Gupta P D

Freelancer

Objective: Studies on hormonal changes is an effective method for assessing infertility conditions. A widely used pesticide 1, 2 Dibromo 3 Chloropropane (DBCP) causes infertility by damaging testis in humans. This in turn disturbs Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), sex steroid hormone levels. The seed extract of Mucuna...

Recently with the advancements in reproductive technology there fairly good chances of developing human clones. Many laboratories are involve in these technologies In the present note chances of human cloning have improved and are discussed here.

Before humans evolved on this planet Nature created conditions for him to remain healthy and active. Among those, sleep is one. To sleep better, dark and light cycles were created by the rotation of the earth. However, man has modified the condidions by creating artificial light which reduced the dark hours and due to this many health problem are p...

The visual system in humans is unique and privileged in many ways. The reflected light from the object passes through the transparent cornea and lens gets converted into electrical signals by the retina, which is richly supplied with blood, passing through the optic nerve to the brain where these signals are processed and form the image. Because th...

Over the years technologies were developed such as cloning, IVF, artificial uterus, embryoids produced by totipotent stem cells which are hopefully able to give birth of babies in the laboratory rather than hospital

It is very difficult to answer the question, what is sugar? The possible answers may be surprising. It is easy to become confused by the various sugars and sweeteners described in the literature. All sweet things are not sugars and all sugars are not sweet. So it is important to know about and from where did "Sugar" originated. The results suggest...

Introduction to the theme Humans have had a long and beneficial relationship with salt, sugar, and fat that dates back to the origin of the species. Salt is essential for fluid balance, sugar provides the energy for physical and mental activity while fats of various types make up most of the mass of the brain. Their ability to “flavorize” a vast ar...

Abatract: Osteoporosis, the silent disease can take hold of at any age both males and females. In addition to common causing factors such as age, race, family history, low calcium intake, major difference lies between male and female etiologic is the sex hormone. Women are more at risk of developing osteoporosis than men because the hormone changes...

A mitochondrion is a double-membrane-bound organelle found in most eukaryotic cells its primary function is to generate adenosine triphosphate, (ATP) which is utilized as a source of chemical energy by the organism. Lately in addition to generating ATP, they are involved several other functions according the requirement of the cell. In this review...

Our body is capable of producing alcohol naturally. This endogenous ethanol formation either in some disease, commonly known as gut fermentation syndrome, which is not common, but a regular formation of alcohol in human intestine of non drinker is a regular phenomena. It is need based phenomenon i.e. our body requires a certain quantity of alcohol...

Like other body organs reproductive organs also precede towards senescence. Infect female organs physiologically lose their ability to function much earlier to other female body organs. The female reproductive system is more complex than the male's because the female in addition to produce and deliver gametes also provide nutrition and safe harbour...

Nature has provided immune system to protect the body from the invasions of Non-self-biological and/or chemicals including toxins. These non-self-items, called as antigens produce immune response in the body which in turn produce antibodies. These antibodies inactivate antigens by making antigen antibody complexes Due to various reasons, both genet...

Estrogens are the group of hormones which makes a woman a woman. Girls at menarche start making it and under normal conditions sufficient levels are maintained in the women's body until menopause. During perimenopause, menopause and postmenopause the hormone levels start fluctuating and if maintained low for a longer period, it starts giving variou...

The breast tissue is sensitive equally to estrogen or xenoestrogens. If the hormone levels are high enough, they promote breast size by stimulating growth of breast tissue. Because of this an early maturity is recorded in young girls now. They disrupt the endocrine system due to which there is an overwhelming response to early maturity and initiati...

Since inflammation is a protective response normally should not be translated; indeed it is essential for maintaining health and for fighting disease. Acute inflammation was previously recognized as a passive process; a natural decay of pro-inflammatory signals, however, in general many types of chronic inflammations resulted in various diseases de...

Even our early ancestors knew the Sunlight’s importance for life. It gives “life” to life. Most living things have benefitted with it, not only animals, plants, it but even some germs also need it. Both men and women are benefitted with the sunlight, however it is noticed that women is more benefitted by the sunlight than men.

The Sun Light plays an important role in regulating life (microbes,plants and animals including human beings). During earlier times light energy was used to kill pathogens. After the discovery that.white light is composed of 7 different components and each one has different energy levels, scientists wanted to know the interaction of life with each...

A new virus SARS-CoV2 is responsible for Covid-19. Many existing drugs were tried but failed to treat Covid-19 patients. To begin with our immune system also couldn’t cope with Covid-19, therefore within no time it became pandemic. It is a well-known fact that our body fights against all infections and inflammations through well-organized immune sy...

In old age quality of life further deteriorate because of macular degeneration (AMD). Both the types dry or wet creates vision problems however dry type is not as bad as wet. The earlier management methods for AMD were cumbersome, the advanced methods such as, gene therapy, artificial retina involving genetic engineering technology, using optical o...

Stress, anxiety and depression are the disorders of brain but these affect even unborn child (foetuses). Various phobias affect expecting mothers. All these happen due to stress hormone Cortisol which is secreted during stress. This along with cortisol and other stress hormones lead to endocrine disorders like Graves' disease, gonadal dysfunction,...

Abstract Keloid etiology is multifactorial. Earlier in our study we advocated that there is a delay in epitheliation and due to continued growth of connective tissue which is coming beyond the surface of the skin and then sealing of the wound takes place. This holds true even now but the mechanism behind this process is still ambiguous. In this rev...

Inflammation clock or iAge clock which was developed recently that can measure inflammation products in the body of an individual and can predict immunological decline. It is also capable of predicting incurring age-associated diseases. The quantity and quantity of these inflammatory products is also related physiological age. This will be useful i...

On discovery of blood groups Nobel Prize was awarded to Karl Landsteiner, this itself shows its importance. The blood type is inherited, so it's predetermined at birth. One cannot change blood type later in life. O negative is devoid of all immunological markers and hence show the lowest risk for heart disease whereas people with types AB and B are...

In the human body practically all organs work in coordination in cooperation with other organs since they are regulated by neurological, hormonal, environmental signals. Scientists have lately found out another regulatory factor the intestinal micro biota. The quality and the quantity of micro biota are also dependent on many internal and external...

The first scientific evidence that microorganisms are part of the normal human system emerged in the mid-1880s but not much importance was attached to it. Human are dependent on these bacteria for digestion, to produce certain vitamins, regulate the immune system, and fight with disease-causing bacteria. Babies born by c-section lacked strains of c...

For clear vision, the cornea, which is not supplied with blood, has to be continually kept wet and it is done by basal tears. Tears are the maintenance fluid of the eye; the watery eyes or epiphora is the most common symptoms of many ocular pathologies; this is due to either overproduction or under drainage of tears. The watery eyes may also be due...

All living beings have tendency to get rid of those who harms them. Presence of viruses in the host went unnoticed until they remain as either commencel or symbiont but not as a pathogen. Viruses are resistant to drugs because neither they have their own metabolic activity nor ability to reproduce. Soap-water disfigure their structural organization...

ABSTRACT Ancel Keys gave the formula devised in the 1840's a new name, Waist to Hip Ratio (WHR) in the early 70’s. Since then it has become an important parameter for measurement of health. The Waist-to-Hip Ratio (WHR) gives more meaningful information rather than Body Mass Index (BMI). Here we have described the applications of WHR in prediction...

Some are born blind and some become due to old age diseases, such as cataract, glaucoma and macular degeneration. As it is mentioned that we see with our brain not with eyes, because whatever light is gathered by the lens retina receives these through photoreceptors, convert in to electric signals and sends through optic nerve to the brain where th...

Pregnancy is a special event in woman's life; during this time period and sometimes after childbirth, not only her lifestyle changes but her physiology, endocrinology, and neuropsychology also changes. Because of all these, her body structure and nutritional status along with her likings and dislikings and behavior patterns also changes.

Microbiota is a life line for human being, however if the balance in interspecies of microbiota is disturb, it can cause not only serious diseases but can kill also. Collectively the microbiotal species act as epigenetic factor for humans. First exposure to microbiota is in utero. The whole health programming of the individuals stars even before bi...

C- Section babies are easy target for Corona infection, since they do not develop their own immune system. Therefore they are more prone to Covid-19 then why to take risk and have C-section babies and later regret. Clinicians as far as possible should avoid cesarean deliveries except the essential cases. In order not to regret later, mothers are ad...

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Cancer is not a single disease but uncontrolled, fast proliferating cells can be checked by one common method. Initial methods of cancer treatments such as.Chemo and radio therapies are now less in use, Many new methods of treatments based on immunology were evolved, some of those became a sort of "game changers'' in cancer therapy. Nevertheless ca...

Short and Intermittent fasting brings many structural and functional changes in the GI tract.Now it has been shown that changes are beneficial in terms of postponing the onset of NCDs prolonging the healthage,That might be the reason for Ancient Indian saints todo fasting. These benefits have been described in a series of research papers by us and...

"Metabolic Depressions" is a new term for ancient Indian practice through which Saints used to prolong their physiological age. This is also practiced by many animals, frog is the best example who undergoes Hibernation. Lately crayo preserved preserved rotifer was revived to life after 2400 years later. probably

Light energy is the most essential part of life. The relationship of this planet with the prime source of light, the sun, is made in such a way that most of the inmates will get light from the sun only 12h., which is healthy too. On the polar region where people get either too much or very little depending on the season; such conditions are not hea...

Honey is a natural energy source and used in traditional Indian Ayurvedic medicine, it is used as a digestive remedy, and used for worshiping “Gods”. Ancient Egyptians applied it as an ointment for skin ulcers. It was the first sweetener used by humans – 8,000-year-old cave paintings in Spain depict the same. It never goes bad

Placenta is all in all for the growing foetus; more so it also helps pregnant mothers during pregnancy in many ways, however, the most poorly researched organ. Generally, placentas are discarded after the deliveries but recent findings have shown that even it is useful after deliveries too. Histologically, it has very simple structure, its trophobl...

Tiny Corona has no brain but still it is very choosy, it does not infect equally to all the human population. It infects more men than women more older population than younger one. There are reasons for that. Men are on the priority list because of certain reasons; if they are bald more venerable. However, the subjects who are carrying blood group...

Pregnancy is a special event in woman's life; during this time period and sometimes after child birth, not only her lifestyle changes, but her physiology, endocrinology and neuropsychology also changes. Because of all these, her body stucture and nutritional status along with her likings and dislikings and behaviour patterns also changes.

The 1918 influenza pandemic was caused by an H1N1 virus with genes of avian origin. It spread worldwide and lasted for about 2 years. About 500 million people (around one-third of the world's population at that time) became infected with this virus and the number of deaths was estimated to be at least 50 million globally. This episode compelled hum...

Corona virus is added to the family of pathogenic viruses in 2019. Nearly 18/20 months passed since this virus started infecting human beings and soon it became pandemic. Its behavioural pattern is not well defined towards special conditions/phases of humans. Logically speaking expecting women are immune-compromised and therefore they are vulnerabl...

According to CDC guidelines to prevent spreading of SARS-CoV2 virus one should take extra precaution to protect first line of defense mucus secreting organs, such as, nose, mouth, and eyes. Once a person gets infection eyes become a source of infection. The eye and its tear drainage apparatus can track the SARS-CoV-2 from the eye into the respirato...

Stem cell therapy gained momentum for the past three decades in therapeutics. Alternative strategies are indispensable for the treatment of many diseases in the present scenario due to side effects of synthetic chemicals as drugs. Mesenchymal cells of different origin have been in use with good results, though ethical issues and limited availabilit...

Several lifestyle factors have been identified that might modify epigenetic patterns, among them light is one. Disruption of epigenetic processes through biorhythm can also lead to altered gene function and malignant cellular transformation. Normally, menopausal women are more vulnerable to breast cancer, but we found none of the blind menopausal w...

Environment and diet regulate menstrual cycle in human females. The length of the period between menarche (activation of ovarian hormones) and menopause (inactivation of ovarian hormones) depends on 4 hormones, estrogens, progesterone, follicular stimulating hormone and luteinizing hormone [1]. In our epidemiological survey we found now menarcheal...

Aging is the total outcome of interactions among genetic, environmental and lifestyle factors at a given time. Survival events such as, well-beyond average life expectancy, delayed onset of age-related diseases (before 80 years of age) and/or preservation of good health/function is very common presently may be due to improvement in health and nutri...

The human placenta once was thrown after the delivery, found to be a very useful organ though it has very short life. With more and new research the old concept about placenta has changed. Now it is well established that health of growing embryo depends on the health of the placenta. To begin with immunology of neonate also depends on transplacenta...

Discovery of SARS-CoV2 belonging to SARS family to begin with confused scientists and clinicians both and they were concentrat-ing only on lung infection. But when it became pandemic and millions of people suffered, clinicians started examine each and every organs of the Covid-19 patients, they found that eyes are also getting infected. The eyes su...

Abstract: In Natures’ creation some organisms are friendly to humans whereas others are enemies, some prey on humans and others act as pathogens. Recently evolved, SARS-Cov2 (Carona virus) which became pandemic in no time became the worst pathogen of the century, The only diagnostic test was RT- PCR which is very expensive as well time consuming wa...

We are soaked in microbiota, both, externally and internally. The balance between harmful and beneficial keeps us healthy, however even slight imbalance in their ratio may make cause of ill health. Many of the species of Lactobacillus keeps the vagina healthy; even some species of Lactobacillus are troublesome to the vagina. Other pathogenic bacter...

During the policy making and development of vaccine to curb the pandemic disease Covid-19 two new words were coined "Vaccine Nationalism" and "Vaccine Cosmopolitanism". These terminologies are very important to understand and act upon to eliminate the pandemic situation of covid-19 and these also warn not to adopt the previously practiced Vaccine N...

The discovery of biological clock has changed many established concepts and hypotheses in pharmacology and medicine. Diseases borne due to disturbances or deregulation of biological clock are set right only by setting the clock right. There are many natural and life style factors which deregulate the clock. Recently many chronotherapeutic drugs wer...

Abstract The period of menstrual cycle lies in between menarche to menopause in woman’s life. This is the golden period; during this period a woman can produce babies naturally. Because of this, during this period sex steroids play a major role in regulating physiological processes in females. Recent researches have shown the brain functioning duri...

Estrogen are very important chemical compounds very essential for our body functions. The cholesterol, what we eat through food, gets converted by the action of various enzymes. Scientists have synthesized estrogenic molecules in the laboratory and used them for oral contraceptives and other therapeutic purposes. Environmental estrogenic molecules...

A small particle of the size about 100 micrometers (SARS-V2) has shaken the world. In some Covid-19 patients a severe immune reaction was found in which cells release too many cytokines into the blood too quickly. Cytokines are regulators of host responses to infection, immune responses, inflammation, and trauma. In addition, cytokines activate tho...

Mitochondria are an essential cell organelle for all living cells, if they are eliminated from the cell that means the cell has undergone terminal differentiation. It works like sub-kingdom in the cell; in addition to provide energy to the cell it has its own gasket of synthetic machinery. In each individual it is contributed by mother. If there is...

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Ayurveda had recognized that you can listen by holding blood vessels at certain points by your finger tips. Encouraged by this in 1816 French physician R. Laennec first Stethoscope. Later, Ultra sound machine were developed.

1. Abstract Majority of mild Covid-19 patients are respiratory problems, however, patients with serious infections manifest some other organs in the body, including eyes. About 20% patients show conjunctivitis. Among children about 15% show eye infections. Prolonged sick patients also show changes on retina. Clinical Journal of Ophthalmology and Ey...

1. Abstract Cell transplant therapies are now in vogue. Many scientists are in search of new sources of stem cells which can be obtained without ethical problems, very frequently and easily and at low cost. Menstrual blood proved to be a good source. Menstrual blood-derived stem cells (MenSCs) are multipotent cells capable of differentiating into c...

Why Covid-19? It is Nature’s responsibility to maintain balance on this earth. From time to time she brings on this earth something unique to control the imbalance. Tsunamis, earth-quakes, eruption of volcanoes, forest fires are some known examples. If population overshoots, it is also controlled. Dinosaurs are an example of population control; now...

Aging is the total outcome of interactions among genetic, environmental and lifestyle factors at a given time. Survival events such as, well-beyond average life expectancy, delayed onset of age-related diseases (before 80 years of age) and/or preservation of good health/function is very common presently may be due to improvement in health and nutri...

At any age one can become sick, however, it is pathetic when someone is born with a disease that too which is not expressed immediately. Such diseases show up weeks later and some years later. The causes of such diseases are multifactorial. In this mini-review, we are trying to focus on some important risk factors which should be considered before...

Multani mitti (MM) has specifically great ability for clearing off the stubborn oil and sebum that sit on face during the day. It provoked us to consider that ash or MM is helpful in clearing up any less than-natural things that may be residing on skin, like microbes including bacteria and viruses. This may also include corona virus attached to the...

Clin J Ophthalmol Eye Care 1 Volume 1(2): 2020 Clinical Journal of Ophthalmology and Eye Care Review Article Volume: 2, Issue: 1 Scientific Knowledge Extra Visual Function of the Human Eye (F) PD Gupta1* and K Pushkala2 1Founder Director, Iladevi Cataract and IOL Research Centre, India 2Department of Ophthalmology, SDNB Vaishnav College for Women,...

In this paper we have described some of the factors if we have Covid-19 may not be able to attack on us. These variable factors are the female sex hormone estrogen, which appears to play a role in immunity, and the fact that women carry two X chromosomes, which contain immune-related genes.Men, of course, carry only one.

A false hunger leads to cravings for highly specific food, which in turn makes a person “Food Addict” Food addicts become dependent upon the “good” feelings that are obtained from consuming certain foods, which often perpetuates a continued need to eat, even when not hungryWe simply aren’t used to not eating. A feel real hunger will be there if one...

Certain antibodies can pass through placenta and therefore the new born baby carries some immunoglobulins at the time of birth to protect from worldly pathogens, this natural passive immunisation does not long last and new born has to develop immune system of its own. The fully grown immune system loses its capacity in old age. The immune system mo...

Certain antibodies can pass through placenta and therefore the new born baby carries some immunoglobulins at the time of birth to protect from worldly pathogens, this natural passive immunisation does not long last and new born has to develop immune system of its own. The fully grown immune system loses its capacity in old age. The immune system mo...

In the human body blood is the only liquid organ made up of various types of cells suspended in the plasma; the plasma makes it easy to flow in arteries and veins through heart. Red blood cells (RBCs) gives it red colour due to the presence of hemoglobin which helps in exchange of gases. White blood cells constitute the part of immune system which...

CRISPR Technology was developed in 2012 by Doudna and Charpentier which is now used for gene editing. It acts like a pair of molecular scissors for cutting of DNA molecules at desire site. On transplanted CRISPR edited stem cell HIV infected person was treated.

With all advancements in drug discoveries and diagnostic technologies incidence of cancer rate should have come down, but it is not so. Between the years of 2010 to 2014, the breast cancer incidence rate was 124.9 per 100,000 women per year.

The environmental and synthetic estrogenic compounds adversely affect many estrogenic responsive tissues and their proper functioning even from childhood. Early menarche and teen pregnancies are the examples. This raised many health issues in human including the embryonic development and implantation. Parabens and phthalates are another class of co...

The placenta is an organ that develops in the uterus only during pregnancy. It remained a fascinating and puzzling organ and has undergone various phases of research; from waste material after delivery to a source of potential material for human welfare. It grows into the wall of the uterus and is joined to the fetus by the umbilical cord.

Abstract Developing embryo draws food and nutrition from mother during pregnancy. The nutritional requirement and the physiology of digestive system of a pregnant woman change and therefore during this period the pregnant woman has to take care of her diet for proper development of the growing embryo. In this short review the role of dietary fibers...

Liver is a gland and performs both exocrine and endocrine functions. It also possesses the capacity to regenerate. The liver is the only organ that can grow back when part of it is damaged or removed surgically. That's why people are able to donate part of their liver to the patients suffering with serious disease like cirrhosis.

Cancer is not a new era disease; the earliest evidence of human breast cancer hails from ancient Egypt in 1500 B.C. Nevertheless, some scientists are of the opinion that cancer is a life style disease and it is man made. Cancer-causing factors exist only in modern, industrialized societies-and cancer is fueled by the excesses of modern life. The ca...

Here we described the conflicting views whether intelligentsia depends on race? The Nobel Laureate Dr Watson was criticized for his views by many, however What Science of Genetics and Epigenetics say.

Aging research has put restorative medicine on forefront. It is in fact that during aging metabolism becomes slow and we become deficient in many proteins; collagen is one of those. Since human body has more collagen than any other protein, its gluing action keeps organs in the body tight and fit. It is crucial for the strength of bones. Its supple...

Background. Starch and dietary fibers as well as carbohydrates that are not digested and absorbed in the small intestine, are chemically heterogeneous components derived from plants consumed by humans. These chemical components undergo a full or partial fermentation process in the large intestine. Starch and other carbohydrates are the main sources...

Bacteria through evolution suffered a lot and therefore they have adopted for their survival to live in extreme environmental conditions. From Free living to they became commensal, symbiotic, parasitic and pathogenic too. During their adaptation their properties also change, some are extremely beneficial to other organisms in various ways. But some...

Our survey data show that menarcheal age, both in sighted and blind girls has drifted towards younger years compared to 50 years back, however, in sighted girls it has gone further down compared to blind girls. In this paper we have explained the reasons, why it is so? For the comparison sake we were very careful to select sighted and blind girls f...

Abstract To take care of health issues of next generation we must stop the use of antibiotics. However, we must find the ways and means to control the bacterial infection of present population. Here in this review we described some of the novel methods and their mode of action to protect the present inhabitants

This article explians why we do age. What are the factors of aging and how the mechnisms are operating.

Preventive Measures for Post Surgical Infectionsclini

Starch is a major component of our food; it metabolises easily and gets converted in to sugars which release energy instantly. Diabetic patients are debarred from consuming starchy and sugary foods. World over, potato and rice constitute the major component of human diet; both are starchy foods and forbidden for diabetics. In this review we describ...

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