Gundu H R Rao

• PhD
• Professor Emeritus at University of Minnesota

This article describes a phenomenon called membrane modulation, which is capable of restoring the response of refractory platelets to the action of agonists.

Cardiometabolic diseases, including ischemic heart disease, hypertensive heart disease, and associated vascular conditions, have experienced a sharp global increase in prevalence and mortality over recent decades. According to the World Heart Federation, the global death toll from cardiovascular diseases grew from 12 million in 1990 to 20.5 million...

Role of professionals in scientific research and education.

About a very unique job in the Lower Himalayas in Dalhousie, which launched my research career in 1958.

Biomedical and Therapeutics Letters ISSN 2394-2274 : A peer reviewed journal for research in Biomedical Sciences, Clinical Reports, Medical Sciences, Molecular Medicine, Molecular Genetics, Medicinal Chemistry, Drug Discovery, Immunology, Pharmaceutical Sciences, Clinical Research, research advances in drug design and development.

Inflammation is the body’s non-specific response to injury or infection. It is a natural defense mechanism that helps to maintain homeostasis and promotes tissue repair. However, excessive inflammation can lead to cellular, tissue, or organ dysfunction, as well as contribute to the development of acute vascular events and diseases like Crohn’s dise...

South Asians have the highest incidence of coronary artery disease at an young age. The professional Society, -South Asian Society on Atherosclerosis and Thrombosis (www.sasat.org) was started at the University of Minnesota in 1993. The society has organized conferences in India and abroad. It has sponsored the publication of ten monographs on rela...

South Asian Society on Atherosclerosis and Thrombosis (SASAT) was started a the University of Minnesota campus in 1993 to serve the South Asian Community worldwide. It has organized ten International conferences in India and several symposiums with various international professional societies. It has sponsored the publications of several monnograph...

The article reviews the contribution of a Professional society that was started at the University of Minnesota in 1993. The society has organized international conferences in India and abroad, It has sponsored publication of ten monographs on related topics.

The case study presented underscores the importance of early identification of metabolic risks, effective management, and lifestyle modifications in preventing clinical complications associated with cardiometabolic diseases (CMDs). The individual in the study, a South Asian immigrant, experienced the development of essential hypertension in his mid...

Metabolic diseases, such as hypertension, obesity, type-2 diabetes, and vascular diseases, have reached epidemic proportions globally, contributing significantly to non-communicable disease (NCD)-related mortality. Non-communicable diseases account for 71% of global deaths annually, with cardiovascular diseases (CVDs) leading the statistics. The So...

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. An estimated 17.9 million individuals died from CVDs in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to heart attack and stroke. Cardiometabolic risks, such as hypertension, excess weight, obesity, type 2 diabetes, and vascular diseases, contribut...

The adiposity, and the risks associated with this altered metabolic state, with acute cardiovascular events are poorly understood, and the relationship is a complex one. Abdominal obesity is known to cause alterations in adipocyte biology, leading to inflammation, dysglycemia, insulin resistance, increased blood pressure, endothelial dysfunction an...

Metabolic diseases such as hypertension, excess weight, obesity, and diabetes have increased to epidemic proportions globally, in the last four decades and contributed significantly to the excess morbidity and mortality. Cardiovascular diseases rank as number one killers, with over 17.8 million deaths per year worldwide. Framingham heart studies ha...

History of a professional society devoted to the development of novel approaches to the management and prevention of cardiometabolic diseases. Details the contribution of this professional society for over three decades: 1934-2023.

Several decades ago, we at the University of Minnesota, initiated studies to explore cell signaling mechanisms, that modulate the physiology/pathology, functions/dysfunctions, at cellular, tissue, and organ levels. We used a variety of molecules, to study the process at the ultrastructure level, as well as at biochemical, and molecular levels [1,2]...

These are some thoughts about the aging process and how there are multiple research groups.- trying to find an answer to the fundamental causes of aging. It also discusses some current clinical trials related to the development of anti-aging drugs.

Framingham Heart Study is a one-of-a-kind observational study, which discovered probable causes for developing risk for cardio-vascular diseases (CVDs). Based on this information, a large multinational, standardized case control study concluded, "that management of modifiable risks for CVDs, significantly reduced premature mortality". Data are avai...

This research proposal brings together the expertise of the staff of Lillehei Heart Institute(LHI), University of Minnesota, USA, Institute of Bioinformatics and Applied Biotechnology(IBAB), Bangalore, India, and Narayana Hrudayalaya (NH) a heart specialty hospital in Bangalore, India to address this very important health issue. We propose to devel...

Current coronavirus pandemic is unprecedented and the global response to a great extent, has demonstrated how unprepared we were, despite the past experiences of earlier 'flu' pandemics. Now we are in the third year of the pandemic, with the fifth COVID surge rising in many countries. The pandemic started, with the emergence of Alpha variant from W...

Altered blood glucose metabolism is ultimately responsible for all the clinical complications of type-2 diabetes. In this overview, we explain some of the mechanisms that are influenced or modulated by increased blood glucose levels.

A novel respiratory virus has developed into a severe killer and has caused unprecedented health and economic crisis worldwide. The standard clinical features of this disease include fever, dry cough, sore throat, headache, fatigue, and breathlessness. Considering that this is a closely related strain of the severe respiratory disease virus, clinic...

In the 1990s, DNA sequencing technologies could only read bite-sized pieces of DNA. Then came the human genome project (HGP), a thirteen-year international effort, 1990-2003, with the primary goal of discovering the complete set of human genes, sequencing nucleotides, and making the information accessible worldwide for further biological studies. W...

Severity of Covid-19 is enhanced by underlying comorbidities.

Unprecedented spread of a killer coronavirus from Wuhan, China, has caused a catastrophic public health and economic crisis worldwide. Since its initial discovery in late 2019, the virus has spread to all the countries, infected 237 million individuals, and caused death of 4.8 million individuals. No country was prepared to face such a devastating...

Some thoughts on the effect of man-made blunders on climate changes and its effect on planet earth.

Unprecedented pandemic of coronavirus has infected 250 million individuals, and killed 5 million people worldwide, since it was discovered in Wuhan, China, in 2019. Clinical studies conducted at several geographic locations, have observed that people with underlying health conditions experience, severe illness compared to those with no underlying h...

Pain, pleasure and adventures of eight-dollar immigrants to the USA from India.

What if the controversies are really true?

In an earlier essay on 'Unstructured Life," I wrote about my career development, and how I started a professional society (www.sasat.org) and edited several books on 'Cardiometabolic Diseases.' Last year I edited two books,-one on Type-2 diabetes and the other on coronary artery disease for JP Medical Publishers, New Delhi. I should have quit,-when...

According to one of the earliest definitions, biomedicine means “clinical medicine based on the principles of physiology and biochemistry.” Clinicians for quite some time preferred the use of the term medical research to describe what they considered the clinical findings pertaining to various issues related to clinical studies. Since the time when...

It is about the adventures of my life, -reflections.

Metabolic diseases, like hypertension, excess weight, obesity, type 2 diabetes, and vascular diseases, have rapidly increased to epidemic proportions worldwide. Metabolic risks (such as oxidative stress, chronic inflammation, insulin resistance, altered glucose and lipid metabolism, changes in hemodynamics, endothelial dysfunction, and subclinical...

Ravages of a 16 trillion-dollar killer virus (SARS-CoV2) worldwide, has caused an unprecedented healthcare crisis [1]. According to the global health experts, the coronavirus disease (COVID-19) pandemic has demonstrated the critical need, to reimagine and repair the broken systems of global health. Global experts in public health write in the Journ...

As is with any new innovations, from discovery to application, takes several decades of meticulous work, financial support by the various stakeholders, and dedicated work by the team of investigators. Consider, for instance, the success of biotechnology research during the last ten years. They have proved very useful in biomarker assays, molecular...

The role of Protein couple mechanisms in platelet activation mechanisms is well characterized, In this study we have demonstrated the use of specific inhibitor of these receptors to illustrate the role of GTP binding proteins in platelet activation.

According to the National Institutes of Health (NIH) USA, and the US Food and Drug Administration (FDA), there are no approved therapies for COVID-19 management. FDA has created a special emergency program for possible coronavirus therapies, the Coronavirus Treatment Acceleration Program(CTAP). Currently, there are 590 drug development programs in...

Metabolic disease such as hypertension, excess weight, obesity, type-2 diabetes, and vascular diseases, have reached epidemic proportions worldwide. Metabolic risks like oxidative stress, chronic inflammation, insulin resistance, glucose intolerance, altered blood flow dynamics, hardening of the arteries, endothelial dysfunction, and subclinical at...

Metabolic diseases such as hypertension, overweight, obesity, type-2 diabetes (T2D), cardiovascular disease, and cerebrovascular diseases have reached epidemic proportions worldwide. NCD Risk Factor Collaborators report (2016), “If post-2000 trends in the increase in the incidence of cardiometabolic diseases (CMDs) continue, the probability of meet...

Metabolic diseases, like hypertension, excess weight, obesity, type 2 diabetes, and vascular diseases, have rapidly increased to the progress of vascular disease and drive it eventually to acute vascular events like heart attacks and stroke. Although this situation has been noticed and discussed extensively by the global public health experts, and...

Need for the development of immunomodulators.

Purpose of life is a highly debated issue. No one seems to provide a real meaningful insight on this topic

General discussion about death, afterlife and purpose of life

Platelet adhesion on protein coated surfaces

Brief Review of Coronavirus Biochemistry, Transmission and Prevention

Unprecedented pandemic of coronavirus has caused serious health acn economic crisis worldwide. This killer virus has taken advantage of an existing pandemic, -cardiometabolic diseases (CMDs). Those with comorbidities seems to have much severe disease than those without these conditions. Furthermore, this virus unlike the SARS-CoV, which affects res...

Cardiometabolic diseases such as hypertension, excess weight, obesity, type-2 diabetes, and vascular diseases have reached epidemic proportions worldwide [1-8]. Globally, an estimated 26% of the population of the World's population (972 million) has hypertension. To achieve the global target to reduce the prevalence of hypertension by 25% by 2025,...

The new novel coronavirus was discovered by a Scottish virologist in London in 1964. As is usual with new discoveries, it seems the article she wrote about this discovery, was rejected by a peer reviewed journal. Dr Almeida wrote to the prestigious journal Nature (Nature 220, 1968), outlining her findings and proposed the name "coronavirus" for the...

Comorbidities for Covid-19 severity discussed.

According to the World Health Organization (WHO), cardiovascular diseases (CVD) are the number one cause of death globally, taking an estimated 18 million lives each year. Framingham Heart Study Group in Boston developed, the very first 10-year CVD risk prediction model. The WHO recently derived a 10-year risk prediction model, for fatal and non-fa...

If you want to be a true professional, you will do something outside yourself. Something to repair tears in your community. Something to make life a little better for people less fortunate than you. THAT’S WHAT I THINK A MEANINGFUL LIFE IS-LIVING NOT FOR ONE’S SELF, BUT FOR ONE’S COMMUNITY. Justice Ruth Bader Ginsburg.

Public Health Strategies for Prevention of Covid-19

Metabolic diseases such as hypertension, excess weight, obesity, type-2 diabetes, and vascular diseases, have reached epidemic proportions worldwide [1-4]. These diseases contribute significantly, to the overall morbidity and mortality related to cardiovascular diseases and stroke. Vascular diseases have remained the number one killers for over a c...

A bioassay method is described for fumigants.

Metabolic diseases such as hypertension, excess weight, obesity, type-2 diabetes, and vascular diseases, have reached epidemic proportions worldwide [1-4]. These diseases contribute significantly, to the overall morbidity and mortality related to cardiovascular diseases and stroke. Vascular diseases have remained number one killers for over a centu...

Anxiety, stress, fear to increase the circulating catecholamines, increase activation of platelet, and coagulation pathways. In this editorial, several examples have been provided to show that sudden trauma can indeed trigger acute vascular events. At the time of this writing, we do not know the impact of these emotional stressors on CVD events.

Metabolic diseases have rapidly progressed to epidemic proportions worldwide. In the last four decades, obesity has increased by four-fold and type-2 diabetes by twofold. Vascular diseases (VDs) have remained the number one killer and have retained this status for over a century. Despite some decline in the morbidity and premature mortality related...

SARS-CoV-2 is the most powerful killer virus. Coronavirus disease has caused an unprecedented pandemic worldwide. Clinical manifestations as they relate to acute vascular events are discussed

Legacy of Tibetan Medicine: Sparring between China and India: Who owns the legacy for this ancient art of healing? Of course, TIBETANS.

Editorial It gives me a great pleasure, to write this editorial to the journal of Acta Scientific; Pharmacology (AS Pharmacology). Editorials by nature, are opinion articles expressing a point of view. In this day and age of Personalized or Precision Medicine, definitions and boundaries of various medical specialties are fast disappearing. Pharmaco...

SARS CoV-2 virus has been considered to be a pathogen that causes respiratory illness. We propose that it also causes disease of the blood vessels.

Coronavirus 2019, a highly contagious pathogen has caused an unprecedented public health pandemic. In this editorial, we describe the comorbidity associated with this disease (COVID-19) and the clinical manifestations.

Increase in the incidence of metabolic risks, such as oxidative stress, low grade inflammation, excess weight, obesity, endothelial dysfunction, hardening of the arteries, subclinical atherosclerosis, type-2 diabetes, and vascular diseases is rapidly occurring worldwide. These chains of metabolic alterations, leading to acute vascular events like h...

Citation: Gundu HR Rao. "COVID-19 and Cardiometabolic Diseases". EC Cardiology 7.6 (2020): 08-12. Communicable diseases (CDs) as well as noncommunicable diseases (NCDs), are great public health problems, which create catastrophic economic damage, cause loss of precious lives, and are preventable. According to Harvard Gazette (August 08, 2018), "eig...

Coronavirus, Facts, controversies and predictions

The unprecedented pandemic of SARS CoV-2 has caused unexplainable fear, anxiety, agony, and frustration worldwide. People are hoping to see the light at the end of the tunnel not knowing when that happens.

Incidence and prevalence of cardiometabolic diseases have increased in the last four decades, to epidemic proportions worldwide. Despite a significant decline in the morbidity and mortality related, to cardiovascular diseases in industrialized nations, diabetes-related deaths are on the rise. Patients with type-2 diabetes, suffer from a greater ris...

Chronic metabolic diseases are basically diseases of lifestyle and an unhealthy diet. Hence lifestyle changes, healthy diet, and increased physical activity will reduce the incidence of these metabolic diseases

Citation: Rao HRG. Cardiometabolic diseases: biochemistry, pathophysiology and medical innovations (2020) Biochem Modern Appl 3: 1-5. Abstract It gives us great pleasure, to write this invited overview on, Biochemistry, Pathophysiology and Medical Innovations, to the Journal of Biochemistry and Modern Applications. In an earlier article on a simila...

Incidence and prevalence of cardiometabolic diseases have increased in the last four decades, to epidemic proportions worldwide. Despite a significant decline in the morbidity and mortality related, to cardiovascular diseases in industrialized nations, diabetes-related deaths are on the rise. Patients with type-2 diabetes, suffer from a greater ris...

Increase in the incidence of metabolic risks, such as oxidative stress, low grade inflammation, excess weight, obesity, endothelial dysfunction, hardening of the arteries, subclinical atherosclerosis, type-2 diabetes, and vascular diseases is rapidly occurring worldwide. These chains of metabolic alterations, leading to acute vascular events like h...

In 1885, the first-ever recorded use of oxygen was documented for a medical purpose. The medical procedure was, to treat a patient with pneumonia. Oxygen was mainly used in hospitals, to treat patients with a variety of respiratory issues. The first form of portable medical grade oxygen was developed in the 1950s, which led to the clinical use of o...

There is a considerable interest and lot of scientific pursuits, to reverse or stop biological aging process. A new study suggests, that scientist may be able to reverse ageing. In this study, volunteers who were given a cocktail of drugs for a year, actually "aged back-wards" losing an average of 2.5 years from their biological ages, according to...

There is a considerable interest and lot of scientific pursuits, to reverse or stop biological aging process. A new study suggests, that scientist may be able to revers ageing. In this study, volunteers who were given a cocktail of drugs for a year, actually "aged backwards" losing an average of 2.5 years from their biological ages, according to th...

Editorial about Cardiometabolic Diseases

An editorial expressing my viewpoints about this topic.

Strengths and constraints of Internet Search Engines

About an extraordinary clinician and a surgeon of Indian origin, who made a name for himself and for his fellow country men