Guoxing Li

Guoxing Li
Peking University | PKU · Department of Occupational and Environmental Health Sciences

PhD

About

106
Publications
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Introduction
Skills and Expertise

Publications

Publications (106)
Article
Background The Air Quality Index (AQI) has been criticized because it does not adequately account for the health effect of multi-pollutants. Although the developed Air Quality Health Index (AQHI) is a more effective communication tool, little is known about the best method to construct AQHI on long time and large spatial scales. Objectives To furt...
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What is already known about this topic?: Long-term temperature variability (TV) has been examined to be associated with cardiovascular disease (CVD). TV-related dyslipidemia helps us understand the mechanism of how climate change affects CVD. What is added by this report?: Based on the China Health and Retirement Longitudinal Study (CHARLS) from...
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Objective To estimate the impact of short- and long-term exposure to PM2.5 on hospital admission (HA) risks of circulatory diseases, respiratory diseases, mental disorders, endocrine and metabolic diseases, allergic diseases, urogenital diseases and malignant tumors respectively in an exposed population (by gender and age groups). Methods Based on...
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Background Greenness is an emerging modifiable environmental factor of high blood pressure and hypertension. However, current evidence is inconsistent, and high-quality studies are urgently needed, especially in developing country with high disease burden of hypertension. Methods A longitudinal study was designed and 9649 participants (aged ≥45 ye...
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Background Limited health literacy is a public health challenge contributing to the rising health care costs. We assess the economic costs of limited health literacy in China using data from the National Health Literacy Surveillance survey. Methods Our data includes a sample of 6316 residents aged 15–69 years old living in Ningbo, China, in 2019....
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Introduction There is an increasing interest in understanding whether air pollutants modify the quantitative relationships between temperature and health outcomes. The results of available studies were, however, inconsistent. This study aims to sum up the current evidence and provide a comprehensive understanding of this topic. Methods We conducte...
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Background Ambient fine particle (PM 2.5 ) pollution is an important public health problem in China. Short-term ambient PM 2.5 exposure is associated with increased mortality of respiratory diseases. However, few evidence was available on the effect of exposure to ambient PM 2.5 on the years of life lost (YLL) from respiratory diseases in the elder...
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Background Phthalic acid esters (PAEs) are widely used as plasticizers in industrial process and consumer products. Nowadays, PAEs are ubiquitous in the environment and are reported to be associated with cardiorespiratory diseases. However, studies about the association between indoor airborne PAEs exposure and cardiorespiratory health were limited...
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Background Ozone (O3) has become a prominent air pollutant problem as other pollutants concentrations have decreased obviously since China published Air Pollution Action Plan Pollution Prevention Action Plan in 2013. Few studies examined the association between O3 and diabetes especially in developing countries. This study was designed to investiga...
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(1) Background: Years of life lost (YLL) as a surrogate of health is important for supporting ambient air pollution related policy decisions. However, there has been little comprehensive evaluation of the short-term impact of air pollution on cause-specific YLL, especially in China. Hence in this study, we selected China as sentinel region in order...
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Although the lockdown policy implemented during the COVID-19 pandemic indeed improved the air quality and reduced the related health risks, the real effects of the lockdown and its resulting health risks remain unclear considering the effects of unobserved confounders and the longstanding efforts of the government regarding air pollution. We compar...
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We evaluate the impacts that health supporting environments have on residents’ health and well-being. Using a stratified multi-stage sampling method, we select a sample of 12,360 permanent adult residents aged 15–69, and collect information on their health literacy level, as well as their demographic background and health. This individual level dat...
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Objectives: To evaluate the long- and short-term effects of air pollution on COVID-19 transmission simultaneously, especially in high air pollution level countries. Methods: Quasi-Poisson regression was applied to estimate the association between exposure to air pollution and daily new confirmed cases of COVID-19, with mutual adjustment for long- a...
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What is already known about this topic? Climate change and air pollution are two important environmental issues in China. It is important to investigate particulate matter with aerodynamic diameter less than 2.5 μm (PM2.5)-related health impacts from climate change and air pollution emission control. What is added by this report? Deaths and year...
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What is already known about this topic? Skin diseases are common, affect society and individuals, and have high incidences to relapse, which reduces the quality of life. In 2019, skin diseases were the seventh leading global causes of years lived with disability (YLDs). What is added by this report? All-age disability-adjusted life years (DALYs)...
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(1) Background: The health effect of temperature has become a rising public health topic. The objective of this study is to assess the association between apparent temperature and non-accidental deaths, and the mortality burden attributed to cold and heat temperature; (2) Methods: The daily data on temperature and deaths were collected from 10 citi...
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Research on the relationship between short-term exposure to fine particulate matter (PM2.5) and urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) is sparse in the nonoccupationally exposed populations. A quasi-experimental observation of haze events nested within a randomized crossover trial of alternative 1-week real or sham indoor ai...
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Limited empirical work has been done to compare the effects that health knowledge and advice from doctors have on smokers’ intentions to quit. This paper examines the association of smokers’ intentions to quit with health knowledge, advice from doctors, and self-perceived health. A sample of 2509 smokers aged 15–69 years old in Ningbo was used from...
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Ambient fine particulate matter (PM2.5), as one of the predominant air pollutants, has achieved effective control in recent years in China. Whether the use of indoor air purifiers is still necessary needs further exploration. A randomized crossover trial was conducted in 54 healthy students in Beijing, China. Participants were randomized assigned t...
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The most common currently used air quality risk communication tool, the Air Quality Index (AQI), has been criticized. As a result, Canada proposed the Air Quality Health Index (AQHI) to communicate the health risks of multiple pollutants. However, the AQHI is calculated by directly summing the excess risks from single-pollutant models, which may ov...
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Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, and nitrogen dioxide (NO2) is a potential environmental risk factor for COPD. However, association between ambient NO2 and COPD risk remains underrecognized, especially in the elderly. This study aimed to explore association between NO2...
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Background: Fine particulate matter (PM2.5) is an important environmental risk factor for cardiopulmonary diseases. However, the association between PM2.5 and risk of CKD remains under-recognized, especially in regions with high levels of PM2.5, such as China. Methods: To explore the association between long-term exposure to ambient PM2.5 and CK...
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Background and objectives Sulfur dioxide (SO2) is a ubiquitous air pollutant and its concentration in China remains at a higher level in the world. However, evidence regarding short-term effect of SO2 on years of life lost (YLL) from stroke is scarce. We aim to estimate the short-term association between SO2 pollution and YLL for stroke and the rel...
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Background Sulfur dioxide (SO2) is one of the major gaseous pollutants in China and other developing countries. Few multicity studies have been done to examine the short-term effect of SO2 on cause-specific years of life lost (YLL). This study was designed to investigate the burden of chronic obstructive pulmonary disease (COPD) associated with SO2...
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Few multicity studies have been conducted in developing countries to distinguish the acute effects of ambient nitrogen dioxide (NO2) on the years of life lost (YLL) from different subtypes of stroke. We aimed to differentiate the associations between NO2 exposure and YLL from major pathological types of stroke in China, and estimate the relevant ec...
Article
The adverse impact of ozone on public health has attracted worldwide attention. However, few studies have addressed the contribution of ozone to disease burden caused by cardiovascular diseases. This study aimed to examine the association between short-term ozone exposure and years of life lost (YLL) from stroke in 48 Chinese cities. City-specific...
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Background Evidence on the acute effect of short-term exposure to nitrogen dioxide (NO2) on years of life lost (YLL) is rare, especially in multicity setting. Methods We conducted a time series study among 48 major Chinese cities covering more than 403 million people from 2013 to 2017. The relative percentage changes of NO2-YLL were estimated by g...
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The traditional PAR process (Poisson autoregressive process) assumes that the arrival process is the equi-dispersed Poisson process, with its mean being equal to its variance. Whereas the arrival process in the real DGP (data generating process) could either be over-dispersed, with variance being greater than the mean, or under-dispersed, with vari...
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In recent years, many researchers have investigated the association between air pollution and children. However, there has been little research to provide a macroscopic overview in this field. The aim of this study is to characterize the scientific production around the world in this area and map the trends. The relevant literature was searched fro...
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Background: Few studies have estimated the attributable risk and economic cost of mental disorders (MDs) due to particulate matters with aerodynamic diameter of <2.5 μm (PM2.5) exposure in Beijing. Objectives: This study aims to identify the possible correlation between PM2.5 and risk of hospital admissions (HAs) for MDs in Beijing and calculate...
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Birth season is an important factor that reflects prenatal nutritional conditions during early development, and which might have lifelong impacts on health. Moreover, ambient ozone pollution has been considered an important environmental risk factor for hypertension. However, whether birth season affects vulnerability to the effect of ambient ozone...
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The current air quality index (AQI) has been argued for failing to respond to the combined health effects of multiple air pollutants. Thus, it is a challenge to construct a new indicator, air quality health index (AQHI) to comprehensively assess and predict air quality and the health effects caused by air pollution. Here, we have comprehensively co...
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Background: Ischemic heart disease (IHD) is one of the leading causes of deaths worldwide and causes a tremendous disease burden. Temperature is an important environmental determinant among the many risk factors for IHD. However, the emerging temperature-related health risks of IHD in the elderly is limited because of the lack of estimates that in...
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Background Chronic kidney disease is a serious global public health challenge, for which PM2·5 is suggested to be a potential environmental risk factor. However, little evidence is available on the associations between PM2·5 exposure and the prevalence of chronic kidney disease in the general Chinese population. We investigated the associations bet...
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Objective: Road safety is an important public health issue worldwide. However, few studies have analyzed the association between criminalizing drunk driving and years of life lost (YLL) due to road traffic deaths (RTDs). Our study can provide useful information about this policy. Methods: We used interrupted time-series analysis to find the changes...
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Air pollution is associated with stroke, but few previous studies have explored the impact of exposure to a sustained high air pollution level (which we define as an air pollution wave) on stroke. We decomposed the effect estimates of air pollution waves into a main effect estimate and an added effect estimate. The main effect estimate was due to t...
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Currently, the quantitative assessment of the public excess risk for the update of the air quality guidelines only considered the mortality and morbidity without disease burden indicators. To provide evidences for the update of air quality guidelines and the policy analysis of air control, a simple framework to identify the excess disease burden of...
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Background: To mitigate the serious levels of air pollution in China, the State Council of China issued the Air Pollution Prevention and Control Action Plan (APPCAP) in 2013. This policy is a milestone in air quality control in China. We aimed to evaluate the effects of the APPCAP on long-term air quality management and the related health impacts...
Article
Background and purpose: Global warming has attracted worldwide attention. Numerous studies have indicated that stroke is associated with temperature; however, few studies are available on the projections of the burden of stroke attributable to future climate change. We aimed to investigate the future trends of stroke years of life lost (YLL) assoc...
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Objective: Air pollution is considered one of the most important risk factors for ischemic heart disease (IHD), which is a major public health concern. The disease burden of IHD has continued to rise in China in the past two decades. However, epidemiological studies examining the associations between air pollution and IHD have been scarce in China...
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It is widely accepted that temperatures is associated with cardiovascular mortality, however, few studies have explored the effects of temperature on years of life lost (YLL) from cardiovascular mortality in China under future global warming scenarios. Therefore, there is an urgent need to obtain projections of YLL from cardiovascular diseases. Her...
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Limited studies have explored the impacts of exposure to sustained high levels of air pollution (air pollution wave) on mortality. Given that the frequency, intensity and duration of air pollution wave has been increasing in highly polluted regions recently, understanding the impacts of air pollution wave is crucial. In this study, air pollution wa...
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目的: 探讨天津市大气可吸入颗粒物(PM(10))浓度与暴露人群循环系统疾病负担之间的定量关系。 方法: 收集并整理2001年1月1日至2010年12月31日天津市每日大气主要污染物[PM(10)、二氧化氮(NO(2))、二氧化硫(SO(2))]的日均浓度、温度、相对湿度和人群死亡监测数据等,以死亡人数和寿命损失年作为疾病负担指标,采用广义相加模型,利用非参数平滑函数控制时间序列资料中的长期趋势、季节、气象因素和其他一些与时间长期变异有关的混杂因素,定量评价天津市大气PM(10)与循环系统疾病每日死亡和每日寿命损失年的暴露反应关系。 结果: 天津市2001年1月1日至2010年12月31日10年期间,大气PM(10)的日均浓度为117.6 μg/m³;天津市人群循环系统疾病、脑血管病和缺血性...
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Human health faces unprecedented challenges caused by climate change. Thus, studies of the effect of temperature change on total mortality have been conducted in numerous countries. However, few of those studies focused on temperature-related mortality due to cardiovascular disease (CVD) or considered future population changes and adaptation to cli...
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Though some studies have explored the association between temperature and years of life lost (YLL), limited evidence is available regarding the effect of temporal variation on the temperature-YLL relationship, especially in developing countries. We explored temporal variation in the associations between temperature and YLL before and after 2013 hea...
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Temperature has been associated with population health, but few studies have projected the future temperature-related years of life lost attributable to climate change. To project future temperature-related disease burden in Tianjin, we selected years of life lost (YLL) as the dependent variable to explore YLL attributable to climate change. A gene...
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Satellite-driven statistical models have been proven to be able to provide spatially resolved PM2.5 estimates worldwide. The North China Plain has been suffering from severe PM2.5 pollution in recent years. An accurate assessment of the spatiotemporal characteristics of PM2.5 levels in this region is crucial to design effective air pollution contro...
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We estimated PM2.5 concentrations using satellite data and population mortality values for cause-specific diseases and employed the integrated exposure–response model to obtain the associations between exposure and response. PM2.5 source apportionment data were then used to evaluate the excess mortality attributable to PM2.5 from different emission...
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Background Chronic obstructive pulmonary disease (COPD) has become the fourth-leading cause of death. The association between air pollution and years of life lost (YLL) caused by COPD is currently a hot topic; however, few studies have been published regarding COPD YLL around the world, especially in China, a highly polluted area. Aim We investiga...
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In January 2013, severe haze events over northeastern China sparked substantial health concerns. This study explores the associations of fine particulate matter less than 2.5 _m (PM2.5) and black carbon (BC) with hospital emergency room visits (ERVs) during a haze season in Beijing. During that period, daily counts of ERVs for respiratory, cardiova...
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Objective: To use vertical and humidity correcting method to calibrate aerosol optical depth (AOD), and to explore the feasibility of calibrated-AOD as exposure index to measure the level of air pollutants from the ground and to establish the exposure-response relationship between calibrated-AOD and people's health outcomes. Methods: First of al...
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Background Numerous studies have found associations between ambient fine particulate matter (PM2.5) and increased mortality risk. However, little evidence is available on associations between PM2.5 and years of life lost (YLL). We aimed to estimate the YLL due to chronic obstructive pulmonary disease (COPD) mortality related to ambient PM2.5 exposu...
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Short-term exposure to outdoor fine particulate matter air pollution is associated with adverse health effects. However, existing literature have been limited in size and scope in countries with high air pollution level, especially in China. The study aims to examine the association of fine particulate matter with daily total mortality in 160 Chine...
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Objective: To explore the effect of carbon monoxide (CO) and ozone (O(3)) in the air on the myocardial infarction mortality in Ningbo, Zhejiang province, from 2011 to 2015. Methods: The data of daily air quality surveillance and the causes of deaths in Ningbo from January 1, 2011 to December 31, 2015 were collected and the time series study using a...
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Years of life lost (YLL) is a more informative and accurate indicator than daily death counts for assessing air pollution related premature death. However, there is limited evidence available about the relationship of air pollution with YLL, especially in China. We conducted a ten-year (from January 1st, 2001 to December 31st, 2010) multi-district...
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Heat waves are associated with increased mortality, however, few studies have examined the added effect of heat waves. Moreover, there is limited evidence for the influence of different heat wave definitions (HWs) on cardiovascular mortality in Beijing, the capital of China. The aim of this study was to find the best HW definitions for cardiovascul...