Gustav Komlaga

Gustav Komlaga
Kwame Nkrumah University Of Science and Technology | KNUST · Department of Pharmacognosy

PhD

About

37
Publications
21,672
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
502
Citations
Citations since 2017
17 Research Items
425 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Additional affiliations
August 2019 - August 2020
Kwame Nkrumah University Of Science and Technology
Position
  • Professor (Associate)

Publications

Publications (37)
Article
Full-text available
Background: Duranta erecta is used in traditional medicine for the treatment of myriad of diseases in most developing countries. The potential safety concerns associated with the administration of hydroethanolic fruit extracts of the plants were investigated in rats. Materials and Methods: Extracts were screened for their possible antioxidant activ...
Article
Ethnopharmacological significance and aim Hura crepitans is commonly used to treat liver diseases in Nigeria and Ghana. Previous studies have supported its ethnomedicinal use in protecting the liver. The present study aimed at assessing the effect of H. crepitans stem bark on the subacute carbon tetrachloride (CCl4)-induced liver damage in rats. M...
Article
Full-text available
The leaf of Theobroma cacao L. is used in traditional medicine in Ghana for the treatment of malaria, yet, with no scientific evidence of its antimalarial property in animals. It was, therefore, studied to validate the antimalarial property in Plasmodium berghei-infected mice. Infected mice were treated with an aqueous extract of T. cacao leaf at d...
Article
Full-text available
Amphimas pterocarpoides is used traditionally for the treatment of oedema, infections, malaria and skin diseases. This study described pharmacognostic and physicochemical parameters of the leaf and stem bark. The carrageenan-induced foot oedema and the baker’s yeast-induced pyrexia were used to assess the anti-inflammatory and antipyretic activitie...
Article
Full-text available
Liver disease is a major health problem and its treatment is costly in most developing countries with attendant adverse effects. This study aimed at determining the acute hepatoprotective efficacy of Duranta erecta hydroethanolic extracts of leaves, ripe and unripe fruits against CCl4-, and acetaminophen-induced hepatotoxicity in animals. Materials...
Article
Full-text available
Medicinal plants play a vital role in the healthcare of many people in Africa and other developing countries. Of these, Hura crepitans L. is used in some parts of Nigeria and Ghana in the management of liver diseases. This study evaluated the hepato-protective effects of the aqueous (AE) and ethanolic extracts (EE) of H. crepitans stem bark in CCl...
Article
Five new cassane-type diterpenoid heterosides, i. e. two cassane-type amides (1–2), two erythrophlamine-type amine esters (3–4) and a non‑nitrogenous erythrophlamine analogue (5) were isolated from the root barks (1–2) and the seeds (3–5) of Erythrophleum suaveolens. Their structures were unambiguously established by interpretation of their HRESIMS...
Article
Full-text available
The use of herbal products has increased and become more popularized globally; however, limited studies coupled with questions related to the quality and safety of these herbal products have been raised. Herbal products with hope of their nontoxicity may play a role of alternative to overcome the problems of multi-drug resistant pathogens. Medicina...
Article
Full-text available
Background and Objectives: Medicinal plants have become popular in the search ofa cure for various hepatopathies with a considerable number of herbal products being used for the management of liver ailments. However, most, including Hura crepitans (HC), have not been Original Research Article Owojuyigbe et al.; EJMP, 31(8): 1-16, 2020; Article no.E...
Article
Full-text available
Background and Objectives: Duranta erecta is used in folklore medicine for the treatment of myriad of diseases in Africa. The study was carried out to evaluate the safety of hydroethanolic leaves extract of D. erecta in experimental rats in order to ascertain its potential toxic effects. Materials and Methods: The acute toxicity study was performed...
Article
Full-text available
Herbal medicines are the main source of treatment of diseases in non-urban centres of the developing world. Secondary metabolites obtained from herbal sources contain bioactive phytochemicals, many of which have been the origin for the development of novel pharmaceutical drugs. Hura crepitans L. (Euphorbiaceae) or sandbox tree has been beneficial i...
Article
Full-text available
The use of plant-based medicine is popular amongst individuals and communities in developing countries. Duranta erecta has been used in Africa and Asia to treat a wide range of diseases. This study evaluated the phytochemical profile and antioxidant and antimicrobial activities of D. erecta to ascertain its health benefits in traditional medicine....
Article
Full-text available
The use of leafy vegetables in diet is a common practice among the people of the Northern ethnic groups of Ghana. In this study, a survey was conducted in the Bunkpurugu-Yunyoo district and Kanvilli of the Tamale Metropolis of the Northern Region of Ghana, to document the indigenous leafy vegetables routinely consumed as part of their alimentary cu...
Article
The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanth...
Article
Full-text available
Leishmaniasis and trypanosomiasis are protozoan diseases caused respectively by the kinetoplastid protozoan Leishmania parasites transmitted by the female phlebotomine sandflies and Trypanosoma parasites transmitted by the tsetse fly. In the search for agents from tropical medicinal plants to treat these two neglected tropical diseases, serially ex...
Article
Full-text available
The use of medicinal plants for the treatment of diseases including malaria is commonplace in Ghanaian traditional medicine, though the therapeutic claims for most plants remain unvalidated. Antiplasmodial activity of the aqueous extracts and successively obtained petroleum ether, ethyl acetate and methanol fractions of the whole Phyllanthus frater...
Article
Phytochemical investigation of the methanol extract of the root bark of Dichostachys cinerea (Fabaceae) led to the isolation and characterization of 3 new pyrrolidine-derived compounds with 12 carbon side chain and their glycosides. The structures of these compounds (1–3) were established using spectroscopic analytical methods comprising NMR experi...
Article
Full-text available
The Antimalarial Potential of Three Ghanaian Medicinal Plants Objective: Malaria is a major public health problem in Ghana and many indigenes, especially those in rural areas, resort to the use of medicinal plants to treat the disease. The plants: Persea americana Mill. (Lauraceae), Theobroma cacao L. (Malvaceae) and Tridax procumbens (L.) L. (Com...
Article
Phytochemical investigation of the stem bark of Erythrophleum suaveolens yielded four new cassane diterpenoids; 6α-hydroxy-cassamic acid, methyl ester, 4β-carbomethoxy-14-methyltotarol, 6α-hydroxy-nor-cassamine, and 8,9-dehydro-nor-cassamine, along with four known cassane diterpenoids. All structures were elucidated on the basis of one- and two-dim...
Article
Objective: Malaria is a major public health problem in Ghana and many indigenes, especially those in rural areas, resort to the use of medicinal plants to treat the disease. The plants: Persea americana Mill. (Lauraceae), Theobroma cacao L. (Malvaceae) and Tridax procumbens (L.) L. (Compositae) are used solely or in combination with other medicinal...
Article
Full-text available
The leaves of Solanum macrocarpon (Solanaceae) was evaluated for its pharmacognostic characteristics and antioxidant properties. Microscopic studies showed the presence of both anomocytic and anisocytic types of stomata on both the upper and the lower epidermis, unicellular and branched clothing trichomes as well as glandular trichomes with unicell...
Article
Full-text available
Euadenia eminens Hook f. (Capparaceae) has traditional uses in the management of conjunctivitis, iritis, ophthalmia, tuberculosis, otalgia and rectal prolapse. The fruit pulp is also eaten as an aphrodisiac. In this paper, we report on the antiinflammatory, antioxidant and antibacterial effects of its roots. A 70 % ethanol extract was tested for an...
Article
Full-text available
Euadenia eminens Hook f. (Capparaceae) has traditional uses in the management of conjunctivitis, iritis, ophthalmia, tuberculosis, otalgia and rectal prolapse. The fruit pulp is also eaten as an aphrodisiac. In this paper, we report on the anti-inflammatory, antioxidant and antibacterial effects of its roots. A 70 % ethanol extract was tested for a...
Article
Full-text available
This work was conducted in order to investigate the hypoglycaemic and antioxidant activity ofthe stem bark of Morinda lucida Benth (Rubiaceae), which has traditionally been used in Ghana for the management of diabetes mellitus. Methods: The powdered stem bark was successively Soxhlet-extracted with petroleum ether and 70% vi ethanol, respectively,...
Article
Full-text available
Csesslpinis benthsmisns (8aill.) Herend. and Zarucchi (Mezoneuron benthsmisnum Baill.) (Caesalpiniaceae) has been traditionally used in management of erectile dysfunction, dysentery, urethral discharges, skin diseases and wounds. Despite a long tradition of use in the treatment of various ailments, no systematic pharmacognostic standardization work...
Article
Full-text available
Glyphaea brevis (Spreng) Monachino (Tiliaceae) have traditional uses in the management of conditions characterized by infections, inflammatory disorders and oxidative stress. The paper aims to report the comparative data on the leaves and stem bark of Glyphaea brevis with respect to their antibacterial, anti-inflammatory and antioxidant effects. Th...
Article
Full-text available
Hoslundia opposita Vahl. (Lamiaceae), a common local shrub in Ghana, is traditionally known not only for its pharmacological benefits but also for its insecticidal properties. Its acaricidal property, however, has not been investigated. To test the acaricidal effects of the crude extract and fractions of H. opposita leaves as well as to isolate and...
Article
Full-text available
This work was carried out to determine antihypertensive effect of ethanolic extract of Imperata cylindrical leaves using cat and rabbit models. A freeze dried 70% ethanolic extract was prepared and increasing concentrations from 10 to 320 mg/ml were administered in vivo to anaesthetized cats and in vitro to rabbit jejunum. Adrenaline and phentolami...
Article
Full-text available
Xylopia aethiopica is a medicinal plant of great repute in West Africa which produces a variety of complex chemical compounds. The fresh and dried fruits, leaf, stem bark and root bark essential oils showed various degrees of activity against the Gram positive bacteria, Bacillus subtilis and Staphylococcus aureus, the Gram negative bacteria Pseudom...
Article
Secamone afzelii has been used traditionally for wound healing. To confirm the fokloric uses of the plant, the methanol extract of the plant was tested for antimicrobial and antioxidant activities, since antimicrobial agents and antioxidants facilitate wound healing. The extract showed some level of antimicrobial and antioxidant activities. The sel...
Article
Phytochemical investigation of the ethanolic extract of the mature fruit of Tetrapheura tetraptera led to the isolation of three flavonoid constituents namely 2', 4, 4'-trihydroxychalcone, 2', 3, 4, 4'- tetrahydroxychalcone and 4', 5, 7-trihydroxyflavanone. The structures were established from 1D and 2D NMR experiments. This is the first isolation...
Article
Full-text available
Investigation was carried out on two plants (Hymenostegia afzelii and Napoleanea vogelii) used in traditional medicine to establish the scientific basis of their use for treating wounds, sores, chest infections and as chewing sticks. The methanol and petroleum ether extracts of the two plants showed some levels of antimicrobial activity. The antimi...

Questions

Question (1)
Question
I have isolated two compounds (alkaloids) from two consecutive fractions (1 and 2). These fractions were obtained from a silica column. NMR analysis in CD3Cl showed similar peaks and same NOESY resulting in same elucidated chemical structure. Mass spec analysis gave similar peaks with a difference of only 0.0006 in their mass. However both compounds gave opposite optical rotations of αD = [-15.71]  and αD = [+12.94]. My challenge is I do not know if enantiomers can be separated on silica gel as in this case or not. I would be grateful if this can be clarified for me. Thank you. 

Network

Cited By

Projects

Projects (5)
Project
Define quality parameters, establish safety and determine the hypoglycemic activity of DBT Herbal Mixture in the management of type 2 diabetes mellitus.