Gulyaim Sagandykova

Gulyaim Sagandykova
Nicolaus Copernicus University | umk · Department of Environmental Chemistry and Bioanalytics

PhD

About

24
Publications
10,733
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
281
Citations
Citations since 2016
23 Research Items
281 Citations
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
Education
September 2015 - June 2017
September 2011 - June 2015

Publications

Publications (24)
Article
Full-text available
Nanostructures-assisted laser desorption/ionization mass spectrometry (NALDI-MS) is gaining attention for the analysis of a wide range of molecules. In this present investigation, Pseudostaurosira trainorii mediated biosynthesized iron-oxide nanoparticles (IONPs) have been utilized as nanostructures assisting ionization and desorption for laser des...
Article
Full-text available
The aim of the study was to investigate the process of Fe3+ binding to bLTF. Moreover, the physicochemical characterization of the respective supersaturated complex was studied. The knowledge should be important for the description of processes that may take place in dairy products fortified with iron. Additionally, the synthesized complex can be u...
Article
Full-text available
Mass spectrometric techniques can provide data on the composition of a studied sample, utilizing both targeted and untargeted approaches to solve various research problems. Analysis of compounds in the low mass range has practical implications in many areas of research and industry. Laser desorption ionization techniques are utilized for the analys...
Article
Full-text available
Antibiotic-resistant bacteria pose one of the major threats to human health worldwide. The issue is fundamental in the case of chronic wound treatment. One of the latest trends to overcome the problem is the search for new antibacterial agents based on silver. Thus, the aim of this research was to synthesize the silver-lactoferrin complex as a new...
Article
Full-text available
A facile approach for the synthesis of a silver nanostructured layer for application in surface-assisted laser desorption/ionization mass spectrometry of low-molecular-weight biomolecules was developed using electrochemical deposition. The deposition was carried out using the following silver salts: trifluoroacetate, acetate and nitrate, varying th...
Article
Full-text available
Anisotropy at the nanoscale fascinates researchers in various areas of science and technology. Well-known applications of anisotropic nanoparticles include biosensors and catalysis. However, utilization of gold nanostars in analytical chemistry is limited to surface enhanced Raman spectroscopy. LDI-MS assisted with gold nanostars has not been addre...
Article
Full-text available
One trend of the modern world is the search for new biologically active substances based on renewable resources. Milk proteins can be a solution for such purposes as they have been known for a long time as compounds that can be used for the manufacturing of multiple food and non-food products. Thus, the goal of the work was to investigate the param...
Chapter
Spectroscopic techniques have become an indispensable tool in research of biocolloids due to its advantages. Research and characterization of biocolloidal systems can be valuable to gain insights into their properties and, subsequently, applications. Spectroscopic analytical techniques can serve as complementary to each other, thus providing the ev...
Article
One of the significant trends that contemporary analytical chemistry follows is development of methodologies according to green chemistry concepts. There are several ways to make the separation techniques based methodologies “greener”. In this opinion all-aqueous chromatography as well as miniaturized separation systems are briefly discussed. Unequ...
Article
Quantitative structure-retention relationships (QSRRs) have found numerous applications in analytical science. Since first adaptation of linear free energy relationships for process of chromatographic separation, the significant progress in development of QSRR models has been achieved. Models gained statistical significance and improved values of p...
Article
The aim of the study was to develop an approach for synthesis of polypyrrole coating material and further fabrication of solid-phase microextraction fiber by direct electropolymerization on a stainless-steel wire. Surface morphology, porosity and thermal stability were evaluated by different physico-chemical methods. Synthesized polypyrrole fiber w...
Article
Full-text available
Predictive approaches on the activity of natural compounds based on the fragmentation by instrumental techniques are important for consideration of such molecules as drug candidates and defining new structures with promising properties. Since flavonoids are well‐known antioxidants, their redox properties can be related to their pharmacological acti...
Article
Full-text available
A combination of electrochemistry (EC) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (off-line EC-MALDI-TOF-MS) was applied for determination of the studied biologically active compounds (D-glucose, D-fructose, D-galactose, D-pinitol, L-chiro-inositol, and myo-inositol) and their possible electrochemical metabolit...
Chapter
Bioanaliza zaczyna odgrywać kluczową rolę w szybko rozwijających się dziedzinach współczesnej bionauki w ramach genomiki, proteomiki, metabolomiki, lipidomiki i innych. Umiejętność doboru odpowiednich metod i narzędzi, w zależności od rodzaju podejmowanego problemu, jest niezwykle ważne i często decyduje o powodzeniu zarówno kolejnych etapów jak i...
Article
Full-text available
Whey proteins tend to interact with metal ions, which have implications in different fields related to human life quality. There are two impacts of such interactions: they can provide opportunities for applications in food and nutraceuticals, but may lead to analytical challenges related to their study and outcomes for food processing, storage, and...
Article
Full-text available
This work aimed to unravel the retention mechanisms of 30 structurally different flavonoids separated on three chromatographic columns: conventional Kinetex C18 (K-C18), Kinetex F5 (K-F5), and IAM.PC.DD2. Interactions between analytes and chromatographic phases governing the retention were analyzed and mechanistically interpreted via quantum chemic...
Article
Flavonoids are natural compounds defined as plant secondary metabolites with various beneficial properties for human health that make them perspective drug candidates. However, research in this area should be deepened to collect reasonable amount of data to suggest biochemical mechanism of action that can be a key for evaluation of drug efficacy, s...
Article
Full-text available
The work presents the kinetic and isotherm studies of silver binding on casein, which was carried out using batch sorption technique. Moreover, the influence of light irradiation on the process was shown. In order to investigate the mechanism of metal ions sorption by casein the zero, pseudo-first order kinetics and Weber-Morris intra-particle diff...
Article
Due to the structural diversity of natural compounds in plants kingdom and a wide range of beneficial properties for health, they are attractive to use for various applications. Natural bioactivity means pharmacological effects induced by compounds of interest, which can be a subject of change under different conditions and dependent on individual...
Article
Full-text available
In this work, a target-based drug screening method is proposed exploiting the synergy effect of ligand-based and structure-based computer-assisted drug design. The new method provides great flexibility in drug design and drug candidates with considerably lower risk in an efficient manner. As a model system, 45 sulphonamides (33 training, 12 testing...
Article
Parameters of headspace solid-phase microextraction, such as fiber coating (85 μm CAR/PDMS), extraction time (2 min for white and 3 min for red wines), temperature (85 °C), pre-incubation time (15 min) were optimized for identification and quantification of semi-volatile additives (propylene glycol, sorbic and benzoic acids) in wines. To overcome p...

Questions

Questions (2)
Question
I need to find a free software that can help me to identify the structure of the compound based on m/z from mass spectra and show possible addition/deletion/cleavage of ring/functional groups (with indication of mass changes). Can somebody kindly advice me such one and send me the link?
Question
I've observed that my procedure of mobile phase preparation affects the reproducibility of results. I used volumetric flasks, cylinders (for addition of second solvent) that is not so comfortable also for everyday use as flasks have limited number of volumes and Eppendorf pippettes for addition of organic modifiers. How to make the procedure more accurate?
1. I am thinking about bottle-top dispensette for measuring volumes of solvents:
2. I also used Glassco filtering system, hovewer after 2 months it started to leak and I could not see the reason of it (probably glass had some cracks). Nylon 0.2 um filters were used together with mentioned system.
Could you please share with your experience and advice devices (for measuring solvents volumes and vacuum filtration) that you usually use for LC mobile phases preparation?
I usually work with acetonitrile, methanol and TFA, formic, acetic acids, ammonium acetate and formate as modifiers.

Network

Cited By

Projects

Projects (3)
Project
Dear Colleagues, Laser desorption ionization (LDI-MS) techniques allow for rapid, sensitive analysis of biomolecules such as proteins and peptides, as well as low molecular weight compounds requiring low sample volume. Great endeavors have been undertaken to propose organic matrices and inorganic materials with enhanced LDI-MS efficiency. Therefore, we would like to attract attention to advances in the studies for characterization of crystalline materials, their interactions with analytes, and subsequent applications in matrix-assisted and nano-assisted laser desorption/ionization. We encourage submissions reporting novel matrices for SALDI/NALDI/SELDI/MALDI techniques and their characterization using analytical techniques such as XRD, surface-enhanced Raman spectroscopy (SERS), UV–Vis-NIR, DLS, microscopic techniques (SEM, TEM, AFM), etc. as well as advanced techniques for the characterization of plasmonic and optical properties of materials. Furthermore, we welcome original research articles, communications, and review papers on applications of new matrices in LDI-MS techniques for applications in various areas of research. We hope that the Special Issue ‘Interactions of Crystalline Materials in the Light of LDI-MS Efficiency’ will become a global interdisciplinary platform to discuss recent advances in LDI-MS techniques. https://www.mdpi.com/journal/crystals/special_issues/Interactions_Crystalline_Materials_LDI_MS With kind regards, Dr. Gulyaim N. Sagandykova Dr. Paweł Pomastowski Guest Editors
Project
Development of selective coating materials based on conductive polymers with surface modification for analyses of volatile organic compounds from different biological matrixes.
Project
The project aims to develop cheap, fast and efficient methods for preparation of plates for nanoassisted laser desorption ionization of low molecular weight compounds to tackle the limitations of classical MALDI. Development of creative methods that reduce the time and costs of chemical synthesis of metal and metal oxide nanoparticles assisting ionization of small molecules is the main objective of the project.