Guoqiang Yuan

Guoqiang Yuan
Lanzhou University Second Hospital · Key Lab of Neurology of Gansu Province

About

36
Publications
2,099
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210
Citations
Citations since 2017
21 Research Items
178 Citations
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
Introduction
Skills and Expertise

Publications

Publications (36)
Article
Full-text available
Background Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemotherapy. However, the long-term survival rate has not signifificantly increased. Pyroptosis is a new form of pro...
Article
Full-text available
Glioma is the most common intracranial malignant tumor, and the current main standard treatment option is a combination of tumor surgical resection, chemotherapy and radiotherapy. Due to the terribly poor five-year survival rate of patients with gliomas and the high recurrence rate of gliomas, some new and efficient therapeutic strategies are expec...
Article
Full-text available
Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is an uncommon non-Hodgkin lymphoma subtype, and its clinical and pathological characteristics remain unclear. PCNS-DLBCL patient data were retrospectively evaluated to determine clinical and pathological characteristics and prognostic factors. Furthermore, prognoses were cal...
Article
Glioma is the most common primary malignant intracranial tumor in humans, and glioblastoma (GBM) has been associated with a more aggressive histology and poorer prognosis. There is growing evidence that circular RNAs (circRNAs) are involved in the progression of various malignancies; however, the role and molecular mechanism of circRNAs in glioma r...
Article
Full-text available
IntroductionCathepsin L (CTSL) is a kind of the SARS-entry-associated CoV-2's proteases, which plays a key role in the virus's entry into the cell and subsequent infection. We investigated the association between the expression level of CTSL and overall survival in Glioblastoma multiforme (GBM) patients, to better understand the possible route and...
Article
Full-text available
Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a potent sensitizer of TMZ in GBM. We observed that BCA significantly enhanced cell sensitivity to TMZ in vitro and in vivo. Mechanistically, the specific chemosensitizin...
Article
Full-text available
Glioma is a highly heterogeneous and lethal tumor with an extremely poor prognosis. Through analysis of TCGA data, we identified that OLFML2A is a key promotor of gliomagenesis. However, the molecular function of OLFML2A and its underlying mechanism of action in glioma remain unclear. In this study, we found that OLFML2A expression was significantl...
Article
Alzheimer’s disease (AD) has become a serious threat to the developed nations with burgeoning patients and annual costs on health care system in modern society. Neuroinflammation, as one of the specific biochemical factors in the progress of neurodegeneration diseases, performs a crucial role in the pathogenesis and development of AD. Therefore, it...
Preprint
Full-text available
Background: Macropinocytosis serves as an internalization pathway for extracellular fluid, albumin and dissolved molecules. Assessing macropinocytosis has been challenging in the past because manual acquisition in combination with visual evaluation of images is laborious, making it difficult for high-throughput applications. So, there is a need to...
Article
Full-text available
Abnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a flavonoid phenolic compound found in edible and herbal plants, has antioxidative and antitumor activities. However, it remains unclear whether BCA has an effect on energy metabolism. The aim of the present study was to evaluate the anticancer effects and molecula...
Preprint
Full-text available
CTSL is one of the SARS-entry-associated CoV-2's proteases and plays a key role in the virus's entry into the cell and subsequent infection. We investigated the association between the expression level of CTSL and overall survival in TCGA and CGGA databases, in order to better understand the possible route and risks of new coronavirus infection for...
Preprint
Full-text available
Background: Glioma is a highly heterogeneous and lethal tumor with extremely poor prognosis. Through analysis of TCGA data, we found that OLFML2A was significantly upregulated in glioma tissues and positively correlated with glioma grade and worse prognosis. However, the molecular function of OLFML2A and its underlying mechanism in glioma remain un...
Preprint
Full-text available
Background: Glioma is a highly heterogeneous and lethal tumor with extremely poor prognosis. Through analysis of TCGA data, we found that OLFML2A was significantly upregulated in glioma tissues and positively correlated with glioma grade and worse prognosis. However, the molecular function of OLFML2A and its underlying mechanism in glioma remain un...
Article
Full-text available
CD44 is involved in malignant processes including cell motility, tumor growth and angiogenesis. To explore the potential role of CD44 as a prognostic biomarker in low grade gliomas (LGG), the mRNA expression levels of CD44 in tissues from 12 patients with glioma were evaluated by microarray analysis. The mRNA level of CD44 in LGG and glioblastoma m...
Article
Full-text available
Objectives: Despite the availability of effective antiepileptic drugs, epileptic patients still suffer from intractable seizures and adverse events. Better control of both seizures and fewer side effects is needed in order to enhance the patient's quality of life. We performed the present study with an attempt to explore the effect that HDAC4 gene...
Article
Full-text available
Certain microRNAs (miRNAs/miRs) may be used as prognostic biomarkers in various types of cancer. The purpose of the present study was to identify miRNAs that were abnormally expressed in glioma of different grades, and to evaluate their clinical implications in patients with glioma. The differentially expressed miRNAs were evaluated from the expres...
Article
This study aimed to identify the genes related to epilepsy and their effects on epilepsy, as well as the underlying mechanism. Using microarray analysis, differentially expressed genes (DEGs) were screened out and then used to build weighted gene coexpression networks using WGCNA. Module membership and evaluation of gene significance (GS) were adop...
Article
Full-text available
The World Health Organization classification distinguishes four grades for gliomas. Grade III gliomas, which are brain malignant brain tumors with variable biological behavior and propensity, have been not widely investigated. The objective of the present study was to identify specific gene modules and valuable hubs associated with gliomagenesis an...
Article
Background: Although O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation status is an important marker for glioblastoma multiforme (GBM), there is considerable variability in the clinical outcome of patients with similar methylation profles. Objective: We examined whether a MicroRNA (miRNA) signature can be identified for predic...
Article
Full-text available
Resistance to temozolomide (TMZ) chemotherapy poses a significant challenge in the treatment of glioblastoma (GBM). Hypermethylation in O(6)-methylguanine-DNA methyltransferase (MGMT) promoter is thought to play a critical role in this resistance. Pyrosequencing (PSQ) has been shown to be accurate and robust for MGMT promoter methylation testing. T...
Article
Full-text available
Medulloblastoma is the most common malignant brain tumor of the central nervous system among children. Medulloblastoma is an embryonal tumor, of which little is known about the pathogenesis. Several efforts have been made to understand the molecular aspects of its tumorigenic pathways; however, these are poorly understood. microRNA (miRNA), a type...
Article
Full-text available
Vascular endothelium play an essential role in regulating endothelial functions by maintaining normal vascular tone, modulating hemostasis, and preventing thromobogenesis. The aim of present study was to reveal ultrastructure features of coronary artery endothelium in Bactrian Camels by means of scanning electron microscope (SEM) technology. The re...
Article
Full-text available
Higher levels of fibrinogen, a critical element in hemostasis, are associated with increased postoperative survival rates, especially for patients with massive operative blood loss. Fibrinogen deficiency after surgical management of intracranial tumors may result in postoperative intracranial bleeding and severely worsen patient outcomes. However,...
Data
Linear regression model data. (XLSX)
Data
Fibrinogen deficiency group data. (XLSX)
Data
Non-fibrinogen-deficiency group data. (XLSX)
Article
The hyoid bone of the bactrian camel was studied for the first time by means of anatomy and three-dimensional reconstruction. The results showed that the hyoid bone was composed of one body (basihyoideum) and four pairs of cornua, viz., thyroid cornu (thyrohyoideum), small cornu (ceratohyoideum), middle cornu (epihyoideum) and great cornu (stylohyo...
Article
The present study was carried out to gain species-specific data on density, distribution of cardiac mast cell and the relationship between mast cells density (MCD) and microvessels density (MVD) in the heart of camel embryo. Specimens were stained with either toluidine blue or immunohistochemically to identify mast cells. Rare mast cells were obser...
Article
Anatomical localisation and histology of tonsils were studied in 10 adult bactrian camels (Camelus bactrianus) aged between 5 to 10 years. Six tonsils were present: the palatine tonsil, the lingual tonsil, the tonsil of the soft palate in the oropharynx, the pharyngeal tonsil, the tubal tonsil in the nasopharynx, and the paraepiglottic tonsil in th...
Article
The blood supply of the septum interventriculare in bactrian camel was studied in 10 healthy hearts by means of injecting A. coronaria sinistra and A. coronaria dextra with red and white coloured 15% ABS (Acrylonitrile, Butadiene and Styrene, Lanzhou Petrochemical Company, Gansu, China), followed by corrosion with concentrated hydrochloric acid, an...
Article
The distribution of lymphoid tissue in the larynx mucosa of the bactrian camel was investigated by means of both macroscopy and microscopy. The results showed that paraepiglottic tonsil was located . lateral to the epiglottis in the ventromedial segment of the pharyngeal sidewall. The tonsil was made up of 3 to 8 nodular elevations with 2 or 3 narr...
Article
The aim of this study was to define the anatomic characteristics of the principal arterial source of the atrioventricular node, known as the artery of the atrioventricular node. Ten healthy hearts of bactrian camel were studied by means of injecting a. coronaria sinistra and a. coronaria dextra with red and white coloured 15% ABS (Acrylonitrile, Bu...
Article
The special structure and function of the external and middle ears of the bactrian camel (Camelus bactrianus) were described and various anatomical and physiological parameters of the ear, such as the length of external acoustic meatus and ossicular chain lever, the areas of tympanic membrane and oval window were measured. Our data on the middle ea...
Article
The aim of present study was to determine the origin, distribution and course of the coronary arteries in Bactrian camels. Ten hearts of adult healthy Bactrian camels of different sex constituted the material. Following exposition of the arteries by means of injection of 15% ABS coloured with red carmine to a. coronaria sinistra and a. coronaria de...
Article
The lingual papillae of adult bactrian camel were studied using light and scanning electron microscopy (SEM). Five types of lingual papillae were found on the dorsal surface of the tongue. Two types of filiform papillae could be distinguished. The filiform papillae had a primary papilla and a few slender secondary papillae. Fungiform papillae were...
Article
The tongue's structure of bactrian camel was studied using gross anatomical and morphological methods. The result shows that the tongue consists of root, body and apex, as is likely same with other ruminants in the basic structure. The papillae include filiform (Fl), lenticular (L), conical (Co), fungiform (Fu) and vallate papillae (CV). But the to...

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