated in vitro, in vivo as well as through clinical studies in humans. Some of them include antimicrobial, antioxidant, anti-inflammatory and central nervous system protective effects. Further, curcumin is considered a Generally Recognized as Saf...
Article
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Purpose The purpose of this study was to screen wild GABA-producing lactic acid bacteria (LAB) isolated from artisanal Mexican cheeses and to evaluate the fermentation conditions for the enhancement of the GABA yield in fermented milk. Methods A qualitative test was carried out to select the GABA-producing LAB and the GABA was quantified by revers...
Article
The genus Annona belongs to the family Annonaceae and includes several species of tropical and subtropical crops characterized by their edible and exotic fruits. Twenty species of Annona have been reported in Mexico, localized mainly in the tropical southeastern regions of the country. Most species, however, are not marketable and remain underutili...
Article
The increased demand for avocado, and therefore production and consumption, generate large quantities of by-products such as seeds, peel, and defatted pulp, which account for approximately 30% of fruit weight, and which are commonly discarded and wasted. The present review focuses on various compounds present in avocado fruit and its by-products, w...
Article
Full-text available
Heterocyclic amines (HCA) are compounds formed by heating meat at a high temperature. Formation of HCA in meat products should be minimized by applying different approaches. The objective of this study was to investigate the effects of roselle extract (RE, 0%–1%), potato peel flour (PP, 0%–2%), and beef fat (BF, 0%–15%) on the formation of HCA in b...
Article
Mango processing discards phenolic‐rich by‐products. The present work evaluated the effects of supplementing corn chips with mango cv. “Ataulfo” peel (0, 10, 15, and 20%), regarding sensory acceptability, phenolic content, profile and in vitro bioaccessibility, antioxidant activity, and in vitro dialyzed glucose. Addition of up to 15% mango peel ma...
Article
Bursera microphylla is an endemic plant from Sonora desert, used in folk medicine, however, there is a few scientific information about compounds profile and antioxidant activity. The objective of the study was to determine the phenolic profile and antioxidant activity of B. mycrophylla leaves (BMLE) and fruits (BMFE) extracts. Phenolic content was...
Article
BACKGROUND Oxidative stress has been implicated in the pathogenesis and progression of diabetes mellitus, both can damage the brain. Mango and its by‐products are sources of bioactive compounds with antioxidant properties. We hypothesized that mango cv. ‘Ataulfo’ peel and pulp mitigate oxidative stress in the brain of streptozotocin‐induced diabeti...
Article
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The objective of the present study is to evaluate the effect of individual and combined coatings of chitosan (0.008 g·mL−1) and carnauba wax (0.1 g·mL−1) with oregano essential oil (OEO, 0.08 g·mL−1) to reduce dehydration and microbial decay of fresh cucumbers stored at 10 °C. Chitosan-OEO-wax films showed the lowest water vapor transmission rate (...
Article
Inhibition of pancreatic lipase (PL) is used to treat dyslipidemias and obesity. Phenolic compounds are highly bioactive molecules that can inhibit various enzymes. Our aim was to evaluate the inhibitory activity of selected phenolic compounds of increasing molecular complexity, namely, phenolic acids, mangiferin, penta-O-galloyl-β-d-glucose (PGG)...
Article
The objective of this study was to assess the effects of roselle extract (0%–1%), potato peel flour (0%–2%), and beef fat (0%–15%) on physicochemical properties (instrumental color, pH, cooking properties, and texture profile analysis), antioxidant capacity (DPPH, ABTS, and ORAC), and total phenols in beef patties using response surface methodology...
Article
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The effect of elicitation in butterhead lettuce on carotenoid and polyphenol metabolism was evaluated. Different concentrations of arachidonic acid (AA), salicylic acid (SA), methyl jasmonate (MJ) (15, 45, and 90 μM) and Harpin protein (HP) (30, 60, and 120 mg/L) were applied on red and green butterhead lettuces. Total phenolic and flavonoid conten...
Article
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Small berries are rich in polyphenols whose first-pass metabolism may alter their ultimate physiological effects. The antioxidant capacity and polyphenol profile of three freeze-dried berries (blackberry, raspberry, Red Globe grape) were measured and their apparent permeability (Papp) and first-pass biotransformation were tracked with an ex vivo bi...
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Intensive horticultural crop production usually involves challenges from excessive application of fertilizer, mainly nitrogen (N). The effect of N fertilizer on the fruit quality and antioxidant status of two cherry tomato cultivars (Caballero and Victoria) under greenhouse conditions was performed. Nitrogen treatments were applied ranging from con...