Guram Karazanashvili

• Professor, Chief of Urology
• JSC "Modern Medical Technologies"

Background Galectins—galactose-specific lectins are involved in various types of cell activities, including apoptosis, cell cycle regulation, inflammation and cell transformation. Galectins are implicated in prostate malignat transformation. It is not known yet if prostate glands with different grade of pathologies are expressing different galectin...

Context: Because pelvic lymph node (LN)-positive prostate cancer (PCa) is generally considered a regionally metastatic disease, surgery needs to be better defined. Objective: To review the impact of radical prostatectomy (RP) and pelvic lymph node dissection (PLND), possibly in conjunction with a multimodal approach using local radiotherapy and/...

posters / european urology supplements 11 (2012) 191–235 231 At 3 mo, median T declined 89% to 0.78 ng/dL (n = 31), DHEA declined 85% to 197 nmol/L (n = 34), cortisol declined 21% to 260 nmol/L (n = 34), still within the normal range of 138–690 n/mol/L, and ACTH increased 171% to 43 ng/L (n = 33); results were similar at 6 mo. Conclusions: Ortl pro...

Galactose-specific lectins (Gal-lectins) were isolated from the mitochondrial fraction of prostate post-operational hyperplasic tissue of two diagnoses: benign prostate hyperplasic tissue with low-grade intraepithelial neoplasia (LGPIN) and benign prostate hyperplasic tissue with atypical adenomatous hyperplasia (AAH). They had similar molecular we...

Objective: The ongoing REDUCE trial is a 4-yr, phase 3, placebo-controlled study to determine if daily dutasteride 0.5 mg reduces the risk of biopsy detectable prostate cancer. Prostate biopsies performed in all men prior to entry were centrally reviewed, thus allowing an examination of the relationship between inflammatory changes and lower urinar...

Long term survival of men with high-risk (T3 and/or PSA>20 ng/ml and/or Gleason>or=8) prostate cancer is still far from satisfaction. Common treatment options for these patients usually include hormonal therapy, radiation therapy or a combination of both. Radical prostatectomy has not been considered as the standard treatment strategy in these case...

Prostate cancer is a most common endocrine tumor in men and about every one from six men in northern countries is under the risk of this tumor in old ages. Most common problem in treatment of PC is the development of androgen resistance, the mechanisms of which are not yet completely understood. HER2 may have a role in development of androgen indep...

Several tumor markers have recently been applied for prostate cancer screening. We analyze the effectiveness of prostate specific antigen (PSA), age specific PSA, PSA velocity, volume adjusted PSA densities, change in PSA level following antibacterial therapy, free-to-total PSA ratio, alpha1-antichymotrypsin bound PSA, alpha2-macroglobulin bound PS...

Investigation of the possibilities of improving the accuracy of prostate cancer (PC) screening among patients with a PSA value of 4-10 ng/ml and nonsuspicious results of digital rectal examination (DRE), using as diagnostic method the PSA value change (PSA-VCh) after antibacterial treatment of prostate inflammation. The study included 61 patients w...

Screening based on the measurement of prostate specific antigen (PSA) in the blood is the basic method for early detection of prostatic cancer. However the specificity of this method even in combination with the digital rectal examination (DRE) or with PSA derivatives remains disputable in cases when PSA concentrations in the blood vary between 4 a...

Upon the exposure to remote or combined radiotherapy, the patients with uterine cervical cancer often develop ureterostenosis due to recurrence or postradiation alterations in the walls and adjacent tissues of the ureter. Etiology of the urodynamic defect is essential for the treatment policy choice. Therefore, in attempt to find out effective mean...

gamma-Beam therapy of combined radiation therapy are frequently followed by ureteral obstruction, caused by a cervical cancer recurrence or pelvic postradiation fibrosis. The knowledge of a cause is very important for a choice of therapeutic tactics of obstructive uropathy. The purpose was to define the potentialities of transvesical ultrasound sca...